Appendix 1. EAU panel search strategy

Courtesy of the EAU panel, reproduced with permission.

MEDLINE 1946 to November week 3 2014
MEDLINE‐In‐Process and other Non‐Indexed Citations December 11 2014

1. randomized controlled trial.pt.
2. controlled clinical trial.pt.
3. randomi?ed.ab.
4. placebo.ab.
5. drug therapy.fs.
6. randomly.ab.
7. trial.ab.
8. groups.ab.
9. or/1‐8
10. Carcinoma, Renal Cell/
11. (metastas* adj5 ((kidney or renal) adj2 (cancer* or carcinoma* or neoplasm* or tum?or* or mass*))).tw.
12. or/10‐11
13. Chemotherapy, Cancer, Regional Perfusion/
14. thalidomide/
15. exp Antineoplastic Protocols/
16. exp Antineoplastic agents/
17. (axitinib or bevacizumab or dovitinib or erlotinib or everolimus or lapatinib or pazapanib or sorafenib or sunitinib or temsirolimus or thalidomide or tivozanib).tw.
18. antineoplastic$.tw.
19. or/13‐18
20. 9 and 12 and 19
21. (conference or letter or editorial or comment*).pt.
22. exp animals/ not humans/
23. 20 not (21 or 22)
24. Limit 23 to yr="2001 ‐Current"

Embase 1974 to 2014 December 22

1. kidney carcinoma/
2. (metastas* adj5 ((kidney or renal) adj2 (cancer* or carcinoma* or neoplasm* or tum?or* or mass*))).tw.
3. 1 or 2
4. exp cancer chemotherapy/
5. exp Antineoplastic agent/
6. sorafenib/
7. sunitinib/
8. bevacizumab/
9. axitinib/
10. pazopanib/
11. everolimus/
12. temsirolimus/
13. interferon/
14. interleukin 2/
15. dovitinib/
16. tivozanib/
17. erlotinib/
18. (axitinib or bevacizumab or dovitinib or erlotinib or everolimus or lapatinib or pazapanib or sorafenib or sunitinib or temsirolimus or thalidomide or tivozanib).tw.
19. antineoplastic$.tw.
20. or/4‐19
21. random.tw.
22. placebo.mp.
23. double‐blind.tw.
24. or/21‐23
25. 3 and 20 and 24
26. exp animals/ not humans/
27. (conference or letter or editorial or comment*).pt.
28. 25 not (26 or 27)
29. Limit 28 to yr="2001 ‐Current"

Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials
(The Cochrane Library, Issue 11 of 12, November 2014) www.thecochranelibrary.com

1. MeSH descriptor Carcinoma, Renal Cell, this term only
2. (metastas* near/5 ((kidney or renal) near/2 (cancer* or carcinoma* or neoplasm* or tum?or* or mass*)))
3. (#1 OR #2)
4. (#3), from 2001 to current

LILACS
December 2014
http://lilacs.bvsalud.org/en/

(tw:(renal cell carcinoma or renal cancer or renal tumour$ or renal tumor$ or renal carcinoma$ or renal neoplasm$ or renal mass$ or kidney cancer or kidney tumour$ or kidney tumor$ or kidney neoplasm$ or kidney mass$)) OR (mh:(kidney neoplasms))
Type of study: Controlled Clinical Trial

Clinicaltrials.gov: http://clinicaltrials.gov
Basic search: metastatic renal cell carcinoma

WHO International Clinical Trials Registry Platform http://apps.who.int/
Basic search: metastatic renal cell carcinoma