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Cochrane Database of Systematic Reviews

Melatonin for tinnitus

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Information

DOI:
https://doi.org/10.1002/14651858.CD011435Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 17 December 2014see what's new
Type:
  1. Intervention
Stage:
  1. Protocol
Cochrane Editorial Group:
  1. Cochrane ENT Group

Copyright:
  1. Copyright © 2014 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Olakunle V Ajayi

    Correspondence to: ENT Department, Essex County Hospital, Colchester Hospital University NHS Foundation Trust, Colchester, UK

    [email protected]

  • John S Phillips

    Department of Otolaryngology, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK

  • Malinee Laopaiboon

    Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand

  • Don McFerran

    ENT Department, Essex County Hospital, Colchester Hospital University NHS Foundation Trust, Colchester, UK

Contributions of authors

OVA: lead author, protocol development, design of search strategy, review preparation, quality assessment, data extraction and analysis.

JSP: protocol development, design of search strategy, review preparation, quality assessment, data extraction and analysis.

DM: protocol development, review preparation, quality assessment, data extraction and analysis.

Sources of support

Internal sources

  • None, Other.

External sources

  • None, Other.

Declarations of interest

Olakunle Ajayi: none known.

Don McFerran: does occasional work at the Tinnitus and Hyperacusis Centre, which was one of the departments that developed tinnitus retraining therapy (TRT). However, he was not involved in that development process and has not published specifically on the topic of TRT. He has also conducted research into a possible drug treatment for tinnitus with GlaxoSmithKline but this is unrelated to melatonin. It was a study regarding a novel compound called vestipitant, related to antidepressants. The work has finished and been published: Roberts C, Inamdar A, Koch A, Kitchiner P, Dewit O, Merlo‐Pich E, et al. A randomized, controlled study comparing the effects of vestipitant or vestipitant and paroxetine combination in subjects with tinnitus. Otology & Neurotology 2011;32:721‐7. Since starting this review Don McFerran has become involved with another drug company, Autifony, and he is receiving payment for consultancy work. This trial is investigating another novel compound, AUT00063, and is also unrelated to melatonin.

John Phillips: currently conducting research into a possible drug treatment for tinnitus with Auris, but this is unrelated to melatonin. This trial is investigating a novel compound called AM101.

Malinee Laopaiboon: none known.

Acknowledgements

We would like to acknowledge the work done on antidepressants for patients with tinnitus by Baldo 2012. This review shares a similar format to both the work done on antidepressants (Baldo 2012) and tinnitus retraining therapy (Phillips 2010) to conserve clarity with respect to reviews of tinnitus.

The paragraphs in Description of the condition are based on the Cochrane review 'Amplification with hearing aids for patients with tinnitus and co‐existing hearing loss' and reproduced with permission (Hoare 2014).

Version history

Published

Title

Stage

Authors

Version

2020 Mar 11

Melatonin for tinnitus

Protocol

Olakunle V Ajayi, John S Phillips, Malinee Laopaiboon, Don McFerran

https://doi.org/10.1002/14651858.CD011435.pub2

2014 Dec 17

Melatonin for tinnitus

Protocol

Olakunle V Ajayi, John S Phillips, Malinee Laopaiboon, Don McFerran

https://doi.org/10.1002/14651858.CD011435

Table 1. Tinnitus questionnaires

Title

No. of items/factors

Psychometrics

Tinnitus Questionnaire (Hallam 1996)

52 items, 5 factors

a = 0.91 for total scale; for subscales a = 0.76 to a = 0.94

Tinnitus Handicap Questionnaire (Kuk 1990)

27 items, 3 factors

a = 0.93 for total scale

Tinnitus Severity Scale (Sweetow 1990)

15 items

Alpha not reported

Tinnitus Reaction Questionnaire (Wilson 1991)

26 items, 4 factors

a = 0.96 and a test‐retest correlation of r = 0.88

Subjective Tinnitus Severity Scale (Halford 1991)

16 items

a = 0.84

Tinnitus Handicap/Support Scale (Erlandsson 1992)

28 items, 3 factors

Alpha not reported

Tinnitus Handicap Inventory (Newman 1996)

25 items, 3 scales

a = 0.93 for total scale

Tinnitus Coping Strategy Questionnaire (Henry 1995)

33

a = 0.88

Tinnitus Coping Style Questionnaire (Budd 1995)

40

Tinnitus Cognitions Questionnaire (Wilson 1998)

Tinnitus Severity Index (Meikle 1995)

Tinnitus Acceptance Questionnaire (Westin 2008)

Figures and Tables -
Table 1. Tinnitus questionnaires