Screening hysteroscopy in subfertile women and women undergoing assisted reproduction
Appendices
Appendix 1. Cochrane Gynaecology and Fertility Group Specialised Register search strategy
From inception to present
Procite platform
Keywords CONTAINS "hysteroscopic "or "hysteroscope diameter" or "hysteroscope size" or "hysteroscopy" or "hysteroscopy, techniques" or "hysteroscopy‐second look" or "hysterscope" or "uterine cavity assessment" or "mini‐hysteroscopy" or "minihysteroscopy" or "endometrial polypectomy" or "endometrial polyps" or "endoscopy" or Title CONTAINS "hysteroscopic "or "hysteroscope diameter"or "hysteroscope size" or "hysteroscopy" or "hysteroscopy, techniques" or "hysteroscopy‐second look" or "hysterscope" or "uterine cavity assessment" or "mini‐hysteroscopy" or "minihysteroscopy" or "endometrial polypectomy" or "endometrial polyps" or "endoscopy"
AND
Keywords CONTAINS "IVF" or "ICSI" or "subfertility" or "in vitro fertilisation" or "in vitro fertilization" or "intracytoplasmic sperm injection" or "assisted conception" or "assisted reproduction" or "ART" or "infertility" or "IUI" or "Intrauterine Insemination" or "artificial insemination" or "ovarian hyperstimulation" or "ovarian stimulation" or "ovulation induction" or "COH" or "controlled ovarian " or "insemination" or "insemination‐intrauterine" or "subfertility‐female" or "IUI" or "recurrent miscarriage" or "pregnancy" or Title CONTAINS "IVF" or "ICSI" or "subfertility" or "in vitro fertilisation" or "in vitro fertilization" or "intracytoplasmic sperm injection" or "assisted conception" or "assisted reproduction" or "ART" or "infertility" or "IUI" or "Intrauterine Insemination" or "artificial insemination" or "ovarian hyperstimulation" or "ovarian stimulation" or "ovulation induction" or "COH" or "controlled ovarian " or "insemination" or "insemination‐intrauterine" or "subfertility‐female" or "IUI" or "pregnancy"
Appendix 2. Cochrane Central Register of Controlled Trials (CENTRAL) search strategy
From inception to present
Cochrane Register of Studies Online (CRSO) web platform
#1 MESH DESCRIPTOR Hysteroscopy EXPLODE ALL TREES
#2 Hysteroscop*:TI,AB,KY
#3 Uteroscop*:TI,AB,KY
#4 minihysteroscop*:TI,AB,KY
#5 (Uter* adj3 Endoscop*):TI,AB,KY
#6 #1 OR #2 OR #3 OR #4 OR #5
#7 MESH DESCRIPTOR Infertility, Female EXPLODE ALL TREES
#8 MESH DESCRIPTOR Reproductive Techniques, Assisted EXPLODE ALL TREES
#9 (subfertil* or infertil*):TI,AB,KY
#10 (IVF or ICSI):TI,AB,KY
#11 (artificial insemination):TI,AB,KY
#12 (assisted reproducti*):TI,AB,KY
#13 (intrauterine insemination):TI,AB,KY
#14 IUI:TI,AB,KY
#15 pregnancy:TI,AB,KY
#16 conception:TI,AB,KY
#17 fertility:TI,AB,KY
#18 MESH DESCRIPTOR Abortion, Habitual EXPLODE ALL TREES
#19 miscarriage*:TI,AB,KY
#20 (pregnancy loss):TI,AB,KY
#21 conceive:TI,AB,KY
#22 MESH DESCRIPTOR Gynatresia EXPLODE ALL TREES
#23 Gynatresia:TI,AB,KY
#24 (implant* adj3 failure*):TI,AB,KY
#25 IVF‐ET:TI,AB,KY
#26 (ovulation induction):TI,AB,KY
#27 #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26
#28 #6 AND #27
Appendix 3. MEDLINE search strategy
From 1946 to present
Ovid platform
1 exp Hysteroscopy/
2 Hysteroscop$.tw.
3 Uteroscop$.tw.
4 minihysteroscop$.tw.
5 (Uter$ adj3 Endoscop$).tw.
6 or/1‐5
7 exp Infertility/
8 subfertil$.tw.
9 (IVF or ICSI).tw.
10 artificial insemination.tw.
11 assisted conception.tw.
12 intrauterine insemination.tw.
13 iui.tw.
14 reproductive techniques, assisted/ or exp embryo transfer/ or exp fertilization in vitro/ or exp sperm injections, intracytoplasmic/ or in vitro oocyte maturation techniques/ or exp insemination, artificial/ or exp ovulation induction/ or exp superovulation/ (50541)
15 exp Infertility, Female/
16 Infertil$.tw.
17 pregnancy.tw.
18 conception.tw.
19 fertility.tw.
20 Abortion, Habitual/
21 miscarriage$.tw.
22 recurrent pregnancy loss$.tw.
23 conceive.tw.
24 Gynatresia/
25 (implant$ adj3 failure$).tw.
26 IVF‐ET.tw.
27 ovulation induction.tw.
28 or/7‐27
29 randomized controlled trial.pt.
30 controlled clinical trial.pt.
31 randomized.ab.
32 randomised.ab.
33 placebo.tw.
34 clinical trials as topic.sh.
35 randomly.ab.
36 trial.ti.
37 (crossover or cross‐over or cross over).tw.
38 or/29‐37
39 exp animals/ not humans.sh.
40 38 not 39
41 6 and 28 and 40
Appendix 4. Embase search strategy
From 1980 to present
Ovid platform
1 exp Hysteroscopy/
2 Hysteroscop$.tw.
3 Uteroscop$.tw.
4 minihysteroscop$.tw.
5 (Uter$ adj3 Endoscop$).tw.
6 or/1‐5
7 subfertil$.tw.
8 (IVF or ICSI).tw.
9 artificial insemination.tw.
10 assisted conception.tw.
11 intrauterine insemination.tw.
12 iui.tw.
13 Infertil$.tw.
14 pregnancy.tw.
15 conception.tw.
16 fertility.tw.
17 miscarriage$.tw.
18 recurrent pregnancy loss$.tw.
19 conceive.tw.
20 (implant$ adj3 failure$).tw.
21 IVF‐ET.tw.
22 ovulation induction.tw.
23 exp infertility/ or exp female infertility/ or exp infertility therapy/
24 assisted reproducti$.tw.
25 exp intracytoplasmic sperm injection/
26 exp artificial insemination/
27 exp ovulation induction/
28 exp superovulation/
29 exp recurrent abortion/
30 or/7‐29
31 6 and 30
32 Clinical Trial/
33 Randomized Controlled Trial/
34 exp randomization/
35 Single Blind Procedure/
36 Double Blind Procedure/
37 Crossover Procedure/
38 Placebo/
39 Randomi?ed controlled trial$.tw.
40 Rct.tw.
41 random allocation.tw.
42 randomly allocated.tw.
43 allocated randomly.tw.
44 (allocated adj2 random).tw.
45 Single blind$.tw.
46 Double blind$.tw.
47 ((treble or triple) adj blind$).tw.
48 placebo$.tw.
49 prospective study/
50 or/32‐49
51 case study/
52 case report.tw.
53 abstract report/ or letter/
54 or/51‐53
55 50 not 54
56 31 and 55
Appendix 5. PsycINFO search strategy
From 1806 to present
Ovid platform
1 subfertil$.tw.
2 (IVF or ICSI).tw.
3 artificial insemination.tw.
4 assisted conception.tw.
5 intrauterine insemination.tw.
6 iui.tw.
7 Infertil$.tw.
8 pregnancy.tw.
9 conception.tw.
10 fertility.tw.
11 miscarriage$.tw.
12 recurrent pregnancy loss$.tw.
13 conceive.tw.
14 (implant$ adj3 failure$).tw.
15 IVF‐ET.tw.
16 ovulation induction.tw.
17 assisted reproducti$.tw.
18 exp Infertility/
19 exp Reproductive Technology/
20 exp Spontaneous Abortion/
21 or/1‐20
22 Hysteroscop$.tw.
23 21 and 22
Appendix 6. CINAHL search strategy
From 1961 to present
Ebsco platform
| # | Query |
| S47 | S32 AND S46 |
| S46 | S33 OR S34 or S35 or S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 OR S43 OR S44 OR S45 |
| S45 | TX allocat* random* |
| S44 | (MH "Quantitative Studies") |
| S43 | (MH "Placebos") |
| S42 | TX placebo* |
| S41 | TX random* allocat* |
| S40 | (MH "Random Assignment") |
| S39 | TX randomi* control* trial* |
| S38 | TX ( (singl* n1 blind*) or (singl* n1 mask*) ) or TX ( (doubl* n1 blind*) or (doubl* n1 mask*) ) or TX ( (tripl* n1 blind*) or (tripl* n1 mask*) ) or TX ( (trebl* n1 blind*) or (trebl* n1 mask*) ) |
| S37 | TX ( (trebl* n1 blind*) or (trebl* n1 mask*) ) |
| S36 | TX ( (trebl* n1 blind*) or (trebl* n1 mask*) ) |
| S35 | TX clinic* n1 trial* |
| S34 | PT Clinical trial |
| S33 | (MH "Clinical Trials+") |
| S32 | S6 AND S31 |
| S31 | S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 |
| S30 | TX ovulation induction |
| S29 | TX IVF‐ET |
| S28 | TX (implant* N3 fail*) |
| S27 | TX conceive |
| S26 | TX (recurrent pregnancy loss) |
| S25 | TX miscarriage |
| S24 | (MM "Abortion, Habitual") |
| S23 | TX fertility |
| S22 | TX conception |
| S21 | TX pregnancy |
| S20 | TX Infertil* |
| S19 | TX superovulation |
| S18 | (MM "Ovulation Induction") |
| S17 | TX (sperm injection* intracytoplasmic) |
| S16 | (MM "Fertilization in Vitro") |
| S15 | (MH "Reproduction Techniques+") |
| S14 | TX iui |
| S13 | TX intrauterine insemination |
| S12 | TX assisted conception |
| S11 | (MM "Insemination, Artificial") |
| S10 | TX artificial insemination |
| S9 | TX (IVF or ICSI) |
| S8 | TX subfertil* |
| S7 | (MM "Infertility") OR (MM "Embryo Transfer") |
| S6 | S1 OR S2 OR S3 OR S4 OR S5 |
| S5 | TX (Uter* N3 Endoscop*) |
| S4 | TX minihysteroscop* |
| S3 | TX Uteroscop* |
| S2 | TX Hysteroscop* |
| S1 | (MM "Hysteroscopy") |
Appendix 7. Data extraction form
| Study information | |||||||||
| 1. Ref ID | |||||||||
| 2. First author | |||||||||
| 3. Year | |||||||||
| 4. Published | q Yes | q No | |||||||
| 5. Language | |||||||||
| Criteria for eligibility: | YES | NO | |||||||
| Patients: | Couples undergoing hysteroscopy prior to IVF/ICSI | q | q | ||||||
| Intervention | Screening/routine hysteroscopy a) Prior to the first IVF/ICSI cycle b) Prior to 2 or more failed IVF cycles | q | q | ||||||
| Comparison | No hysteroscopy | q | q | ||||||
| Outcome | Primary: Live‐birth rate (per randomised couple) Secondary: Clinical pregnancy rate (per randomised couple) (positive pregnancy test, gestational sac on ultrasound) Multiple pregnancy rate (per randomised couple) Miscarriage rate (per randomised couple) Congenital anomalies (per randomised couple) Additional: | q q q q q q q q q | q q q q q q q q q | ||||||
| Study characteristics | |||||||||
| Design | |||||||||
| 1. Study design | q RCT q Parallel (intervention vs control) q Cross‐over (participants used as intervention and control group) q ………………………………. Quotes: ……………………………………………………………………………………………………………………………………………………………………………………………………………………………… | ||||||||
| 2. Setting | q Single‐centre | q Multicentre | |||||||
| Country: .……………………………………………………………………………………………………………… | |||||||||
| Participants: in‐ and exclusion | |||||||||
| 3. Study criteria for patient inclusion | ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ | ||||||||
| 4. Study criteria for patient exclusion | _____________________________________________________________________________________________________________________________________________________________________________________________ | ||||||||
| 5. Description control/ comparison treatment | ……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………… | ||||||||
| Baseline characteristics | |||||||||
| Previous IVF and/or ICSI treatment | q Reported | q Not reported | |||||||
| Intervention | |||||||||
| Embryo transfer after IVF, ICSI | |||||||||
| 1. Time of randomisation during cycle | q Prior to commencement of treatment cycle | ||||||||
| 2. Nature of intervention | q Hysteroscopy q No hysteroscopy | ||||||||
| 3. Timing of intervention | q Late luteal phase in the preceding cycle Follicular phase in the preceding cycle | ||||||||
