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'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 1

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
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Figure 2

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

Forest plot of comparison: 2 Etoricoxib 120 mg vs placebo, outcome: 2.1 Participants with at least 50% pain relief over 6 hours.
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Figure 3

Forest plot of comparison: 2 Etoricoxib 120 mg vs placebo, outcome: 2.1 Participants with at least 50% pain relief over 6 hours.

Forest plot of comparison: 2 Etoricoxib 120 mg vs placebo, outcome: 2.4 Participants using rescue medication within 24 hours.
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Figure 4

Forest plot of comparison: 2 Etoricoxib 120 mg vs placebo, outcome: 2.4 Participants using rescue medication within 24 hours.

Forest plot of comparison: 6 Etoricoxib (all doses) versus placebo, outcome: 6.1 Participants with any adverse event.
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Figure 5

Forest plot of comparison: 6 Etoricoxib (all doses) versus placebo, outcome: 6.1 Participants with any adverse event.

L'Abbé plot of etoricoxib 120 mg versus placebo for at least 50% pain relief. Size of circle is proportional to size of study (inset scale). Cream circles ‐ dental studies; pink circle ‐ orthopaedic study.
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Figure 6

L'Abbé plot of etoricoxib 120 mg versus placebo for at least 50% pain relief. Size of circle is proportional to size of study (inset scale). Cream circles ‐ dental studies; pink circle ‐ orthopaedic study.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 1 Participants with at least 50% pain relief over 6 hours.
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Analysis 1.1

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 1 Participants with at least 50% pain relief over 6 hours.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 2 Participants with at least 50% pain relief over 6 hours, dental.
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Analysis 1.2

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 2 Participants with at least 50% pain relief over 6 hours, dental.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 3 Participants using rescue medication within 6 hours.
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Analysis 1.3

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 3 Participants using rescue medication within 6 hours.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 4 Participants using rescue medication within 24 hours.
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Analysis 1.4

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 4 Participants using rescue medication within 24 hours.

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 5 Participants with any adverse event.
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Analysis 1.5

Comparison 1 Etoricoxib 120 mg vs placebo, Outcome 5 Participants with any adverse event.

Comparison 2 Etoricoxib (all doses) versus placebo, Outcome 1 Participants with any adverse event.
Figuras y tablas -
Analysis 2.1

Comparison 2 Etoricoxib (all doses) versus placebo, Outcome 1 Participants with any adverse event.

Comparison 1. Etoricoxib 120 mg vs placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 6 hours Show forest plot

6

798

Risk Ratio (M‐H, Fixed, 95% CI)

5.60 [4.02, 7.81]

2 Participants with at least 50% pain relief over 6 hours, dental Show forest plot

5

643

Risk Ratio (M‐H, Fixed, 95% CI)

6.68 [4.55, 9.82]

3 Participants using rescue medication within 6 hours Show forest plot

2

268

Risk Ratio (M‐H, Fixed, 95% CI)

0.24 [0.17, 0.34]

4 Participants using rescue medication within 24 hours Show forest plot

4

505

Risk Ratio (M‐H, Fixed, 95% CI)

0.60 [0.53, 0.67]

5 Participants with any adverse event Show forest plot

5

643

Risk Ratio (M‐H, Fixed, 95% CI)

0.93 [0.74, 1.17]

Figuras y tablas -
Comparison 1. Etoricoxib 120 mg vs placebo
Comparison 2. Etoricoxib (all doses) versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with any adverse event Show forest plot

5

1059

Risk Ratio (M‐H, Fixed, 95% CI)

0.91 [0.74, 1.12]

Figuras y tablas -
Comparison 2. Etoricoxib (all doses) versus placebo