Community first responders for out‐of‐hospital cardiac arrest
Appendices
Appendix 1. Medline Search Strategy
1. exp Heart Arrest/ or exp Cardiopulmonary Resuscitation/ or ((cardiac or heart or cardiopulmonary or cardio pulmonary or out of hospital) adj3 (arrest or resuscitation*)) or OHCA or CPR or asystole*
2. exp Emergency Responders/ or exp Volunteers/ or ((emergency or first or lay) adj3 responder*).mp. or volunteer*.mp. or CFR.mp.
3. ((randomized controlled trial or controlled clinical trial).pt. or randomi?ed.ab. or placebo.ab. or drug therapy.fs. or randomly.ab. or trial.ab. or groups.ab.) not (exp animals/ not humans.sh.)
4. 1 and 2 and 3
Appendix 2. Data Extraction Form
Data Extraction Form***
| Review title |
| ACE 357 Impact of community first responders in out of hospital cardiac arrest (OHCA) |
| Study ID(surname of first author and year first full report of study was published e.g. Smith 2001) |
| Report IDs of other reports of this study(e.g. duplicate publications, follow‐up studies) |
| Notes: |
Note – Please insure
· Consistency in the order and style used to describe the information for each included study.
· Any missing information recorded as unclear or not described.
General Information
| 1. Date form completed (dd/mm/yyyy) | ||
| 2. ID of person extracting data | ||
| 3. Report title (title of paper/ abstract/ report that data are extracted from) | ||
| 4. Report ID (if there are multiple reports of this study) | ||
| 5. Reference details | ||
| 6. Report author contact details | ||
| 7. Publication type (e.g. full report, abstract, letter) | ||
| 8. Study funding source (including role of funders) | ||
| Possible conflicts of interest (for study authors) | ||
| 9. Notes: | ||
Eligibility
| Study Characteristics | Review Inclusion Criteria | Yes/ No / Unclear | Location in text (pg & ¶/fig/table) | ||
| 10. Type of study | Randomized trial | ||||
| Quasi ‐ randomized trial | |||||
| 11. Participants | Adults and/or children suffering from OHCA excluding studies primarily concerned with infants @ birth | ||||
| 12. Types of intervention | Studies that compare routine statutory EMS with this care plus the mobilisation of community first responders in instances of OHCA | ||||
| 13. Types of outcome measures | At least one of … Primary outcomes 1. Survival to hospital discharge. Secondary outcomes 2. Neurological outcome at hospital discharge (CPC). 3. Survival to hospital admission, defined as a patient admitted to hospital with spontaneous circulation and measurable blood pressure. 4. Cardio Pulmonary Resuscitation performed prior to ambulance service arrival. 5. Defibrillation performed prior to ambulance service arrival. | ||||
| 14. Decision: | |||||
| 15. Reason for exclusion | |||||
| 16. Notes: | |||||
Population and Setting
| Description Include comparative information for each group (i.e. intervention and controls) if available | Location in text (pg & ¶/fig/table) | ||
| 17. Population description (from which study participants are drawn) | |||
| 18. Setting (including location and social context) | |||
| 19. Inclusion criteria | |||
| 20. Exclusion criteria | |||
| 21. Method/s of recruitment of participants | |||
| 22. Notes: | |||
Methods
| Descriptions as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| Aim of study | |||
| Design | |||
| Unit of allocation (by individuals or cluster) | |||
| Start date | |||
| End date | |||
| Duration of participation (from recruitment to last follow‐up) | |||
| Notes: | |||
Risk of Bias Assessment
| Domain | Risk of bias Low/ High/Unclear | Support for judgement | Location in text (pg & ¶/fig/table) | |
| 23. Random sequence generation (selection bias) | ||||
| 24. Allocation concealment (selection bias) | ||||
| 25. Blinding of participants and personnel (performance bias) | ||||
| 26. Blinding of outcome assessment (detection bias) | ||||
| 27. Incomplete outcome data (attrition bias) | ||||
| 28. Selective outcome reporting? (reporting bias) | ||||
| 29. Other bias | ||||
| 30. Notes: | ||||
Participants
Provide overall data and, if available, comparative data for each intervention or comparison group.
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 31. Total no. randomized | |||
| 32. Clusters (if applicable, no., type, no. people per cluster) | |||
| 33. Baseline imbalances | |||
| 34. Withdrawals and exclusions | |||
| 35. Age | |||
| 36. Sex | |||
| 37. Race/Ethnicity | |||
| 38. Witnessed OHCA | |||
| 39. Initial Rhythm | |||
| 40. Co‐morbidities | |||
| 41. Other treatment(s) received (additional to study intervention) | |||
| 42. Other relevant sociodemographics | |||
| 43. Subgroups measured | |||
| 44. Subgroups reported | |||
| 45. Notes: | |||
Intervention Groups
(Provide a table for each intervention and comparison group)
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 46. Group name | |||
| 47. No. randomized to group (specify whether no. people or clusters) | |||
| 48. Description (include sufficient detail for replication) | |||
| 49. Duration of intervention period | |||
| 50. Details of Intervention delivery | |||
| 51. Providers (e.g. no., profession, training,etc.) | |||
| 52. Co‐interventions if any | |||
| 53. Other | |||
| 54. Notes: | |||
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 55. Group name | |||
| 56. No. randomized to group (specify whether no. people or clusters) | |||
| 57. Description (include sufficient detail for replication) | |||
| 58. Duration of intervention period | |||
| 59. Details of Intervention delivery | |||
| 60. Providers (e.g. no., profession, training, etc.) | |||
| 61. Co‐interventions if any | |||
| 62. Other | |||
| 63. Notes: | |||
Outcomes
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 64. Outcome name | Survival to hospital discharge | ||
| 65. Time points measured | |||
| 66. Time points reported | |||
| 67. Outcome definition | |||
| 68. Person measuring/reporting | |||
| 69. Imputation of missing data | |||
| 70. Notes: | |||
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 71. Outcome name | CPC @ Hospital discharge | ||
| 72. Time points measured | |||
| 73. Time points reported | |||
| 74. Outcome definition | |||
| 75. Person measuring/ reporting | |||
| 76. Unit of measurement | |||
| 77. Scale | |||
| 78. Imputation of missing data | |||
| 79. Notes: | |||
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 64a. Outcome name | Survival at 30 days | ||
| 65a. Time points measured | |||
| 66a. Time points reported | |||
| 67a. Outcome definition | |||
| 68a. Person measuring/reporting | |||
| 69a. Imputation of missing data | |||
| 70a. Notes: | |||
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 71a. Outcome name | CPC @ 30 days | ||
| 72a. Time points measured | |||
| 73a. Time points reported | |||
| 74a. Outcome definition | |||
| 75a. Person measuring/ reporting | |||
| 76a. Unit of measurement | |||
| 77a. Scale | |||
| 78a. Imputation of missing data | |||
| 79a. Notes: | |||
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 80. Outcome name | Survival to hospital admission | ||
| 81. Time points measured | |||
| 82. Time points reported | |||
| 83. Outcome definition | |||
| 84. Person measuring/reporting | |||
| 85. Any Imputation of missing data | |||
| 86. Notes: | |||
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 87. Outcome name | CPR before ambulance arrival | ||
| 88. Time points measured | |||
| 89. Time points reported | |||
| 90. Outcome definition | |||
| 91. Person measuring/reporting | |||
| 92. Any Imputation of missing data | |||
| 93. Notes: | |||
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| 94. Outcome name | Defibrillation before ambulance arrival | ||
| 95. Time points measured | |||
| 96. Time points reported | |||
| 97. Outcome definition | |||
| 98. Person measuring/reporting | |||
| 99. Any Imputation of missing data | |||
| 100. Notes | |||
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||
| x1. Outcome name | HRQOL @ 90 Days | ||
| x2. Time points measured | |||
| x3. Time points reported | |||
| x4. Outcome definition | |||
| x5. Person measuring/reporting | |||
| x6. Scale Used + Description | |||
| x7. Any Imputation of missing data | |||
| x8. Notes | |||
Results
Additional tables will be generated for each outcomes and subgroup as required
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | ||||||
| 101. Comparison | |||||||
| 102. Outcome | Survival to hospital discharge | ||||||
| 103. Subgroup | |||||||
| 104. Results Note whether: Adjusted OR Unadjusted | Intervention | Comparison | |||||
| No. events | No. participants | No. events | No. participants | ||||
| 105. No. missing participants and reasons | |||||||
| 106. No. participants moved from other group and reasons | |||||||
| 107. Any other results reported | |||||||
| 108. Unit of analysis | |||||||
| 109. Statistical methods used and appropriateness of these methods | |||||||
| 110. Reanalysis required? (if yes, specify why) | Yes/No/Unclear | ||||||
| 111. Reanalysis possible? | Yes/No/Unclear | ||||||
| 112. Reanalysed results | |||||||
| 113. Notes: | |||||||
Applicability
| 114. Have important populations been excluded from the study? | ||||
| 115. Does the study directly address the review question? (any issues of partial or indirect applicability) | ||||
| 116. Notes: | ||||
Other Information
| Description as stated in report/paper | Location in text (pg & ¶/fig/table) | |||
| 117. Key conclusions of study authors | ||||
| 118. References to other relevant studies | ||||
| 119. Correspondence required for further study information (what and from whom) | ||||
| 120. Further study information requested (from whom, what and when) | ||||
| 121. Correspondence received (from whom, what and when) | ||||
| 122. Notes: | ||||
*** Adapted from‐ Effective Practice and Organisation of Care (EPOC). Data collection form. EPOC Resources for review authors. Oslo: Norwegian Knowledge Centre for the Health Services; 2013. Available at:epoc.cochrane.org/epoc‐specific‐resources‐review‐authors
