Appendix 1. Search Strategy

((((randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR placebo[tiab] OR drug therapy[sh] OR randomly[tiab] OR trial[tiab] OR groups[tiab])) NOT (animals[mh] NOT humans[mh]))) AND ((((((((prostatic neoplasms[mh] OR prostatic neoplasms[tw])) OR (prostatic intraepithelial neoplasia[mh] OR prostatic intraepithelial neoplasia[tw])) OR (((cancer* OR carcinoma* OR malignan* OR tumor* OR tumour* OR neopla* AND intraepithelial OR adeno*)) AND prostat*))) AND metastatic)) AND (diterpenes OR paclitaxel OR docetaxel OR cabazitaxel OR taxoids))

PubMed

1. prostatic neoplasms[mh] OR prostatic neoplasms[tw]

2. prostatic intraepithelial neoplasia [mh] OR prostatic intraepithelial neoplasia[tw]

3. cancer* OR carcinoma* OR malignan* OR tumor* OR tumour* OR neopla*

4. 1 OR 2 OR 3

5. intraepithelial OR adeno*

6. 4 AND 5

7. prostat* AND metastatic

8. 6 AND 7

9. diterpenes OR paclitaxel OR docetaxel OR cabazital OR toxoids

10. 8 AND 9

11. randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR placebo[tiab] OR drug therapy[sh] OR randomly[tiab] OR trial[tiab] OR groups[tiab

12. 10 AND 11

13. animals

14. humans

15. 12 NOT 13

16. 15 NOT 14