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Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 1 Total pain.
Figuras y tablas -
Analysis 1.1

Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 1 Total pain.

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Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 2 Pelvic pain.
Figuras y tablas -
Analysis 1.2

Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 2 Pelvic pain.

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Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 3 Low back pain.
Figuras y tablas -
Analysis 1.3

Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 3 Low back pain.

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Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 4 Defaecation pain.
Figuras y tablas -
Analysis 1.4

Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 4 Defaecation pain.

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Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 5 Adverse events.
Figuras y tablas -
Analysis 1.5

Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 5 Adverse events.

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Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 6 AFS scores, total ‐ 12 months (six months after stopping treatment).
Figuras y tablas -
Analysis 1.6

Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 6 AFS scores, total ‐ 12 months (six months after stopping treatment).

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Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 7 AFS scores, total ‐ change in.
Figuras y tablas -
Analysis 1.7

Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 7 AFS scores, total ‐ change in.

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Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 8 Total or partial resoultion of peritoneal endometriotic implants.
Figuras y tablas -
Analysis 1.8

Comparison 1 Danazol versus placebo ‐ no surgery, Outcome 8 Total or partial resoultion of peritoneal endometriotic implants.

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 1 Total pain.
Figuras y tablas -
Analysis 2.1

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 1 Total pain.

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 2 Pelvic pain.
Figuras y tablas -
Analysis 2.2

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 2 Pelvic pain.

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 3 Moderate or severe pain 6 months or more after followup.
Figuras y tablas -
Analysis 2.3

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 3 Moderate or severe pain 6 months or more after followup.

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 4 Adverse events.
Figuras y tablas -
Analysis 2.4

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 4 Adverse events.

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 5 Satisfaction with treatment.
Figuras y tablas -
Analysis 2.5

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 5 Satisfaction with treatment.

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 6 Weight gain.
Figuras y tablas -
Analysis 2.6

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 6 Weight gain.

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 7 AFS scores, total ‐ 12 months (six months after stopping treatment).
Figuras y tablas -
Analysis 2.7

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 7 AFS scores, total ‐ 12 months (six months after stopping treatment).

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 8 AFS scores, total ‐ change in.
Figuras y tablas -
Analysis 2.8

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 8 AFS scores, total ‐ change in.

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 9 AFS scores, peritoneal and ovarian ‐ 12 months (six months after stopping treatment).
Figuras y tablas -
Analysis 2.9

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 9 AFS scores, peritoneal and ovarian ‐ 12 months (six months after stopping treatment).

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Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 10 Resolution of endometriotic implants at laparoscopy.
Figuras y tablas -
Analysis 2.10

Comparison 2 Danazol versus placebo ‐ post surgery, Outcome 10 Resolution of endometriotic implants at laparoscopy.

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Table 1. Table of included studies risk of bias

Study ID

Concealed allocation

Method of randomisat

Losses to followup

Post random exclus

Intention to treat

Blinding

Bianci 1999

Not stated

Computer generated list

None

None

yes

Open study

Kaupilla 1988

Not stated

Not stated

None

None

yes

Double blind

Telimaa 1987a

Not stated

Not stated

None

9 ‐ 4 in the MPA group and 2 in the danazol group and 3 in the placebo group (5 for pregnancies)

no

Double blind

Telimaa 1987b

Not stated

Not stated

None

9 ‐ 3 in the MPA group, 2 in the danazol group and 4 in the placebo group, 8 for pregnancies

no

Double blind

Telimaa 1990

Not stated

Not stated

None

None

yes

Unclear
Figuras y tablas -
Table 1. Table of included studies risk of bias
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Comparison 1. Danazol versus placebo ‐ no surgery

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Total pain Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 Three months of treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐4.95 [‐6.61, ‐3.29]

1.2 Six months of treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐5.7 [‐7.51, ‐3.89]

1.3 Six months after stopping treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐7.50 [‐9.38, ‐5.62]

2 Pelvic pain Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 Three months of treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐0.65 [‐0.90, ‐0.40]

2.2 Six months of treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐1.40 [‐1.68, ‐1.12]

2.3 Six months after stopping treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐1.05 [‐1.33, ‐0.77]

3 Low back pain Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 Six months of treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐0.90 [‐1.25, ‐0.55]

3.2 Six months after stopping treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐1.2 [‐1.55, ‐0.85]

4 Defaecation pain Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

4.1 6 months of treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐0.77 [‐1.10, ‐0.44]

4.2 6 months after stopping treatment

1

35

Mean Difference (IV, Fixed, 95% CI)

‐0.68 [‐0.99, ‐0.37]

5 Adverse events Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

5.1 Oedema at six months

1

35

Odds Ratio (M‐H, Fixed, 95% CI)

12.8 [1.38, 118.32]

5.2 Acne at six months

1

35

Odds Ratio (M‐H, Fixed, 95% CI)

25.14 [2.70, 234.17]

5.3 Vaginal spotting at six months

1

35

Odds Ratio (M‐H, Fixed, 95% CI)

1.79 [0.36, 9.05]

5.4 Muscle cramps at six months

1

35

Odds Ratio (M‐H, Fixed, 95% CI)

18.2 [0.94, 353.55]

6 AFS scores, total ‐ 12 months (six months after stopping treatment) Show forest plot

1

31

Mean Difference (IV, Fixed, 95% CI)

‐0.40 [‐1.58, 0.78]

7 AFS scores, total ‐ change in Show forest plot

1

31

Mean Difference (IV, Fixed, 95% CI)

‐1.9 [‐4.16, 0.36]

8 Total or partial resoultion of peritoneal endometriotic implants Show forest plot

1

32

Odds Ratio (M‐H, Fixed, 95% CI)

5.0 [0.83, 30.28]
Figuras y tablas -
Comparison 1. Danazol versus placebo ‐ no surgery
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Comparison 2. Danazol versus placebo ‐ post surgery

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Total pain Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 3 months of treatment

1

34

Mean Difference (IV, Fixed, 95% CI)

‐2.2 [‐3.59, ‐0.81]

1.2 6 months of treatment

1

34

Mean Difference (IV, Fixed, 95% CI)

‐4.2 [‐5.71, ‐2.69]

1.3 6 months or more after treatment

1

34

Mean Difference (IV, Fixed, 95% CI)

‐1.80 [‐3.18, ‐0.42]

2 Pelvic pain Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 3 months of treatment

1

34

Mean Difference (IV, Fixed, 95% CI)

‐0.52 [‐0.80, ‐0.24]

2.2 6 months of treatment

1

34

Mean Difference (IV, Fixed, 95% CI)

‐1.1 [‐1.38, ‐0.82]

2.3 6 months after treatment

1

34

Mean Difference (IV, Fixed, 95% CI)

‐0.47 [‐0.75, ‐0.19]

3 Moderate or severe pain 6 months or more after followup Show forest plot

1

60

Odds Ratio (M‐H, Fixed, 95% CI)

0.65 [0.20, 2.05]

4 Adverse events Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

4.1 vaginal spotting

1

34

Odds Ratio (M‐H, Fixed, 95% CI)

18.75 [2.02, 173.94]

4.2 acne

1

34

Odds Ratio (M‐H, Fixed, 95% CI)

18.75 [2.02, 173.94]

5 Satisfaction with treatment Show forest plot

1

34

Peto Odds Ratio (Peto, Fixed, 95% CI)

9.94 [2.61, 37.81]

6 Weight gain Show forest plot

1

34

Mean Difference (IV, Fixed, 95% CI)

3.0 [1.34, 4.66]

7 AFS scores, total ‐ 12 months (six months after stopping treatment) Show forest plot

1

27

Mean Difference (IV, Fixed, 95% CI)

‐3.50 [‐5.27, ‐1.73]

8 AFS scores, total ‐ change in Show forest plot

1

27

Mean Difference (IV, Fixed, 95% CI)

‐0.90 [‐3.02, 1.22]

9 AFS scores, peritoneal and ovarian ‐ 12 months (six months after stopping treatment) Show forest plot

1

34

Mean Difference (IV, Fixed, 95% CI)

‐2.1 [‐3.90, ‐0.30]

10 Resolution of endometriotic implants at laparoscopy Show forest plot

1

34

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.72 [0.44, 6.74]
Figuras y tablas -
Comparison 2. Danazol versus placebo ‐ post surgery
Ir a la tabla de la revisión