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Interwencje w miejscu pracy stosowane w celu skrócenia czasu spędzanego w pozycji siedzącej

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Información

DOI:
https://doi.org/10.1002/14651858.CD010912.pub3Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 17 marzo 2016see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Salud laboral

Copyright:
  1. Copyright © 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Autores

  • Nipun Shrestha

    Correspondencia a: Health Research and Social Development Forum, Kathmandu, Nepal

    [email protected]

    [email protected]

  • Katriina T Kukkonen‐Harjula

    UKK Institute for Health Promotion Research, Tampere, Finland

    Rehabilitation, South Karelia Social and Health Care District Eksote, Lappeenranta, Finland

  • Jos H Verbeek

    Cochrane Work Review Group, Finnish Institute of Occupational Health, Kuopio, Finland

  • Sharea Ijaz

    Cochrane Work Review Group, Finnish Institute of Occupational Health, Kuopio, Finland

  • Veerle Hermans

    Faculty of Psychology & Educational Sciences, Faculty of Medicine & Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium

  • Soumyadeep Bhaumik

    Kolkata, India

Contributions of authors

Jos Verbeek, Sharea Ijaz and Nipun Shrestha conceptualised the review.

Nipun Shrestha took the lead in writing the protocol.

Kaisa Neuvonen (Trials Search Co‐ordinator, Cochrane Work Review Group) and Nipun Shrestha designed the systematic search strategies.

Nipun Shrestha and Katriina Kukkonen‐Harjula conducted the study selection.

Nipun Shrestha, Suresh Kumar and Chukwudi Nwankwo did the data extraction and risk of bias assessment for the previous version.

Nipun Shrestha, Veerle Hermans and Soumyadeep Bhaumik did the data extraction and risk of bias assessment for the current update.

Nipun Shrestha and Jos Verbeek conducted the data analysis.

Nipun Shrestha wrote the manuscript collaborating with Jos Verbeek, Katriina Kukkonen‐Harjula, Sharea Ijaz, Veerle Hermans and Soumyadeep Bhaumik.

Sources of support

Internal sources

  • Cochrane Work Review Group, Finland.

    Nipun Shrestha attended a three‐month internship to learn about Cochrane systematic review methodology.

  • Cochrane, UK.

    Nipun Shrestha received a developing country stipend for attending the 22nd Cochrane Colloquium in 2014 in Hyderabad India.

  • Mesenaatti.me, Finland.

    The author team collected EUR 1600 through the Mesenaatti.me crowdfunding platform to support Nipun Shrestha complete the review

External sources

  • No sources of support supplied

Declarations of interest

Nipun Shrestha: None known.

Jos Verbeek: I am employed by the Finnish Institute of Occupational Health to coordinate the Cochrane Work Review Group.

Sharea Ijaz: None known.

Katriina T Kukkonen‐Harjula: None known.

Veerle Hermans: None known.

Soumyadeep Bhaumik: None known.

Acknowledgements

We thank Jani Ruotsalainen, Managing Editor, Cochrane Work Group for providing administrative and logistical support for the conduct of the current review, and Kaisa Neuvonen, Trials Search Co‐ordinator, Cochrane Work Group for developing and executing the search strategies.

We would also like to thank the Cochrane Work Group's Editors Esa‐Pekka Takala and Anneli Ojajärvi and external peer referees Kimi Sawada, Kristel King, Rintaro Mori and Hidde van der Ploeg for their comments. We thank Joey Kwong, Elizabeth Royle and Jani Ruotsalainen for copy editing the text.

We also like to thank Suresh Kumar and Chukwudi P Nwankwo for their contribution in the previous version of this review.

We would also like to thank all who donated in the crowdfunding campaign to support the review.

Version history

Published

Title

Stage

Authors

Version

2018 Dec 17

Workplace interventions for reducing sitting at work

Review

Nipun Shrestha, Katriina T Kukkonen‐Harjula, Jos H Verbeek, Sharea Ijaz, Veerle Hermans, Zeljko Pedisic

https://doi.org/10.1002/14651858.CD010912.pub5

2018 Jun 20

Workplace interventions for reducing sitting at work

Review

Nipun Shrestha, Katriina T Kukkonen‐Harjula, Jos H Verbeek, Sharea Ijaz, Veerle Hermans, Zeljko Pedisic

https://doi.org/10.1002/14651858.CD010912.pub4

2016 Mar 17

Workplace interventions for reducing sitting at work

Review

Nipun Shrestha, Katriina T Kukkonen‐Harjula, Jos H Verbeek, Sharea Ijaz, Veerle Hermans, Soumyadeep Bhaumik

https://doi.org/10.1002/14651858.CD010912.pub3

2015 Jan 26

Workplace interventions for reducing sitting at work

Review

Nipun Shrestha, Sharea Ijaz, Katriina T Kukkonen‐Harjula, Suresh Kumar, Chukwudi P Nwankwo

https://doi.org/10.1002/14651858.CD010912.pub2

2014 Jan 10

Workplace interventions for reducing sitting at work

Protocol

Nipun Shrestha, Sharea Ijaz, Katriina T Kukkonen‐Harjula, Suresh Kumar, Chukwudi P Nwankwo

https://doi.org/10.1002/14651858.CD010912

Differences between protocol and review

Even though in the protocol we stated that in cases where we would include more than one comparison from a trial with multiple arms in the same meta‐analysis, we would halve the numbers of control group participants to prevent them from being included twice, this does not work for the inverse variance input method. Neuhaus 2014a reported only the results from Ancova and could not provide us with the raw data. For this trial we modelled the means and standard deviations from the intervention and the control group in RevMan as closely to the real data as possible to achieve the same mean difference and standard error. Then we halved the number of participants in the control group and entered the resulting standard errors into RevMan.

We judged studies to be at low risk for selective outcome reporting if the final publications of the trial reported what had been planned and registered in international databases (trial registries), such as ClinicalTrials.gov, ANZCTR.org.au (Australia and New Zealand), NTR (Netherland’s Trial Registry). We judged those studies that were not registered in trial registries as being at low risk for selective outcome reporting if they reported all the outcomes mentioned in the methods section.

Initially we planned to pool interventions that were categorised under broad headings like physical changes in workplace environment, policy changes and information and counselling, but later we found that the interventions were quite different from one another and decided not to combine them under these broad headings. We also added a new category consisting of approaches that used multiple categories of interventions at the same time.

Keywords

MeSH

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

PRISMA Study flow diagram
Figuras y tablas -
Figure 1

PRISMA Study flow diagram

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies
Figuras y tablas -
Figure 2

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies

Risk of bias summary: review authors' judgements about each risk of bias item for each included study
Figuras y tablas -
Figure 3

Risk of bias summary: review authors' judgements about each risk of bias item for each included study

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 1 Mean difference in time spent sitting at work, follow‐up three months.
Figuras y tablas -
Analysis 1.1

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 1 Mean difference in time spent sitting at work, follow‐up three months.

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 2 Mean difference in time spent sitting at work. follow‐up six months.
Figuras y tablas -
Analysis 1.2

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 2 Mean difference in time spent sitting at work. follow‐up six months.

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 3 Mean difference in time in sitting episodes lasting 30 minutes or more, follow‐up three months.
Figuras y tablas -
Analysis 1.3

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 3 Mean difference in time in sitting episodes lasting 30 minutes or more, follow‐up three months.

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 4 Mean difference in total time spent sitting at and outside work, follow‐up three months.
Figuras y tablas -
Analysis 1.4

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 4 Mean difference in total time spent sitting at and outside work, follow‐up three months.

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 5 Work performance (1‐10 scale), follow‐up three months.
Figuras y tablas -
Analysis 1.5

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 5 Work performance (1‐10 scale), follow‐up three months.

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 6 Proportion with ≥ 1 sick days in the last three months.
Figuras y tablas -
Analysis 1.6

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 6 Proportion with ≥ 1 sick days in the last three months.

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 7 Proportion with ≥ 1 sick days in the last month.
Figuras y tablas -
Analysis 1.7

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 7 Proportion with ≥ 1 sick days in the last month.

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 8 Musculoskeletal symptoms.
Figuras y tablas -
Analysis 1.8

Comparison 1 Sit‐stand desks with or without counselling versus no intervention CBA, Outcome 8 Musculoskeletal symptoms.

Comparison 2 Sit‐stand desks +counselling versus sit‐stand desks CBA, Outcome 1 Mean difference in time spent sitting at work, follow‐up three months.
Figuras y tablas -
Analysis 2.1

Comparison 2 Sit‐stand desks +counselling versus sit‐stand desks CBA, Outcome 1 Mean difference in time spent sitting at work, follow‐up three months.

Comparison 2 Sit‐stand desks +counselling versus sit‐stand desks CBA, Outcome 2 Mean difference in time in sitting episodes lasting ≥ 30 minutes, follow‐up three months.
Figuras y tablas -
Analysis 2.2

Comparison 2 Sit‐stand desks +counselling versus sit‐stand desks CBA, Outcome 2 Mean difference in time in sitting episodes lasting ≥ 30 minutes, follow‐up three months.

Comparison 2 Sit‐stand desks +counselling versus sit‐stand desks CBA, Outcome 3 Work performance (1‐10 scale), follow‐up three months.
Figuras y tablas -
Analysis 2.3

Comparison 2 Sit‐stand desks +counselling versus sit‐stand desks CBA, Outcome 3 Work performance (1‐10 scale), follow‐up three months.

Comparison 2 Sit‐stand desks +counselling versus sit‐stand desks CBA, Outcome 4 Proportion with ≥ 1 sick days in the last month.
Figuras y tablas -
Analysis 2.4

Comparison 2 Sit‐stand desks +counselling versus sit‐stand desks CBA, Outcome 4 Proportion with ≥ 1 sick days in the last month.

Comparison 3 Sit‐stand desks versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow up short term.
Figuras y tablas -
Analysis 3.1

Comparison 3 Sit‐stand desks versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow up short term.

Comparison 3 Sit‐stand desks versus no intervention RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up eight weeks.
Figuras y tablas -
Analysis 3.2

Comparison 3 Sit‐stand desks versus no intervention RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up eight weeks.

Comparison 3 Sit‐stand desks versus no intervention RCT, Outcome 3 Mean difference in musculoskeletal symptoms, follow‐up eight weeks.
Figuras y tablas -
Analysis 3.3

Comparison 3 Sit‐stand desks versus no intervention RCT, Outcome 3 Mean difference in musculoskeletal symptoms, follow‐up eight weeks.

Comparison 4 Treadmill desks plus counselling versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up three months.
Figuras y tablas -
Analysis 4.1

Comparison 4 Treadmill desks plus counselling versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up three months.

Comparison 5 Cycling workstations + information and counselling versus information and counselling only RCT, Outcome 1 Mean difference in time spent in inactive sitting at work, follow‐up 16 weeks.
Figuras y tablas -
Analysis 5.1

Comparison 5 Cycling workstations + information and counselling versus information and counselling only RCT, Outcome 1 Mean difference in time spent in inactive sitting at work, follow‐up 16 weeks.

Comparison 6 Walking strategies versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up 10 weeks.
Figuras y tablas -
Analysis 6.1

Comparison 6 Walking strategies versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up 10 weeks.

Comparison 6 Walking strategies versus no intervention RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up 21 weeks.
Figuras y tablas -
Analysis 6.2

Comparison 6 Walking strategies versus no intervention RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up 21 weeks.

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up short term.
Figuras y tablas -
Analysis 7.1

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up short term.

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up 13 weeks.
Figuras y tablas -
Analysis 7.2

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up 13 weeks.

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 3 Mean difference in number of sitting episodes lasting 30 minutes or more, follow‐up 10 days.
Figuras y tablas -
Analysis 7.3

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 3 Mean difference in number of sitting episodes lasting 30 minutes or more, follow‐up 10 days.

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 4 Mean difference in time in sitting episodes lasting 30 minutes or more, follow‐up 10 days.
Figuras y tablas -
Analysis 7.4

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 4 Mean difference in time in sitting episodes lasting 30 minutes or more, follow‐up 10 days.

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 5 Mean difference in energy expenditure, follow‐up 13 weeks.
Figuras y tablas -
Analysis 7.5

Comparison 7 Computer prompts + information versus information alone RCT, Outcome 5 Mean difference in energy expenditure, follow‐up 13 weeks.

Comparison 8 Computer prompts to step versus computer prompts to stand RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up six days.
Figuras y tablas -
Analysis 8.1

Comparison 8 Computer prompts to step versus computer prompts to stand RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up six days.

Comparison 8 Computer prompts to step versus computer prompts to stand RCT, Outcome 2 Mean difference in number of sitting episodes lasting 30 minutes or more, follow‐up six days.
Figuras y tablas -
Analysis 8.2

Comparison 8 Computer prompts to step versus computer prompts to stand RCT, Outcome 2 Mean difference in number of sitting episodes lasting 30 minutes or more, follow‐up six days.

Comparison 9 E‐newsletters on workplace sitting versus e‐newsletters on health education RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up 10 weeks.
Figuras y tablas -
Analysis 9.1

Comparison 9 E‐newsletters on workplace sitting versus e‐newsletters on health education RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up 10 weeks.

Comparison 10 Counselling versus no intervention cluster RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up medium term.
Figuras y tablas -
Analysis 10.1

Comparison 10 Counselling versus no intervention cluster RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up medium term.

Comparison 10 Counselling versus no intervention cluster RCT, Outcome 2 Mean difference in total time spent sitting at and outside work, follow‐up six months.
Figuras y tablas -
Analysis 10.2

Comparison 10 Counselling versus no intervention cluster RCT, Outcome 2 Mean difference in total time spent sitting at and outside work, follow‐up six months.

Comparison 10 Counselling versus no intervention cluster RCT, Outcome 3 Work engagement (0‐6 scale), follow‐up 12 months.
Figuras y tablas -
Analysis 10.3

Comparison 10 Counselling versus no intervention cluster RCT, Outcome 3 Work engagement (0‐6 scale), follow‐up 12 months.

Comparison 11 Mindfulness training versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up six months.
Figuras y tablas -
Analysis 11.1

Comparison 11 Mindfulness training versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up six months.

Comparison 11 Mindfulness training versus no intervention RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up 12 months.
Figuras y tablas -
Analysis 11.2

Comparison 11 Mindfulness training versus no intervention RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up 12 months.

Comparison 11 Mindfulness training versus no intervention RCT, Outcome 3 Work engagement (0 ‐ 6 scale), follow‐up six months.
Figuras y tablas -
Analysis 11.3

Comparison 11 Mindfulness training versus no intervention RCT, Outcome 3 Work engagement (0 ‐ 6 scale), follow‐up six months.

Comparison 11 Mindfulness training versus no intervention RCT, Outcome 4 Work engagement (0‐6 scale), follow‐up 12 months.
Figuras y tablas -
Analysis 11.4

Comparison 11 Mindfulness training versus no intervention RCT, Outcome 4 Work engagement (0‐6 scale), follow‐up 12 months.

Comparison 12 Multiple interventions versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up 6 months.
Figuras y tablas -
Analysis 12.1

Comparison 12 Multiple interventions versus no intervention RCT, Outcome 1 Mean difference in time spent sitting at work, follow‐up 6 months.

Comparison 12 Multiple interventions versus no intervention RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up 12 months.
Figuras y tablas -
Analysis 12.2

Comparison 12 Multiple interventions versus no intervention RCT, Outcome 2 Mean difference in time spent sitting at work, follow‐up 12 months.

Comparison 12 Multiple interventions versus no intervention RCT, Outcome 3 Mean difference in time spent sitting at work, follow‐up 12 weeks.
Figuras y tablas -
Analysis 12.3

Comparison 12 Multiple interventions versus no intervention RCT, Outcome 3 Mean difference in time spent sitting at work, follow‐up 12 weeks.

Comparison 12 Multiple interventions versus no intervention RCT, Outcome 4 Work engagement (0‐6 scale), follow‐up 12 months.
Figuras y tablas -
Analysis 12.4

Comparison 12 Multiple interventions versus no intervention RCT, Outcome 4 Work engagement (0‐6 scale), follow‐up 12 months.

Summary of findings for the main comparison. Sit‐stand desks with or without counselling for reducing sitting at work: CBAs

Sit‐stand desks with or without counselling versus no intervention for reducing sitting at work

Patient or population: employees who sit at work

Settings: workplace

Intervention: sit‐stand desk with or without counselling

Comparison: no intervention

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

No intervention

Sit‐stand desk

Time spent sitting at work /8‐hour workday
Accelerometer‐inclinometer
Follow‐up: median 3 months

The mean time spent sitting at work in the control groups was
346 minutes4

The mean time spent sitting at work in the intervention groups was
113 minutes less (143 to 84 less)

61
(2 studies)

⊕⊝⊝⊝
very low1,2

Work performance (1‐10 scale)
Self‐reported
Follow‐up: median 3 months

The median work performance (1‐10 scale) in the control groups was 8.15

The mean change in work performance (1‐10) in the intervention groups was
0.35 higher
(0.1 lower to 0.79 higher)

109
(3 studies)

⊕⊝⊝⊝
very low1,2

Time spent sitting at work /8‐hour workday
Accelerometer‐inclinometer
Follow‐up: median 6 months

The mean time spent sitting at work in the control group was
389 minutes3

The mean time spent sitting at work in the intervention group was
56 minutes less
(101 to 12 less)

45

(1 study)

⊕⊝⊝⊝

very
low1, 2

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: confidence interval; RR: risk ratio

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Non‐randomised controlled before‐after study/studies with high risk of bias, downgraded one level

2 Small sample size, no further downgrading possible

3 Value from the control group

4 Mean value from control groups

5 Median of the scores in the three control groups

Figuras y tablas -
Summary of findings for the main comparison. Sit‐stand desks with or without counselling for reducing sitting at work: CBAs
Summary of findings 2. Sit‐stand desks for reducing sitting at work: RCTs

Sit‐stand desks versus no intervention for reducing sitting at work

Patient or population: employees who sit at work
Settings: workplace
Intervention: sit‐stand desk

Comparison: no intervention

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Sit‐stand desk

no intervention

Time spent sitting at work /8‐hour workday
Accelerometer‐inclinometer

Follow‐up: short term

The mean time spent sitting at work in the control group was
343 minutes 4

The mean time spent sitting at work in the intervention group was
96 minutes less
(110 to 83 less)

70
(2 studies)

⊕⊕⊝⊝
low1,2

Time spent sitting at work /8‐hour workday

Self‐reported questionnaires
Follow‐up: median 8 weeks

The mean time spent sitting at work in the control group was 387 minutes5

The mean time spent sitting at work in the intervention group was

80 minutes less

(129 to 31 less)

44

(1 study)

⊕⊕⊝⊝
low1,3

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk Ratio.

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Risk of bias high due to unconcealed allocation and lack of blinding of participants and personnel, downgraded one level

2 Unrealistic confidence interval, downgraded one level

3 Imprecision with wide confidence intervals, small sample size, downgraded one level

4 Mean value from control groups

5 Sitting time in the control group

Figuras y tablas -
Summary of findings 2. Sit‐stand desks for reducing sitting at work: RCTs
Summary of findings 3. Treadmill desks plus counselling for reducing sitting at work: RCT

Treadmill desks plus counselling versus no intervention for reducing sitting at work

Patient or population: employees who sit at work
Settings: workplace
Intervention: Treadmill desk + counselling

Comparison: no intervention

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

no intervention

Treadmill desk

Time spent sitting at work /8‐hour workday
Accelerometer‐inclinometer
Follow‐up: median 3 months

The mean time spent sitting at work in the control group was
342 minutes 3

The mean time spent sitting at work in the intervention group was
29 minutes less
(55 to 2 less)

31
(1 study)

⊕⊕⊝⊝
low1,2

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk Ratio.

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 lack of blinding of participants and personnel, downgraded one level

2 Imprecision with wide confidence intervals, small sample size, downgraded one level

3 Sitting time in the control group

Figuras y tablas -
Summary of findings 3. Treadmill desks plus counselling for reducing sitting at work: RCT
Summary of findings 4. Cycling workstations + information and counselling compared to information and counselling alone for reducing sitting at work: RCT

Cycling workstations + information and counselling compared with information and counselling for reducing sitting at work

Patient or population: employees who sit at work
Settings: workplace

Intervention: Cycling workstation + information and counselling

Comparison: Information and counselling

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Information and counselling

Pedalling workstation + information and counselling

Time spent sitting at work /8‐hour workday
Accelerometer‐inclinometer

Follow‐up: median 16 weeks

The mean time spent in sitting at work in the control group was 413 minutes3

The mean time spent in sitting at work in the intervention groups was
12 minutes less
(24 less to 1 more)

54

(1 study)

⊕⊕⊝⊝
low1,2

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Imprecision with wide confidence intervals, small sample size, downgraded with one level

2 Lack of blinding of participants and attrition bias, downgraded with one level

3 Sitting time in the control group

Figuras y tablas -
Summary of findings 4. Cycling workstations + information and counselling compared to information and counselling alone for reducing sitting at work: RCT
Summary of findings 5. Walking strategies for reducing sitting at work: RCT

Walking strategies for reducing sitting at work

Patient or population: employees who sit at work
Settings: workplace
Intervention: walking strategies

Comparison: no intervention

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

No intervention

Walking strategies

Time spent sitting at work
Log book
Follow‐up: median 10 weeks

The mean time spent sitting at work in the control group was
344 minutes/day 4

The mean time spent sitting at work in the intervention group was
16 minutes less
(54 less to 23 more)

179
(1 study)

⊕⊕⊝⊝
low1,2

Time spent sitting at work
Self‐reported questionnaires
Follow‐up: median 21 weeks

The mean time spent sitting at work in the control group was
389 minutes/day 4

The mean time spent sitting at work in the intervention group was
17 minutes less
(65 less to 32 more)

190

(1 study)

⊕⊕⊝⊝
low2,3

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval

GRADE Working Group grades of evidence
High quality: further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: we are very uncertain about the estimate

1 Risk of bias high due to unblinded outcome assessment and lack of allocation concealment, downgraded with one level
2 Imprecision with wide confidence intervals, downgraded with one level

3 Lack of blinding of participants and personnel and attrition bias, downgraded with one level

4 Sitting time in the control group

Figuras y tablas -
Summary of findings 5. Walking strategies for reducing sitting at work: RCT
Summary of findings 6. Computer prompts + information compared to information alone for reducing sitting at work

Computer prompts + information compared to information alone for reducing sitting at work

Patient or population: employees who sit at work
Settings: workplace
Intervention: computer prompt + information
Comparison: information alone

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Information alone

Computer prompt + information

Time spent sitting at work
Accelerometer‐inclinometer
Follow‐up: short term

The mean time spent sitting at work in the control group was
289 minutes/day4

The mean time spent sitting at work in the intervention group was 17 minutes less
(48 less to 14 more)

59
(2 studies)

⊕⊕⊕⊝
low1,2

Time spent sitting at work
Self‐reported
Follow‐up: median 13 weeks

The mean time spent sitting at work in the control group was
362 minutes/day4

The mean time spent sitting at work in the intervention group was 55 minutes less
(96 to 14 less)

34
(1 study)

⊕⊕⊝⊝
low2,3

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval

GRADE Working Group grades of evidence
High quality: further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very low quality: we are very uncertain about the estimate

1 Risk of bias high due to selective reporting and attrition bias, downgraded with one level
2 Small sample size, downgraded with one level
3 Risk of bias high due to unblinded outcome assessment, downgraded with one level

4 Sitting time in the control group

Figuras y tablas -
Summary of findings 6. Computer prompts + information compared to information alone for reducing sitting at work
Summary of findings 7. Counselling for reducing sitting at work

Counselling for reducing sitting at work

Patient or population: employees who sit at work
Settings: workplace
Intervention: counselling
Comparison: no intervention

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Usual care

Counselling

Time spent sitting at work
Self‐reported questionnaires
Follow‐up: medium term

The mean time spent in sitting at work in the control group was 462 minutes/day3

The mean time spent in sitting at work in the intervention groups was 28 minutes less (52 to 5 less)

747
(2 studies)

⊕⊕⊝⊝
low1,2

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval

GRADE Working Group grades of evidence
High quality: further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very low quality: we are very uncertain about the estimate

1 Risk of bias, allocation not concealed, lack of blinding, high attrition rate, downgraded with one level

2 Imprecision with wide confidence intervals, small sample size, downgraded with one level

3 Mean value from control groups

Figuras y tablas -
Summary of findings 7. Counselling for reducing sitting at work
Summary of findings 8. Mindfulness training for reducing sitting at work

Mindfulness training versus no intervention for reducing sitting at work

Patient or population: employees who sit at work
Settings: workplace
Intervention: mindfulness training

Comparison: no intervention

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

No intervention

Mindful training

Time spent sitting at work /day
Self‐reported questionnaires
Follow‐up: median 6 months

The mean time spent in sitting at work in the control group was 295 minutes2

The mean time spent in sitting at work in the intervention groups was
2 minutes less
(22 less to 18 more)

257
(1 study)

⊕⊕⊝⊝
low1

Time spent sitting at work /day
Self‐reported questionnaires
Follow‐up: median 12 months

The mean time spent in sitting at work in the control groups was
316 minutes2

The mean time spent in sitting at work in the intervention groups was
16 minutes less
(45 less to 12 more)

257
(1 study)

⊕⊕⊝⊝
low1

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval

GRADE Working Group grades of evidence
High quality: further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very low quality: we are very uncertain about the estimate

1 Risk of bias high due to unconcealed allocation and unblinded outcome assessment, downgraded with two levels

2 Sitting time in the control group

Figuras y tablas -
Summary of findings 8. Mindfulness training for reducing sitting at work
Summary of findings 9. Multiple interventions for reducing sitting at work

Multiple interventions versus no intervention for reducing sitting at work

Patient or population: employees who sit at work
Settings: workplace
Intervention: multiple interventions

Comparison: no intervention

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

No intervention

Multiple environment interventions with or without counselling

Time spent sitting at work
Self‐reported questionnaires
Follow‐up: median six months

The mean time spent sitting at work in the control group was
415 minutes/day5

The mean time spent sitting at work in the intervention group was
61 minutes less
(115 to 7 less)

294

(1 study)

⊕⊕⊝⊝
low1,2

Time spent sitting at work
Self‐reported questionnaires
Follow‐up: median 12 months

The mean time spent sitting at work in the control group was
415 minutes/day5

The mean time spent sitting at work in the intervention group was
48 minutes less
(103 less to 8 more)

294

(1 study)

⊕⊕⊝⊝
low1,2

Time spent sitting at work /8‐hour workday
Activity log and accelerometer‐inclinometer

Follow‐up: median 12 weeks

The mean time spent in sitting at work in the control group was 370 minutes5

The mean time spent in sitting at work in the intervention groups was 117 minutes less
(168 to 67 less)

25

(1 study)

⊕⊕⊝⊝
very low3,4

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk Ratio.

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Risk of bias high due to un blinded outcome assessment and attrition bias, downgraded with one level

2 Imprecision with wide confidence intervals, downgraded with one level

3 Imprecision with wide confidence intervals, small sample size, downgraded with two levels

4 Lack of blinding of personnel, downgraded with one level

5 Sitting time in the control group

Figuras y tablas -
Summary of findings 9. Multiple interventions for reducing sitting at work
Comparison 1. Sit‐stand desks with or without counselling versus no intervention CBA

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up three months Show forest plot

2

Mean Difference (Fixed, 95% CI)

Subtotals only

1.1 Sit‐stand desk + information and counselling

2

61

Mean Difference (Fixed, 95% CI)

‐113.07 [‐142.59, ‐83.55]

2 Mean difference in time spent sitting at work. follow‐up six months Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Mean difference in time in sitting episodes lasting 30 minutes or more, follow‐up three months Show forest plot

2

74

Mean Difference (Fixed, 95% CI)

‐52.33 [‐78.56, ‐26.11]

3.1 Sit‐stand desk only

1

20

Mean Difference (Fixed, 95% CI)

‐13.00 [‐70.80, 40.80]

3.2 Sit‐stand desk + information and counselling

2

54

Mean Difference (Fixed, 95% CI)

‐62.92 [‐92.62, ‐33.21]

4 Mean difference in total time spent sitting at and outside work, follow‐up three months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

5 Work performance (1‐10 scale), follow‐up three months Show forest plot

3

109

Mean Difference (Random, 95% CI)

0.35 [‐0.10, 0.79]

5.1 Sit‐stand desk only

2

52

Mean Difference (Random, 95% CI)

0.82 [0.00, 1.63]

5.2 Sit‐stand desk + information and counselling

2

57

Mean Difference (Random, 95% CI)

0.15 [‐0.38, 0.68]

6 Proportion with ≥ 1 sick days in the last three months Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

7 Proportion with ≥ 1 sick days in the last month Show forest plot

2

78

Risk Ratio (M‐H, Fixed, 95% CI)

0.77 [0.49, 1.21]

7.1 Sit‐stand desk only

1

20

Risk Ratio (M‐H, Fixed, 95% CI)

0.94 [0.42, 2.13]

7.2 Sit‐stand desk + information and counselling

2

58

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.41, 1.24]

8 Musculoskeletal symptoms Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 1. Sit‐stand desks with or without counselling versus no intervention CBA
Comparison 2. Sit‐stand desks +counselling versus sit‐stand desks CBA

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up three months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

2 Mean difference in time in sitting episodes lasting ≥ 30 minutes, follow‐up three months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3 Work performance (1‐10 scale), follow‐up three months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4 Proportion with ≥ 1 sick days in the last month Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 2. Sit‐stand desks +counselling versus sit‐stand desks CBA
Comparison 3. Sit‐stand desks versus no intervention RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow up short term Show forest plot

2

70

Mean Difference (Fixed, 95% CI)

‐96.35 [‐109.55, ‐83.15]

2 Mean difference in time spent sitting at work, follow‐up eight weeks Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Mean difference in musculoskeletal symptoms, follow‐up eight weeks Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 3. Sit‐stand desks versus no intervention RCT
Comparison 4. Treadmill desks plus counselling versus no intervention RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up three months Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 4. Treadmill desks plus counselling versus no intervention RCT
Comparison 5. Cycling workstations + information and counselling versus information and counselling only RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent in inactive sitting at work, follow‐up 16 weeks Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 5. Cycling workstations + information and counselling versus information and counselling only RCT
Comparison 6. Walking strategies versus no intervention RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up 10 weeks Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

1.1 Route versus no intervention

1

Mean Difference (Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 Incidental versus no intervention

1

Mean Difference (Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Mean difference in time spent sitting at work, follow‐up 21 weeks Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 6. Walking strategies versus no intervention RCT
Comparison 7. Computer prompts + information versus information alone RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up short term Show forest plot

2

59

Mean Difference (IV, Fixed, 95% CI)

‐16.84 [‐48.10, 14.41]

2 Mean difference in time spent sitting at work, follow‐up 13 weeks Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3 Mean difference in number of sitting episodes lasting 30 minutes or more, follow‐up 10 days Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4 Mean difference in time in sitting episodes lasting 30 minutes or more, follow‐up 10 days Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

5 Mean difference in energy expenditure, follow‐up 13 weeks Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 7. Computer prompts + information versus information alone RCT
Comparison 8. Computer prompts to step versus computer prompts to stand RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up six days Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2 Mean difference in number of sitting episodes lasting 30 minutes or more, follow‐up six days Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 8. Computer prompts to step versus computer prompts to stand RCT
Comparison 9. E‐newsletters on workplace sitting versus e‐newsletters on health education RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up 10 weeks Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 9. E‐newsletters on workplace sitting versus e‐newsletters on health education RCT
Comparison 10. Counselling versus no intervention cluster RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up medium term Show forest plot

2

747

Mean Difference (Fixed, 95% CI)

‐28.38 [‐51.49, ‐5.26]

2 Mean difference in total time spent sitting at and outside work, follow‐up six months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3 Work engagement (0‐6 scale), follow‐up 12 months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 10. Counselling versus no intervention cluster RCT
Comparison 11. Mindfulness training versus no intervention RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up six months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

2 Mean difference in time spent sitting at work, follow‐up 12 months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3 Work engagement (0 ‐ 6 scale), follow‐up six months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4 Work engagement (0‐6 scale), follow‐up 12 months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 11. Mindfulness training versus no intervention RCT
Comparison 12. Multiple interventions versus no intervention RCT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean difference in time spent sitting at work, follow‐up 6 months Show forest plot

1

294

Mean Difference (IV, Fixed, 95% CI)

‐60.87 [‐114.40, ‐7.34]

1.1 Environmental interventions only

1

149

Mean Difference (IV, Fixed, 95% CI)

‐84.40 [‐162.48, ‐6.32]

1.2 Environmental interventions + counselling

1

145

Mean Difference (IV, Fixed, 95% CI)

‐40.0 [‐113.53, 33.53]

2 Mean difference in time spent sitting at work, follow‐up 12 months Show forest plot

1

294

Mean Difference (IV, Fixed, 95% CI)

‐47.98 [‐103.42, 7.45]

2.1 Environmental interventions only

1

149

Mean Difference (IV, Fixed, 95% CI)

‐66.1 [‐146.03, 13.83]

2.2 Environmental interventions + counselling

1

145

Mean Difference (IV, Fixed, 95% CI)

‐31.20 [‐108.14, 45.74]

3 Mean difference in time spent sitting at work, follow‐up 12 weeks Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4 Work engagement (0‐6 scale), follow‐up 12 months Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4.1 Environmental interventions only

1

Mean Difference (Fixed, 95% CI)

0.0 [0.0, 0.0]

4.2 Environmental interventions + counselling

1

Mean Difference (Fixed, 95% CI)

0.0 [0.0, 0.0]

Figuras y tablas -
Comparison 12. Multiple interventions versus no intervention RCT