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Cochrane Database of Systematic Reviews

Trastuzumab containing regimens for early breast cancer

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view the current version 18 April 2012

Information

DOI:
https://doi.org/10.1002/14651858.CD006243Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 18 October 2006see what's new
Type:
  1. Intervention
Stage:
  1. Protocol
Cochrane Editorial Group:

  1. Cochrane Breast Cancer Group

Copyright:
  1. Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Lorenzo Moja

    Correspondence to: Centro Cochrane Italiano, Istituto Mario Negri, Milano, Italy

    [email protected]

  • Cinzia Brambilla

    Italian Cochrane Centre, Mario Negri Institute, Milan, Italy

  • Anna Compagnoni

    Laboratorio per la Ricerca Clinica Oncologica, Instituto Mario Negri, Milan, Italy

  • Vanna Pistotti

    Centro Cochrane Italiano, Milano, Italy

Contributions of authors

Lorenzo Moja (LPM), Anna Compagnoni (AC) and Cinzia Brambilla (CB) conceived the study and participated in developing the protocol. LPM and AC developed the search strategies and the quality assessment for observational studies. Vanna Pistotti (VP) revised all the search strategies.

Sources of support

Internal sources

  • Mario Negri Institute, Italy.

External sources

  • No sources of support supplied

Declarations of interest

None known.

Acknowledgements

The authors gratefully acknowledge Su Golder and Carol Lefebvre for valuable suggestions about bibliographic researches; Deirdre Price, Jessica Thomas and Andrew Herxheimer for valuable suggestions about methodological issues in analysing adverse events; Davina Ghersi, Sharon Parker, Nancy Owens and Nicholas Wilcken for their helpful assistance during all the phases of the preparation of the protocol.

Version history

Published

Title

Stage

Authors

Version

2012 Apr 18

Trastuzumab containing regimens for early breast cancer

Review

Lorenzo Moja, Ludovica Tagliabue, Sara Balduzzi, Elena Parmelli, Vanna Pistotti, Valentina Guarneri, Roberto D'Amico

https://doi.org/10.1002/14651858.CD006243.pub2

2006 Oct 18

Trastuzumab containing regimens for early breast cancer

Protocol

Lorenzo Moja, Cinzia Brambilla, Anna Compagnoni, Vanna Pistotti

https://doi.org/10.1002/14651858.CD006243

Keywords

MeSH

Medical Subject Headings (MeSH) Keywords

Medical Subject Headings Check Words

Female; Humans;

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.

Table 1. Potential list of cardiac adverse events

Cardiac toxicity

Left ventricular ejection fraction (LVEF) abnormal by multiple‐gated acquisition (MUGA) or echocardiogram

Uncontrolled arterial hypertension

Myocardial infarction

Unstable angina or angina pectoris

Congestive heart failure

Serious cardiac arrhythmia

QTc interval greater than 440 msec

Rhythm abnormalities requiring permanent therapy

Prolonged PR interval or atrioventricular block on electrocardiogram (ECG)

Second or third‐degree heart blocks

Peripheral vascular disease

Cardiomyopathy

Signs and symptoms of cardiac dysfunction (such as dyspnea, increased cough, paroxysmal nocturnal dyspnea, peripheral edema)

Other clinically significant cardiovascular disease
Figures and Tables -
Table 1. Potential list of cardiac adverse events
Navigate to table in Protocol