RIFLE classification

AKIN classification

KDIGO classification

Class

GFR/serum creatinine

Urine output

Stage

Serum creatinine

Urine output

Stage

Serum creatinine

Urine output

Risk

↑ SCr ≥ 1.5 OR ↓ GFR ≥ 25%

< 0.5 mL/kg/h for 6 h

1

↑ SCr ≥ 26.5 μmol/L OR ↑SCr ≥ 150% to 200% from baseline

< 0.5 mL/kg/h for > 6 h

1

↑SCr to ≥ 1.5 to 1.9 times baseline OR ≥ 26.5 mmol/L increase

≤ 0.5 mL/kg/h for 6 to 12 h

Injury

↑ SCr ≥2 OR ↓ GFR ≥50%

< 0.5 mL/kg/h for 12 h

2

↑ SCr > 200% to 300% from baseline

< 0.5 mL/kg/h for > 6 h

2

↑SCr to 2.0 to 2.9 times baseline

0.5 mL/kg/h for ≥ 12 h

Failure

↑ SCr ≥ 3 OR ↓ GFR ≥ 75% OR if baseline SCr ≥ 353.6 μmol/L ↑ SCr > 44.2 μmol/L

< 0.3 mL/kg/h for 24 h OR anuria for 12 h

3

↑ SCr > 300% (> 3 fold) from baseline or if baseline SCr ≥ 353.6 μmol/L ↑SCr ≥ 44.2 μmol/L; also includes patients requiring RRT independent of stage

< 0.3 mL/kg/h for 24 h OR anuria for 12 h

3

↑SCr to 3.0 times baseline OR ↑ SCr to ≥ 353.6 mmol/L OR Initiation of RRT OR In patients ≤ 18 years, ↓ eGFR to ≤ 35 mL/min/1.73 m²

< 0.3 mL/kg/h for ≥ 24 OR anuria for ≥ 12 h

Loss

Complete loss of kidney function > 4 weeks

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ESKD

Complete loss of kidney function > 3 months

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