Levonorgestrel‐releasing intrauterine system for endometrial hyperplasia
Appendices
Appendix 1. Cochrane Gynaecology and Fertility Group Specialised Register search strategy
From inception to present
PROCITE platform
Keywords CONTAINS "Levonorgestrel"or"Levonorgestrel‐Therapeutic‐Use"or"levonorgestrel‐releasing intrauterine system" or "levonorgestrel‐releasing intrauterine device" or "levonorgestrel intrauterine system" or "intrauterine contraceptive devices" or "intrauterine device" or "intrauterine devices" or "Intrauterine Devices, Medicated" or "Mirena" or "LNG‐IUS" or "Nova T 380" or "LNG20" or "IUD" or Title CONTAINS"Levonorgestrel"or"Levonorgestrel‐Therapeutic‐Use"or"levonorgestrel‐releasing intrauterine system" or "levonorgestrel‐releasing intrauterine device" or "levonorgestrel intrauterine system" or "intrauterine contraceptive devices" or "intrauterine device" or "intrauterine devices" or "Intrauterine Devices, Medicated" or "Mirena" or "LNG‐IUS" or "Nova T 380"or "LNG20" or "IUD"
AND
Keywords CONTAINS "endometrial abnormalities" or "endometrial hyperplasia" or "endometrial thickness" or "endometrial vascularity" or "hyperplasia" or "proliferation" or "endometrial proliferation" or "endometrial safety" or "endometrial" or "endometrial bleeding" or "endometrial adhesions" or "endometrial cancer" or "endometrial activity" or "endometrial assessment" or "endometrial dysfunction" or "endometrioma" or "Endometrium" or "endometrium profile" or "endometrial parameters" or "endometrial pathology" or "endometrial response" or Title CONTAINS "endometrial abnormalities" or "endometrial hyperplasia" or "endometrial thickness" or "endometrial vascularity" or "hyperplasia" or "proliferation" or "endometrial proliferation" or "endometrial safety"
Appendix 2. CENTRAL search strategy
From inception to present
OVID platform
1 exp Levonorgestrel/
2 d‐norgestrel.tw.
3 exp Intrauterine Devices, Medicated/
4 Levonorgestrel.tw.
5 (LNG‐IUS or LNG‐IUD).tw.
6 Levonova$.tw.
7 Mirena$.tw.
8 Femilis$.tw.
9 Fibroplant$.tw.
10 LNG releasing.tw.
11 (progest$ adj5 intrauterine).tw.
12 (progest$ adj5 intra‐uterine).tw.
13 intrauterine device$.tw.
14 intra‐uterine device$.tw.
15 intra‐uterine system$.tw.
16 (Skyla or Jaydess).tw.
17 (IUS or IUD).tw.
18 or/1‐17
19 exp Endometrial Hyperplasia/
20 (endometri$ adj4 hyperplas$).tw.
21 (atypi$ adj2 hyperplas$).tw.
22 (atypi$ adj2 endometri$).tw.
23 (simple adj2 hyperplas$).tw.
24 (complex adj2 hyperplas$).tw.
25 (endometri$ adj2 proliferat$).tw.
26 (endometri$ adj2 thick$).tw.
27 Adenocarcinoma/ and endometri$.tw.
28 (endometri$ adj5 (biops$ or histology)).tw.
29 (proliferat$ adj4 endometri$).tw.
30 endometrium.tw.
31 (endometri$ adj2 histopatholog$).tw.
32 (endometri$ adj5 effect$).tw.
33 (endometri$ adj2 safety).tw.
34 or/19‐33
35 18 and 34
Appendix 3. MEDLINE search strategy
From 1946 to present
OVID platform
1 exp Levonorgestrel/
2 d‐norgestrel.tw.
3 exp Intrauterine Devices, Medicated/
4 Levonorgestrel.tw.
5 (LNG‐IUS or LNG‐IUD).tw.
6 Levonova$.tw.
7 Mirena$.tw.
8 Femilis$.tw.
9 Fibroplant$.tw.
10 LNG releasing.tw.
11 (progest$ adj5 intrauterine).tw.
12 (progest$ adj5 intra‐uterine).tw.
13 intrauterine device$.tw.
14 intra‐uterine device$.tw.
15 intra‐uterine system$.tw.
16 (Skyla or Jaydess).tw.
17 (IUS or IUD).tw.
18 or/1‐17
19 exp Endometrial Hyperplasia/
20 (endometri$ adj4 hyperplas$).tw.
21 (atypi$ adj2 hyperplas$).tw.
22 (atypi$ adj2 endometri$).tw.
23 (simple adj2 hyperplas$).tw.
24 (complex adj2 hyperplas$).tw.
25 (endometri$ adj2 proliferat$).tw.
26 (endometri$ adj2 thick$).tw.
27 Adenocarcinoma/ and endometri$.tw.
28 (endometri$ adj5 (biops$ or histology)).tw.
29 (proliferat$ adj4 endometri$).tw.
30 endometrium.tw.
31 (endometri$ adj2 histopatholog$).tw.
32 (endometri$ adj5 effect$).tw.
33 (endometri$ adj2 safety).tw.
34 or/19‐33
35 randomized controlled trial.pt.
36 controlled clinical trial.pt.
37 randomized.ab.
38 placebo.tw.
39 clinical trials as topic.sh.
40 randomly.ab.
41 trial.ti.
42 (crossover or cross‐over or cross over).tw.
43 or/35‐42
44 exp animals/ not humans.sh.
45 43 not 44
46 18 and 34 and 45
Appendix 4. Embase search strategy
From 1980 to present
OVID platform
1 exp LEVONORGESTREL/
2 d‐norgestrel.tw.
3 exp intrauterine contraceptive device/
4 Levonorgestrel.tw.
5 (LNG‐IUS or LNG‐IUD).tw.
6 Levonova$.tw.
7 Mirena$.tw.
8 Femilis$.tw.
9 Fibroplant$.tw.
10 LNG releasing.tw.
11 (progest$ adj5 intrauterine).tw.
12 (progest$ adj5 intra‐uterine).tw.
13 intrauterine device$.tw.
14 intra‐uterine device$.tw.
15 intra‐uterine system$.tw.
16 (Skyla or Jaydess).tw.
17 (IUS or IUD).tw.
18 or/1‐17
19 exp endometrium hyperplasia/
20 (endometri$ adj4 hyperplas$).tw.
21 (proliferat$ adj4 endometri$).tw.
22 (endometri$ adj4 atypi$).tw.
23 (atypi$ adj2 hyperplas$).tw.
24 (atypi$ adj2 endometri$).tw.
25 (simple adj2 hyperplas$).tw.
26 (complex adj2 hyperplas$).tw.
27 (endometri$ adj2 proliferat$).tw.
28 (endometri$ adj2 thick$).tw.
29 (endometri$ adj5 (biops$ or histology)).tw.
30 (proliferat$ adj4 endometri$).tw.
31 endometrium.tw.
32 (endometri$ adj2 histopatholog$).tw.
33 (endometri$ adj5 effect$).tw.
34 (endometri$ adj2 safety).tw.
35 or/19‐34
36 18 and 35
37 Clinical Trial/
38 Randomized Controlled Trial/
39 exp randomization/
40 Single Blind Procedure/
41 Double Blind Procedure/
42 Crossover Procedure/
43 Placebo/
44 Randomi?ed controlled trial$.tw.
45 Rct.tw.
46 random allocation.tw.
47 randomly allocated.tw.
48 allocated randomly.tw.
49 (allocated adj2 random).tw.
50 Single blind$.tw.
51 Double blind$.tw.
52 ((treble or triple) adj blind$).tw.
53 placebo$.tw.
54 prospective study/
55 or/37‐54
56 case study/
57 case report.tw.
58 abstract report/ or letter/
59 or/56‐58
60 55 not 59
61 36 and 60
62 62 or 63
63 61 and 64
Appendix 5. PsychINFO search strategy
From 1806 to present
OVID platform
1 exp Intrauterine Devices/
2 d‐norgestrel.tw.
3 Levonorgestrel.tw.
4 (LNG‐IUS or LNG‐IUD).tw.
5 Levonova$.tw.
6 Mirena$.tw.
7 Femilis$.tw.
8 Fibroplant$.tw.
9 LNG releasing.tw.
10 (progest$ adj5 intrauterine).tw.
11 (progest$ adj5 intra‐uterine).tw.
12 intrauterine device$.tw.
13 intra‐uterine device$.tw.
14 intra‐uterine system$.tw.
15 (Skyla or Jaydess).tw.
16 (IUS or IUD).tw.
17 or/1‐16
18 (endometrial or endometrium).tw.
19 17 and 18
Appendix 6. CINAHL search strategy
From 1961 to present
EBSCO platform
| # | Query |
| S49 | S20 AND S36 AND S48 |
| S48 | S37 OR S38 OR S39 OR S40 OR S41 OR S42 OR S43 OR S44 OR S45 OR S46 OR S47 |
| S47 | TX allocat* random* |
| S46 | (MH "Quantitative Studies") |
| S45 | (MH "Placebos") |
| S44 | TX placebo* |
| S43 | TX random* allocat* |
| S42 | (MH "Random Assignment") |
| S41 | TX randomi* control* trial* |
| S40 | TX ( (singl* n1 blind*) or (singl* n1 mask*) ) or TX ( (doubl* n1 blind*) or (doubl* n1 mask*) ) or TX ( (tripl* n1 blind*) or (tripl* n1 mask*) ) or TX ( (trebl* n1 blind*) or (trebl* n1 mask*) ) |
| S39 | TX clinic* n1 trial* |
| S38 | PT Clinical trial |
| S37 | (MH "Clinical Trials+") |
| S36 | S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 |
| S35 | TX (IUS or IUD) |
| S34 | TX (Skyla or Jaydess) |
| S33 | TX intrauterine system* |
| S32 | TX intra‐uterine system* |
| S31 | TX intra‐uterine device* |
| S30 | TX intrauterine device* |
| S29 | TX progest* N5 intra‐uterine |
| S28 | TX (progest* N5 intrauterine) |
| S27 | TX LNG releasing |
| S26 | TX LNG‐IUD |
| S25 | TX LNG‐IUS |
| S24 | TX mirena |
| S23 | TX levonorgestrel |
| S22 | (MM "Intrauterine Devices") |
| S21 | (MM "Levonorgestrel") |
| S20 | S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 |
| S19 | TX (endometri* N2 safety) |
| S18 | TX(endometri* N5 effect*) |
| S17 | TX (endometri* N2 histopatholog*) |
| S16 | TX endometrium |
| S15 | TX(endometri* N2 thick*) |
| S14 | TX(endometri* N2 proliferat*) |
| S13 | TX(complex N2 hyperplas*) |
| S12 | TX(simple N2 hyperplas*) |
| S11 | TX(atypi* N2 endometri*) |
| S10 | TX(atypi* N2 hyperplas*) |
| S9 | TX (endometri* N2 effect*) |
| S8 | TX (endometri* N2 safety) |
| S7 | TX endometrium |
| S6 | TX (bleed* or spotting*) |
| S5 | TX (hysteroscop* or hysterectomy) |
| S4 | TX (endometri* N5 (biops$ or histology)) |
| S3 | TX (endometri* N3 cancer*) |
| S2 | TX (endometri* N3 carcinoma) |
| S1 | TX endometri* N2 hyperplas* |
