| 1 50% responder rate ‐ post‐titration Show forest plot | 4 | | Risk Ratio (M‐H, Fixed, 95% CI) | Subtotals only |
|
| 1.1 Any dose | 4 | 850 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.98 [1.51, 2.59] |
| 1.2 300 ‐ 500 mg zonisamide | 4 | 793 | Risk Ratio (M‐H, Fixed, 95% CI) | 2.04 [1.55, 2.67] |
| 2 50% responder rate ‐ whole treatment period Show forest plot | 4 | | Risk Ratio (M‐H, Fixed, 95% CI) | Subtotals only |
|
| 2.1 Any dose | 4 | 850 | Risk Ratio (M‐H, Fixed, 95% CI) | 2.35 [1.74, 3.17] |
| 2.2 300 ‐ 500 mg zonisamide | 4 | 793 | Risk Ratio (M‐H, Fixed, 95% CI) | 2.44 [1.81, 3.30] |
| 3 50% responder rate ‐ best case Show forest plot | 4 | 850 | Risk Ratio (M‐H, Fixed, 95% CI) | 2.57 [1.99, 3.31] |
|
| 4 50% responder rate ‐ worst case Show forest plot | 4 | 850 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.43 [1.14, 1.81] |
|
| 5 50% responder rate ‐ dose effect Brodie 2005 Show forest plot | 1 | | Risk Ratio (M‐H, Fixed, 95% CI) | Totals not selected |
|
| 5.1 100 mg per day | 1 | | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 5.2 300 mg per day | 1 | | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 5.3 500 mg per day | 1 | | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 6 50% responder rate ‐ dose effect Faught 2001 Show forest plot | 1 | | Risk Ratio (M‐H, Fixed, 95% CI) | Totals not selected |
|
| 6.1 100 mg per day | 1 | | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 6.2 200 mg per day | 1 | | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 6.3 400 mg per day | 1 | | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Withdrawal rates Show forest plot | 4 | | Risk Ratio (M‐H, Fixed, 95% CI) | Subtotals only |
|
| 7.1 Any dose | 4 | 850 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.47 [1.07, 2.02] |
| 7.2 300 ‐ 500 mg zonisamide | 4 | 793 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.64 [1.20, 2.26] |
| 8 Adverse events Show forest plot | 4 | | Risk Ratio (M‐H, Fixed, 99% CI) | Subtotals only |
|
| 8.1 Ataxia | 3 | 499 | Risk Ratio (M‐H, Fixed, 99% CI) | 4.50 [1.05, 19.22] |
| 8.2 Dizziness | 4 | 850 | Risk Ratio (M‐H, Fixed, 99% CI) | 1.77 [1.00, 3.12] |
| 8.3 Nausea | 3 | 499 | Risk Ratio (M‐H, Fixed, 99% CI) | 1.50 [0.69, 3.28] |
| 8.4 Fatigue | 3 | 499 | Risk Ratio (M‐H, Fixed, 99% CI) | 1.32 [0.69, 2.50] |
| 8.5 Somnolence | 4 | 850 | Risk Ratio (M‐H, Fixed, 99% CI) | 1.96 [1.12, 3.44] |
| 8.6 Agitation/irritability | 3 | 499 | Risk Ratio (M‐H, Fixed, 99% CI) | 2.37 [1.00, 5.64] |
| 8.7 Anorexia | 3 | 499 | Risk Ratio (M‐H, Fixed, 99% CI) | 3.00 [1.31, 6.88] |
