Antimicrobial prophylaxis for colorectal surgery

Richard L Nelson; Anne Marie Glenny; Fujian Song

doi:10.1002/14651858.CD001181.pub3

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Analysis 1.1

Comparison 1 Antibiotic versus no antibiotic/placebo, Outcome 1 Surgical wound infection (SWI).

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Analysis 2.1

Comparison 2 Duration of therapy, Outcome 1 Surgical wound infection (SWI).

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Analysis 2.2

Comparison 2 Duration of therapy, Outcome 2 Surgical wound infection (SWI).

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Analysis 3.1

Comparison 3 Additional aerobic coverage, Outcome 1 Surgical wound infection (SWI).

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Analysis 4.1

Comparison 4 Additional anaerobic coverage, Outcome 1 Surgical wound infection (SWI).

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Analysis 5.1

Comparison 5 Oral versus intravenous, Outcome 1 Surgical wound infection (SWI).

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Analysis 6.1

Comparison 6 Combined oral and intravenous versus oral or intravenous alone, Outcome 1 Surgical wound infection: oral + iv versus iv alone.

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Analysis 6.2

Comparison 6 Combined oral and intravenous versus oral or intravenous alone, Outcome 2 Surgical wound infection: combined oral and iv versus oral alone.

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Analysis 7.1

Comparison 7 Antibiotic choice versus a gold standard, Outcome 1 Surgical wound infection (SWI).

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Comparison 1. Antibiotic versus no antibiotic/placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Surgical wound infection (SWI) Show forest plot	10	813	Risk Ratio (M‐H, Random, 95% CI)	0.30 [0.22, 0.41]

Comparison 1. Antibiotic versus no antibiotic/placebo

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Comparison 2. Duration of therapy

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Surgical wound infection (SWI) Show forest plot	24	3541	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.88, 1.27]

2 Surgical wound infection (SWI) Show forest plot	3	522	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.67, 2.05]

Comparison 2. Duration of therapy

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Comparison 3. Additional aerobic coverage

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Surgical wound infection (SWI) Show forest plot	11	1269	Risk Ratio (M‐H, Random, 95% CI)	0.41 [0.23, 0.71]

Comparison 3. Additional aerobic coverage

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Comparison 4. Additional anaerobic coverage

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Surgical wound infection (SWI) Show forest plot	15	2394	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.35, 0.85]

Comparison 4. Additional anaerobic coverage

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Comparison 5. Oral versus intravenous

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Surgical wound infection (SWI) Show forest plot	1	72	Risk Ratio (M‐H, Random, 95% CI)	2.11 [0.20, 22.29]

Comparison 5. Oral versus intravenous

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Comparison 6. Combined oral and intravenous versus oral or intravenous alone

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Surgical wound infection: oral + iv versus iv alone Show forest plot	13	2362	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.41, 0.74]

2 Surgical wound infection: combined oral and iv versus oral alone Show forest plot	3	283	Risk Ratio (M‐H, Random, 95% CI)	0.34 [0.13, 0.87]

Comparison 6. Combined oral and intravenous versus oral or intravenous alone

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Comparison 7. Antibiotic choice versus a gold standard

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Surgical wound infection (SWI) Show forest plot	28		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only

Comparison 7. Antibiotic choice versus a gold standard

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