Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants

Scolaris Content Display Scolaris Content Display

Ir a:

Figure 1

Forest plot of comparison: 1 Slow versus faster rates of feed advancement, outcome: 1.1 Incidence of necrotising enterocolitis.

Figure 2

Forest plot of comparison: 1 Slow versus faster rates of feed advancement, outcome: 1.2 Mortality.

Figure 3

Forest plot of comparison: 1 Slow versus faster rates of feed advancement, outcome: 1.3 Feeds intolerance (causing interruption of enteral feeding).

Figure 4

Forest plot of comparison: 1 Slow versus faster rates of feed advancement, outcome: 1.4 Incidence of invasive infection.

Figure 5

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Analysis 1.1

Comparison 1 Slow versus faster rates of feed advancement, Outcome 1 Incidence of necrotising enterocolitis.

Analysis 1.2

Comparison 1 Slow versus faster rates of feed advancement, Outcome 2 Mortality.

Analysis 1.3

Comparison 1 Slow versus faster rates of feed advancement, Outcome 3 Feeds intolerance (causing interruption of enteral feeding).

Analysis 1.4

Comparison 1 Slow versus faster rates of feed advancement, Outcome 4 Incidence of invasive infection.

Comparison 1. Slow versus faster rates of feed advancement

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incidence of necrotising enterocolitis Show forest plot	6		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

1.1 All trials	6	618	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.55, 1.70]
1.2 Trials in which most infants were small for gestational age or growth restricted	2	83	Risk Ratio (M‐H, Fixed, 95% CI)	0.34 [0.06, 2.04]
2 Mortality Show forest plot	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

2.1 All trials	5	460	Risk Ratio (M‐H, Fixed, 95% CI)	1.57 [0.92, 2.70]
2.2 Trials in which most infants were small for gestational age or growth restricted	2	83	Risk Ratio (M‐H, Fixed, 95% CI)	2.13 [1.02, 4.47]
3 Feeds intolerance (causing interruption of enteral feeding) Show forest plot	4	275	Risk Ratio (M‐H, Fixed, 95% CI)	1.23 [0.87, 1.73]

4 Incidence of invasive infection Show forest plot	3	222	Risk Ratio (M‐H, Fixed, 95% CI)	1.58 [0.81, 3.09]

Comparison 1. Slow versus faster rates of feed advancement