Appendix 1. Search strategy

Ovid MEDLINE(R), Ovid MEDLINE(R) In‐Process & Other Non‐Indexed Citations, Ovid MEDLINE(R) Daily and Ovid OLDMEDLINE(R)

1. exp Dopamine Agents/ or exp Dopamine Agonists/
2. Dopamine/ or exp Receptors, Dopamine/
3. Amantadine/ or Memantine/
4. Apomorphine/
5. Bromocriptine/or Dihydroergotoxine/
6. Fenoldopam/
7. Levodopa/ or Carbidopa/
8. Lisuride/ or Metergoline/ or Pergolide/
9. Piribedil/
10. Quinpirole/
11. (amantadine or amphetamine or dextroamphetamine or lisamphetamine or methamphetamine or psychostimulant* or apomorphine or bromocriptine or carbidopa or cabergoline or dihydroergotoxine or hydergine or dopamine*).ab,ti,kf,rn.
12. (fenoldopam or hydergine or levodopa or lisuride or memantine or mesulergine or metergoline or methylphenidate or pergolide or piperazines or piribedil or pramipexol or quinagolide or quinpirole or ropinirole or rotigotine or terguride).ab,ti,kf,rn.
13. or/1‐12
14. exp Craniocerebral Trauma/
15. Brain Edema/
16. Glasgow Coma Scale/
17. Glasgow Outcome Scale/
18. exp Unconsciousness/
19. exp Cerebrovascular Trauma/
20. ((head or crani* or cerebr* or capitis or brain* or forebrain* or skull* or hemispher* or intra‐cran* or intracran* or intra‐cereb* or intracereb*) adj3 (infarct* or injur* or trauma* or damag* or wound* or fracture* or contusion*)).ab,ti,kf.
21. ((head or crani* or cerebr* or brain* or intra‐cran* or intracran* or intra‐cereb* or intracereb*) adj3 (haematoma* or hematoma* or haemorrhag* or hemorrhag* or hernia* or bleed* or pressure or hypertension or oedema or edema or swell* )).ti,ab,kf.
22. (Glasgow adj3 (coma or outcome) adj3 (scale* or score*)).ab,ti,kf.
23. rancho los amigos scale.ti,ab,kf.
24. (diffuse axonal injur*).ti,ab,kf.
25. ((unconscious* or coma* or concuss* or postconcuss* or 'persistent vegetative state') adj3 (injur* or trauma* or damag* or wound* or fracture*)).ti,ab.
26. (subarachnoid h?emorrhage or tSAH).ti,ab.kf.
27. ((midbrain or mid brain) adj syndrome).ti,ab,kf.
28. or/14‐27
29. 13 and 28
30. randomi?ed.ab,ti.
31. randomized controlled trial.pt.
32. controlled clinical trial.pt.
33. placebo.ab.
34. clinical trials as topic.sh.
35. double blind method.sh.
36. randomly.ab.
37. (RCT or at random or (random* adj (assign* or allocat* or divid* or division or number))).ti,ab,kf.
38. trial.ti.
39. or/29‐37
40. (animals not (humans and animals)).sh.
41. 39 not 40
42. 29 and 41