Scolaris Content Display Scolaris Content Display

Topical azelaic acid, salicylic acid, nicotinamide, and sulphur for acne

This is not the most recent version

References

Additional references

Akarsu 2012

Akarsu S, Fetil E, Yucel F, Gul E, Gunes AT. Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris. Journal of Dermatology 2012;39(5):433‐8.

Akhavan 2003

Akhavan A, Bershad S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. American Journal of Clinical Dermatology 2003;4(7):473‐92.

Altman 1996

Altman DG, Bland JM. Detecting skewness from summary information. BMJ 1996;313(7066):1200.

Antoniou 2009

Antoniou C, Dessinioti C, Stratigos AJ, Katsambas AD. Clinical and therapeutic approach to childhood acne: an update. Pediatric Dermatology 2009;26(4):373‐80. [MEDLINE: 19689511]

Arowojolu 2012

Arowojolu AO, Gallo MF, Lopez LM, Grimes DA. Combined oral contraceptive pills for treatment of acne. Cochrane Database of Systematic Reviews 2012, Issue 7. [DOI: 10.1002/14651858.CD004425.pub6]

Babayeva 2011

Babayeva L, Akarsu S, Fetil E, Gunes AT. Comparison of tretinoin 0.05% cream and 3% alcohol‐based salicylic acid preparation in the treatment of acne vulgaris. Journal of the European Academy of Dermatology & Venereology 2011;25(3):328‐33.

Bhate 2013

Bhate K, Williams HC. Epidemiology of acne vulgaris. British Journal of Dermatology 2013;168(3):474‐85.

Boissel 1999

Boissel JP, Cucherat M, Li W, Chatellier G, Gueyffier F, Buyse M, et al. The problem of therapeutic efficacy indices. 3. Comparison of the indices and their use. Therapie 1999;54(4):405‐11.

Boutli 2003

Boutli F, Zioga M, Koussidou T, Ioannides D, Mourellou O. Comparison of chloroxylenol 0.5% plus salicylic acid 2% cream and benzoyl peroxide 5% gel in the treatment of acne vulgaris: a randomized double‐blind study. Drugs Under Experimental & Clinical Research 2003;29(3):101‐5.

Bozzo 2011

Bozzo P, Chua‐Gocheco A, Einarson A. Safety of skin care products during pregnancy. Canadian Family Physician 2011;57(6):665‐7.

Breneman 1993

Breneman DL, Ariano MC. Successful treatment of acne vulgaris in women with a new topical sodium sulfacetamide/sulfur lotion. International Journal of Dermatology 1993;32(5):365‐7.

Choi 2010

Choi YS, Suh HS, Yoon MY, Min SU, Kim JS, Jung JY, et al. A study of the efficacy of cleansers for acne vulgaris. Journal of Dermatological Treatment 2010;21(3):201‐5.

Danto 1966

Danto JL, Maddin WS, Stewart WD, Nelson AJ. A controlled trial of benzoyl peroxide and precipitated sulfur cream in acne vulgaris. Applied Therapeutics 1966;8(7):624‐5.

Deeks 2002

Deeks JJ. Issues in the selection of a summary statistic for meta‐analysis of clinical trials with binary outcomes. Statistics in Medicine 2002;21(11):1575‐600.

Degitz 2008

Degitz K, Ochsendorf F. Pharmacotherapy of acne. Expert Opinion on Pharmacotherapy 2008;9(6):955‐71. [MEDLINE: 18377339]

Del Rosso 2009

Del Rosso JQ. The use of sodium sulfacetamide 10%‐sulfur 5% emollient foam in the treatment of acne vulgaris. Journal of Clinical & Aesthetic Dermatology 2009;2(8):26‐9.

Draelos 2006

Draelos ZD. The effect of a daily facial cleanser for normal to oily skin on the skin barrier of subjects with acne. Cutis 2006;78(1 Suppl):34‐40.

Dunn 2011

Dunn LK, O'Neill JL, Feldman SR. Acne in adolescents: quality of life, self‐esteem, mood, and psychological disorders. Dermatology Online Journal 2011;17(1):1.

Fitton 1991

Fitton A, Goa KL. Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs 1991;41(5):780‐98.

Friedlander 2010

Friedlander SF, Eichenfield LF, Fowler JF, Fried RG, Levy ML, Webster GF. Acne epidemiology and pathophysiology. Seminars in Cutaneous Medicine & Surgery 2010;29(2 Suppl 1):2‐4. [MEDLINE: 20610306]

Gamble 2012

Gamble R, Dunn J, Dawson A, Petersen B, McLaughlin L, Small A, et al. Topical antimicrobial treatment of acne vulgaris: an evidence‐based review. American Journal of Clinical Dermatology 2012;13(3):141‐52. [MEDLINE: 22268388]

Garg 2009

Garg VK, Sinha S, Sarkar R. Glycolic acid peels versus salicylic‐mandelic acid peels in active acne vulgaris and post‐acne scarring and hyperpigmentation: a comparative study. Dermatologic Surgery 2009;35(1):59‐65.

Garner 2012

Garner SE, Eady A, Bennett C, Newton JN, Thomas K, Popescu CM. Minocycline for acne vulgaris: efficacy and safety. Cochrane Database of Systematic Reviews 2012, Issue 8. [DOI: 10.1002/14651858.CD002086.pub2]

Gerlinger 2011

Gerlinger C, Schmelter T. Determining the non‐inferiority margin for patient reported outcomes. Pharmaceutical Statistics 2011;10(5):410‐3. [MEDLINE: 21932298]

Gollnick 2003

Gollnick HP, Krautheim A. Topical treatment in acne: current status and future aspects. Dermatology 2003;206(1):29‐36.

Grange 2009

Grange PA, Raingeaud J, Calvez V, Dupin N. Nicotinamide inhibits Propionibacterium acnes‐induced IL‐8 production in keratinocytes through the NF‐kappaB and MAPK pathways. Journal of Dermatological Science 2009;56(2):106‐12.

Graupe 1996

Graupe K, Cunliffe WJ, Gollnick HP, Zaumseil RP. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. Cutis 1996;57(1 Suppl):20‐35.

Gupta 2004

Gupta AK, Nicol K. The use of sulfur in dermatology. Journal of Drugs in Dermatology 2004;3(4):427‐31.

Haider 2004

Haider A, Shaw JC. Treatment of acne vulgaris. JAMA 2004;292(6):726‐35. [MEDLINE: 15304471]

Hay 2014

Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP, Margolis DJ, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. Journal of Investigative Dermatology 2014;134(6):1527‐34. [MEDLINE: 24166134]

Higgins 2011

Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org. The Cochrane Collaboration.

Iraji 2007

Iraji F, Sadeghinia A, Shahmoradi Z, Siadat AH, Jooya A. Efficacy of topical azelaic acid gel in the treatment of mild‐moderate acne vulgaris. Indian Journal of Dermatology, Venereology & Leprology 2007;73(2):94‐6.

Karimkhani 2014

Karimkhani C, Boyers LN, Prescott L, Welch V, Delamere FM, Nasser M, et al. Global burden of skin disease as reflected in Cochrane Database of Systematic Reviews. JAMA Dermatology 2014;150(9):945‐51. [PUBMED: 24807687]

Katsambas 2008

Katsambas A, Dessinioti C. New and emerging treatments in dermatology: acne. Dermatologic Therapy 2008;21(2):86‐95.

Kempiak 2008

Kempiak SJ, Uebelhoer N. Superficial chemical peels and microdermabrasion for acne vulgaris. Seminars in Cutaneous Medicine & Surgery 2008;27(3):212‐20.

Kharfi 2001

Kharfi M, Tekaya N, Zeglaoui F, Ezzine N, Mokhtar I, Kamoun F, et al. Comparative study of the efficacy and tolerance of 12% glycolic acid cream and 0.05% retinoic acid cream for polymorphic acne [Etude comparative de l'efficacite et de la tolerance d'une creme a 12% d'acide glycolyque et d'une creme a 0.05% d'acide retinoique dans l'acne polymorphe]. La Tunisie Medicale 2001;79(6‐7):374‐7. [PUBMED: 11771434]

Khodaeiani 2013

Khodaeiani E, Fouladi RF, Amirnia M, Saeidi M, Karimi ER. Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris. International Journal of Dermatology 2013;52(8):999‐1004.

Khunger 2012

Khunger N, Kumar C. A clinico‐epidemiological study of adult acne: is it different from adolescent acne?. Indian Journal of Dermatology, Venereology & Leprology 2012;78(3):335‐41. [MEDLINE: 22565434]

Kim 2005

Kim J. Review of the innate immune response in acne vulgaris: activation of Toll‐like receptor 2 in acne triggers inflammatory cytokine responses. Dermatology 2005;211(3):193‐8.

Krakowski 2007

Krakowski AC, Eichenfield LF. Pediatric acne: clinical presentations, evaluation, and management. Journal of Drugs in Dermatology 2007;6(6):589‐93. [MEDLINE: 17668524]

Lee 2003

Lee HS, Kim IH. Salicylic acid peels for the treatment of acne vulgaris in Asian patients. Dermatologic Surgery 2003;29(12):1196‐9; discussion 1199.

Lehmann 2001

Lehmann HP, Andrews JS, Robinson KA, Holloway VL, Goodman SN. Management of acne. Summary, Evidence Report/Technology Assessment: Number 17. AHRQ Publication No. 01‐E018, March 2001. Agency for Healthcare Research and Quality, Rockville, MD.

Lehmann 2002

Lehmann HP, Robinson KA, Andrews JS, Holloway V, Goodman SN. Acne therapy: a methodologic review. Journal of the American Academy of Dermatology 2002;47(2):231‐40. [MEDLINE: 12140469]

McLeod 2003

McLeod LD, Fehnel SE, Brandman J, Symonds T. Evaluating minimal clinically important differences for the acne‐specific quality of life questionnaire. Pharmacoeconomics 2003;21(15):1069‐79. [MEDLINE: 14596626]

Mills 1972

Mills OH, Kligman AM. Is sulphur helpful or harmful in acne vulgaris?. British Journal of Dermatology 1972;86(6):620‐7.

Misery 2011

Misery L. Consequences of psychological distress in adolescents with acne. Journal of Investigative Dermatology 2011;131(2):290‐2.

Morganti 2011

Morganti P, Berardesca E, Guarneri B, Guarneri F, Fabrizi G, Palombo P, et al. Topical clindamycin 1% vs. linoleic acid‐rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre‐randomized trial. International Journal of Cosmetic Science 2011;33(5):467‐76.

NilFroushzadeh 2009

NilFroushzadeh MA, Siadat AH, Baradaran EH, Moradi S. Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial. Indian Journal of Dermatology, Venereology & Leprology 2009;75(3):279‐82.

O'Brien 1998

O'Brien SC, Lewis JB, Cunliffe WJ. The Leeds Revised Acne Grading System. Journal of Dermatological Treatments 1998;9(4):215‐20.

Pace 1965

Pace WE. A benzoyl peroxide‐sulfur cream for acne vulgaris. Canadian Medical Association Journal 1965;93:252‐4. [MEDLINE: 14328040]

Passi 1989

Passi S, Picardo M, De Luca C, Nazzaro‐Porro M. Mechanism of azelaic acid action in acne. Giornale Italiano di Dermatologia e Venereologia 1989;124(10):455‐63.

Pazoki‐Toroudi 2010

Pazoki‐Toroudi H, Nassiri‐Kashani M, Tabatabaie H, Ajami M, Habibey R, Shizarpour M, et al. Combination of azelaic acid 5% and erythromycin 2% in the treatment of acne vulgaris. Journal of Dermatological Treatment 2010;21(3):212‐6.

Pazoki‐Toroudi 2011

Pazoki‐Toroudi H, Nilforoushzadeh M A, Ajami M, Jaffary F, Aboutaleb N, Nassiri‐Kashani M, et al. Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. Cutaneous & Ocular Toxicology 2011;30(4):286‐91.

Purdy 2011

Purdy S, de Berker D. Acne vulgaris. Clinical Evidence 2011;2011:1714. [MEDLINE: 21477388]

Rademaker 2014

Rademaker M, Wishart JM, Birchall NM. Isotretinoin 5 mg daily for low‐grade adult acne vulgaris‐‐a placebo‐controlled, randomized double‐blind study. Journal of the European Academy of Dermatology & Venereology 2014;28(6):747‐54. [MEDLINE: 23617693]

Ramli 2012

Ramli R, Malik AS, Hani AF, Jamil A. Acne analysis, grading and computational assessment methods: an overview. Skin Research & Technology 2012;18(1):1‐14. [MEDLINE: 21605170]

RevMan 2014 [Computer program]

The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.

Seidler 2010

Seidler EM, Kimball AB. Meta‐analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne. Journal of the American Academy of Dermatology 2010;63(1):52‐62.

Shahmoradi 2013

Shahmoradi Z, Iraji F, Siadat AH, Ghorbaini A. Comparison of topical 5% nicotinamid gel versus 2% clindamycin gel in the treatment of the mild‐moderate acne vulgaris: A double‐blinded randomized clinical trial. Journal of Research in Medical Sciences 2013;18(2):115‐7.

Shalita 1995

Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. International Journal of Dermatology 1995;34(6):434‐7.

Spellman 1998

Spellman MC, Pincus SH. Efficacy and safety of azelaic acid and glycolic acid combination therapy compared with tretinoin therapy for acne. Clinical Therapeutics 1998;20(4):711‐21.

Strauss 2007

Strauss JS, Krowchuk DP, Leyden JJ, Lucky AW, Shalita AR, Siegfried EC, et al. Guidelines of care for acne vulgaris management. Journal of the American Academy of Dermatology 2007;56(4):651‐63.

Tarimci 1997

Tarimci N, Sener S, Kilinc T. Topical sodium sulfacetamide/sulfur lotion. Journal of Clinical Pharmacy & Therapeutics 1997;22(4):301.

Thiboutot 2008

Thiboutot D. Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris. Journal of Drugs in Dermatology 2008;7(1):13‐6. [MEDLINE: 18246693]

Thiboutot 2009

Thiboutot D, Gollnick H, Bettoli V, Dreno B, Kang S, Leyden JJ, et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. Journal of the American Academy of Dermatology 2009;60(5 Suppl):S1‐50. [MEDLINE: 19376456]

Titus 2012

Titus S, Hodge J. Diagnosis and treatment of acne. American Family Physician 2012;86(8):734‐40. [MEDLINE: 23062156]

Touitou 2008

Touitou E, Godin B, Shumilov M, Bishouty N, Ainbinder D, Shouval R, et al. Efficacy and tolerability of clindamycin phosphate and salicylic acid gel in the treatment of mild to moderate acne vulgaris. Journal of the European Academy of Dermatology & Venereology 2008;22(5):629‐31.

Well 2013

Well D. Acne vulgaris: A review of causes and treatment options. Nurse Practitioner 2013;38(10):22‐31; quiz 32. [MEDLINE: 24048347]

Wilkinson 1966

Wilkinson RD, Adam JE, Murray JJ, Craig GE. Benzoyl peroxide and sulfur: foundation for acne management. Canadian Medical Association Journal 1966;95(1):28‐9.

Williams 2006

Williams C, Layton AM. Persistent acne in women: implications for the patient and for therapy. American Journal of Clinical Dermatology 2006;7(5):281‐90. [MEDLINE: 17007539]

Xia 2007

Xia J, Adams CE, Bhagat N, Bhagat V, Bhoopathi P, El‐Sayeh H, et al. The Leeds Outcomes Stakeholders Survey (LOSS) Study. Proceedings of the 15th Cochrane Colloquium. Sao Paulo: The Cochrane Collaboration, 2007 Oct 23‐27.

Xia 2009

Xia J, Adams C, Bhagat N, Bhagat V, Bhoopathi P, El‐Sayeh H, et al. Losing participants before the trial ends erodes credibility of findings. Psychiatric Bulletin 2009;33(7):254‐7.

Yang 2014

Yang Z, Zhang Y, Lazic ME, Li H, Hu J, Zhang Y, et al. Topical benzoyl peroxide for acne. Cochrane Database of Systematic Reviews 2014, Issue 6. [DOI: 10.1002/14651858.CD011154]

Zander 1992

Zander E, Weisman S. Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics 1992;14(2):247‐53.

Zheng 2013

Zheng Y, Wan M, Chen H, Ye C, Zhao Y, Yi J, et al. Clinical evidence on the efficacy and safety of an antioxidant optimized 1.5% salicylic acid (SA) cream in the treatment of facial acne: an open, baseline‐controlled clinical study. Skin Research & Technology 2013;19(2):125‐30.
Table 1. Glossary of medical terms

Medical term

Explanation

Acne conglobata

A severe form of acne presenting with numerous comedones and large abscessesa

Acne fulminans

A severe form of cystic acne presenting with highly inflammatory nodules and plaquesa

Acne mechanica

A form of acne caused by the pressure of tight clothing or frictionb

Acne vulgaris

A common chronic skin disorder of sebaceous follicles, mainly affecting the face, chest, and backa

Chemokine

A group of small cytokines that act as chemical messengers to induce chemotaxis in leukocytesc

Comedone

A clogged hair follicle in the skin. It can present as a blackhead or whiteheada

Cytokine

A small protein released by cells that function as molecular messengers between cellsc

Erythema

Redness of the skin, caused by vascular congestion or increased perfusionb

Excoriated acne

Compulsive squeezing and scratching of acne lesions with resultant scabs and scarsa

Halogen acne

A form of acne caused by iodides, bromides, and halogensb

Hyperkeratosis

Thickening of the outer layer of skin often associated with a quantitative abnormality of keratinb

Keratinocytes

The predominant cell type in the epidermis, forming a touch protective layera

Microcomedones

Early and small plugging of the follicle with excess keratin and sebumb

Nodule

A solid mass in the skin, more than 0.5 cm in diameterb

Papule

A circumscribed palpable elevation, less than 0.5 cm in diameterb

Pilosebaceous unit

A structure consisting of a hair follicle, sebaceous gland, and an arrector pili muscleb

Propionibacterium acnes

Gram‐positive bacterium related to acne developmentb

Pustule

A visible accumulation of free pusb

Scar

Skin areas of fibrous tissue replacing normal skin after injuryb

Sebum

The oily, waxy substance produced by sebaceous glandsb

Stratum corneum

The outermost layer of the epidermis, where cells have lost nuclei and cytoplasmic organellesb

Toll‐like receptor

A class of proteins that recognise conserved products unique to microbial metabolism in immune responsec

aAndrews' Diseases of the Skin: Clinical Dermatology, 11th Edition, 2011, Elsevier Inc.

bRook's Textbook of Dermatology, Eighth Edition, 2010, Blackwell Publishing Ltd.

cImmunology, Sixth Edition, 2001, Harcourt Asia Pte Ltd.

Figures and Tables -
Table 1. Glossary of medical terms
Table 2. Clinical classification of acnea

Acne vulgaris

Acne variants:

Neonatal acne

Infantile acne

Acne conglobata

Acne fulminans

SAPHO syndrome

PAPA syndrome

Acne excoriee des jeunes filles

Acne mechanica

Acne with solid facial oedema

Acne with associated endocrinology abnormalities

Acneiform eruptions:

Steroid folliculitis

Drug‐induced acne

Epidermal growth factor receptor inhibitor associated eruption

Occupational acne and chloracne

Gram‐negative folliculitis

Radiation acne

Tropical acne

Acne aestivalis

Pseudoacne of the nasal crease

Apert syndrome

aFitzpatrick's Dermatology in General Medicine, Eighth edition, 2012, The McGraw‐Hill Companies, Inc.

Figures and Tables -
Table 2. Clinical classification of acnea