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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 1 FVC (L).
Figuras y tablas -
Analysis 1.1

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 1 FVC (L).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 2 MVV (L/min).
Figuras y tablas -
Analysis 1.2

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 2 MVV (L/min).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 3 FEV1/FVC (%).
Figuras y tablas -
Analysis 1.3

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 3 FEV1/FVC (%).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 4 RV (L).
Figuras y tablas -
Analysis 1.4

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 4 RV (L).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 5 Heart rate (bpm).
Figuras y tablas -
Analysis 1.5

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 5 Heart rate (bpm).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 6 VE (L/min).
Figuras y tablas -
Analysis 1.6

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 6 VE (L/min).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 7 Arterial pH (units).
Figuras y tablas -
Analysis 1.7

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 7 Arterial pH (units).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 8 PaCO2 (mm Hg).
Figuras y tablas -
Analysis 1.8

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 8 PaCO2 (mm Hg).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 9 PaO2 (mm Hg).
Figuras y tablas -
Analysis 1.9

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 9 PaO2 (mm Hg).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 10 Distance walked on pedometer (miles/day).
Figuras y tablas -
Analysis 1.10

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 10 Distance walked on pedometer (miles/day).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 11 6MWD (meters).
Figuras y tablas -
Analysis 1.11

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 11 6MWD (meters).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 12 Borg score ‐ dyspnea (higher score worse).
Figuras y tablas -
Analysis 1.12

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 12 Borg score ‐ dyspnea (higher score worse).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 13 Desaturation (% fall in SaO2).
Figuras y tablas -
Analysis 1.13

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 13 Desaturation (% fall in SaO2).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 14 Quality of life (Chronic respiratory disease questionnaire).
Figuras y tablas -
Analysis 1.14

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 14 Quality of life (Chronic respiratory disease questionnaire).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 15 Step exercise testing (number of steps).
Figuras y tablas -
Analysis 1.15

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 15 Step exercise testing (number of steps).

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Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 16 DLco (ml/min/mm Hg).
Figuras y tablas -
Analysis 1.16

Comparison 1 Ambulatory oxygen therapy versus Placebo (air), Outcome 16 DLco (ml/min/mm Hg).

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Comparison 1. Ambulatory oxygen therapy versus Placebo (air)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 FVC (L) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

0.03 [‐0.53, 0.59]

2 MVV (L/min) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

‐1.0 [‐8.45, 6.45]

3 FEV1/FVC (%) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

‐4.0 [‐18.33, 10.33]

4 RV (L) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

‐0.22 [‐1.47, 1.03]

5 Heart rate (bpm) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

5.1 At rest

1

18

Mean Difference (IV, Fixed, 95% CI)

‐6.0 [‐13.97, 1.97]

5.2 Maximal exercise

1

18

Mean Difference (IV, Fixed, 95% CI)

0.0 [‐9.08, 9.08]

6 VE (L/min) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

6.1 At rest

1

18

Mean Difference (IV, Fixed, 95% CI)

‐0.40 [‐5.50, 4.70]

6.2 Maximal exercise

1

18

Mean Difference (IV, Fixed, 95% CI)

‐11.0 [‐17.53, ‐4.47]

7 Arterial pH (units) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

7.1 At rest

1

18

Mean Difference (IV, Fixed, 95% CI)

‐0.02 [‐0.12, 0.08]

7.2 Maximal exercise

1

18

Mean Difference (IV, Fixed, 95% CI)

‐0.04 [‐0.30, 0.22]

8 PaCO2 (mm Hg) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

8.1 At rest

1

18

Mean Difference (IV, Fixed, 95% CI)

2.0 [‐9.56, 13.56]

8.2 Maximal exercise

1

18

Mean Difference (IV, Fixed, 95% CI)

‐4.0 [‐20.37, 12.37]

9 PaO2 (mm Hg) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

9.1 At rest

1

18

Mean Difference (IV, Fixed, 95% CI)

17.0 [9.13, 24.87]

9.2 Maximal exercise

1

18

Mean Difference (IV, Fixed, 95% CI)

15.0 [‐2.59, 32.59]

10 Distance walked on pedometer (miles/day) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

0.32 [‐0.31, 0.95]

11 6MWD (meters) Show forest plot

1

52

Mean Difference (IV, Fixed, 95% CI)

15.0 [‐33.94, 63.94]

12 Borg score ‐ dyspnea (higher score worse) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

12.1 During 6MWD

1

52

Mean Difference (IV, Fixed, 95% CI)

‐0.10 [‐0.79, 0.59]

12.2 During step exercise test

1

52

Mean Difference (IV, Fixed, 95% CI)

‐0.30 [‐0.98, 0.38]

13 Desaturation (% fall in SaO2) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

13.1 During 6MWD

1

52

Mean Difference (IV, Fixed, 95% CI)

0.60 [‐2.25, 3.45]

13.2 During step exercise test

1

52

Mean Difference (IV, Fixed, 95% CI)

0.60 [‐1.36, 2.56]

14 Quality of life (Chronic respiratory disease questionnaire) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

14.1 Dyspnea

1

52

Mean Difference (IV, Fixed, 95% CI)

2.0 [‐1.26, 5.26]

14.2 Fatigue

1

52

Mean Difference (IV, Fixed, 95% CI)

1.0 [‐1.17, 3.17]

14.3 Emotional function

1

52

Mean Difference (IV, Fixed, 95% CI)

1.0 [‐3.63, 5.63]

14.4 Mastery

1

52

Mean Difference (IV, Fixed, 95% CI)

1.0 [‐2.00, 4.00]

15 Step exercise testing (number of steps) Show forest plot

1

52

Mean Difference (IV, Fixed, 95% CI)

3.0 [‐6.52, 12.52]

16 DLco (ml/min/mm Hg) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

‐0.30 [‐8.47, 7.87]
Figuras y tablas -
Comparison 1. Ambulatory oxygen therapy versus Placebo (air)
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