'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

Forest plot of comparison: 2 Etoricoxib 120 mg vs placebo, outcome: 2.1 Participants with at least 50% pain relief over 6 hours.

Forest plot of comparison: 2 Etoricoxib 120 mg vs placebo, outcome: 2.4 Participants using rescue medication within 24 hours.

Forest plot of comparison: 6 Etoricoxib (all doses) versus placebo, outcome: 6.1 Participants with any adverse event.

L'Abbé plot of etoricoxib 120 mg versus placebo for at least 50% pain relief. Size of circle is proportional to size of study (inset scale). Cream circles ‐ dental studies; pink circle ‐ orthopaedic study.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 1 Participants with at least 50% pain relief over 6 hours.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 2 Participants with at least 50% pain relief over 6 hours, dental.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 3 Participants using rescue medication within 6 hours.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 4 Participants using rescue medication within 24 hours.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 5 Participants with any adverse event.

Comparison 2 Etoricoxib (all doses) versus placebo, Outcome 1 Participants with any adverse event.