Intermittent pneumatic compression (IPC) compared with medical therapy alone for critical limb ischaemia (CLI) at 12 months

Patient or population: patients with CLI

Settings: hospital

Intervention: IPC^a

Comparison: medical therapy^b

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No. of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Medical therapy

IPC

Amputation

12 months

Major adverse limb events (MALE)

12 months

Amputation‐free survival

12 months

Major adverse cardiovascular events (MACE)

12 months

Ulcer healing

12 months

Death

12 months

Health‐related quality of life

12 months

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval (CI)) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CLI: critical limb ischaemia; IPC: Intermittent pneumatic compression; RR: risk ratio.

GRADE Working Group grades of evidence.
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.