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Cochrane Database of Systematic Reviews

Milnacipran for neuropathic pain and fibromyalgia in adults

This is not the most recent version

view the current version 20 October 2015

Information

DOI:
https://doi.org/10.1002/14651858.CD008244.pub2Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 14 March 2012see what's new
Type:
  1. Intervention
Stage:
  1. Review
Cochrane Editorial Group:

  1. Cochrane Pain, Palliative and Supportive Care Group

Copyright:
  1. Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Sheena Derry

    Correspondence to: Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Oxford, UK

    [email protected]

  • Dipender Gill

    Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Oxford, UK

  • Tudor Phillips

    Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Oxford, UK

  • R Andrew Moore

    Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Oxford, UK

Contributions of authors

RAM and SD wrote the protocol. DG and TP carried out searches and assessed studies for inclusion. SD, DG, and TP extracted data and carried out analyses. RAM acted as arbitrator. All authors were involved in writing the review. RAM will be responsible for updating the review.

Sources of support

Internal sources

  • Oxford Pain Research Trust, UK.

External sources

  • No sources of support supplied

Declarations of interest

SD and RAM have received research support from charities, government, and industry sources at various times. RAM has consulted for various pharmaceutical companies and received lecture fees from pharmaceutical companies related to analgesics and other healthcare interventions. DG and TP have no interests to declare. No company with any interest in milnacipran had any involvement in the production of this review.

Acknowledgements

We would like to thank several peer reviewers for constructive criticism, and the excellent editorial support of the Cochrane PaPaS Group.

Version history

Published

Title

Stage

Authors

Version

2015 Oct 20

Milnacipran for pain in fibromyalgia in adults

Review

Malene Cording, Sheena Derry, Tudor Phillips, R Andrew Moore, Philip J Wiffen

https://doi.org/10.1002/14651858.CD008244.pub3

2012 Mar 14

Milnacipran for neuropathic pain and fibromyalgia in adults

Review

Sheena Derry, Dipender Gill, Tudor Phillips, R Andrew Moore

https://doi.org/10.1002/14651858.CD008244.pub2

2010 Jan 20

Milnacipran for neuropathic pain and fibromyalgia in adults

Protocol

Sheena Derry, Henry J McQuay, R Andrew Moore

https://doi.org/10.1002/14651858.CD008244

Differences between protocol and review

We have included analyses of two composite efficacy outcomes that were not prespecified in the protocol. We chose to do this because they more closely reflect what is desirable in clinical practice (what patients want), and because they were calculated using baseline observation carried forward, without imputation for missing data, which reflects the situation in clinical practice (if you cannot take the medication you cannot get any benefit from it).

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.