Scolaris Content Display Scolaris Content Display

CGI‐I funnel plot.
Figures and Tables -
Figure 1

CGI‐I funnel plot.

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 1 Global Impressions scale change item (CGI‐I) (or similar scale) non‐response.
Figures and Tables -
Analysis 1.1

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 1 Global Impressions scale change item (CGI‐I) (or similar scale) non‐response.

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 2 Clinical Global Impressions scale severity item (CGI‐S).
Figures and Tables -
Analysis 1.2

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 2 Clinical Global Impressions scale severity item (CGI‐S).

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 3 Other SP Symptom Severity Scale.
Figures and Tables -
Analysis 1.3

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 3 Other SP Symptom Severity Scale.

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 4 Clinician‐rated: Liebowitz Social Anxiety Scale (LSAS): Fear.
Figures and Tables -
Analysis 1.4

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 4 Clinician‐rated: Liebowitz Social Anxiety Scale (LSAS): Fear.

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 5 Clinician‐rated: Liebowitz Social Anxiety Scale (LSAS): Avoidance.
Figures and Tables -
Analysis 1.5

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 5 Clinician‐rated: Liebowitz Social Anxiety Scale (LSAS): Avoidance.

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 6 Clinician‐rated: Liebowitz Social Anxiety Scale (LSAS): Total.
Figures and Tables -
Analysis 1.6

Comparison 1 Medication vs Placebo: Global and SP symptoms, Outcome 6 Clinician‐rated: Liebowitz Social Anxiety Scale (LSAS): Total.

Comparison 2 Medication vs Placebo: Comorbid symptoms, Outcome 1 Depression Scale.
Figures and Tables -
Analysis 2.1

Comparison 2 Medication vs Placebo: Comorbid symptoms, Outcome 1 Depression Scale.

Comparison 3 Medication vs Placebo: Disability (Sheehan Disability Scale), Outcome 1 Work subscale.
Figures and Tables -
Analysis 3.1

Comparison 3 Medication vs Placebo: Disability (Sheehan Disability Scale), Outcome 1 Work subscale.

Comparison 3 Medication vs Placebo: Disability (Sheehan Disability Scale), Outcome 2 Social subscale.
Figures and Tables -
Analysis 3.2

Comparison 3 Medication vs Placebo: Disability (Sheehan Disability Scale), Outcome 2 Social subscale.

Comparison 3 Medication vs Placebo: Disability (Sheehan Disability Scale), Outcome 3 Family subscale.
Figures and Tables -
Analysis 3.3

Comparison 3 Medication vs Placebo: Disability (Sheehan Disability Scale), Outcome 3 Family subscale.

Comparison 4 Medication vs Placebo: Drop‐out Rate, Outcome 1 Drop‐out Rate.
Figures and Tables -
Analysis 4.1

Comparison 4 Medication vs Placebo: Drop‐out Rate, Outcome 1 Drop‐out Rate.

Comparison 5 Medication vs Placebo: Performance anxiety, Outcome 1 Performance anxiety scale.
Figures and Tables -
Analysis 5.1

Comparison 5 Medication vs Placebo: Performance anxiety, Outcome 1 Performance anxiety scale.

Comparison 6 Medication vs Placebo: Maintenance studies, Outcome 1 Clinical Global Impressions scale change item (CGI‐I) non‐response.
Figures and Tables -
Analysis 6.1

Comparison 6 Medication vs Placebo: Maintenance studies, Outcome 1 Clinical Global Impressions scale change item (CGI‐I) non‐response.

Comparison 6 Medication vs Placebo: Maintenance studies, Outcome 3 Drop‐out Rate.
Figures and Tables -
Analysis 6.3

Comparison 6 Medication vs Placebo: Maintenance studies, Outcome 3 Drop‐out Rate.

Comparison 7 Medication vs Placebo: Relapse Prevention, Outcome 1 Relapse rate.
Figures and Tables -
Analysis 7.1

Comparison 7 Medication vs Placebo: Relapse Prevention, Outcome 1 Relapse rate.

Comparison 8 Subgroup analysis: Multi vs single centre, Outcome 2 Global Impressions scale change item (CGI‐I) (or similar scale) non‐response.
Figures and Tables -
Analysis 8.2

Comparison 8 Subgroup analysis: Multi vs single centre, Outcome 2 Global Impressions scale change item (CGI‐I) (or similar scale) non‐response.

Comparison 9 Subgroup analysis: Generalized vs inclusive SP, Outcome 1 Clinical Global Impressions ‐ Improvement (CGI‐I or similar) scale.
Figures and Tables -
Analysis 9.1

Comparison 9 Subgroup analysis: Generalized vs inclusive SP, Outcome 1 Clinical Global Impressions ‐ Improvement (CGI‐I or similar) scale.

Comparison 1. Medication vs Placebo: Global and SP symptoms

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Global Impressions scale change item (CGI‐I) (or similar scale) non‐response Show forest plot

26

3696

Risk Ratio (M‐H, Random, 95% CI)

0.64 [0.57, 0.73]

1.1 Moclobemide

5

1063

Risk Ratio (M‐H, Random, 95% CI)

0.89 [0.80, 0.98]

1.2 Brofaromine

2

177

Risk Ratio (M‐H, Random, 95% CI)

0.44 [0.20, 0.97]

1.3 SSRI

11

2031

Risk Ratio (M‐H, Random, 95% CI)

0.67 [0.59, 0.76]

1.4 MAOI

3

173

Risk Ratio (M‐H, Random, 95% CI)

0.43 [0.24, 0.76]

1.5 Other medication

5

252

Risk Ratio (M‐H, Random, 95% CI)

0.47 [0.26, 0.87]

2 Clinical Global Impressions scale severity item (CGI‐S) Show forest plot

11

1641

Mean Difference (IV, Random, 95% CI)

‐1.02 [‐1.52, ‐0.51]

2.1 SSRIs

2

582

Mean Difference (IV, Random, 95% CI)

‐0.43 [‐0.63, ‐0.23]

2.2 SSRIs ‐ difference scores

1

203

Mean Difference (IV, Random, 95% CI)

‐0.81 [‐1.31, ‐0.31]

2.3 MAOIs

3

156

Mean Difference (IV, Random, 95% CI)

‐1.46 [‐2.53, ‐0.39]

2.4 RIMAs

3

565

Mean Difference (IV, Random, 95% CI)

‐0.31 [‐0.65, 0.02]

2.5 Other medication

2

135

Mean Difference (IV, Random, 95% CI)

‐2.19 [‐4.17, ‐0.21]

3 Other SP Symptom Severity Scale Show forest plot

12

1143

Std. Mean Difference (IV, Random, 95% CI)

‐0.80 [‐1.16, ‐0.43]

3.1 SSRIs

4

655

Std. Mean Difference (IV, Random, 95% CI)

‐0.44 [‐0.79, ‐0.08]

3.3 MAOIs

2

96

Std. Mean Difference (IV, Random, 95% CI)

‐0.89 [‐2.20, 0.41]

3.4 RIMAs

2

179

Std. Mean Difference (IV, Random, 95% CI)

‐0.29 [‐0.92, 0.34]

3.5 Other medication

4

213

Std. Mean Difference (IV, Random, 95% CI)

‐1.51 [‐2.71, ‐0.32]

4 Clinician‐rated: Liebowitz Social Anxiety Scale (LSAS): Fear Show forest plot

14

1803

Mean Difference (IV, Random, 95% CI)

‐7.30 [‐9.58, ‐5.02]

4.1 Moclobemide

3

517

Mean Difference (IV, Random, 95% CI)

‐3.53 [‐8.75, 1.70]

4.2 Brofaromine

3

207

Mean Difference (IV, Random, 95% CI)

‐7.58 [‐12.66, ‐2.50]

4.3 SSRIs

5

884

Mean Difference (IV, Random, 95% CI)

‐9.07 [‐13.15, ‐4.98]

4.4 MAOIs

1

51

Mean Difference (IV, Random, 95% CI)

‐5.23 [‐13.97, 3.51]

4.5 Other medication

2

144

Mean Difference (IV, Random, 95% CI)

‐9.14 [‐13.55, ‐4.73]

5 Clinician‐rated: Liebowitz Social Anxiety Scale (LSAS): Avoidance Show forest plot

14

1804

Mean Difference (IV, Random, 95% CI)

‐6.60 [‐8.68, ‐4.51]

5.1 Moclobemide

3

517

Mean Difference (IV, Random, 95% CI)

‐4.03 [‐9.02, 0.95]

5.2 Brofaromine

2

178

Mean Difference (IV, Random, 95% CI)

‐6.38 [‐10.63, ‐2.12]

5.3 SSRIs

5

884

Mean Difference (IV, Random, 95% CI)

‐8.12 [‐12.09, ‐4.15]

5.4 MAOIs

1

51

Mean Difference (IV, Random, 95% CI)

‐5.42 [‐14.69, 3.85]

5.5 Other medication

3

174

Mean Difference (IV, Random, 95% CI)

‐6.59 [‐11.77, ‐1.41]

6 Clinician‐rated: Liebowitz Social Anxiety Scale (LSAS): Total Show forest plot

16

2086

Mean Difference (IV, Random, 95% CI)

‐18.00 [‐25.17, ‐10.83]

6.1 SSRIs

5

746

Mean Difference (IV, Random, 95% CI)

‐13.99 [‐24.07, ‐3.91]

6.2 SSRIs ‐ difference scores

2

367

Mean Difference (IV, Random, 95% CI)

‐13.97 [‐19.77, ‐8.17]

6.3 MAOIs

2

103

Mean Difference (IV, Random, 95% CI)

‐26.01 [‐56.92, 4.90]

6.4 RIMAs

3

657

Mean Difference (IV, Random, 95% CI)

‐7.24 [‐12.14, ‐2.35]

6.5 Other medication

4

213

Mean Difference (IV, Random, 95% CI)

‐31.82 [‐55.13, ‐8.51]

Figures and Tables -
Comparison 1. Medication vs Placebo: Global and SP symptoms
Comparison 2. Medication vs Placebo: Comorbid symptoms

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Depression Scale Show forest plot

18

1998

Std. Mean Difference (IV, Random, 95% CI)

‐0.21 [‐0.30, ‐0.11]

1.1 Moclobemide

3

506

Std. Mean Difference (IV, Random, 95% CI)

‐0.06 [‐0.24, 0.11]

1.2 SSRIs

6

960

Std. Mean Difference (IV, Random, 95% CI)

‐0.26 [‐0.48, ‐0.03]

1.3 MAOIs

3

154

Std. Mean Difference (IV, Random, 95% CI)

‐0.14 [‐0.46, 0.18]

1.5 Other types of medication

3

171

Std. Mean Difference (IV, Random, 95% CI)

‐0.34 [‐0.64, ‐0.04]

1.6 Brofaromine

3

207

Std. Mean Difference (IV, Random, 95% CI)

‐0.29 [‐0.57, ‐0.02]

Figures and Tables -
Comparison 2. Medication vs Placebo: Comorbid symptoms
Comparison 3. Medication vs Placebo: Disability (Sheehan Disability Scale)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Work subscale Show forest plot

13

1854

Mean Difference (IV, Random, 95% CI)

‐1.23 [‐1.94, ‐0.51]

1.1 SSRIs

4

829

Mean Difference (IV, Random, 95% CI)

‐0.85 [‐1.22, ‐0.49]

1.2 SSRIs ‐ difference scores

1

187

Mean Difference (IV, Random, 95% CI)

‐1.22 [‐2.01, ‐0.43]

1.3 MAOIs

2

95

Mean Difference (IV, Random, 95% CI)

‐2.13 [‐3.53, ‐0.74]

1.4 RIMAs

4

608

Mean Difference (IV, Random, 95% CI)

‐0.13 [‐1.05, 0.80]

1.5 Other medication

2

135

Mean Difference (IV, Random, 95% CI)

‐3.58 [‐6.39, ‐0.78]

2 Social subscale Show forest plot

13

1853

Mean Difference (IV, Random, 95% CI)

‐1.10 [‐1.48, ‐0.72]

2.1 SSRIs

4

829

Mean Difference (IV, Random, 95% CI)

‐0.88 [‐1.28, ‐0.48]

2.2 SSRIs ‐ difference scores

1

187

Mean Difference (IV, Random, 95% CI)

‐1.38 [‐2.21, ‐0.55]

2.3 MAOIs

2

94

Mean Difference (IV, Random, 95% CI)

‐2.58 [‐6.40, 1.24]

2.4 RIMAs

4

608

Mean Difference (IV, Random, 95% CI)

‐0.64 [‐1.13, ‐0.15]

2.5 Other medication

2

135

Mean Difference (IV, Random, 95% CI)

‐2.31 [‐3.79, ‐0.83]

3 Family subscale Show forest plot

13

1854

Mean Difference (IV, Random, 95% CI)

‐0.56 [‐0.95, ‐0.17]

3.1 SSRIs

4

829

Mean Difference (IV, Random, 95% CI)

‐0.42 [‐0.73, ‐0.11]

3.2 SSRIs ‐ difference scores

1

187

Mean Difference (IV, Random, 95% CI)

‐0.68 [‐1.35, ‐0.01]

3.3 MAIOs

2

95

Mean Difference (IV, Random, 95% CI)

‐1.48 [‐4.41, 1.44]

3.4 RIMAs

4

608

Mean Difference (IV, Random, 95% CI)

‐0.11 [‐0.75, 0.52]

3.5 Other medication

2

135

Mean Difference (IV, Random, 95% CI)

‐2.02 [‐4.26, 0.22]

Figures and Tables -
Comparison 3. Medication vs Placebo: Disability (Sheehan Disability Scale)
Comparison 4. Medication vs Placebo: Drop‐out Rate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Drop‐out Rate Show forest plot

28

3646

Risk Ratio (M‐H, Random, 95% CI)

0.96 [0.85, 1.09]

1.1 Moclobemide

3

637

Risk Ratio (M‐H, Random, 95% CI)

0.76 [0.57, 1.00]

1.2 Brofaromine

3

212

Risk Ratio (M‐H, Random, 95% CI)

0.94 [0.55, 1.61]

1.3 SSRIs

13

2367

Risk Ratio (M‐H, Random, 95% CI)

1.05 [0.88, 1.25]

1.4 MAOIs

2

121

Risk Ratio (M‐H, Random, 95% CI)

1.13 [0.46, 2.77]

1.5 Other medication

7

309

Risk Ratio (M‐H, Random, 95% CI)

0.94 [0.63, 1.42]

Figures and Tables -
Comparison 4. Medication vs Placebo: Drop‐out Rate
Comparison 5. Medication vs Placebo: Performance anxiety

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Performance anxiety scale Show forest plot

2

44

Mean Difference (IV, Random, 95% CI)

‐0.45 [‐0.90, 0.00]

Figures and Tables -
Comparison 5. Medication vs Placebo: Performance anxiety
Comparison 6. Medication vs Placebo: Maintenance studies

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Clinical Global Impressions scale change item (CGI‐I) non‐response Show forest plot

4

453

Risk Ratio (M‐H, Random, 95% CI)

0.62 [0.50, 0.77]

3 Drop‐out Rate Show forest plot

3

172

Risk Ratio (M‐H, Random, 95% CI)

0.61 [0.27, 1.36]

Figures and Tables -
Comparison 6. Medication vs Placebo: Maintenance studies
Comparison 7. Medication vs Placebo: Relapse Prevention

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Relapse rate Show forest plot

4

425

Risk Ratio (M‐H, Random, 95% CI)

0.33 [0.22, 0.49]

Figures and Tables -
Comparison 7. Medication vs Placebo: Relapse Prevention
Comparison 8. Subgroup analysis: Multi vs single centre

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

2 Global Impressions scale change item (CGI‐I) (or similar scale) non‐response Show forest plot

25

3642

Risk Ratio (M‐H, Random, 95% CI)

0.63 [0.55, 0.72]

2.1 Single‐centre

13

1055

Risk Ratio (M‐H, Random, 95% CI)

0.53 [0.40, 0.70]

2.2 Multi‐centre

12

2587

Risk Ratio (M‐H, Random, 95% CI)

0.69 [0.60, 0.80]

Figures and Tables -
Comparison 8. Subgroup analysis: Multi vs single centre
Comparison 9. Subgroup analysis: Generalized vs inclusive SP

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Clinical Global Impressions ‐ Improvement (CGI‐I or similar) scale Show forest plot

25

3642

Risk Ratio (M‐H, Random, 95% CI)

0.63 [0.55, 0.72]

1.1 Generalized

9

1552

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.58, 0.76]

1.2 Inclusive

16

2090

Risk Ratio (M‐H, Random, 95% CI)

0.61 [0.50, 0.74]

Figures and Tables -
Comparison 9. Subgroup analysis: Generalized vs inclusive SP