绿茶和红茶用于初级预防心血管疾病
Appendices
Appendix 1. Search strategies October 2012
CENTRAL, DARE, HTA, HEE on The Cochrane Library
#1 MeSH descriptor: [Cardiovascular Diseases] explode all trees
#2 cardio*
#3 cardia*
#4 heart*
#5 coronary*
#6 angina*
#7 ventric*
#8 myocard*
#9 pericard*
#10 isch?em*
#11 emboli*
#12 arrhythmi*
#13 thrombo*
#14 atrial next fibrillat*
#15 tachycardi*
#16 endocardi*
#17 sick near sinus
#18 MeSH descriptor: [Stroke] explode all trees
#19 stroke or stokes
#20 cerebrovasc*
#21 cerebral next vascular
#22 apoplexy
#23 brain near/2 accident*
#24 brain* near/2 infarct*
#25 cerebral near/2 infarct*
#26 lacunar near/2 infarct*
#27 MeSH descriptor: [Hypertension] explode all trees
#28 hypertensi*
#29 peripheral next arter* next disease*
#30 high near/2 blood next pressure
#31 increased near/2 blood next pressure
#32 elevated near/2 blood next pressure
#33 MeSH descriptor: [Hyperlipidemias] explode all trees
#34 hyperlipid*
#35 hyperlip?emia*
#36 hypercholesterol*
#37 hypercholester?emia*
#38 hyperlipoprotein?emia*
#39 hypertriglycerid?emia*
#40 MeSH descriptor: [Arteriosclerosis] explode all trees
#41 MeSH descriptor: [Cholesterol] explode all trees
#42 cholesterol
#43 "coronary risk factor*"
#44 MeSH descriptor: [Blood Pressure] this term only
#45 "blood pressure"
#46 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28 or #29 or #30 or #31 or #32 or #33 or #34 or #35 or #36 or #37 or #38 or #39 or #40 or #41 or #42 or #43 or #44 or #45
#47 MeSH descriptor: [Tea] this term only
#48 tea or teas
#49 (green and black) near/3 (tea or teas)
#50 (tea or teas) near/3 (extract*)
#51 MeSH descriptor: [Catechin] this term only
#52 (catechuic or catechinic or catechin)
#53 cyanidanol
#54 zyma
#55 epicatechin
#56 kb 53
#57 flavanpentol
#58 z 7300
#59 catergen*
#60 #47 or #48 or #49 or #50 or #51 or #52 or #53 or #54 or #55 or #56 or #57 or #58 or #59
#61 #46 and #60
MEDLINE OVID
1. exp Cardiovascular Diseases/
2. cardio*.tw.
3. cardia*.tw.
4. heart*.tw.
5. coronary*.tw.
6. angina*.tw.
7. ventric*.tw.
8. myocard*.tw.
9. pericard*.tw.
10. isch?em*.tw.
11. emboli*.tw.
12. arrhythmi*.tw.
13. thrombo*.tw.
14. atrial fibrillat*.tw.
15. tachycardi*.tw.
16. endocardi*.tw.
17. (sick adj sinus).tw.
18. exp Stroke/
19. (stroke or stokes).tw.
20. cerebrovasc*.tw.
21. cerebral vascular.tw.
22. apoplexy.tw.
23. (brain adj2 accident*).tw.
24. ((brain* or cerebral or lacunar) adj2 infarct*).tw.
25. exp Hypertension/
26. hypertensi*.tw.
27. peripheral arter* disease*.tw.
28. ((high or increased or elevated) adj2 blood pressure).tw.
29. exp Hyperlipidemias/
30. hyperlipid*.tw.
31. hyperlip?emia*.tw.
32. hypercholesterol*.tw.
33. hypercholester?emia*.tw.
34. hyperlipoprotein?emia*.tw.
35. hypertriglycerid?emia*.tw.
36. exp Arteriosclerosis/
37. exp Cholesterol/
38. cholesterol.tw.
39. "coronary risk factor*".tw.
40. Blood Pressure/
41. blood pressure.tw.
42. or/1‐41
43. Tea/
44. (tea or teas).tw.
45. ((green or black) adj3 (tea or teas)).tw.
46. ((tea or teas) adj3 extract$).tw.
47. Catechin/
48. (catechuic or catechinic or catechin).tw.
49. cyanidanol.tw.
50. zyma.tw.
51. epicatechin.tw.
52. kb 53.tw.
53. flavanpentol.tw.
54. z 7300.tw.
55. catergen$.tw.
56. or/43‐55
57. 42 and 56
58. randomized controlled trial.pt.
59. controlled clinical trial.pt.
60. randomized.ab.
61. placebo.ab.
62. drug therapy.fs.
63. randomly.ab.
64. trial.ab.
65. groups.ab.
66. 58 or 59 or 60 or 61 or 62 or 63 or 64 or 65
67. exp animals/ not humans.sh.
68. 66 not 67
69. 57 and 68
EMBASE OVID
1. exp cardiovascular disease/
2. cardio*.tw.
3. cardia*.tw.
4. heart*.tw.
5. coronary*.tw.
6. angina*.tw.
7. ventric*.tw.
8. myocard*.tw.
9. pericard*.tw.
10. isch?em*.tw.
11. emboli*.tw.
12. arrhythmi*.tw.
13. thrombo*.tw.
14. atrial fibrillat*.tw.
15. tachycardi*.tw.
16. endocardi*.tw.
17. (sick adj sinus).tw.
18. exp cerebrovascular disease/
19. (stroke or stokes).tw.
20. cerebrovasc*.tw.
21. cerebral vascular.tw.
22. apoplexy.tw.
23. (brain adj2 accident*).tw.
24. ((brain* or cerebral or lacunar) adj2 infarct*).tw.
25. exp hypertension/
26. hypertensi*.tw.
27. peripheral arter* disease*.tw.
28. ((high or increased or elevated) adj2 blood pressure).tw.
29. exp hyperlipidemia/
30. hyperlipid*.tw.
31. hyperlip?emia*.tw.
32. hypercholesterol*.tw.
33. hypercholester?emia*.tw.
34. hyperlipoprotein?emia*.tw.
35. hypertriglycerid?emia*.tw.
36. exp Arteriosclerosis/
37. exp Cholesterol/
38. cholesterol.tw.
39. "coronary risk factor*".tw.
40. Blood Pressure/
41. blood pressure.tw.
42. or/1‐41
43. tea/
44. green tea extract/
45. black tea extract/
46. (tea or teas).tw.
47. ((green or black) adj3 (tea or teas)).tw.
48. ((tea or teas) adj3 extract$).tw.
49. catechin/
50. (catechuic or catechin).tw.
51. catechinic.tw.
52. cyanidanol.tw.
53. zyma.tw.
54. epicatechin.tw.
55. kb 53.tw.
56. flavanpentol.tw.
57. z 7300.tw.
58. catergen$.tw.
59. or/43‐58
60. 42 and 59
61. random$.tw.
62. factorial$.tw.
63. crossover$.tw.
64. cross over$.tw.
65. cross‐over$.tw.
66. placebo$.tw.
67. (doubl$ adj blind$).tw.
68. (singl$ adj blind$).tw.
69. assign$.tw.
70. allocat$.tw.
71. volunteer$.tw.
72. crossover procedure/
73. double blind procedure/
74. randomized controlled trial/
75. single blind procedure/
76. 61 or 62 or 63 or 64 or 65 or 66 or 67 or 68 or 69 or 70 or 71 or 72 or 73 or 74 or 75
77. (animal/ or nonhuman/) not human/
78. 76 not 77
79. 60 and 78
Web of Science
#36 #35 AND #34 AND #33
#35 #32 OR #31 OR #30 OR #29 OR #28 OR #27 OR #26
#34 #25 OR #24 OR #23 OR #22 OR #21 OR #20 OR #19 OR #18 OR #17 OR #16 OR #15 OR #14 OR #13 OR #12 OR #11 OR #10 OR #9 OR #8 OR #7 OR #6 OR #5 OR #4 OR #3 OR #2 OR #1
#33 TS=(random* or blind* or allocat* or assign* or trial* or placebo* or crossover* or cross‐over*)
#32 TS=(catergen* or (z 7300) or flavanpentol or (kb 53) or epicatechin)
#31 TS=(zyma)
#30 TS=(cyanidanol)
#29 TS=((catechuic or catechinic or catechin))
#28 TS=(((tea or teas) near/3 extract*))
#27 TS=(((green or black) near/3 (tea or teas)))
#26 TS=(tea or teas)
#25 TS=(arteriosclerosis or cholesterol or "coronary risk factor*" or "blood pressure")
#24 TS=(hypercholester?emia* or hyperlipoprotein?emia* or hypertriglycerid?emia*)
#23 TS=(hyperlipid* or hyperlip?emia* or hypercholesterol*)
#22 TS=(((brain* or cerebral or lacunar) near/2 infarct*))
#21 TS=(brain near/2 accident*)
#20 TS=(apoplexy)
#19 TS=("cerebral vascular")
#18 TS=(cerebrovasc*)
#17 TS=(stroke or strokes)
#16 TS=("sick sinus")
#15 TS=(endocardi*)
#14 TS=(tachycardi*)
#13 TS=((atrial fibrillat*))
#12 TS=(thrombo*)
#11 TS=(arrhythmi*)
#10 TS=(emboli*)
#9 TS=(isch?em*)
#8 TS=(pericard*)
#7 TS=(myocard*)
#6 TS=(ventric*)
#5 TS=(angina*)
#4 TS=(coronary*)
#3 TS=(heart*)
#2 TS=(cardia*)
#1 TS=(cardio*)
Appendix 2. Search strategies for trial registers
metaRegister of controlled trials (mRCT), Clinical trials.gov, the WHO International Clinical Trials Registry platform (ICTRP)
1. Green AND/OR Black AND Tea
Study flow diagram.
'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
Comparison 1 Black Tea, Outcome 1 LDL‐Cholesterol.
Comparison 1 Black Tea, Outcome 2 HDL‐Cholesterol.
Comparison 1 Black Tea, Outcome 3 Triglycerides.
Comparison 1 Black Tea, Outcome 4 Total Cholesterol.
Comparison 1 Black Tea, Outcome 5 Systolic blood pressure.
Comparison 1 Black Tea, Outcome 6 Diastolic blood pressure.
Comparison 2 Green Tea, Outcome 1 Total Cholesterol.
Comparison 2 Green Tea, Outcome 2 LDL Cholesterol.
Comparison 2 Green Tea, Outcome 3 Triglycerides.
Comparison 2 Green Tea, Outcome 4 HDL‐Cholesterol.
Comparison 2 Green Tea, Outcome 5 Systolic Blood Pressure.
Comparison 2 Green Tea, Outcome 6 Diastolic Blood Pressure.
Comparison 3 All Tea, Outcome 1 Total Cholesterol.
Comparison 3 All Tea, Outcome 2 LDL‐Cholesterol.
Comparison 3 All Tea, Outcome 3 HDL‐Cholesterol.
Comparison 3 All Tea, Outcome 4 Triglycerides.
Comparison 3 All Tea, Outcome 5 Systolic Blood Pressure.
Comparison 3 All Tea, Outcome 6 Diastolic Blood Pressure.
| Study | Green/Black or extracts? | Dose | Duration |
| Black and Green tea | 6 g/d | 2 wks | |
| Green tea and Green tea extract | 4 cups/d or 2 capsules and 4 cups of water /d | 8 wks | |
| Green tea and Green tea extract | 4 cups/d or 2 capsules and 4 cups of water /d | 8 wks | |
| Green tea extract | 250 mg/d | 8 wks | |
| Green tea extract | 500 mg | 4 hrs | |
| Black tea | 6 mugs/d | 4 wks | |
| Green tea extract | 530 mg twice a day | 6 wks | |
| Black tea | 5 servings a day | 3 wks | |
| Black tea, Green tea and Green tea extract | 6 cups (150 mL)/day or 6 x 4 capsules/day with 6 x 150 mL of control beverage | 4 wks | |
| Green tea extract | In a beverage consumed once a day | 21 days | |
| Black tea | 5 servings (200 mL)/d | 6 wks | |
| Green tea extract | 6 capsules/d | 3 wks | |
| Green tea extract | 3 g a day | 4 wks | |
| Black tea | 0mg, 100 mg, 200 mg, 400 mg or 800 mg twice a day | 1 wk | |
| Black tea | 450 mL | 2hrs | |
| Black tea | 1250 mL/d | 4 wks | |
| Black or Green tea | 5 cups/d | 7 d | |
| Black tea | 5 cups/d | 4 wks | |
| Green tea extract | 500 mg | 4 wks | |
| Black tea | 5 cups/d (750 mL) | 4 wks | |
| Black tea | > 200 mL twice a day | 8 wks | |
| Green tea | 400ml | 2 hrs | |
| Green tea or Green tea extract | 4 cups a day or 2 capsules and 4 cups of water a day | 8 wks | |
| Black or Green tea | 6 cups/d of Black or Green tea or 3,6g tablet of Green tea polyphenols/day | 4 wks | |
| Black tea | 400 mL | 60 mins | |
| Black tea | 300 mL | 105 mins | |
| Black tea | 5 cups per day | 2 weeks | |
| Black tea | 1 litre | 7 hours | |
| Black tea extract | one capsule/d | 11 wks | |
| Black or Green tea | 6 gm | 3 hrs | |
| Black and Green tea | 1000 mL/d or 250 mL/d | 7 d or 4 wks | |
| Black tea | one cup | 4 hrs | |
| Green tea extract | 1.06 g | 90 mins | |
| Green tea | 2 cups | 42 days | |
| Green tea extract | 400 mg or 800 mg per day | 2 mths | |
| Green tea | 6 g | 120 mins | |
| Black tea | 1 cup | 6 hours | |
| Tea | 10, 224 or 674 mg of tea catechins | 6 hours | |
| Tea | 1069 mg/day of total catechins | 1 wk | |
| Black tea | 4 sachets a day | 6 wks | |
| d:day | |||
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 LDL‐Cholesterol Show forest plot | 4 | 147 | Mean Difference (IV, Random, 95% CI) | ‐0.43 [‐0.56, ‐0.31] |
| 2 HDL‐Cholesterol Show forest plot | 4 | 146 | Mean Difference (IV, Random, 95% CI) | ‐0.01 [‐0.06, 0.04] |
| 3 Triglycerides Show forest plot | 4 | Mean Difference (IV, Random, 95% CI) | Totals not selected | |
| 4 Total Cholesterol Show forest plot | 3 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 5 Systolic blood pressure Show forest plot | 2 | 123 | Mean Difference (IV, Fixed, 95% CI) | ‐1.85 [‐3.21, ‐0.48] |
| 6 Diastolic blood pressure Show forest plot | 2 | 123 | Mean Difference (IV, Fixed, 95% CI) | ‐1.27 [‐3.06, 0.53] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Total Cholesterol Show forest plot | 4 | 327 | Mean Difference (IV, Fixed, 95% CI) | ‐0.62 [‐0.77, ‐0.46] |
| 2 LDL Cholesterol Show forest plot | 4 | 327 | Mean Difference (IV, Fixed, 95% CI) | ‐0.64 [‐0.77, ‐0.52] |
| 3 Triglycerides Show forest plot | 4 | 327 | Mean Difference (IV, Fixed, 95% CI) | ‐0.08 [‐0.24, 0.07] |
| 4 HDL‐Cholesterol Show forest plot | 4 | 327 | Mean Difference (IV, Random, 95% CI) | 0.01 [‐0.08, 0.11] |
| 5 Systolic Blood Pressure Show forest plot | 2 | 167 | Mean Difference (IV, Fixed, 95% CI) | ‐3.18 [‐5.25, ‐1.11] |
| 6 Diastolic Blood Pressure Show forest plot | 2 | 167 | Mean Difference (IV, Fixed, 95% CI) | ‐3.42 [‐4.54, ‐2.30] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Total Cholesterol Show forest plot | 7 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 2 LDL‐Cholesterol Show forest plot | 8 | 474 | Mean Difference (IV, Random, 95% CI) | ‐0.48 [‐0.61, ‐0.35] |
| 3 HDL‐Cholesterol Show forest plot | 8 | 473 | Mean Difference (IV, Random, 95% CI) | 0.00 [‐0.04, 0.04] |
| 4 Triglycerides Show forest plot | 8 | 476 | Mean Difference (IV, Random, 95% CI) | ‐0.06 [‐0.19, 0.06] |
| 5 Systolic Blood Pressure Show forest plot | 4 | 290 | Mean Difference (IV, Fixed, 95% CI) | ‐2.25 [‐3.39, ‐1.11] |
| 6 Diastolic Blood Pressure Show forest plot | 4 | 290 | Mean Difference (IV, Fixed, 95% CI) | ‐2.81 [‐3.77, ‐1.86] |
