Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma
Information
- DOI:
- https://doi.org/10.1002/14651858.CD004329.pub2Copy DOI
- Database:
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- Cochrane Database of Systematic Reviews
- Version published:
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- 18 October 2006see what's new
- Type:
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- Intervention
- Stage:
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- Review
- Cochrane Editorial Group:
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Cochrane ENT Group
- Copyright:
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- Copyright © 2015 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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Authors
Contributions of authors
B Baujat supervised the data analysis and wrote the paper. H Audry did the data collection and the statistical analysis. J Bourhis and JP Pignon had the original idea, designed the study and revised the paper. JP Pignon also supervised data collection and statistical analyses. The investigators provided the data, answered queries sent to secretariat and validated the re‐analysis of trials. The other authors reviewed and commented on the preliminary results and the manuscript. The members of the Steering Committee also reviewed the protocol and the data from trials with eligibility problems. K Thephamongkhol contributed to data collection and revised the paper.
Sources of support
Internal sources
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Institut Gustave‐Roussy, France.
External sources
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Aventis, France.
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Sanofi‐Synthelabo, France.
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Schering‐Plough, France.
Declarations of interest
Aventis had a general agreement with Institut Gustave Roussy to support meta‐analyses on lung and head and neck cancers. Sanofi supported part of the investigator meeting. Schering‐Plough (a company not directly interested in the project) provided a travelling expenses grant for the first author to attend the ASTRO meeting to present the MAC‐NPC project. The grant was awarded after the acceptance of the abstract. The study sponsors played no role in the study design, data collection, data analysis, data interpretation or writing of the report.
The authors declare that they have no conflict of interest.
Acknowledgements
We are grateful to Denise Avenell for secretariat support, Francine Courtial for trial search, Catherine Hill for her comments on the manuscript and Lorna Saint Ange for editing.
Version history
| Published | Title | Stage | Authors | Version |
| 2006 Oct 18 | Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma | Review | Bertrand Baujat, Hélène Audry, Jean Bourhis, Anthony TC Chan, Haluk Onat, Daniel TT Chua, Dora LW Kwong, Muhyi Al‐Sarraf, Kwan‐Hwa Chi, Masato Hareyama, Singh F Leung, Kullathorn Thephamongkhol, Jean Pierre Pignon, MAC‐NPC Collaborative Group | |
| 2003 Apr 22 | Chemotherapy for nasopharyngeal carcinoma | Protocol | G roup MAC‐NPC (Meta‐Analysis of Chemotherapy in Naso‐Pharynx Carcinoma), Jean‐Pierre Pignon, François Eschwege, Jean Pierre Armand, Jean Bourhis | |
Notes
May 2009: updating of this review
This is a review of individual patient data. Whilst standard Cochrane Reviews are updated every two years, we believe that the updating of this review is premature because:
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induction chemotherapy is a major issue since the onset of TPF (taxane, platinum, 5FU) protocols. We know of two ongoing trials which are testing TPF for nasopharyngeal carcinoma and think it would be pertinent to defer the update of this review until they publish at least their preliminary results;
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two newly published trials confirm the results of the previously published trials and no different conclusions would be drawn from their inclusion. This systematic review was not underpowered, as concomitant chemotherapy was shown to provide a significant benefit in terms of survival.
