Appendix 1. Appendix 1 ‐ Search Strategy

MEDLINE

1. random$.tw.

2. factorial$.tw.

3. (crossover$ or cross over$ or cross‐over$).tw.

4. placebo$.tw.

5. single blind.mp.

6. double blind.mp.

7. triple blind.mp.

8. (singl$ adj blind$).tw.

9. (double$ adj blind$).tw.

10. (tripl$ adj blind$).tw.

11. assign$.tw.

12. allocat$.tw.

13. randomized controlled trial/

14. or/1‐13

15. Exp Ulcerative colitis/

16. UC.mp.

17. Ulcerative Colitis*.mp.

18. IBD.mp.

19. Inflammatory bowel disease*.mp.

20. Or/15‐19

21. Exp Marijuana/

22. Cannabis*.mp.

23. Weed*.mp.

24. Marijuana*.mp.

25. Cannabi*.mp.

26. Dronabinol.mp.

27. Cannabichromene.mp.

28. 8‐THC.mp.

29. Nabilone.mp.

30. Tetrahydrocannabivarin.mp.

31. Sativ*.mp.

32. Indica.mp.

33. THC.mp.

34. CBD.mp.

35. Tetrahydrocannabinol.mp.

36. Marinol.mp.

37. Syndros.mp.

38. Or/21‐37

39. 14 and 20 and 38

Embase

1. random$.tw.

2. factorial$.tw.

3. (crossover$ or cross over$ or cross‐over$).tw.

4. placebo$.tw.

5. single blind.mp.

6. double blind.mp.

7. triple blind.mp.

8. (singl$ adj blind$).tw.

9. (double$ adj blind$).tw.

10. (tripl$ adj blind$).tw.

11. assign$.tw.

12. allocat$.tw.

13. crossover procedure/

14. double blind procedure/

15. single blind procedure/

16. triple blind procedure/

17. randomized controlled trial/

18. or/1‐17

19. Exp Ulcerative colitis/

20. UC.mp.

21. Ulcerative colitis*.mp

22. IBD.mp.

23. Inflammatory bowel disease*.mp.

24. Or/19‐23

25. Exp Marijuana/

26. Cannabis*.mp.

27. Weed*.mp.

28. Marijuana*.mp.

29. Cannabi*.mp.

30. Dronabinol.mp.

31. Cannabichromene.mp.

32. 8‐THC.mp.

33. Nabilone.mp.

34. Tetrahydrocannabivarin.mp.

35. Sativ*.mp.

36. Indica.mp.

37. THC.mp.

38. CBD.mp.

39. Tetrahydrocannabinol.mp.

40. Marinol.mp.

41. Syndros.mp.

42. Or/25‐41

43. 18 and 24 and 42

AMED (Allied & Alternative Medicine)

1. Exp Inflammatory bowel disease/

2. UC.mp.

3. Ulcerative colitis*.mp

4. IBD.mp.

5. Or/1‐4

6. Exp Marijuana/

7. Cannabis*.mp.

8. Weed*.mp.

9. Marijuana*.mp.

10. Cannabi*.mp.

11. Dronabinol.mp.

12. Cannabichromene.mp.

13. 8‐THC.mp.

14. Nabilone.mp.

15. Tetrahydrocannabivarin.mp.

16. Sativ*.mp.

17. Indica.mp.

18. THC.mp.

19. CBD.mp.

20. Tetrahydrocannabinol.mp.

21. Marinol.mp.

22. Syndros.mp.

23. Or/6‐22

24. 5 and 23

Psych INFO

ti((Cannabi* OR marijuana OR weed* OR droning OR Cannabichromene OR 8‐tic OR Nabilone OR Tetrahydrocannabivarin OR Sativ* OR Indica OR THC OR CBD OR Tetrahydrocannabinol OR Marinol OR Syndros)) AND ti(( Ulcerative Colitis OR Inflammatory Bowel Disease OR UC))

CENTRAL

#1 MeSH: [Ulcerative colitis] explode all trees

#2 UC

#3 Inflammatory bowel disease

#4 IBD

#5 #1 or #2 or #3 or #4

#6 MeSH: [Cannabis] explode all trees

#7 Cannabis

#8 Marijuana

#9 Weed

#10 Cannabinoid

#11 cannabidiol

#12 cannabigerol

#13 dronabinol

#14 cannabichromene

#15 8 THC

#16 Nabilone

#17 Tetrahydrocannabivarin

#18 Sativ*

#19 Indica

#20 THC

#21 CBD

#22 Tetrahydrocannabinol

#23 Marinol

#24 Syndros

#25 #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24

#26 #5 and #25

Clinical trials.gov

1. Ulcerative colitis and Cannabis

2. Ulcerative colitis and Marijuana

3. UC and cannabinoids

4. UC and Cannabis

5. IBD and Cannabis

6. THC and inflammatory bowel disease

European clinical trials register

1. Cannabis and Ulcerative colitis

2. Marijuana and Ulcerative colitis

3. Cannabis and inflammatory bowel disease

4. THC and inflammatory bowel disease

ICTRP

1. Cannabis and Ulcerative colitis

2. Marijuana and Ulcerative colitis

3. Cannabis and inflammatory bowel disease

4. THC and inflammatory bowel disease