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Study flow diagram.
Figuras y tablas -
Figure 1

Study flow diagram.

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'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies. Seven studies are included in this review.
Figuras y tablas -
Figure 2

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies. Seven studies are included in this review.

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'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 3

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

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Comparison 1 Barbiturate vs no barbiturate, Outcome 1 Death at the end of follow‐up.
Figuras y tablas -
Analysis 1.1

Comparison 1 Barbiturate vs no barbiturate, Outcome 1 Death at the end of follow‐up.

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Comparison 1 Barbiturate vs no barbiturate, Outcome 2 Death or severe disability at the end of follow‐up.
Figuras y tablas -
Analysis 1.2

Comparison 1 Barbiturate vs no barbiturate, Outcome 2 Death or severe disability at the end of follow‐up.

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Comparison 1 Barbiturate vs no barbiturate, Outcome 3 Uncontrolled ICP during treatment.
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Analysis 1.3

Comparison 1 Barbiturate vs no barbiturate, Outcome 3 Uncontrolled ICP during treatment.

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Comparison 1 Barbiturate vs no barbiturate, Outcome 4 Mean ICP during treatment.
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Analysis 1.4

Comparison 1 Barbiturate vs no barbiturate, Outcome 4 Mean ICP during treatment.

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Comparison 1 Barbiturate vs no barbiturate, Outcome 5 Mean arterial pressure during treatment.
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Analysis 1.5

Comparison 1 Barbiturate vs no barbiturate, Outcome 5 Mean arterial pressure during treatment.

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Comparison 1 Barbiturate vs no barbiturate, Outcome 6 Hypotension during treatment.
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Analysis 1.6

Comparison 1 Barbiturate vs no barbiturate, Outcome 6 Hypotension during treatment.

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Comparison 1 Barbiturate vs no barbiturate, Outcome 7 Mean body temperature during treatment.
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Analysis 1.7

Comparison 1 Barbiturate vs no barbiturate, Outcome 7 Mean body temperature during treatment.

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Comparison 2 Barbiturate vs Mannitol, Outcome 1 Death at the end of follow‐up (1 year).
Figuras y tablas -
Analysis 2.1

Comparison 2 Barbiturate vs Mannitol, Outcome 1 Death at the end of follow‐up (1 year).

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Comparison 2 Barbiturate vs Mannitol, Outcome 2 Uncontrolled ICP during treatment.
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Analysis 2.2

Comparison 2 Barbiturate vs Mannitol, Outcome 2 Uncontrolled ICP during treatment.

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Comparison 3 Pentobarbital vs Thiopental, Outcome 1 Death at the end of follow‐up (6 months).
Figuras y tablas -
Analysis 3.1

Comparison 3 Pentobarbital vs Thiopental, Outcome 1 Death at the end of follow‐up (6 months).

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Comparison 3 Pentobarbital vs Thiopental, Outcome 2 Death or severe disability at the end of follow‐up (6 months).
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Analysis 3.2

Comparison 3 Pentobarbital vs Thiopental, Outcome 2 Death or severe disability at the end of follow‐up (6 months).

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Comparison 3 Pentobarbital vs Thiopental, Outcome 3 Uncontrolled ICP during treatment.
Figuras y tablas -
Analysis 3.3

Comparison 3 Pentobarbital vs Thiopental, Outcome 3 Uncontrolled ICP during treatment.

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Comparison 3 Pentobarbital vs Thiopental, Outcome 4 Hypotension during treatment.
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Analysis 3.4

Comparison 3 Pentobarbital vs Thiopental, Outcome 4 Hypotension during treatment.

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Comparison 1. Barbiturate vs no barbiturate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Death at the end of follow‐up Show forest plot

3

208

Risk Ratio (M‐H, Fixed, 95% CI)

1.09 [0.81, 1.47]

2 Death or severe disability at the end of follow‐up Show forest plot

2

135

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.81, 1.64]

3 Uncontrolled ICP during treatment Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Mean ICP during treatment Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5 Mean arterial pressure during treatment Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6 Hypotension during treatment Show forest plot

2

126

Risk Ratio (M‐H, Fixed, 95% CI)

1.80 [1.19, 2.70]

7 Mean body temperature during treatment Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 1. Barbiturate vs no barbiturate
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Comparison 2. Barbiturate vs Mannitol

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Death at the end of follow‐up (1 year) Show forest plot

1

59

Risk Ratio (M‐H, Fixed, 95% CI)

1.21 [0.75, 1.94]

1.1 Haematoma

1

29

Risk Ratio (M‐H, Fixed, 95% CI)

0.8 [0.36, 1.80]

1.2 No haematoma

1

30

Risk Ratio (M‐H, Fixed, 95% CI)

1.63 [0.91, 2.94]

2 Uncontrolled ICP during treatment Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 2. Barbiturate vs Mannitol
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Comparison 3. Pentobarbital vs Thiopental

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Death at the end of follow‐up (6 months) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Death or severe disability at the end of follow‐up (6 months) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Uncontrolled ICP during treatment Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Hypotension during treatment Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 3. Pentobarbital vs Thiopental
Ir a la tabla de la revisión