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Cochrane Database of Systematic Reviews

Quimioterapia como adyuvante a la radioterapia en carcinomas nasofaríngeos localmente avanzados

Information

DOI:
https://doi.org/10.1002/14651858.CD004329.pub2Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 18 October 2006see what's new
Type:
  1. Intervention
Stage:
  1. Review
Cochrane Editorial Group:
  1. Cochrane ENT Group

Copyright:
  1. Copyright © 2015 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Bertrand Baujat

    Correspondence to: Service ORL‐CCF, Hôpital Tenon, Paris, France

    [email protected]

  • Hélène Audry

    Biostatistique et Epidémiologie, Institut Gustave‐Roussy, 94805 Villejuif Cedex, France

  • Jean Bourhis

    Département de Radiothérapie, Institut Gustave Roussy, Villejuif Cedex, France

  • Anthony TC Chan

    Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong

  • Haluk Onat

    Institute of Oncology, Istanbul University, Istanbul, Turkey

  • Daniel TT Chua

    Clinical Oncology, Queen Mary Hospital, Hong Kong Island, Hong Kong

  • Dora LW Kwong

    Clinical Oncology, Queen Mary Hospital, Hong Kong Island, Hong Kong

  • Muhyi Al‐Sarraf

    Department of Internal Medicine, Wayne State University, Detroit, USA

  • Kwan‐Hwa Chi

    Taiwan Co‐operative Oncology Group, Taipei, Taiwan

  • Masato Hareyama

    Radiology, Sapporo Medical University, Sapporo, Japan

  • Singh F Leung

    Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong

  • Kullathorn Thephamongkhol

    Div of Radiation Oncology Department of Radiology, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, Thailand

  • Jean Pierre Pignon

    Plateforme LNCC de Méta‐analyse en Oncologie et Service de Biostatistique et d’Epidémiologie, Gustave Roussy Cancer Campus, Villejuif, France

  • MAC‐NPC Collaborative Group

    Head and Neck Surgery, Hôpital Foch, Suresnes, France

Contributions of authors

B Baujat supervised the data analysis and wrote the paper. H Audry did the data collection and the statistical analysis. J Bourhis and JP Pignon had the original idea, designed the study and revised the paper. JP Pignon also supervised data collection and statistical analyses. The investigators provided the data, answered queries sent to secretariat and validated the re‐analysis of trials. The other authors reviewed and commented on the preliminary results and the manuscript. The members of the Steering Committee also reviewed the protocol and the data from trials with eligibility problems. K Thephamongkhol contributed to data collection and revised the paper.

Sources of support

Internal sources

  • Institut Gustave‐Roussy, France.

External sources

  • Aventis, France.

  • Sanofi‐Synthelabo, France.

  • Schering‐Plough, France.

Declarations of interest

Aventis had a general agreement with Institut Gustave Roussy to support meta‐analyses on lung and head and neck cancers. Sanofi supported part of the investigator meeting. Schering‐Plough (a company not directly interested in the project) provided a travelling expenses grant for the first author to attend the ASTRO meeting to present the MAC‐NPC project. The grant was awarded after the acceptance of the abstract. The study sponsors played no role in the study design, data collection, data analysis, data interpretation or writing of the report.

The authors declare that they have no conflict of interest.

Acknowledgements

We are grateful to Denise Avenell for secretariat support, Francine Courtial for trial search, Catherine Hill for her comments on the manuscript and Lorna Saint Ange for editing.

Version history

Published

Title

Stage

Authors

Version

2006 Oct 18

Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma

Review

Bertrand Baujat, Hélène Audry, Jean Bourhis, Anthony TC Chan, Haluk Onat, Daniel TT Chua, Dora LW Kwong, Muhyi Al‐Sarraf, Kwan‐Hwa Chi, Masato Hareyama, Singh F Leung, Kullathorn Thephamongkhol, Jean Pierre Pignon, MAC‐NPC Collaborative Group

https://doi.org/10.1002/14651858.CD004329.pub2

2003 Apr 22

Chemotherapy for nasopharyngeal carcinoma

Protocol

G roup MAC‐NPC (Meta‐Analysis of Chemotherapy in Naso‐Pharynx Carcinoma), Jean‐Pierre Pignon, François Eschwege, Jean Pierre Armand, Jean Bourhis

https://doi.org/10.1002/14651858.CD004329

Notes

May 2009: updating of this review

This is a review of individual patient data.  Whilst standard Cochrane Reviews are updated every two years, we believe that the updating of this review is premature because:

  • induction chemotherapy is a major issue since the onset of TPF (taxane, platinum, 5FU) protocols. We know of two ongoing trials which are testing TPF for nasopharyngeal carcinoma and think it would be pertinent to defer the update of this review until they publish at least their preliminary results;

  • two newly published trials confirm the results of the previously published trials and no different conclusions would be drawn from their inclusion. This systematic review was not underpowered, as concomitant chemotherapy was shown to provide a significant benefit in terms of survival.

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.