Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis

Larry C Lands; Sanja Stanojevic

doi:10.1002/14651858.CD001505.pub4

Scolaris Content Display Scolaris Content Display

Contenido relacionado

Ir a:

Revisiones y protocolos relacionados
Guías
Temas

Revisiones y protocolos relacionados

Topics

Temas

Analysis 1.1

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 1 Annual rate of change in % predicted FEV1.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.2

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 2 Annual rate of change in % predicted FEV1 (split by age).

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.3

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 3 Annual rate of change in % predicted FVC.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.4

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 4 Annual rate of change in % predicted FVC (split by age).

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.5

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 5 Annual rate of change in % predicted FEF25‐75%.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.6

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 6 Annual rate of change in % predicted FEF25‐75% (split by age).

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.7

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 7 Proportion with at least one respiratory hospitalisation.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.8

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 8 Proportion with at least one hospital admission.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.9

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 9 Number of deaths.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.10

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 10 Annual rate of change in % ideal body weight.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.11

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 11 Annual rate of change in % ideal body weight (split by age).

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.12

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 12 Chest X‐ray score.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.13

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 13 Chest X‐ray score (split by age).

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.14

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 14 Increase in abdominal pain.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.15

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 15 Decrease in abdominal pain.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.16

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 16 Proportion with at least one gastrointestinal hospitalisation.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.17

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 17 Stool frequency.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.18

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 18 Occult blood.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.19

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 19 Increase in epistaxis.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.20

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 20 Decrease in epistaxis.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.21

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 21 Increase in conjunctivitis.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.22

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 22 Decrease in conjunctivitis.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.23

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 23 Increase in nausea.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Analysis 1.24

Comparison 1 Oral nonsteroidal anti‐inflammatory drug versus placebo, Outcome 24 Increase in diarrhoea.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 1. Oral nonsteroidal anti‐inflammatory drug versus placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Annual rate of change in % predicted FEV1 Show forest plot	2	226	Mean Difference (IV, Fixed, 95% CI)	1.32 [0.21, 2.42]

2 Annual rate of change in % predicted FEV1 (split by age) Show forest plot	2	226	Mean Difference (IV, Fixed, 95% CI)	1.16 [0.07, 2.25]

2.1 Under 13 years at randomisation	2	147	Mean Difference (IV, Fixed, 95% CI)	1.41 [0.03, 2.80]
2.2 13 years or over at randomisation	2	79	Mean Difference (IV, Fixed, 95% CI)	0.75 [‐1.02, 2.52]
3 Annual rate of change in % predicted FVC Show forest plot	2	226	Mean Difference (IV, Fixed, 95% CI)	1.27 [0.26, 2.28]

4 Annual rate of change in % predicted FVC (split by age) Show forest plot	2	226	Mean Difference (IV, Fixed, 95% CI)	1.09 [0.12, 2.06]

4.1 Under 13 years at randomisation	2	147	Mean Difference (IV, Fixed, 95% CI)	1.32 [0.04, 2.60]
4.2 13 years and over at randomisation	2	79	Mean Difference (IV, Fixed, 95% CI)	0.78 [‐0.71, 2.27]
5 Annual rate of change in % predicted FEF25‐75% Show forest plot	2	218	Mean Difference (IV, Fixed, 95% CI)	1.80 [0.15, 3.45]

6 Annual rate of change in % predicted FEF25‐75% (split by age) Show forest plot	2	214	Mean Difference (IV, Fixed, 95% CI)	1.72 [0.10, 3.34]

6.1 Under 13 years at randomisation	2	138	Mean Difference (IV, Fixed, 95% CI)	2.03 [‐0.09, 4.16]
6.2 13 years or older at randomisation	2	76	Mean Difference (IV, Fixed, 95% CI)	1.28 [‐1.22, 3.79]
7 Proportion with at least one respiratory hospitalisation Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

8 Proportion with at least one hospital admission Show forest plot	4	286	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.61 [0.37, 1.01]

9 Number of deaths Show forest plot	3	245	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]

10 Annual rate of change in % ideal body weight Show forest plot	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected

11 Annual rate of change in % ideal body weight (split by age) Show forest plot	1	84	Mean Difference (IV, Fixed, 95% CI)	0.81 [0.08, 1.53]

11.1 Under 13 years at randomisation	1	49	Mean Difference (IV, Fixed, 95% CI)	1.45 [0.33, 2.57]
11.2 13 years or older at randomisation	1	35	Mean Difference (IV, Fixed, 95% CI)	0.34 [‐0.61, 1.29]
12 Chest X‐ray score Show forest plot	2	226	Mean Difference (IV, Fixed, 95% CI)	0.37 [‐0.08, 0.81]

13 Chest X‐ray score (split by age) Show forest plot	1	84	Mean Difference (IV, Fixed, 95% CI)	0.51 [‐0.04, 1.07]

13.1 Under 13 years at randomisation	1	49	Mean Difference (IV, Fixed, 95% CI)	0.45 [‐0.24, 1.14]
13.2 13 years or older at randomisation	1	35	Mean Difference (IV, Fixed, 95% CI)	0.63 [‐0.30, 1.56]
14 Increase in abdominal pain Show forest plot	2	226	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.54 [0.20, 1.48]

15 Decrease in abdominal pain Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

16 Proportion with at least one gastrointestinal hospitalisation Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

17 Stool frequency Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

18 Occult blood Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

19 Increase in epistaxis Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

20 Decrease in epistaxis Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

21 Increase in conjunctivitis Show forest plot	2	226	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.72 [0.22, 2.40]

22 Decrease in conjunctivitis Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

23 Increase in nausea Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

24 Increase in diarrhoea Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

Comparison 1. Oral nonsteroidal anti‐inflammatory drug versus placebo

Ir a la tabla de la revisión

The Cochrane Library

Scolaris Language Selector Scolaris Language Selector

Idioma de la Revisión Cochrane

Idioma de la web

Scolaris Content Language Banner Portlet Scolaris Content Language Banner Portlet