Scolaris Content Display Scolaris Content Display

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 1 Vaginal delivery not achieved within 24 hours.
Figures and Tables -
Analysis 1.1

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 1 Vaginal delivery not achieved within 24 hours.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 1.2

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 1.3

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 3 Caesarean section.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 1.4

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 5 Serious maternal morbidity or death.
Figures and Tables -
Analysis 1.5

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 5 Serious maternal morbidity or death.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 1.8

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 9 Uterine rupture.
Figures and Tables -
Analysis 1.9

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 9 Uterine rupture.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 1.10

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 10 Epidural analgesia.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 1.11

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 11 Instrumental vaginal delivery.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 12 Meconium‐stained liquor.
Figures and Tables -
Analysis 1.12

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 12 Meconium‐stained liquor.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 1.13

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 14 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 1.14

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 14 Neonatal intensive care unit admission.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 16 Perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 1.16

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 16 Perinatal death, excluding major congenital anomalies.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 19 Nausea.
Figures and Tables -
Analysis 1.19

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 19 Nausea.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 20 Vomiting.
Figures and Tables -
Analysis 1.20

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 20 Vomiting.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 21 Diarrhoea.
Figures and Tables -
Analysis 1.21

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 21 Diarrhoea.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 1.23

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 23 Postpartum haemorrhage.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 26 Woman not satisfied.
Figures and Tables -
Analysis 1.26

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 26 Woman not satisfied.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 28 Chorioamnionitis.
Figures and Tables -
Analysis 1.28

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 28 Chorioamnionitis.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 29 Endometritis.
Figures and Tables -
Analysis 1.29

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 29 Endometritis.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 30 Maternal antibiotics.
Figures and Tables -
Analysis 1.30

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 30 Maternal antibiotics.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 31 Neonatal infection.
Figures and Tables -
Analysis 1.31

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 31 Neonatal infection.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 32 Neonatal antibiotics.
Figures and Tables -
Analysis 1.32

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 32 Neonatal antibiotics.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 33 Neonatal jaundice.
Figures and Tables -
Analysis 1.33

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 33 Neonatal jaundice.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 34 Neonatal respiratory distress syndrome.
Figures and Tables -
Analysis 1.34

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 34 Neonatal respiratory distress syndrome.

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 35 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 1.35

Comparison 1 Oxytocin alone vs placebo/expectant mx: all women, Outcome 35 Apgar score < 7 at 1 minute.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 1 Vaginal delivery not achieved within 24 hours.
Figures and Tables -
Analysis 2.1

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 1 Vaginal delivery not achieved within 24 hours.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 2.3

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 3 Caesarean section.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 2.4

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 5 Serious maternal morbidity or death.
Figures and Tables -
Analysis 2.5

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 5 Serious maternal morbidity or death.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 2.8

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 2.10

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 10 Epidural analgesia.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 2.11

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 11 Instrumental vaginal delivery.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 2.13

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 14 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 2.14

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 14 Neonatal intensive care unit admission.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 16 Perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 2.16

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 16 Perinatal death, excluding major congenital anomalies.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 2.23

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 23 Postpartum haemorrhage.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 28 Chorioamnionitis.
Figures and Tables -
Analysis 2.28

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 28 Chorioamnionitis.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 29 Endometritis.
Figures and Tables -
Analysis 2.29

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 29 Endometritis.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 31 Neonatal infection.
Figures and Tables -
Analysis 2.31

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 31 Neonatal infection.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 32 Neonatal antibiotics.
Figures and Tables -
Analysis 2.32

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 32 Neonatal antibiotics.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 33 Neonatal jaundice.
Figures and Tables -
Analysis 2.33

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 33 Neonatal jaundice.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 34 Neonatal respiratory distress syndrome.
Figures and Tables -
Analysis 2.34

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 34 Neonatal respiratory distress syndrome.

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 35 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 2.35

Comparison 2 Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix, Outcome 35 Apgar score < 7 at 1 minute.

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 3.3

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 3 Caesarean section.

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 3.4

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 3.10

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 10 Epidural analgesia.

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 3.11

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 11 Instrumental vaginal delivery.

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 12 Meconium‐stained liquor.
Figures and Tables -
Analysis 3.12

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 12 Meconium‐stained liquor.

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 3.13

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 14 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 3.14

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 14 Neonatal intensive care unit admission.

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 16 Perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 3.16

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 16 Perinatal death, excluding major congenital anomalies.

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 32 Neonatal antibiotics.
Figures and Tables -
Analysis 3.32

Comparison 3 Oxytocin alone vs placebo/expectant mx: all women, favourable cervix, Outcome 32 Neonatal antibiotics.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 1 Caesarean section.
Figures and Tables -
Analysis 4.1

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 1 Caesarean section.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 2 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 4.2

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 2 Apgar score < 7 at 1 minute.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 3 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 4.3

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 3 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 4 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 4.4

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 4 Uterine hyperstimulation without FHR changes.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 4.11

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 11 Instrumental vaginal delivery.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 4.13

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 16 Perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 4.16

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 16 Perinatal death, excluding major congenital anomalies.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 4.23

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 23 Postpartum haemorrhage.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 28 Chorioamnionitis.
Figures and Tables -
Analysis 4.28

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 28 Chorioamnionitis.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 29 Endometritis.
Figures and Tables -
Analysis 4.29

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 29 Endometritis.

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 31 Neonatal infection.
Figures and Tables -
Analysis 4.31

Comparison 4 Oxytocin alone vs placebo/expectant mx: all women, intact membranes, Outcome 31 Neonatal infection.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 1 Vaginal delivery not achieved within 24 hours.
Figures and Tables -
Analysis 5.1

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 1 Vaginal delivery not achieved within 24 hours.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 5.2

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 5.3

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 3 Caesarean section.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 5.4

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 5 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 5.5

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 5 Uterine hyperstimulation without FHR changes.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 6 Uterine rupture.
Figures and Tables -
Analysis 5.6

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 6 Uterine rupture.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 7 Epidural analgesia.
Figures and Tables -
Analysis 5.7

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 7 Epidural analgesia.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 8 Instrumental vaginal delivery.
Figures and Tables -
Analysis 5.8

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 8 Instrumental vaginal delivery.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 9 Meconium‐stained liquor.
Figures and Tables -
Analysis 5.9

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 9 Meconium‐stained liquor.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 10 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 5.10

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 10 Apgar score < 7 at 5 minutes.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 11 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 5.11

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 11 Neonatal intensive care unit admission.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 12 Perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 5.12

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 12 Perinatal death, excluding major congenital anomalies.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 13 Nausea.
Figures and Tables -
Analysis 5.13

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 13 Nausea.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 14 Vomiting.
Figures and Tables -
Analysis 5.14

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 14 Vomiting.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 15 Diarrhoea.
Figures and Tables -
Analysis 5.15

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 15 Diarrhoea.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 16 Postpartum haemorrhage.
Figures and Tables -
Analysis 5.16

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 16 Postpartum haemorrhage.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 17 Woman not satisfied.
Figures and Tables -
Analysis 5.17

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 17 Woman not satisfied.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 18 Chorioamnionitis.
Figures and Tables -
Analysis 5.18

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 18 Chorioamnionitis.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 19 Endometritis.
Figures and Tables -
Analysis 5.19

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 19 Endometritis.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 20 Maternal antibiotics.
Figures and Tables -
Analysis 5.20

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 20 Maternal antibiotics.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 21 Neonatal infection.
Figures and Tables -
Analysis 5.21

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 21 Neonatal infection.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 22 Neonatal antibiotics.
Figures and Tables -
Analysis 5.22

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 22 Neonatal antibiotics.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 24 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 5.24

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 24 Apgar score < 7 at 1 minute.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 25 Neonatal jaundice.
Figures and Tables -
Analysis 5.25

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 25 Neonatal jaundice.

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 26 Neonatal respiratory distress syndrome.
Figures and Tables -
Analysis 5.26

Comparison 5 Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes, Outcome 26 Neonatal respiratory distress syndrome.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 6.3

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 3 Caesarean section.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 4 Serious neonatal morbidity/perinatal death.
Figures and Tables -
Analysis 6.4

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 4 Serious neonatal morbidity/perinatal death.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 6.8

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 6.10

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 10 Epidural analgesia.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 6.11

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 11 Instrumental vaginal delivery.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 12 Meconium‐stained liquor.
Figures and Tables -
Analysis 6.12

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 12 Meconium‐stained liquor.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 6.13

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 14 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 6.14

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 14 Neonatal intensive care unit admission.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 16 Perinatal death, excluding major congenital anomalies.
Figures and Tables -
Analysis 6.16

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 16 Perinatal death, excluding major congenital anomalies.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 20 Vomiting.
Figures and Tables -
Analysis 6.20

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 20 Vomiting.

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 6.23

Comparison 6 Oxytocin alone vs placebo/expectant mx: all primiparae, Outcome 23 Postpartum haemorrhage.

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 7.3

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 3 Caesarean section.

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 4 Serious neonatal morbidity/perinatal death.
Figures and Tables -
Analysis 7.4

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 4 Serious neonatal morbidity/perinatal death.

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 7.8

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 7.10

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 10 Epidural analgesia.

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 7.11

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 11 Instrumental vaginal delivery.

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 7.13

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 14 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 7.14

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 14 Neonatal intensive care unit admission.

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 20 Vomiting.
Figures and Tables -
Analysis 7.20

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 20 Vomiting.

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 7.23

Comparison 7 Oxytocin alone vs placebo/expectant mx: all multiparae, Outcome 23 Postpartum haemorrhage.

Comparison 8 Oxytocin alone vs placebo/expectant mx : all women, previous CS, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 8.3

Comparison 8 Oxytocin alone vs placebo/expectant mx : all women, previous CS, Outcome 3 Caesarean section.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 1 Vaginal delivery not achieved in 24 hours.
Figures and Tables -
Analysis 9.1

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 1 Vaginal delivery not achieved in 24 hours.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 9.2

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 9.3

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 3 Caesarean section.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.
Figures and Tables -
Analysis 9.4

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 5 Serious maternal morbidity or death.
Figures and Tables -
Analysis 9.5

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 5 Serious maternal morbidity or death.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.
Figures and Tables -
Analysis 9.6

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 9.8

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 9 Uterine rupture.
Figures and Tables -
Analysis 9.9

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 9 Uterine rupture.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 9.10

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 10 Epidural analgesia.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 9.11

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 11 Instrumental vaginal delivery.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 12 Meconium‐stained liquor.
Figures and Tables -
Analysis 9.12

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 12 Meconium‐stained liquor.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 9.13

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 14 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 9.14

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 14 Neonatal intensive care unit admission.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 16 Perinatal death, excluding major congenital malformations.
Figures and Tables -
Analysis 9.16

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 16 Perinatal death, excluding major congenital malformations.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 18 Maternal side effects (all).
Figures and Tables -
Analysis 9.18

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 18 Maternal side effects (all).

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 19 Maternal nausea.
Figures and Tables -
Analysis 9.19

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 19 Maternal nausea.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 20 Maternal vomiting.
Figures and Tables -
Analysis 9.20

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 20 Maternal vomiting.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 21 Maternal diarrhoea.
Figures and Tables -
Analysis 9.21

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 21 Maternal diarrhoea.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 9.23

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 23 Postpartum haemorrhage.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 26 Women not satisfied.
Figures and Tables -
Analysis 9.26

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 26 Women not satisfied.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 28 Chorioamnionitis.
Figures and Tables -
Analysis 9.28

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 28 Chorioamnionitis.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 29 Endometritis.
Figures and Tables -
Analysis 9.29

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 29 Endometritis.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 30 Maternal antibiotics.
Figures and Tables -
Analysis 9.30

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 30 Maternal antibiotics.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 31 Neonatal infection.
Figures and Tables -
Analysis 9.31

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 31 Neonatal infection.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 32 Neonatal antibiotics.
Figures and Tables -
Analysis 9.32

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 32 Neonatal antibiotics.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 33 Neonatal jaundice.
Figures and Tables -
Analysis 9.33

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 33 Neonatal jaundice.

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 35 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 9.35

Comparison 9 Oxytocin alone vs vaginal PGE2: all women, Outcome 35 Apgar score < 7 at 1 minute.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 1 Vaginal delivery not achieved in 24 hours.
Figures and Tables -
Analysis 10.1

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 1 Vaginal delivery not achieved in 24 hours.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 10.2

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 10.3

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 3 Caesarean section.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.
Figures and Tables -
Analysis 10.4

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 5 Serious maternal morbidity or death.
Figures and Tables -
Analysis 10.5

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 5 Serious maternal morbidity or death.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.
Figures and Tables -
Analysis 10.6

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 10.8

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 10.10

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 10 Epidural analgesia.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 10.11

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 11 Instrumental vaginal delivery.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 12 Meconium‐stained liquor.
Figures and Tables -
Analysis 10.12

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 12 Meconium‐stained liquor.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 10.13

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 16 Perinatal death, excluding major congenital malformations.
Figures and Tables -
Analysis 10.16

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 16 Perinatal death, excluding major congenital malformations.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 19 Maternal nausea.
Figures and Tables -
Analysis 10.19

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 19 Maternal nausea.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 20 Maternal vomiting.
Figures and Tables -
Analysis 10.20

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 20 Maternal vomiting.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 21 Maternal diarrhoea.
Figures and Tables -
Analysis 10.21

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 21 Maternal diarrhoea.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 10.23

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 23 Postpartum haemorrhage.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 26 Women not satisfied.
Figures and Tables -
Analysis 10.26

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 26 Women not satisfied.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 29 Endometritis.
Figures and Tables -
Analysis 10.29

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 29 Endometritis.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 30 Maternal antibiotics.
Figures and Tables -
Analysis 10.30

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 30 Maternal antibiotics.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 31 Neonatal infection.
Figures and Tables -
Analysis 10.31

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 31 Neonatal infection.

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 32 Neonatal antibiotics.
Figures and Tables -
Analysis 10.32

Comparison 10 Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix, Outcome 32 Neonatal antibiotics.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 11.2

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 11.3

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 3 Caesarean section.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 5 Serious maternal morbidity or death.
Figures and Tables -
Analysis 11.5

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 5 Serious maternal morbidity or death.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.
Figures and Tables -
Analysis 11.6

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 11.8

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 11.11

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 11 Instrumental vaginal delivery.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 11.13

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 18 Maternal side effects (all).
Figures and Tables -
Analysis 11.18

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 18 Maternal side effects (all).

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 19 Maternal nausea.
Figures and Tables -
Analysis 11.19

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 19 Maternal nausea.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 11.23

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 23 Postpartum haemorrhage.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 26 Women not satisfied.
Figures and Tables -
Analysis 11.26

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 26 Women not satisfied.

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 35 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 11.35

Comparison 11 Oxytocin alone vs vaginal PGE2: all women, favourable cervix, Outcome 35 Apgar score < 7 at 1 minute.

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 1 Cervix unfavourable or unchanged after 12/24 hours.
Figures and Tables -
Analysis 12.1

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 1 Cervix unfavourable or unchanged after 12/24 hours.

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 2 Caesarean section.
Figures and Tables -
Analysis 12.2

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 2 Caesarean section.

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 3 Serious maternal morbidity or death.
Figures and Tables -
Analysis 12.3

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 3 Serious maternal morbidity or death.

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 5 Uterine hyperstimulation.
Figures and Tables -
Analysis 12.5

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 5 Uterine hyperstimulation.

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 12.11

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 11 Instrumental vaginal delivery.

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 12.13

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 35 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 12.35

Comparison 12 Oxytocin alone vs vaginal PGE2: all women, intact membranes, Outcome 35 Apgar score < 7 at 1 minute.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 1 Vaginal delivery not achieved in 24 hours.
Figures and Tables -
Analysis 13.1

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 1 Vaginal delivery not achieved in 24 hours.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 13.2

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 13.3

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 3 Caesarean section.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.
Figures and Tables -
Analysis 13.4

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 5 Serious maternal morbidity or death.
Figures and Tables -
Analysis 13.5

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 5 Serious maternal morbidity or death.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 6 Cervix unfavourable or unchanged after 12/24 hours.
Figures and Tables -
Analysis 13.6

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 6 Cervix unfavourable or unchanged after 12/24 hours.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 13.8

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 9 Uterine rupture.
Figures and Tables -
Analysis 13.9

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 9 Uterine rupture.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 13.10

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 10 Epidural analgesia.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 13.11

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 11 Instrumental vaginal delivery.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 12 Meconium‐stained liquor.
Figures and Tables -
Analysis 13.12

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 12 Meconium‐stained liquor.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 13.13

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 14 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 13.14

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 14 Neonatal intensive care unit admission.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 16 Perinatal death, excluding major congenital malformations.
Figures and Tables -
Analysis 13.16

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 16 Perinatal death, excluding major congenital malformations.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 19 Maternal nausea.
Figures and Tables -
Analysis 13.19

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 19 Maternal nausea.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 20 Maternal vomiting.
Figures and Tables -
Analysis 13.20

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 20 Maternal vomiting.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 21 Maternal diarrhoea.
Figures and Tables -
Analysis 13.21

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 21 Maternal diarrhoea.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 13.23

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 23 Postpartum haemorrhage.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 26 Women not satisfied.
Figures and Tables -
Analysis 13.26

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 26 Women not satisfied.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 28 Chorioamnionitis.
Figures and Tables -
Analysis 13.28

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 28 Chorioamnionitis.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 29 Endometritis.
Figures and Tables -
Analysis 13.29

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 29 Endometritis.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 30 Maternal antibiotics.
Figures and Tables -
Analysis 13.30

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 30 Maternal antibiotics.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 31 Neonatal infection.
Figures and Tables -
Analysis 13.31

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 31 Neonatal infection.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 32 Neonatal antibiotics.
Figures and Tables -
Analysis 13.32

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 32 Neonatal antibiotics.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 33 Neonatal jaundice.
Figures and Tables -
Analysis 13.33

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 33 Neonatal jaundice.

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 35 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 13.35

Comparison 13 Oxytocin alone vs vaginal PGE2: all women, ruptured membranes, Outcome 35 Apgar score < 7 at 1 minute.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 1 Vaginal delivery not achieved in 24 hours.
Figures and Tables -
Analysis 14.1

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 1 Vaginal delivery not achieved in 24 hours.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 14.2

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 14.3

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 3 Caesarean section.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.
Figures and Tables -
Analysis 14.4

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 14.8

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 14.10

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 10 Epidural analgesia.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 14.11

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 11 Instrumental vaginal delivery.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 14.13

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 14 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 14.14

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 14 Neonatal intensive care unit admission.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 19 Maternal nausea.
Figures and Tables -
Analysis 14.19

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 19 Maternal nausea.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 20 Maternal vomiting.
Figures and Tables -
Analysis 14.20

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 20 Maternal vomiting.

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 21 Maternal diarrhoea.
Figures and Tables -
Analysis 14.21

Comparison 14 Oxytocin alone vs vaginal PGE2: all primiparae, Outcome 21 Maternal diarrhoea.

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 15.2

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 15.3

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 3 Caesarean section.

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.
Figures and Tables -
Analysis 15.4

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 4 Serious neonatal morbidity/perinatal death excluding major congenital malformations.

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 15.8

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 10 Epidural analgesia.
Figures and Tables -
Analysis 15.10

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 10 Epidural analgesia.

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 15.11

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 11 Instrumental vaginal delivery.

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 15.13

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 14 Neonatal intensive care unit admission.
Figures and Tables -
Analysis 15.14

Comparison 15 Oxytocin alone vs vaginal PGE2, all multiparae, Outcome 14 Neonatal intensive care unit admission.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 1 Vaginal delivery not achieved in 24 hours.
Figures and Tables -
Analysis 16.1

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 1 Vaginal delivery not achieved in 24 hours.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 16.2

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 16.3

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 3 Caesarean section.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 5 Serious maternal morbidity or death.
Figures and Tables -
Analysis 16.5

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 5 Serious maternal morbidity or death.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.
Figures and Tables -
Analysis 16.6

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 16.8

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 16.11

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 11 Instrumental vaginal delivery.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 16.13

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 16 Perinatal death excluding major congenital malformations.
Figures and Tables -
Analysis 16.16

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 16 Perinatal death excluding major congenital malformations.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 18 Maternal side effects (all).
Figures and Tables -
Analysis 16.18

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 18 Maternal side effects (all).

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 19 Maternal nausea.
Figures and Tables -
Analysis 16.19

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 19 Maternal nausea.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 20 Maternal vomiting.
Figures and Tables -
Analysis 16.20

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 20 Maternal vomiting.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 21 Maternal diarrhoea.
Figures and Tables -
Analysis 16.21

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 21 Maternal diarrhoea.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 16.23

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 23 Postpartum haemorrhage.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 26 Women not satisfied.
Figures and Tables -
Analysis 16.26

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 26 Women not satisfied.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 28 Chorioamnionitis.
Figures and Tables -
Analysis 16.28

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 28 Chorioamnionitis.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 29 Endometritis.
Figures and Tables -
Analysis 16.29

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 29 Endometritis.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 31 Neonatal infection.
Figures and Tables -
Analysis 16.31

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 31 Neonatal infection.

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 35 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 16.35

Comparison 16 Oxytocin alone vs intracervical PGE2: all women, Outcome 35 Apgar score < 7 at 1 minute.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 1 Vaginal delivery not achieved in 24 hours.
Figures and Tables -
Analysis 17.1

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 1 Vaginal delivery not achieved in 24 hours.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 17.2

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 17.3

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 3 Caesarean section.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.
Figures and Tables -
Analysis 17.6

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 6 Cervix unfavourable/unchanged after 12‐24 hours.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 17.8

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 17.11

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 11 Instrumental vaginal delivery.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 17.13

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 18 Maternal side effects (all).
Figures and Tables -
Analysis 17.18

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 18 Maternal side effects (all).

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 20 Maternal vomiting.
Figures and Tables -
Analysis 17.20

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 20 Maternal vomiting.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 21 Maternal diarrhoea.
Figures and Tables -
Analysis 17.21

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 21 Maternal diarrhoea.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 23 Postpartum haemorrhage.
Figures and Tables -
Analysis 17.23

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 23 Postpartum haemorrhage.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 26 Women not satisfied.
Figures and Tables -
Analysis 17.26

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 26 Women not satisfied.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 28 Chorioamnionitis.
Figures and Tables -
Analysis 17.28

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 28 Chorioamnionitis.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 29 Endometritis.
Figures and Tables -
Analysis 17.29

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 29 Endometritis.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 31 Neonatal infection.
Figures and Tables -
Analysis 17.31

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 31 Neonatal infection.

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 35 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 17.35

Comparison 17 Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix, Outcome 35 Apgar score < 7 at 1 minute.

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 1 Vaginal delivery not achieved in 24 hours.
Figures and Tables -
Analysis 18.1

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 1 Vaginal delivery not achieved in 24 hours.

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 18.2

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 18.8

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 18.13

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 18 Maternal side effects (all).
Figures and Tables -
Analysis 18.18

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 18 Maternal side effects (all).

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 20 Maternal vomiting.
Figures and Tables -
Analysis 18.20

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 20 Maternal vomiting.

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 21 Maternal diarrhoea.
Figures and Tables -
Analysis 18.21

Comparison 18 Oxytocin alone vs intracervical PGE2: all women, favourable cervix, Outcome 21 Maternal diarrhoea.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 1 Vaginal delivery not achieved in 24 hours.
Figures and Tables -
Analysis 19.1

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 1 Vaginal delivery not achieved in 24 hours.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 19.2

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 19.3

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 3 Caesarean section.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 4 Cervix unfavourable/unchanged after 12‐24 hours.
Figures and Tables -
Analysis 19.4

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 4 Cervix unfavourable/unchanged after 12‐24 hours.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 5 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 19.5

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 5 Uterine hyperstimulation without FHR changes.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 6 Instrumental vaginal delivery.
Figures and Tables -
Analysis 19.6

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 6 Instrumental vaginal delivery.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 7 Apgar score < 7 at 1 minute.
Figures and Tables -
Analysis 19.7

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 7 Apgar score < 7 at 1 minute.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 8 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 19.8

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 8 Apgar score < 7 at 5 minutes.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 11 Postpartum haemorrhage.
Figures and Tables -
Analysis 19.11

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 11 Postpartum haemorrhage.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 13 Women not satisfied.
Figures and Tables -
Analysis 19.13

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 13 Women not satisfied.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 18 Maternal side effects (all).
Figures and Tables -
Analysis 19.18

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 18 Maternal side effects (all).

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 19 Maternal nausea.
Figures and Tables -
Analysis 19.19

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 19 Maternal nausea.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 20 Maternal vomiting.
Figures and Tables -
Analysis 19.20

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 20 Maternal vomiting.

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 21 Maternal diarrhoea.
Figures and Tables -
Analysis 19.21

Comparison 19 Oxytocin alone vs intracervical PGE2: all women, intact membranes, Outcome 21 Maternal diarrhoea.

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 20.3

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 3 Caesarean section.

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 20.11

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 11 Instrumental vaginal delivery.

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 20.13

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 28 Chorioamnionitis.
Figures and Tables -
Analysis 20.28

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 28 Chorioamnionitis.

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 29 Endometritis.
Figures and Tables -
Analysis 20.29

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 29 Endometritis.

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 31 Neonatal infection.
Figures and Tables -
Analysis 20.31

Comparison 20 Oxytocin alone vs intracervical PGE2: all women, ruptured membranes, Outcome 31 Neonatal infection.

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 1 Vaginal delivery not achieved in 24 hours.
Figures and Tables -
Analysis 21.1

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 1 Vaginal delivery not achieved in 24 hours.

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 2 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 21.2

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 2 Uterine hyperstimulation with FHR changes.

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 21.3

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 3 Caesarean section.

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 8 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 21.8

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 8 Uterine hyperstimulation without FHR changes.

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 21.11

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 11 Instrumental vaginal delivery.

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 13 Apgar score < 7 at 5 minutes.
Figures and Tables -
Analysis 21.13

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 13 Apgar score < 7 at 5 minutes.

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 18 Maternal side effects (all).
Figures and Tables -
Analysis 21.18

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 18 Maternal side effects (all).

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 19 Maternal nausea.
Figures and Tables -
Analysis 21.19

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 19 Maternal nausea.

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 20 Maternal vomiting.
Figures and Tables -
Analysis 21.20

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 20 Maternal vomiting.

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 21 Maternal diarrhoea.
Figures and Tables -
Analysis 21.21

Comparison 21 Oxytocin alone vs intracervical PGE2: all primiparae, Outcome 21 Maternal diarrhoea.

Comparison 22 Oxytocin alone vs intracervical PGE2: all multiparae, Outcome 3 Caesarean section.
Figures and Tables -
Analysis 22.3

Comparison 22 Oxytocin alone vs intracervical PGE2: all multiparae, Outcome 3 Caesarean section.

Comparison 22 Oxytocin alone vs intracervical PGE2: all multiparae, Outcome 11 Instrumental vaginal delivery.
Figures and Tables -
Analysis 22.11

Comparison 22 Oxytocin alone vs intracervical PGE2: all multiparae, Outcome 11 Instrumental vaginal delivery.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 1 Uterine hyperstimulation with FHR changes.
Figures and Tables -
Analysis 23.1

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 1 Uterine hyperstimulation with FHR changes.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 2 Caesarean section.
Figures and Tables -
Analysis 23.2

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 2 Caesarean section.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 3 Serious neonatal morbidity or perinatal death.
Figures and Tables -
Analysis 23.3

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 3 Serious neonatal morbidity or perinatal death.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 4 Cervix unfavourable or unchanged after 12/24 hours.
Figures and Tables -
Analysis 23.4

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 4 Cervix unfavourable or unchanged after 12/24 hours.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 5 Uterine hyperstimulation without FHR changes.
Figures and Tables -
Analysis 23.5

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 5 Uterine hyperstimulation without FHR changes.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 6 Epidural analgesia.
Figures and Tables -
Analysis 23.6

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 6 Epidural analgesia.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 7 Instrumental vaginal delivery.
Figures and Tables -
Analysis 23.7

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 7 Instrumental vaginal delivery.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 8 Perinatal death.
Figures and Tables -
Analysis 23.8

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 8 Perinatal death.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 9 Vomiting.
Figures and Tables -
Analysis 23.9

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 9 Vomiting.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 10 Diarrhoea.
Figures and Tables -
Analysis 23.10

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 10 Diarrhoea.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 11 Chorioamnionitis.
Figures and Tables -
Analysis 23.11

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 11 Chorioamnionitis.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 12 Endometritis.
Figures and Tables -
Analysis 23.12

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 12 Endometritis.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 13 Neonatal infection.
Figures and Tables -
Analysis 23.13

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 13 Neonatal infection.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 14 Neonatal jaundice.
Figures and Tables -
Analysis 23.14

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 14 Neonatal jaundice.

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 15 Apgar score less than 7 at 1 minute.
Figures and Tables -
Analysis 23.15

Comparison 23 Oxytocin alone vs vaginal PGFalpha: all women, Outcome 15 Apgar score less than 7 at 1 minute.

Table 1. Sensitivity analysis: oxytocin alone vs placebo/expectant mx; trials with adequate vs uncertain or inadequate allocation concealment

Risk ratio with 95% confidence intervals: all women

RR adequate allocation concealment

RR uncertain or inadequate allocation concealment

Vaginal delivery not achieved within 24 hrs

0.16 (0.10 to 0.25)

0.14 (0.07 to 0.29)

0.17 (0.09 to 0.33)

Uterine hyperstimulation with FHR changes

0.16 (0.01 to 3.34)

0.16 (0.01 to 3.34)

No studies

Caesarean section

1.14 (0.95 to 1.37)

1.14 (0.95 to 1.37)

1.11 (0.82 to 1.49)

Serious neonatal morbidity or death

0.63 (0.26 to 1.51)

0.38 (0.11 to 1.29)

1.31 (0.33 to 5.22)

Serious maternal morbidity or death

Not estimable

No studies

Not estimable

Figures and Tables -
Table 1. Sensitivity analysis: oxytocin alone vs placebo/expectant mx; trials with adequate vs uncertain or inadequate allocation concealment
Table 2. Sensitivity analysis: oxytocin vs vaginal PGE2; trials with adequate vs uncertain or inadequate allocation concealment

Risk ratio with 95% confidence intervals: all women

RR adequate allocation concealment

RR uncertain or inadequate allocation concealment

Vaginal delivery not achieved within 24 hrs

2.06 (1.13 to 3.74)

No studies

2.06 (1.13 to 3.74)

Uterine hyperstimulation with FHR changes

0.35 (0.04 to 3.28)

0.35 (0.04 to 3.28)

Not estimable

Caesarean section

1.11 (0.94 to 1.30)

1.02 (0.82 to 1.26)

1.25 (0.98 to 1.59)

Serious neonatal morbidity or death

3.00 (0.31 to 28.82)

3.00 (0.31 to 28.82)

No studies

Serious maternal morbidity or death

0.37 (0.02 to 8.93)

0.37 (0.02 to 8.93)

No studies

Figures and Tables -
Table 2. Sensitivity analysis: oxytocin vs vaginal PGE2; trials with adequate vs uncertain or inadequate allocation concealment
Table 3. Sensitivity analysis: oxytocin vs intracervical PGE2; studies with adequate vs uncertain or poor allocation concealment

Risk ratio with 95% confidence intervals: all women

RR adequate allocation concealment

RR uncertain or inadequate allocation concealment

Vaginal delivery not achieved within 24 hrs

1.47 (1.10 to 1.96)

1.42 (1.01 to 1.99)

1.57 (0.91 to 2.71)

Uterine hyperstimulation with FHR changes

2.02 (0.38 to 10.75)

No studies

2.02 (0.38 to 10.75)

Caesarean section

1.37 (1.08 to 1.74)

1.57 (1.15 to 2.14)

1.05 (0.74 to 1.49)

Serious neonatal morbidity or death

Not estimable

No studies

Not estimable

Serious maternal morbidity or death

No studies

No studies

No studies

Figures and Tables -
Table 3. Sensitivity analysis: oxytocin vs intracervical PGE2; studies with adequate vs uncertain or poor allocation concealment
Comparison 1. Oxytocin alone vs placebo/expectant mx: all women

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved within 24 hours Show forest plot

3

399

Risk Ratio (M‐H, Fixed, 95% CI)

0.16 [0.10, 0.25]

2 Uterine hyperstimulation with FHR changes Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.16 [0.01, 3.34]

3 Caesarean section Show forest plot

24

6620

Risk Ratio (M‐H, Fixed, 95% CI)

1.17 [1.01, 1.35]

4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies Show forest plot

10

4816

Risk Ratio (M‐H, Fixed, 95% CI)

0.63 [0.26, 1.51]

5 Serious maternal morbidity or death Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Uterine hyperstimulation without FHR changes Show forest plot

2

2571

Risk Ratio (M‐H, Fixed, 95% CI)

2.01 [0.37, 10.94]

9 Uterine rupture Show forest plot

1

3782

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.03, 16.40]

10 Epidural analgesia Show forest plot

10

5150

Risk Ratio (M‐H, Fixed, 95% CI)

1.10 [1.04, 1.17]

11 Instrumental vaginal delivery Show forest plot

14

5275

Risk Ratio (M‐H, Fixed, 95% CI)

1.06 [0.94, 1.19]

12 Meconium‐stained liquor Show forest plot

3

2661

Risk Ratio (M‐H, Fixed, 95% CI)

0.83 [0.64, 1.08]

13 Apgar score < 7 at 5 minutes Show forest plot

11

4858

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.44, 1.11]

14 Neonatal intensive care unit admission Show forest plot

7

4387

Risk Ratio (M‐H, Fixed, 95% CI)

0.79 [0.68, 0.92]

16 Perinatal death, excluding major congenital anomalies Show forest plot

8

4506

Risk Ratio (M‐H, Fixed, 95% CI)

0.39 [0.09, 1.64]

19 Nausea Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.16 [0.01, 3.34]

20 Vomiting Show forest plot

1

2521

Risk Ratio (M‐H, Fixed, 95% CI)

1.00 [0.29, 3.46]

21 Diarrhoea Show forest plot

1

2521

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

23 Postpartum haemorrhage Show forest plot

3

2611

Risk Ratio (M‐H, Fixed, 95% CI)

1.24 [0.85, 1.81]

26 Woman not satisfied Show forest plot

1

2521

Risk Ratio (M‐H, Fixed, 95% CI)

0.43 [0.33, 0.56]

28 Chorioamnionitis Show forest plot

14

5515

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.57, 0.85]

29 Endometritis Show forest plot

10

4817

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.51, 1.01]

30 Maternal antibiotics Show forest plot

3

3091

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.57, 0.85]

31 Neonatal infection Show forest plot

14

5226

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.44, 0.95]

32 Neonatal antibiotics Show forest plot

6

4544

Risk Ratio (M‐H, Fixed, 95% CI)

0.60 [0.49, 0.73]

33 Neonatal jaundice Show forest plot

2

431

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.43, 1.80]

34 Neonatal respiratory distress syndrome Show forest plot

1

154

Risk Ratio (M‐H, Fixed, 95% CI)

0.86 [0.24, 3.10]

35 Apgar score < 7 at 1 minute Show forest plot

5

3126

Risk Ratio (M‐H, Fixed, 95% CI)

0.99 [0.82, 1.19]

Figures and Tables -
Comparison 1. Oxytocin alone vs placebo/expectant mx: all women
Comparison 2. Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved within 24 hours Show forest plot

1

182

Risk Ratio (M‐H, Fixed, 95% CI)

0.17 [0.09, 0.33]

3 Caesarean section Show forest plot

13

1366

Risk Ratio (M‐H, Fixed, 95% CI)

1.20 [0.89, 1.62]

4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies Show forest plot

5

645

Risk Ratio (M‐H, Fixed, 95% CI)

0.63 [0.09, 4.57]

5 Serious maternal morbidity or death Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Uterine hyperstimulation without FHR changes Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Epidural analgesia Show forest plot

4

531

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.73, 1.16]

11 Instrumental vaginal delivery Show forest plot

6

631

Risk Ratio (M‐H, Fixed, 95% CI)

1.21 [0.83, 1.76]

12 Meconium‐stained liquor

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

13 Apgar score < 7 at 5 minutes Show forest plot

5

787

Risk Ratio (M‐H, Fixed, 95% CI)

0.37 [0.09, 1.50]

14 Neonatal intensive care unit admission Show forest plot

1

242

Risk Ratio (M‐H, Fixed, 95% CI)

0.30 [0.12, 0.80]

16 Perinatal death, excluding major congenital anomalies Show forest plot

4

491

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 7.72]

23 Postpartum haemorrhage Show forest plot

2

90

Risk Ratio (M‐H, Fixed, 95% CI)

2.0 [0.38, 10.60]

28 Chorioamnionitis Show forest plot

6

1029

Risk Ratio (M‐H, Fixed, 95% CI)

0.83 [0.59, 1.16]

29 Endometritis Show forest plot

6

867

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.36, 1.28]

31 Neonatal infection Show forest plot

7

809

Risk Ratio (M‐H, Fixed, 95% CI)

0.35 [0.13, 0.96]

32 Neonatal antibiotics Show forest plot

1

242

Risk Ratio (M‐H, Fixed, 95% CI)

0.32 [0.11, 0.95]

33 Neonatal jaundice Show forest plot

2

431

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.43, 1.80]

34 Neonatal respiratory distress syndrome Show forest plot

1

154

Risk Ratio (M‐H, Fixed, 95% CI)

0.86 [0.24, 3.10]

35 Apgar score < 7 at 1 minute Show forest plot

3

481

Risk Ratio (M‐H, Fixed, 95% CI)

1.27 [0.52, 3.07]

Figures and Tables -
Comparison 2. Oxytocin alone vs placebo/expectant mx: all women, unfavourable cervix
Comparison 3. Oxytocin alone vs placebo/expectant mx: all women, favourable cervix

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

3 Caesarean section Show forest plot

1

201

Risk Ratio (M‐H, Fixed, 95% CI)

0.99 [0.25, 3.85]

4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

3.0 [0.13, 69.52]

10 Epidural analgesia Show forest plot

1

201

Risk Ratio (M‐H, Fixed, 95% CI)

1.11 [0.76, 1.60]

11 Instrumental vaginal delivery Show forest plot

1

201

Risk Ratio (M‐H, Fixed, 95% CI)

0.99 [0.58, 1.70]

12 Meconium‐stained liquor Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

1.33 [0.34, 5.21]

13 Apgar score < 7 at 5 minutes Show forest plot

1

201

Risk Ratio (M‐H, Fixed, 95% CI)

2.97 [0.12, 72.06]

14 Neonatal intensive care unit admission Show forest plot

1

201

Risk Ratio (M‐H, Fixed, 95% CI)

1.65 [0.62, 4.37]

16 Perinatal death, excluding major congenital anomalies Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

3.0 [0.13, 69.52]

32 Neonatal antibiotics Show forest plot

1

201

Risk Ratio (M‐H, Fixed, 95% CI)

2.23 [0.71, 7.00]

Figures and Tables -
Comparison 3. Oxytocin alone vs placebo/expectant mx: all women, favourable cervix
Comparison 4. Oxytocin alone vs placebo/expectant mx: all women, intact membranes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Caesarean section Show forest plot

4

171

Risk Ratio (M‐H, Fixed, 95% CI)

1.24 [0.62, 2.50]

2 Apgar score < 7 at 1 minute Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

3.0 [0.13, 70.30]

3 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 7.72]

4 Uterine hyperstimulation without FHR changes Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

11 Instrumental vaginal delivery Show forest plot

2

90

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

13 Apgar score < 7 at 5 minutes Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 7.72]

16 Perinatal death, excluding major congenital anomalies Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 7.72]

23 Postpartum haemorrhage Show forest plot

2

90

Risk Ratio (M‐H, Fixed, 95% CI)

2.0 [0.38, 10.60]

28 Chorioamnionitis Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

29 Endometritis Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.01, 3.92]

31 Neonatal infection Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.01, 3.92]

Figures and Tables -
Comparison 4. Oxytocin alone vs placebo/expectant mx: all women, intact membranes
Comparison 5. Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved within 24 hours Show forest plot

3

399

Risk Ratio (M‐H, Fixed, 95% CI)

0.16 [0.10, 0.25]

2 Uterine hyperstimulation with FHR changes Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.16 [0.01, 3.34]

3 Caesarean section Show forest plot

20

6459

Risk Ratio (M‐H, Fixed, 95% CI)

1.19 [1.02, 1.38]

4 Serious neonatal morbidity or perinatal death, excluding major congenital anomalies Show forest plot

9

4776

Risk Ratio (M‐H, Fixed, 95% CI)

0.53 [0.21, 1.37]

5 Uterine hyperstimulation without FHR changes Show forest plot

2

2561

Risk Ratio (M‐H, Fixed, 95% CI)

2.01 [0.37, 10.94]

6 Uterine rupture Show forest plot

1

3782

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.03, 16.40]

7 Epidural analgesia Show forest plot

10

5150

Risk Ratio (M‐H, Fixed, 95% CI)

1.10 [1.04, 1.17]

8 Instrumental vaginal delivery Show forest plot

12

5195

Risk Ratio (M‐H, Fixed, 95% CI)

1.05 [0.93, 1.18]

9 Meconium‐stained liquor Show forest plot

2

2621

Risk Ratio (M‐H, Fixed, 95% CI)

0.82 [0.62, 1.07]

10 Apgar score < 7 at 5 minutes Show forest plot

12

4958

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.44, 1.07]

11 Neonatal intensive care unit admission Show forest plot

7

4387

Risk Ratio (M‐H, Fixed, 95% CI)

0.79 [0.68, 0.92]

12 Perinatal death, excluding major congenital anomalies Show forest plot

7

4466

Risk Ratio (M‐H, Fixed, 95% CI)

0.17 [0.02, 1.37]

13 Nausea Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.16 [0.01, 3.34]

14 Vomiting Show forest plot

1

2521

Risk Ratio (M‐H, Fixed, 95% CI)

1.00 [0.29, 3.46]

15 Diarrhoea Show forest plot

1

2521

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

16 Postpartum haemorrhage Show forest plot

2

2561

Risk Ratio (M‐H, Fixed, 95% CI)

1.18 [0.80, 1.73]

17 Woman not satisfied Show forest plot

1

2521

Risk Ratio (M‐H, Fixed, 95% CI)

0.43 [0.33, 0.56]

18 Chorioamnionitis Show forest plot

14

5515

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.57, 0.85]

19 Endometritis Show forest plot

10

4817

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.51, 1.01]

20 Maternal antibiotics Show forest plot

3

3091

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.57, 0.85]

21 Neonatal infection Show forest plot

14

5226

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.44, 0.95]

22 Neonatal antibiotics Show forest plot

6

4544

Risk Ratio (M‐H, Fixed, 95% CI)

0.60 [0.49, 0.73]

23 Neonatal respiratory distress syndrome

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

24 Apgar score < 7 at 1 minute Show forest plot

4

3076

Risk Ratio (M‐H, Fixed, 95% CI)

0.98 [0.81, 1.18]

25 Neonatal jaundice Show forest plot

2

431

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.43, 1.80]

26 Neonatal respiratory distress syndrome Show forest plot

1

154

Risk Ratio (M‐H, Fixed, 95% CI)

0.86 [0.24, 3.10]

Figures and Tables -
Comparison 5. Oxytocin alone vs placebo/expectant mx: all women, ruptured membranes
Comparison 6. Oxytocin alone vs placebo/expectant mx: all primiparae

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

3 Caesarean section Show forest plot

12

3494

Risk Ratio (M‐H, Fixed, 95% CI)

1.11 [0.93, 1.34]

4 Serious neonatal morbidity/perinatal death Show forest plot

4

3007

Risk Ratio (M‐H, Fixed, 95% CI)

0.74 [0.15, 3.70]

8 Uterine hyperstimulation without FHR changes Show forest plot

1

1493

Risk Ratio (M‐H, Fixed, 95% CI)

2.02 [0.18, 22.22]

10 Epidural analgesia Show forest plot

4

2778

Risk Ratio (M‐H, Fixed, 95% CI)

1.09 [1.02, 1.16]

11 Instrumental vaginal delivery Show forest plot

7

2932

Risk Ratio (M‐H, Fixed, 95% CI)

1.03 [0.91, 1.18]

12 Meconium‐stained liquor Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

1.33 [0.34, 5.21]

13 Apgar score < 7 at 5 minutes Show forest plot

2

251

Risk Ratio (M‐H, Fixed, 95% CI)

3.10 [0.33, 29.20]

14 Neonatal intensive care unit admission Show forest plot

3

1740

Risk Ratio (M‐H, Fixed, 95% CI)

0.70 [0.56, 0.87]

16 Perinatal death, excluding major congenital anomalies Show forest plot

2

484

Risk Ratio (M‐H, Fixed, 95% CI)

3.0 [0.13, 69.52]

20 Vomiting Show forest plot

1

1493

Risk Ratio (M‐H, Fixed, 95% CI)

1.35 [0.30, 5.99]

23 Postpartum haemorrhage Show forest plot

1

1493

Risk Ratio (M‐H, Fixed, 95% CI)

1.16 [0.74, 1.83]

Figures and Tables -
Comparison 6. Oxytocin alone vs placebo/expectant mx: all primiparae
Comparison 7. Oxytocin alone vs placebo/expectant mx: all multiparae

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

3 Caesarean section Show forest plot

9

1791

Risk Ratio (M‐H, Fixed, 95% CI)

1.21 [0.81, 1.80]

4 Serious neonatal morbidity/perinatal death Show forest plot

1

1532

Risk Ratio (M‐H, Fixed, 95% CI)

0.39 [0.02, 8.20]

8 Uterine hyperstimulation without FHR changes Show forest plot

1

1028

Risk Ratio (M‐H, Fixed, 95% CI)

1.99 [0.18, 21.90]

10 Epidural analgesia Show forest plot

2

1400

Risk Ratio (M‐H, Fixed, 95% CI)

1.14 [0.98, 1.33]

11 Instrumental vaginal delivery Show forest plot

5

1495

Risk Ratio (M‐H, Fixed, 95% CI)

1.02 [0.71, 1.48]

13 Apgar score < 7 at 5 minutes Show forest plot

1

43

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

14 Neonatal intensive care unit admission Show forest plot

2

1069

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.46, 0.91]

20 Vomiting Show forest plot

1

1028

Risk Ratio (M‐H, Fixed, 95% CI)

0.50 [0.05, 5.48]

23 Postpartum haemorrhage Show forest plot

1

1028

Risk Ratio (M‐H, Fixed, 95% CI)

1.33 [0.63, 2.78]

Figures and Tables -
Comparison 7. Oxytocin alone vs placebo/expectant mx: all multiparae
Comparison 8. Oxytocin alone vs placebo/expectant mx : all women, previous CS

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

3 Caesarean section Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

1.78 [0.51, 6.18]

Figures and Tables -
Comparison 8. Oxytocin alone vs placebo/expectant mx : all women, previous CS
Comparison 9. Oxytocin alone vs vaginal PGE2: all women

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours Show forest plot

3

260

Risk Ratio (M‐H, Fixed, 95% CI)

1.77 [1.31, 2.38]

2 Uterine hyperstimulation with FHR changes Show forest plot

8

843

Risk Ratio (M‐H, Fixed, 95% CI)

0.35 [0.04, 3.28]

3 Caesarean section Show forest plot

26

4514

Risk Ratio (M‐H, Fixed, 95% CI)

1.11 [0.94, 1.30]

4 Serious neonatal morbidity/perinatal death excluding major congenital malformations Show forest plot

3

2759

Risk Ratio (M‐H, Fixed, 95% CI)

3.00 [0.31, 28.82]

5 Serious maternal morbidity or death Show forest plot

3

175

Risk Ratio (M‐H, Fixed, 95% CI)

0.37 [0.02, 8.93]

6 Cervix unfavourable/unchanged after 12‐24 hours Show forest plot

5

323

Risk Ratio (M‐H, Fixed, 95% CI)

2.42 [1.43, 4.09]

8 Uterine hyperstimulation without FHR changes Show forest plot

12

3681

Risk Ratio (M‐H, Fixed, 95% CI)

0.86 [0.51, 1.48]

9 Uterine rupture Show forest plot

1

2517

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Epidural analgesia Show forest plot

6

2949

Risk Ratio (M‐H, Fixed, 95% CI)

1.09 [1.01, 1.17]

11 Instrumental vaginal delivery Show forest plot

18

3894

Risk Ratio (M‐H, Fixed, 95% CI)

1.00 [0.88, 1.15]

12 Meconium‐stained liquor Show forest plot

3

2801

Risk Ratio (M‐H, Fixed, 95% CI)

0.84 [0.65, 1.08]

13 Apgar score < 7 at 5 minutes Show forest plot

16

3791

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.36, 1.05]

14 Neonatal intensive care unit admission Show forest plot

5

2845

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.70, 1.04]

16 Perinatal death, excluding major congenital malformations Show forest plot

3

2757

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

18 Maternal side effects (all) Show forest plot

3

223

Risk Ratio (M‐H, Fixed, 95% CI)

0.64 [0.29, 1.41]

19 Maternal nausea Show forest plot

4

260

Risk Ratio (M‐H, Fixed, 95% CI)

0.23 [0.05, 1.07]

20 Maternal vomiting Show forest plot

4

2622

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.26, 2.14]

21 Maternal diarrhoea Show forest plot

3

2602

Risk Ratio (M‐H, Fixed, 95% CI)

0.20 [0.01, 4.16]

23 Postpartum haemorrhage Show forest plot

3

2692

Risk Ratio (M‐H, Fixed, 95% CI)

1.00 [0.73, 1.37]

26 Women not satisfied Show forest plot

3

2663

Risk Ratio (M‐H, Fixed, 95% CI)

1.30 [0.96, 1.77]

28 Chorioamnionitis Show forest plot

4

2742

Risk Ratio (M‐H, Fixed, 95% CI)

0.66 [0.47, 0.92]

29 Endometritis Show forest plot

6

2805

Risk Ratio (M‐H, Fixed, 95% CI)

0.84 [0.54, 1.32]

30 Maternal antibiotics Show forest plot

2

2567

Risk Ratio (M‐H, Fixed, 95% CI)

0.83 [0.64, 1.08]

31 Neonatal infection Show forest plot

7

2948

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.42, 1.09]

32 Neonatal antibiotics Show forest plot

2

2564

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.53, 0.87]

33 Neonatal jaundice Show forest plot

1

36

Risk Ratio (M‐H, Fixed, 95% CI)

0.71 [0.11, 4.52]

35 Apgar score < 7 at 1 minute Show forest plot

4

2698

Risk Ratio (M‐H, Fixed, 95% CI)

1.03 [0.85, 1.26]

Figures and Tables -
Comparison 9. Oxytocin alone vs vaginal PGE2: all women
Comparison 10. Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours Show forest plot

2

58

Risk Ratio (M‐H, Fixed, 95% CI)

3.33 [1.61, 6.89]

2 Uterine hyperstimulation with FHR changes Show forest plot

2

209

Risk Ratio (M‐H, Fixed, 95% CI)

0.36 [0.01, 8.69]

3 Caesarean section Show forest plot

15

1041

Risk Ratio (M‐H, Fixed, 95% CI)

1.24 [0.93, 1.65]

4 Serious neonatal morbidity/perinatal death excluding major congenital malformations Show forest plot

2

242

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Serious maternal morbidity or death Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Cervix unfavourable/unchanged after 12‐24 hours Show forest plot

4

236

Risk Ratio (M‐H, Fixed, 95% CI)

2.35 [1.38, 4.01]

8 Uterine hyperstimulation without FHR changes Show forest plot

5

540

Risk Ratio (M‐H, Fixed, 95% CI)

1.32 [0.62, 2.81]

10 Epidural analgesia Show forest plot

2

90

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.43, 1.31]

11 Instrumental vaginal delivery Show forest plot

9

609

Risk Ratio (M‐H, Fixed, 95% CI)

1.09 [0.82, 1.47]

12 Meconium‐stained liquor Show forest plot

1

189

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.37, 1.41]

13 Apgar score < 7 at 5 minutes Show forest plot

6

473

Risk Ratio (M‐H, Fixed, 95% CI)

2.22 [0.35, 13.95]

16 Perinatal death, excluding major congenital malformations Show forest plot

2

242

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

19 Maternal nausea Show forest plot

2

67

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.02, 7.32]

20 Maternal vomiting Show forest plot

3

105

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.04, 3.02]

21 Maternal diarrhoea Show forest plot

2

85

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

23 Postpartum haemorrhage Show forest plot

1

90

Risk Ratio (M‐H, Fixed, 95% CI)

1.34 [0.46, 3.91]

26 Women not satisfied Show forest plot

1

58

Risk Ratio (M‐H, Fixed, 95% CI)

2.32 [0.68, 7.89]

29 Endometritis Show forest plot

2

63

Risk Ratio (M‐H, Fixed, 95% CI)

3.0 [0.14, 65.90]

30 Maternal antibiotics Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.78 [0.14, 4.29]

31 Neonatal infection Show forest plot

2

100

Risk Ratio (M‐H, Fixed, 95% CI)

3.0 [0.13, 69.52]

32 Neonatal antibiotics Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.17 [0.01, 3.07]

Figures and Tables -
Comparison 10. Oxytocin alone vs vaginal PGE2: all women, unfavourable cervix
Comparison 11. Oxytocin alone vs vaginal PGE2: all women, favourable cervix

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Uterine hyperstimulation with FHR changes Show forest plot

1

98

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 7.99]

3 Caesarean section Show forest plot

2

183

Risk Ratio (M‐H, Fixed, 95% CI)

2.12 [0.54, 8.37]

4 Serious neonatal morbidity/perinatal death excluding major congenital malformations

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Serious maternal morbidity or death Show forest plot

1

85

Risk Ratio (M‐H, Fixed, 95% CI)

0.37 [0.02, 8.93]

6 Cervix unfavourable/unchanged after 12‐24 hours Show forest plot

1

85

Risk Ratio (M‐H, Fixed, 95% CI)

3.37 [0.14, 80.36]

8 Uterine hyperstimulation without FHR changes Show forest plot

2

183

Risk Ratio (M‐H, Fixed, 95% CI)

0.41 [0.10, 1.67]

11 Instrumental vaginal delivery Show forest plot

2

183

Risk Ratio (M‐H, Fixed, 95% CI)

0.64 [0.31, 1.32]

13 Apgar score < 7 at 5 minutes Show forest plot

2

183

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 7.99]

16 Perinatal death, excluding major congenital malformations

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

18 Maternal side effects (all) Show forest plot

1

85

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.13, 4.26]

19 Maternal nausea Show forest plot

1

98

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.02, 1.65]

23 Postpartum haemorrhage Show forest plot

1

85

Risk Ratio (M‐H, Fixed, 95% CI)

1.27 [0.54, 2.97]

26 Women not satisfied Show forest plot

1

88

Risk Ratio (M‐H, Fixed, 95% CI)

7.67 [0.98, 59.74]

35 Apgar score < 7 at 1 minute Show forest plot

1

98

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.18, 3.18]

Figures and Tables -
Comparison 11. Oxytocin alone vs vaginal PGE2: all women, favourable cervix
Comparison 12. Oxytocin alone vs vaginal PGE2: all women, intact membranes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Cervix unfavourable or unchanged after 12/24 hours Show forest plot

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

2.67 [1.21, 5.88]

2 Caesarean section Show forest plot

6

494

Risk Ratio (M‐H, Fixed, 95% CI)

1.55 [1.05, 2.30]

3 Serious maternal morbidity or death Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Uterine hyperstimulation Show forest plot

1

158

Risk Ratio (M‐H, Fixed, 95% CI)

1.28 [0.48, 3.45]

11 Instrumental vaginal delivery Show forest plot

3

351

Risk Ratio (M‐H, Fixed, 95% CI)

0.80 [0.53, 1.20]

13 Apgar score < 7 at 5 minutes Show forest plot

2

149

Risk Ratio (M‐H, Fixed, 95% CI)

0.59 [0.08, 4.36]

35 Apgar score < 7 at 1 minute Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.19, 3.01]

Figures and Tables -
Comparison 12. Oxytocin alone vs vaginal PGE2: all women, intact membranes
Comparison 13. Oxytocin alone vs vaginal PGE2: all women, ruptured membranes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours Show forest plot

1

20

Risk Ratio (M‐H, Fixed, 95% CI)

2.25 [1.02, 4.94]

2 Uterine hyperstimulation with FHR changes Show forest plot

6

738

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Caesarean section Show forest plot

14

3635

Risk Ratio (M‐H, Fixed, 95% CI)

1.02 [0.85, 1.23]

4 Serious neonatal morbidity/perinatal death excluding major congenital malformations Show forest plot

2

2557

Risk Ratio (M‐H, Fixed, 95% CI)

3.00 [0.31, 28.82]

5 Serious maternal morbidity or death Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Cervix unfavourable or unchanged after 12/24 hours Show forest plot

1

90

Risk Ratio (M‐H, Fixed, 95% CI)

0.82 [0.30, 2.25]

8 Uterine hyperstimulation without FHR changes Show forest plot

5

2879

Risk Ratio (M‐H, Fixed, 95% CI)

0.64 [0.24, 1.70]

9 Uterine rupture Show forest plot

1

2517

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Epidural analgesia Show forest plot

6

2949

Risk Ratio (M‐H, Fixed, 95% CI)

1.09 [1.01, 1.17]

11 Instrumental vaginal delivery Show forest plot

9

3160

Risk Ratio (M‐H, Fixed, 95% CI)

1.04 [0.90, 1.21]

12 Meconium‐stained liquor Show forest plot

3

2801

Risk Ratio (M‐H, Fixed, 95% CI)

0.84 [0.65, 1.08]

13 Apgar score < 7 at 5 minutes Show forest plot

10

3367

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.35, 1.11]

14 Neonatal intensive care unit admission Show forest plot

5

2845

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.70, 1.04]

16 Perinatal death, excluding major congenital malformations Show forest plot

2

2555

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

19 Maternal nausea Show forest plot

3

162

Risk Ratio (M‐H, Fixed, 95% CI)

0.29 [0.03, 2.60]

20 Maternal vomiting Show forest plot

3

2584

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.27, 2.61]

21 Maternal diarrhoea Show forest plot

1

2517

Risk Ratio (M‐H, Fixed, 95% CI)

0.20 [0.01, 4.16]

23 Postpartum haemorrhage Show forest plot

2

2607

Risk Ratio (M‐H, Fixed, 95% CI)

0.96 [0.68, 1.36]

26 Women not satisfied Show forest plot

1

2517

Risk Ratio (M‐H, Fixed, 95% CI)

1.16 [0.84, 1.60]

28 Chorioamnionitis Show forest plot

4

2742

Risk Ratio (M‐H, Fixed, 95% CI)

0.66 [0.47, 0.92]

29 Endometritis Show forest plot

5

2762

Risk Ratio (M‐H, Fixed, 95% CI)

0.84 [0.54, 1.32]

30 Maternal antibiotics Show forest plot

2

2567

Risk Ratio (M‐H, Fixed, 95% CI)

0.83 [0.64, 1.08]

31 Neonatal infection Show forest plot

7

2948

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.42, 1.09]

32 Neonatal antibiotics Show forest plot

2

2564

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.53, 0.87]

33 Neonatal jaundice Show forest plot

1

36

Risk Ratio (M‐H, Fixed, 95% CI)

0.71 [0.11, 4.52]

35 Apgar score < 7 at 1 minute Show forest plot

2

2550

Risk Ratio (M‐H, Fixed, 95% CI)

1.05 [0.86, 1.28]

Figures and Tables -
Comparison 13. Oxytocin alone vs vaginal PGE2: all women, ruptured membranes
Comparison 14. Oxytocin alone vs vaginal PGE2: all primiparae

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours Show forest plot

1

20

Risk Ratio (M‐H, Fixed, 95% CI)

2.25 [1.02, 4.94]

2 Uterine hyperstimulation with FHR changes Show forest plot

3

152

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Caesarean section Show forest plot

9

1917

Risk Ratio (M‐H, Fixed, 95% CI)

0.98 [0.79, 1.21]

4 Serious neonatal morbidity/perinatal death excluding major congenital malformations Show forest plot

1

1492

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Uterine hyperstimulation without FHR changes Show forest plot

3

152

Risk Ratio (M‐H, Fixed, 95% CI)

2.44 [0.26, 22.80]

10 Epidural analgesia Show forest plot

3

182

Risk Ratio (M‐H, Fixed, 95% CI)

1.18 [0.94, 1.49]

11 Instrumental vaginal delivery Show forest plot

8

1867

Risk Ratio (M‐H, Fixed, 95% CI)

1.05 [0.90, 1.23]

13 Apgar score < 7 at 5 minutes Show forest plot

3

87

Risk Ratio (M‐H, Fixed, 95% CI)

1.63 [0.28, 9.58]

14 Neonatal intensive care unit admission Show forest plot

2

114

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.12, 3.81]

19 Maternal nausea Show forest plot

2

67

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.02, 7.32]

20 Maternal vomiting Show forest plot

2

67

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.02, 7.32]

21 Maternal diarrhoea Show forest plot

1

47

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 14. Oxytocin alone vs vaginal PGE2: all primiparae
Comparison 15. Oxytocin alone vs vaginal PGE2, all multiparae

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Uterine hyperstimulation with FHR changes Show forest plot

2

104

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Caesarean section Show forest plot

4

1172

Risk Ratio (M‐H, Fixed, 95% CI)

1.30 [0.73, 2.30]

4 Serious neonatal morbidity/perinatal death excluding major congenital malformations Show forest plot

1

1027

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 8.12]

5 Serious maternal morbidity or death

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Uterine hyperstimulation without FHR changes Show forest plot

2

104

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.06, 23.88]

10 Epidural analgesia Show forest plot

2

104

Risk Ratio (M‐H, Fixed, 95% CI)

0.89 [0.48, 1.64]

11 Instrumental vaginal delivery Show forest plot

3

1127

Risk Ratio (M‐H, Fixed, 95% CI)

1.26 [0.85, 1.87]

12 Meconium‐stained liquor

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

13 Apgar score < 7 at 5 minutes Show forest plot

1

16

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.06, 23.88]

14 Neonatal intensive care unit admission Show forest plot

1

16

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.06, 23.88]

16 Perinatal death, excluding major congenital malformations

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

23 Postpartum haemorrhage

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 15. Oxytocin alone vs vaginal PGE2, all multiparae
Comparison 16. Oxytocin alone vs intracervical PGE2: all women

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours Show forest plot

2

258

Risk Ratio (M‐H, Fixed, 95% CI)

1.47 [1.10, 1.96]

2 Uterine hyperstimulation with FHR changes Show forest plot

2

265

Risk Ratio (M‐H, Fixed, 95% CI)

2.02 [0.38, 10.75]

3 Caesarean section Show forest plot

14

1331

Risk Ratio (M‐H, Fixed, 95% CI)

1.37 [1.08, 1.74]

5 Serious maternal morbidity or death Show forest plot

1

118

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Cervix unfavourable/unchanged after 12‐24 hours Show forest plot

3

421

Risk Ratio (M‐H, Fixed, 95% CI)

5.03 [2.46, 10.30]

8 Uterine hyperstimulation without FHR changes Show forest plot

3

333

Risk Ratio (M‐H, Fixed, 95% CI)

0.61 [0.13, 2.76]

11 Instrumental vaginal delivery Show forest plot

9

817

Risk Ratio (M‐H, Fixed, 95% CI)

1.12 [0.82, 1.52]

13 Apgar score < 7 at 5 minutes Show forest plot

6

701

Risk Ratio (M‐H, Fixed, 95% CI)

2.05 [0.86, 4.87]

16 Perinatal death excluding major congenital malformations Show forest plot

1

118

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

18 Maternal side effects (all) Show forest plot

2

258

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

19 Maternal nausea Show forest plot

2

256

Risk Ratio (M‐H, Fixed, 95% CI)

0.17 [0.02, 1.35]

20 Maternal vomiting Show forest plot

3

414

Risk Ratio (M‐H, Fixed, 95% CI)

0.25 [0.03, 2.19]

21 Maternal diarrhoea Show forest plot

2

258

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

23 Postpartum haemorrhage Show forest plot

2

105

Risk Ratio (M‐H, Fixed, 95% CI)

2.2 [0.56, 8.69]

26 Women not satisfied Show forest plot

1

98

Risk Ratio (M‐H, Fixed, 95% CI)

0.36 [0.12, 1.06]

28 Chorioamnionitis Show forest plot

4

477

Risk Ratio (M‐H, Fixed, 95% CI)

1.57 [0.79, 3.16]

29 Endometritis Show forest plot

2

198

Risk Ratio (M‐H, Fixed, 95% CI)

1.81 [0.17, 19.38]

31 Neonatal infection Show forest plot

4

414

Risk Ratio (M‐H, Fixed, 95% CI)

1.07 [0.23, 4.94]

35 Apgar score < 7 at 1 minute Show forest plot

1

75

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.04, 2.62]

Figures and Tables -
Comparison 16. Oxytocin alone vs intracervical PGE2: all women
Comparison 17. Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours Show forest plot

2

214

Risk Ratio (M‐H, Fixed, 95% CI)

1.44 [1.09, 1.89]

2 Uterine hyperstimulation with FHR changes Show forest plot

2

221

Risk Ratio (M‐H, Fixed, 95% CI)

2.02 [0.38, 10.75]

3 Caesarean section Show forest plot

10

1003

Risk Ratio (M‐H, Fixed, 95% CI)

1.44 [1.12, 1.86]

6 Cervix unfavourable/unchanged after 12‐24 hours Show forest plot

2

321

Risk Ratio (M‐H, Fixed, 95% CI)

2.52 [1.15, 5.53]

8 Uterine hyperstimulation without FHR changes Show forest plot

3

289

Risk Ratio (M‐H, Fixed, 95% CI)

0.61 [0.13, 2.76]

11 Instrumental vaginal delivery Show forest plot

7

637

Risk Ratio (M‐H, Fixed, 95% CI)

1.11 [0.80, 1.54]

13 Apgar score < 7 at 5 minutes Show forest plot

5

539

Risk Ratio (M‐H, Fixed, 95% CI)

2.05 [0.86, 4.87]

18 Maternal side effects (all) Show forest plot

2

214

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

20 Maternal vomiting Show forest plot

3

370

Risk Ratio (M‐H, Fixed, 95% CI)

0.25 [0.03, 2.19]

21 Maternal diarrhoea Show forest plot

2

214

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

23 Postpartum haemorrhage Show forest plot

1

75

Risk Ratio (M‐H, Fixed, 95% CI)

2.0 [0.43, 9.20]

26 Women not satisfied Show forest plot

1

98

Risk Ratio (M‐H, Fixed, 95% CI)

0.36 [0.12, 1.06]

28 Chorioamnionitis Show forest plot

3

359

Risk Ratio (M‐H, Fixed, 95% CI)

1.60 [0.72, 3.57]

29 Endometritis Show forest plot

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

31 Neonatal infection Show forest plot

3

296

Risk Ratio (M‐H, Fixed, 95% CI)

1.93 [0.27, 13.65]

35 Apgar score < 7 at 1 minute Show forest plot

1

75

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.04, 2.62]

Figures and Tables -
Comparison 17. Oxytocin alone vs intracervical PGE2: all women, unfavourable cervix
Comparison 18. Oxytocin alone vs intracervical PGE2: all women, favourable cervix

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours Show forest plot

1

44

Risk Ratio (M‐H, Fixed, 95% CI)

7.56 [0.43, 132.48]

2 Uterine hyperstimulation with FHR changes Show forest plot

1

44

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Uterine hyperstimulation without FHR changes Show forest plot

1

44

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

13 Apgar score < 7 at 5 minutes Show forest plot

1

44

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

18 Maternal side effects (all) Show forest plot

1

44

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

20 Maternal vomiting Show forest plot

1

44

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

21 Maternal diarrhoea Show forest plot

1

44

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 18. Oxytocin alone vs intracervical PGE2: all women, favourable cervix
Comparison 19. Oxytocin alone vs intracervical PGE2: all women, intact membranes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours Show forest plot

1

200

Risk Ratio (M‐H, Fixed, 95% CI)

1.43 [0.96, 2.12]

2 Uterine hyperstimulation with FHR changes Show forest plot

2

365

Risk Ratio (M‐H, Fixed, 95% CI)

2.02 [0.38, 10.75]

3 Caesarean section Show forest plot

7

614

Risk Ratio (M‐H, Fixed, 95% CI)

1.44 [1.05, 1.97]

4 Cervix unfavourable/unchanged after 12‐24 hours Show forest plot

2

265

Risk Ratio (M‐H, Fixed, 95% CI)

7.24 [3.04, 17.25]

5 Uterine hyperstimulation without FHR changes Show forest plot

2

275

Risk Ratio (M‐H, Fixed, 95% CI)

0.39 [0.02, 7.88]

6 Instrumental vaginal delivery Show forest plot

5

419

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.49, 1.57]

7 Apgar score < 7 at 1 minute Show forest plot

1

75

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.04, 2.62]

8 Apgar score < 7 at 5 minutes Show forest plot

2

365

Risk Ratio (M‐H, Fixed, 95% CI)

4.05 [0.89, 18.50]

11 Postpartum haemorrhage Show forest plot

2

105

Risk Ratio (M‐H, Fixed, 95% CI)

2.2 [0.56, 8.69]

13 Women not satisfied Show forest plot

1

98

Risk Ratio (M‐H, Fixed, 95% CI)

0.36 [0.12, 1.06]

18 Maternal side effects (all) Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

19 Maternal nausea Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

20 Maternal vomiting Show forest plot

1

144

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

21 Maternal diarrhoea Show forest plot

1

144

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 19. Oxytocin alone vs intracervical PGE2: all women, intact membranes
Comparison 20. Oxytocin alone vs intracervical PGE2: all women, ruptured membranes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

3 Caesarean section Show forest plot

5

459

Risk Ratio (M‐H, Fixed, 95% CI)

1.50 [0.92, 2.44]

11 Instrumental vaginal delivery Show forest plot

2

140

Risk Ratio (M‐H, Fixed, 95% CI)

1.41 [0.90, 2.22]

13 Apgar score < 7 at 5 minutes Show forest plot

2

178

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

28 Chorioamnionitis Show forest plot

3

319

Risk Ratio (M‐H, Fixed, 95% CI)

1.72 [0.79, 3.75]

29 Endometritis Show forest plot

2

198

Risk Ratio (M‐H, Fixed, 95% CI)

1.51 [0.38, 6.01]

31 Neonatal infection Show forest plot

4

414

Risk Ratio (M‐H, Fixed, 95% CI)

1.07 [0.23, 4.94]

Figures and Tables -
Comparison 20. Oxytocin alone vs intracervical PGE2: all women, ruptured membranes
Comparison 21. Oxytocin alone vs intracervical PGE2: all primiparae

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Vaginal delivery not achieved in 24 hours Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

1.57 [0.91, 2.71]

2 Uterine hyperstimulation with FHR changes Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Caesarean section Show forest plot

4

355

Risk Ratio (M‐H, Fixed, 95% CI)

1.28 [0.81, 2.02]

8 Uterine hyperstimulation without FHR changes Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

11 Instrumental vaginal delivery Show forest plot

2

197

Risk Ratio (M‐H, Fixed, 95% CI)

1.17 [0.54, 2.53]

13 Apgar score < 7 at 5 minutes Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

18 Maternal side effects (all) Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

19 Maternal nausea Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

20 Maternal vomiting Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

21 Maternal diarrhoea Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 21. Oxytocin alone vs intracervical PGE2: all primiparae
Comparison 22. Oxytocin alone vs intracervical PGE2: all multiparae

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

3 Caesarean section Show forest plot

2

157

Risk Ratio (M‐H, Fixed, 95% CI)

1.01 [0.48, 2.12]

11 Instrumental vaginal delivery Show forest plot

1

61

Risk Ratio (M‐H, Fixed, 95% CI)

0.39 [0.08, 1.84]

Figures and Tables -
Comparison 22. Oxytocin alone vs intracervical PGE2: all multiparae
Comparison 23. Oxytocin alone vs vaginal PGFalpha: all women

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Uterine hyperstimulation with FHR changes Show forest plot

1

23

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Caesarean section Show forest plot

3

280

Risk Ratio (M‐H, Fixed, 95% CI)

1.19 [0.65, 2.18]

3 Serious neonatal morbidity or perinatal death Show forest plot

2

225

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Cervix unfavourable or unchanged after 12/24 hours Show forest plot

1

62

Risk Ratio (M‐H, Fixed, 95% CI)

1.54 [0.50, 4.73]

5 Uterine hyperstimulation without FHR changes Show forest plot

3

291

Risk Ratio (M‐H, Fixed, 95% CI)

0.63 [0.20, 1.96]

6 Epidural analgesia Show forest plot

2

225

Risk Ratio (M‐H, Fixed, 95% CI)

1.99 [1.31, 3.03]

7 Instrumental vaginal delivery Show forest plot

2

225

Risk Ratio (M‐H, Fixed, 95% CI)

0.84 [0.52, 1.35]

8 Perinatal death Show forest plot

2

225

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Vomiting Show forest plot

3

291

Risk Ratio (M‐H, Fixed, 95% CI)

2.09 [0.40, 11.05]

10 Diarrhoea Show forest plot

3

291

Risk Ratio (M‐H, Fixed, 95% CI)

0.06 [0.00, 0.98]

11 Chorioamnionitis Show forest plot

2

225

Risk Ratio (M‐H, Fixed, 95% CI)

0.77 [0.05, 10.85]

12 Endometritis Show forest plot

1

202

Risk Ratio (M‐H, Fixed, 95% CI)

1.44 [0.33, 6.29]

13 Neonatal infection Show forest plot

1

202

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

14 Neonatal jaundice Show forest plot

2

225

Risk Ratio (M‐H, Fixed, 95% CI)

2.51 [1.09, 5.81]

15 Apgar score less than 7 at 1 minute Show forest plot

2

225

Risk Ratio (M‐H, Fixed, 95% CI)

1.14 [0.64, 2.05]

Figures and Tables -
Comparison 23. Oxytocin alone vs vaginal PGFalpha: all women