First‐line uterotonics for treating postpartum haemorrhage: a systematic review and network meta‐analysis
Información
- DOI:
- https://doi.org/10.1002/14651858.CD012754Copiar DOI
- Base de datos:
-
- Cochrane Database of Systematic Reviews
- Versión publicada:
-
- 21 agosto 2017see what's new
- Tipo:
-
- Intervention
- Etapa:
-
- Protocol
- Grupo Editorial Cochrane:
-
Grupo Cochrane de Embarazo y parto
- Copyright:
-
- Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Cifras del artículo
Altmetric:
Citado por:
Autores
Contributions of authors
Ioannis D Gallos (IDG) and Arri Commarasamy (AC) conceived the idea for this study. William R Parry‐Smith (WRPS) drafted the protocol. Helen M Williams (HMW), Malcolm J Price (MJP), Mariana Widmer (MW), Mubashir Angolkar (MA), Aurelio Tobias (AT), Zarko Alfirevic (ZA), Andrew Weeks (AW), G Justus Hofmeyr (GJH), A Metin Gulmezoglu (AMG), IDG and AC designed the meta‐analysis. AT and MJP provided statistical advice and input. IDG, HMW, MW, MJP, AW, GJH, AC reviewed the protocol and provided critical feedback.
Sources of support
Internal sources
-
University of Birmingham, UK.
The authors of this review are employed by the institutions indicated by their respective affiliations except where otherwise stated.
-
World Health Organization, Switzerland.
The authors of this review are employed by the institutions indicated by their respective affiliations except where otherwise stated.
-
University of the Witwatersrand and Walter Sisulu University, South Africa.
The authors of this review are employed by the institutions indicated by their respective affiliations except where otherwise stated.
-
JN Medical College Belgaum, India.
The authors of this review are employed by the institutions indicated by their respective affiliations except where otherwise stated.
-
University of Liverpool, UK.
The authors of this review are employed by the institutions indicated by their respective affiliations except where otherwise stated.
External sources
-
Ammalife Registered Charity Number 1120236, UK.
Financial support for library/literature retrieval costs.
Declarations of interest
William R Parry‐Smith (WRPS) is an Executive Board member of AmmaLife (UK registered charity 1120236), a member of The UK Membership Board of The Royal College of Obstetricians and Gynaecologists, and a Trustee of Baby Lifeline. He does not receive payment for these roles but has received payment from these organisations for travel for activities not related to this review. He has also received payment from the Liverpool School of Tropical Medicine for an invited lecture on cervical cancer and women's health. AmmaLife contributed to this review by funding literature/library costs.
Ioannis D Gallos (IDG) has received support for travel/accommodation/meeting expenses from MSD for Mothers.
Helen M Williams (HMW) none known.
Mariana Widmer (MW) none known.
Mubashir Angolkar (MA) none known.
Aurelio Tobias (AT) none known.
Malcolm J Price (MJP) none known.
Zarko Alfirevic (ZA) has been an external adviser for Gynuity related to the charity's work on PPH.
Andrew Weeks (AW): has worked on PPH research for many years and has multiple interests in it. He voluntarily runs the not‐for‐profit misoprostol.org website that provides information about the optimal doses of misoprostol, including for the treatment of PPH. He also has two large clinical trial grants (from NIHR) on PPH treatment. These studies could potentially be eligible for inclusion in subsequent updates of this review, but he will not participate in decisions regarding these trials. He is also a consultant to Gynuity Health projects (unpaid) and to Azanta A/S and Monash University (both pay consultancy fees to his institution (the University of Liverpool). He is also the inventor of the PPH Butterfly device and one of the inventors of the LifeStart neonatal resuscitation trolley. He may in future receive personal payments in connection to the PPH Butterfly for which the University of Liverpool holds the patent.
G Justus Hofmeyr (GJH) is an author of trials potentially included in the review. GJH will not participate in decisions regarding these trials.
A Metin Gulmezoglu (AMG) none known.
Arri Coomarasamy (AC) is the founder of Ammalife (UK registered charity 1120236), and remains an active member of the Executive Board of this organisation. He does not receive any payment for this relationship.
Acknowledgements
Ammalife contributed to funding this review.
The World Health Organization, William R Parry‐Smith, Ioannis D Gallos, Helen M Williams, Mubashir Angolkar, Malcolm J Price, Aurelio Tobias, Zarko Alfirevic, Andrew Weeks, G Justus Hofmeyr and Arri Coomarasamy retain copyright and all other rights in their respective contributions to the manuscript of this review as submitted for publication.
As part of the prepublication editorial process, this protocol has been commented on by five peers (an editor and four referees who are external to the editorial team), a member of Cochrane Pregnancy and Childbirth's international panel of consumers and the Group's Statistical Adviser.
This project was supported by the National Institute for Health Research (NIHR), via Cochrane Infrastructure funding to Cochrane Pregnancy and Childbirth. The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the Systematic Reviews Programme, NIHR, National Health Service or the Department of Health.
Version history
| Published | Title | Stage | Authors | Version |
| 2020 Nov 24 | Uterotonic agents for first‐line treatment of postpartum haemorrhage: a network meta‐analysis | Review | William R Parry Smith, Argyro Papadopoulou, Eleanor Thomas, Aurelio Tobias, Malcolm J Price, Shireen Meher, Zarko Alfirevic, Andrew D Weeks, G Justus Hofmeyr, Ahmet Metin Gülmezoglu, Mariana Widmer, Olufemi T Oladapo, Joshua P Vogel, Fernando Althabe, Arri Coomarasamy, Ioannis D Gallos | |
| 2017 Aug 21 | First‐line uterotonics for treating postpartum haemorrhage: a systematic review and network meta‐analysis | Protocol | William R Parry Smith, Ioannis D Gallos, Helen M Williams, Mariana Widmer, Mubashir Angolkar, Aurelio Tobias, Malcolm J Price, Zarko Alfirevic, Andrew Weeks, G Justus Hofmeyr, A Metin Gülmezoglu, Arri Coomarasamy | |
Keywords
MeSH
Medical Subject Headings (MeSH) Keywords
- Bias;
- Blood Transfusion [statistics & numerical data];
- Confidence Intervals;
- Drug Therapy, Combination [methods];
- Ergonovine [*therapeutic use];
- Misoprostol [adverse effects, *therapeutic use];
- *Network Meta-Analysis;
- Oxytocics [adverse effects, *therapeutic use];
- Oxytocin [adverse effects, *therapeutic use];
- Postpartum Hemorrhage [chemically induced, *drug therapy, mortality];
- Randomized Controlled Trials as Topic;
Medical Subject Headings Check Words
Female; Humans; Pregnancy;
