Combined large neutral amino acid supplementation for phenylketonuria (PKU)
Appendices
Appendix 1. Keywords
The Cochrane Library
#1 Amino Acids, Neutral explode all trees (MeSH)
#2 Amino Acids [TU](MeSH)
#3 #1 or #2
#4 Phenylalanine hydroxylase deficiency single term (MeSH)
#5 Phenylketonuria or PKU
#6 #4 or #5
#3 AND #6
MEDLINE (Ovid)
1. AMINO ACIDS, NEUTRAL/
2. exp NEUTRAL AMINO ACIDS /
3. or/1‐2
4. exp PHENYLALANINE HYDROXYLASE DEFICIENCY ti,ab.
5. exp PHENYLKETONURIA ti,ab.
6. or/4‐5
7.3 and 6
Embase (Ovid)
1. AMINO ACIDS, NEUTRAL/
2. exp NEUTRAL AMINO ACIDS /
3. or/1‐2
4. exp PHENYLALANINE HYDROXYLASE DEFICIENCY ti,ab.
5. exp PHENYLKETONURIA ti,ab.
6. or/4‐5
7.3 and 6
ClinicalTrials.gov
Study Type: Intervention Studies
Conditions: PHENYLKETONURIA
Search Terms: large neutral amino acid OR LNAA
WHO ICTRP
Title: large neutral amino acid OR LNAA
Condition: PHENYLKETONURIA
Recruitment Status: ALL
| Region | Country | Incidence |
| Asian | China | 1: 17,000 |
| Japan | 1: 125,000 | |
| Turkey | 1: 2600 | |
| Israel | 1: 5300 | |
| European | Scotland | 1: 5300 |
| Czech Republic | 1: 7000 | |
| Hungary | 1: 11,000 | |
| Denmark | 1: 12,000 | |
| France | 1: 13,500 | |
| Norway | 1 : 14,500 | |
| United Kingdom | 1 : 14,300 | |
| Italy | 1 : 17,000 | |
| Canada | 1 : 22,000 | |
| Finland | 1 : 200,000 | |
| Arabic | Up to 1: 6000 | |
| Oceania | Australia | 1: 10,000 |
| Incidence of phenylketonuria (PKU) by population (Williams 2008). | ||
