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PRISMA study flow diagram.
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Figure 1

PRISMA study flow diagram.

Study flow diagram for economics studies.
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Figure 2

Study flow diagram for economics studies.

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 3

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
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Figure 4

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Comparison 1 Yoga versus no specific active intervention, Outcome 1 Number of women who report cure or improvement of urinary incontinence (at short term ‐ 6 weeks).
Figuras y tablas -
Analysis 1.1

Comparison 1 Yoga versus no specific active intervention, Outcome 1 Number of women who report cure or improvement of urinary incontinence (at short term ‐ 6 weeks).

Comparison 1 Yoga versus no specific active intervention, Outcome 2 Urinary incontinence condition‐ or symptom‐specific quality of life (at short term ‐ 6 weeks).
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Analysis 1.2

Comparison 1 Yoga versus no specific active intervention, Outcome 2 Urinary incontinence condition‐ or symptom‐specific quality of life (at short term ‐ 6 weeks).

Comparison 1 Yoga versus no specific active intervention, Outcome 3 Adjusted analysis for condition‐ or symptom‐specific quality of life at short term (6 weeks).
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Analysis 1.3

Comparison 1 Yoga versus no specific active intervention, Outcome 3 Adjusted analysis for condition‐ or symptom‐specific quality of life at short term (6 weeks).

Comparison 1 Yoga versus no specific active intervention, Outcome 4 Number of micturitions (daily) (at short term ‐ 6 weeks).
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Analysis 1.4

Comparison 1 Yoga versus no specific active intervention, Outcome 4 Number of micturitions (daily) (at short term ‐ 6 weeks).

Comparison 1 Yoga versus no specific active intervention, Outcome 5 Adjusted analysis for number of micturitions at short term (6 weeks).
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Analysis 1.5

Comparison 1 Yoga versus no specific active intervention, Outcome 5 Adjusted analysis for number of micturitions at short term (6 weeks).

Comparison 1 Yoga versus no specific active intervention, Outcome 6 Number of episodes of incontinence (daily) (at short term ‐ 6 weeks).
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Analysis 1.6

Comparison 1 Yoga versus no specific active intervention, Outcome 6 Number of episodes of incontinence (daily) (at short term ‐ 6 weeks).

Comparison 1 Yoga versus no specific active intervention, Outcome 7 Adjusted analysis for number of incontinence episodes at short term (6 weeks).
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Analysis 1.7

Comparison 1 Yoga versus no specific active intervention, Outcome 7 Adjusted analysis for number of incontinence episodes at short term (6 weeks).

Comparison 1 Yoga versus no specific active intervention, Outcome 8 Bothersomeness of symptoms (at short term ‐ 6 weeks).
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Analysis 1.8

Comparison 1 Yoga versus no specific active intervention, Outcome 8 Bothersomeness of symptoms (at short term ‐ 6 weeks).

Comparison 1 Yoga versus no specific active intervention, Outcome 9 Adjusted analysis for bothersomeness of symptoms at short term (6 weeks).
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Analysis 1.9

Comparison 1 Yoga versus no specific active intervention, Outcome 9 Adjusted analysis for bothersomeness of symptoms at short term (6 weeks).

Comparison 1 Yoga versus no specific active intervention, Outcome 10 Adverse effects (at short term ‐ 6 weeks).
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Analysis 1.10

Comparison 1 Yoga versus no specific active intervention, Outcome 10 Adverse effects (at short term ‐ 6 weeks).

Comparison 2 Yoga versus an active intervention, Outcome 1 Number of women who report cure or improvement of urinary incontinence (at short term ‐ 8 weeks).
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Analysis 2.1

Comparison 2 Yoga versus an active intervention, Outcome 1 Number of women who report cure or improvement of urinary incontinence (at short term ‐ 8 weeks).

Comparison 2 Yoga versus an active intervention, Outcome 2 Number of women who report cure or improvement of urinary incontinence (at intermediate term ‐ 6 months).
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Analysis 2.2

Comparison 2 Yoga versus an active intervention, Outcome 2 Number of women who report cure or improvement of urinary incontinence (at intermediate term ‐ 6 months).

Comparison 2 Yoga versus an active intervention, Outcome 3 Number of women who report cure or improvement of urinary incontinence (at long term ‐ 1 year).
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Analysis 2.3

Comparison 2 Yoga versus an active intervention, Outcome 3 Number of women who report cure or improvement of urinary incontinence (at long term ‐ 1 year).

Summary of findings for the main comparison. Yoga versus no specific active intervention

Yoga compared with wait‐list for urinary incontinence in women

Patient or population: women with either stress‐predominant or urge‐predominant urinary incontinence

Settings: community

Intervention: yoga

Comparison: wait‐list

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No. of participants
(studies)

Certainty of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Wait‐list

Yoga

Number of women who report they are cured (they no longer experience urinary incontinence)

The study did not report this outcome.

Number of women who report cure or improvement of urinary incontinence at short term (six weeks)

111 per 1000

703 per 1000
(160 to 1000)

RR 6.33 (1.44 to 27.88)

18
(1 study)

⊕⊝⊝⊝
very low1,2

Number of women who reported satisfaction with change in urine leakage.

Urinary incontinence condition‐ or symptom‐specific quality of life

at short term (6 weeks)

Measured by Incontinence Impact Questionnaire Short Form (IIQ‐7) (lower = better)

The mean change in the control group was a decrease of 31 units.

The mean change in the intervention group was 1.74 units higher (33.02 units lower to 36.50 units higher).

Not applicable

18
(1 study)

⊕⊝⊝⊝
very low1,2

Number of micturitions (daily)

at short term (6 weeks)

The mean change in the control group was a decrease of 0.13 micturitions.

The mean change in the intervention group was
0.77 fewer micturitions (2.13 fewer to 0.59 more).

Not applicable

18
(1 study)

⊕⊝⊝⊝
very low1,2

Number of episodes of incontinence (daily)

at short term (6 weeks)

The mean change in the control group was a decrease of 0.27 episodes.

The mean change in the intervention group was
1.57 fewer episodes (2.83 to 0.31 to fewer).

Not applicable

18
(1 study)

⊕⊝⊝⊝
very low1,2

Bothersomeness of symptoms

at short term (6 weeks)

Measured by Urogenital Distress Inventory 6 (UDI‐6) (lower = better)

The mean change in the control group was a decrease of 0.1 units.

The mean change in the intervention group was 0.90 units lower (0.34 to 1.46 lower).

Not applicable

18
(1 study)

⊕⊝⊝⊝
very low1,2

Adverse effects

at short term (6 weeks)

222 per 1000

222 per 1000
(0 to 600)

RD 0% (‐38% to 38%)

18
(1 study)

⊕⊝⊝⊝
very low1,2

2 women in each group reported an adverse effect. However, there were 7 adverse effects overall and the distribution of adverse effects between groups is not reported. None of the adverse effects were considered to be potentially related to the study and none were serious.

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; RD: risk difference; RR: risk ratio

GRADE Working Group grades of evidence
High certainty: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate certainty: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low certainty: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low certainty: We are very uncertain about the estimate.

1Downgraded two levels for risk of bias because there was no blinding of participants or providers (risk of performance bias), and outcome was self assessed and self recorded by participants (risk of detection bias).
2Downgraded one level for imprecision (< 400 participants).

Figuras y tablas -
Summary of findings for the main comparison. Yoga versus no specific active intervention
Summary of findings 2. Yoga versus an active intervention

Yoga compared with mindfulness‐based stress reduction (MBSR) for urinary incontinence in women

Patient or population: women with urge‐predominant urinary incontinence

Settings: community

Intervention: yoga

Comparison: mindfulness‐based stress reduction (MBSR)

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No. of participants
(studies)

Certainty of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

MBSR

Yoga

Number of women who report they are cured (they no longer experience urinary incontinence)

The study did not report this outcome.

Number of women who report cure or improvement of urinary incontinence

at short term (8 weeks)

461 per 1000

42 per 1000
(5 to 660)

RR 0.09 (0.01 to 1.43)

24
(1 study)

⊕⊝⊝⊝
very low1,2,3

Urinary incontinence condition‐ or symptom‐specific quality of life

at short term (8 weeks)

Measured by the Overactive Bladder Health‐Related Quality of Life (OAB‐HRQL) scale (higher per cent improvement = better)

⊕⊝⊝⊝
very low1,2,3

The study reported medians and IQR, therefore we could not extract data for meta‐analysis. The authors reported that the median per cent improvement at 8 weeks was 8.70 (IQR 1.75 to 20.59) in the yoga group (n = 11) and 29.27 (IQR 8.11 to 93.33) in the MBSR group (n = 13) (reported P value = 0.03).

Number of micturitions (daily)

The study did not report this outcome.

Number of episodes of incontinence (daily)

at short term (8 weeks)

⊕⊝⊝⊝
very low1,2,3

The study reported medians and IQR, therefore we could not extract data for meta‐analysis. The authors reported that the median per cent improvement at 8 weeks was ‐33.33 (IQR ‐50.00 to 16.67) in the yoga group (n = 11) and ‐60 (IQR ‐88.89 to ‐50.00) in the MBSR group (n = 13) (reported P value = 0.03).

Bothersomeness of symptoms

at short term (6 weeks)

Measured by the Overactive Bladder Symptom and Quality of Life‐Short Form (OABq‐SF) (lower = better)

⊕⊝⊝⊝
very low1,2,3

The study reported medians and IQR, therefore we could not extract data for meta‐analysis. The authors reported that the median per cent change at 8 weeks was ‐25.0 (IQR ‐35 to 20) in the yoga group (n = 11) and ‐55.6 (IQR ‐50 to ‐87) in the MBSR group (n = 13) (reported P value = 0.005).

Adverse effects

The study did not report on adverse effects.

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; IQR: interquartile range; RR: risk ratio

GRADE Working Group grades of evidence
High certainty: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate certainty: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low certainty: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low certainty: We are very uncertain about the estimate.

1Downgraded two levels for risk of bias because there was no blinding of participants or providers (risk of performance bias), and there was a high percentage of loss to follow‐up that was unbalanced across study arms (risk of attrition bias).
2Downgraded one level for indirectness because the yoga intervention was not designed to treat urinary incontinence.
3Downgraded one level for imprecision (< 400 participants).

Figuras y tablas -
Summary of findings 2. Yoga versus an active intervention
Comparison 1. Yoga versus no specific active intervention

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Number of women who report cure or improvement of urinary incontinence (at short term ‐ 6 weeks) Show forest plot

1

18

Risk Ratio (M‐H, Fixed, 95% CI)

6.33 [1.44, 27.88]

2 Urinary incontinence condition‐ or symptom‐specific quality of life (at short term ‐ 6 weeks) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

1.74 [‐33.02, 36.50]

3 Adjusted analysis for condition‐ or symptom‐specific quality of life at short term (6 weeks) Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐27.7 [‐66.80, 11.40]

4 Number of micturitions (daily) (at short term ‐ 6 weeks) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

‐0.77 [‐2.13, 0.59]

5 Adjusted analysis for number of micturitions at short term (6 weeks) Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐0.12 [‐1.73, 1.49]

6 Number of episodes of incontinence (daily) (at short term ‐ 6 weeks) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

‐1.57 [‐2.83, ‐0.31]

7 Adjusted analysis for number of incontinence episodes at short term (6 weeks) Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐1.4 [‐2.79, ‐0.01]

8 Bothersomeness of symptoms (at short term ‐ 6 weeks) Show forest plot

1

18

Mean Difference (IV, Fixed, 95% CI)

‐0.90 [‐1.46, ‐0.34]

9 Adjusted analysis for bothersomeness of symptoms at short term (6 weeks) Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐0.9 [‐1.40, ‐0.40]

10 Adverse effects (at short term ‐ 6 weeks) Show forest plot

1

18

Risk Difference (M‐H, Fixed, 95% CI)

0.0 [‐0.38, 0.38]

Figuras y tablas -
Comparison 1. Yoga versus no specific active intervention
Comparison 2. Yoga versus an active intervention

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Number of women who report cure or improvement of urinary incontinence (at short term ‐ 8 weeks) Show forest plot

1

24

Risk Ratio (M‐H, Fixed, 95% CI)

0.09 [0.01, 1.43]

2 Number of women who report cure or improvement of urinary incontinence (at intermediate term ‐ 6 months) Show forest plot

1

20

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.03, 1.42]

3 Number of women who report cure or improvement of urinary incontinence (at long term ‐ 1 year) Show forest plot

1

21

Risk Ratio (M‐H, Fixed, 95% CI)

0.22 [0.03, 1.53]

Figuras y tablas -
Comparison 2. Yoga versus an active intervention