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Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
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Figure 1

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
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Figure 2

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

Comparison 1 NSAID versus placebo, Outcome 1 Overall pain relief.
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Analysis 1.1

Comparison 1 NSAID versus placebo, Outcome 1 Overall pain relief.

Comparison 1 NSAID versus placebo, Outcome 2 Unintended effects of treatment.
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Analysis 1.2

Comparison 1 NSAID versus placebo, Outcome 2 Unintended effects of treatment.

Comparison 1 NSAID versus placebo, Outcome 3 Requirements for additional medication.
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Analysis 1.3

Comparison 1 NSAID versus placebo, Outcome 3 Requirements for additional medication.

Summary of findings for the main comparison. NSAID compared with placebo for pain in women with endometriosis

NSAID compared with placebo for pain in women with endometriosis

Patient or population: women with endometriosis
Setting: Finland
Intervention: nonsteroidal anti‐inflammatory drugs (NSAIDs)
Comparison: placebo

Outcomes

Anticipated absolute effects* (95% CI)

Relative effect
(95% CI)

Number of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Risk with placebo

Risk with NSAID

Pain relief assessed with: overall pain relief score follow‐up: median 2 months

50 per 100

77 per 100
(38 to 95)

OR 3.27
(0.61 to 17.69)

24
(1 RCT)

⊕⊝⊝⊝
Very lowa,b

Unintended effects from treatment follow‐up: median 2 months

58 per 100

39 per 100
(11 to 78)

OR 0.46
(0.09 to 2.47)

24
(1 RCT)

⊕⊝⊝⊝
Very lowa,b

Quality of life: not reported

Effects on daily activities: not reported

Absence from work or school: not reported

Number of women requiring more invasive treatment: not reported

Requirements for additional medication follow‐up: median 2 months

83 per 100

38 per 100
(5 to 87)

OR 0.12
(0.01 to 1.29)

24
(1 RCT)

⊕⊝⊝⊝
Very lowa,b

Participant satisfaction with treatment: not reported

*The risk in the intervention group (and its 95% confidence interval) is based on assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: confidence interval; OR: odds ratio.

GRADE Working Group grades of evidence.
High quality: We are very confident that the true effect lies close to the estimate of effect.
Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of effect but may be substantially different.
Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of effect.
Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.

aDowngraded one level owing to overall unclear risk of bias for included trial.

bDowngraded two levels for imprecision because confidence interval is wide, consistent with benefit and harm and evidence based on a single small trial.

Figures and Tables -
Summary of findings for the main comparison. NSAID compared with placebo for pain in women with endometriosis
Comparison 1. NSAID versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Overall pain relief Show forest plot

1

odds ratio (Fixed, 95% CI)

3.27 [0.61, 17.69]

2 Unintended effects of treatment Show forest plot

1

odds ratio (Fixed, 95% CI)

0.46 [0.09, 2.47]

3 Requirements for additional medication Show forest plot

1

odds ratio (Fixed, 95% CI)

0.12 [0.01, 1.29]

Figures and Tables -
Comparison 1. NSAID versus placebo