Renin inhibitors versus angiotensin receptor blockers for primary hypertension
Appendices
Appendix 1. MEDLINE search strategy
1 renin/ai
2 (aliskiren or ciprokiren or ditekiren or enalkiren or remikiren or rasilez or tekturna or terlakiren or zankiren).mp.
3 ((RAS or renin) adj2 inhibit$).tw.
4 or/1‐3
5 exp Angiotensin‐Converting Enzyme Inhibitors/
6 ((angiotensin$ or dipeptidyl$ or kininase ii) adj3 (convert$ or enzyme or inhibit$ or recept$ or block$)).tw.
7 (ace adj2 inhibit$).tw.
8 acei.tw.
9 (alacepril or altiopril or ancovenin or benazepril or captopril or ceranapril or ceronapril or cilazapril or deacetylalacepril or delapril or derapril or enalapril or enalaprilat or epicaptopril or fasidotril or fosinopril or foroxymithine or gemopatrilat or idapril or imidapril or indolapril or libenzapril or lisinopril or moexipril or moveltipril or omapatrilat or pentopril$ or perindopril$ or pivopril or quinapril$ or ramipril$ or rentiapril or saralasin or s nitrosocaptopril or spirapril$ or temocapril$ or teprotide or trandolapril$ or utibapril$ or zabicipril$ or zofenopril$ or Aceon or Accupril or Altace or Capoten or Lotensin or Mavik or Monopril or Prinivil or Univas or Vasotec or Zestril).tw.
10 or/5‐9
11 exp angiotensin receptor antagonists/
12 (angiotensin adj3 (receptor antagon$ or receptor block$)).tw.
13 (arb or arbs).tw.
14 (abitesartan or azilsartan or candesartan or elisartan or embusartan or eprosartan or forasartan or irbesartan or KT3‐671 or losartan or milfasartan or olmesartan or saprisartan or tasosartan or telmisartan or valsartan or zolasartan).tw.
15 or/11‐14
16 hypertension/
17 (antihypertens$ or hypertens$).tw.
18 ((elevat$ or high$ rais$) adj2 (blood pressure or bp)).tw.
19 or/16‐18
20 randomized controlled trial.pt.
21 controlled clinical trial.pt.
22 randomized.ab.
23 placebo.ab.
24 drug therapy.fs.
25 randomly.ab.
26 trial.ab.
27 groups.ab.
28 or/20‐27
29 animals/ not (humans/ and animals/)
30 Pregnancy/ or Hypertension, Pregnancy‐Induced/ or Pregnancy Complications, Cardiovascular/ or exp Ocular Hypertension/
31 (pregnancy‐induced or ocular hypertens$ or preeclampsia or pre‐eclampsia).ti.
32 28 not (29 or 30 or 31)
33 4 and (10 or 15) and 19 and 32
34 remove duplicates from 33
Appendix 2. Cochrane Hypertension Specialized Register search strategy
#1 ((aliskiren or ciprokiren or ditekiren or enalkiren or remikiren or rasilez or tekturna or terlakiren or zankiren))
#2 (RAS or renin) near2 inhibit*
#3 #1 OR #2
#4 MeSH DESCRIPTOR Angiotensin‐Converting Enzyme Inhibitors EXPLODE ALL
#5 ((angiotensin or dipeptidyl or kininase ii) near3 (convert* or enzyme or inhibit* or recept* or block*))
#6 (ace near2 inhibit*)
#7 acei
#8 ((alacepril or altiopril or benazepril or captopril or ceronapril or cilazapril or delapril or enalapril or fosinopril or idapril or imidapril or lisinopril or moexipril or moveltipril or pentopril or perindopril or quinapril or ramipril or spirapril or temocapril or trandolapril or zofenopril))
#9 #4 OR #5 OR #6 OR #7 OR #8
#10 MeSH DESCRIPTOR Angiotensin Receptor Antagonists EXPLODE ALL
#11 angiotensin near3 (receptor antagon* or receptor block*)
#12 arb or arbs
#13 (abitesartan or azilsartan or candesartan or elisartan or embusartan or eprosartan or forasartan or irbesartan or KT3‐671 or losartan or milfasartan or olmesartan or saprisartan or tasosartan or telmisartan or valsartan or zolasartan)
#14 #10 OR #11 OR #12 OR #13
#15 RCT:DE
#16 ((Review OR Meta‐Analysis)):MISC2
#17 #15 OR #16
#18 #3 AND (#9 OR #14) AND #17
Appendix 3. CENTRAL search strategy
#1 ((aliskiren or ciprokiren or ditekiren or enalkiren or remikiren or rasilez or tekturna or terlakiren or zankiren)) AND CENTRAL:TARGET
#2 (RAS or renin) near2 inhibit* AND CENTRAL:TARGET
#3 #1 OR #2
#4 MeSH DESCRIPTOR Angiotensin‐Converting Enzyme Inhibitors EXPLODE ALL AND CENTRAL:TARGET
#5 ((angiotensin or dipeptidyl or kininase ii) near3 (convert* or enzyme or inhibit* or recept* or block*)) AND CENTRAL:TARGET
#6 (ace near2 inhibit*) AND CENTRAL:TARGET
#7 acei AND CENTRAL:TARGET
#8 ((alacepril or altiopril or benazepril or captopril or ceronapril or cilazapril or delapril or enalapril or fosinopril or idapril or imidapril or lisinopril or moexipril or moveltipril or pentopril or perindopril or quinapril or ramipril or spirapril or temocapril or trandolapril or zofenopril)) AND CENTRAL:TARGET
#9 #4 OR #5 OR #6 OR #7 OR #8
#10 MeSH DESCRIPTOR Angiotensin Receptor Antagonists EXPLODE ALL AND CENTRAL:TARGET
#11 angiotensin near3 (receptor antagon* or receptor block*) AND CENTRAL:TARGET
#12 arb or arbs AND CENTRAL:TARGET
#13 (abitesartan or azilsartan or candesartan or elisartan or embusartan or eprosartan or forasartan or irbesartan or KT3‐671 or losartan or milfasartan or olmesartan or saprisartan or tasosartan or telmisartan or valsartan or zolasartan) AND CENTRAL:TARGET
#14 #10 OR #11 OR #12 OR #13
#15 #3 AND (#9 OR #14)
Appendix 4. Embase search strategy
1 exp renin inhibitor/
2 (aliskiren or ciprokiren or ditekiren or enalkiren or remikiren or rasilez or tekturna or terlakiren or zankiren).tw.
3 ((RAS or renin) adj2 inhibit$).tw.
4 or/1‐3
5 exp dipeptidyl carboxypeptidase inhibitor/
6 ((angiotensin$ or dipeptidyl$ or kininase ii) adj3 (convert$ or enzyme or inhibit$ or recept$ or block$)).tw.
7 (ace adj2 inhibit$).tw.
8 acei.tw.
9 (alacepril or altiopril or ancovenin or benazepril or captopril or ceranapril or ceronapril or cilazapril or deacetylalacepril or delapril or derapril or enalapril or enalaprilat or epicaptopril or fasidotril or fosinopril or foroxymithine or gemopatrilat or idapril or imidapril or indolapril or libenzapril or lisinopril or moexipril or moveltipril or omapatrilat or pentopril$ or perindopril$ or pivopril or quinapril$ or ramipril$ or rentiapril or saralasin or s nitrosocaptopril or spirapril$ or temocapril$ or teprotide or trandolapril$ or utibapril$ or zabicipril$ or zofenopril$ or Aceon or Accupril or Altace or Capoten or Lotensin or Mavik or Monopril or Prinivil or Univas or Vasotec or Zestril).tw.
10 or/5‐9
11 exp angiotensin receptor antagonist/
12 (angiotensin adj3 (receptor antagon$ or receptor block$)).tw.
13 (arb or arbs).tw.
14 (abitesartan or azilsartan or candesartan or elisartan or embusartan or eprosartan or forasartan or irbesartan or KT3‐671 or losartan or milfasartan or olmesartan or saprisartan or tasosartan or telmisartan or valsartan or zolasartan).tw.
15 or/11‐14
16 exp hypertension/
17 (antihypertens$ or hypertens$).tw.
18 ((high or elevat$ or rais$) adj2 blood pressure).tw.
19 or/16‐18
20 randomized controlled trial/
21 crossover procedure/
22 double‐blind procedure/
23 (randomi?ed or randomly).tw.
24 (crossover$ or cross‐over$).tw.
25 placebo.ab.
26 (doubl$ adj blind$).tw.
27 assign$.ab.
28 allocat$.ab.
29 or/20‐28
30 (exp animal/ or animal.hw. or nonhuman/) not (exp human/ or human cell/ or (human or humans).ti.)
31 Pregnancy/ or Hypertension, Pregnancy‐Induced/ or Pregnancy Complications, Cardiovascular/ or exp Ocular Hypertension/
32 (pregnancy‐induced or ocular hypertens$ or preeclampsia or pre‐eclampsia).ti.
33 29 not (30 or 31 or 32)
34 4 and (10 or 15) and 19 and 33
35 remove duplicates from 34
Appendix 5. ClinicalTrials.gov search strategy
Search terms: randomized
Study type: Interventional Studies
Interventions:
(renin inhibitor* OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (angiotensin converting enzyme inhibit* OR ace inhibit* OR alacepril OR benazepril OR captopril OR enalapril)
(renin inhibitor* OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (perindopril* OR pivopril OR quinapril* OR ramipril* OR rentiapril OR saralasin OR s nitrosocaptopril)
(renin inhibitor* OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (spirapril* OR temocapril* OR teprotide OR trandolapril* OR utibapril* OR zabicipril* OR zofenopril* or Aceon)
(renin inhibitor* OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (Accupril OR Altace OR Capoten OR Lotensin OR Mavik OR Monopril OR Prinivil OR Univas OR Vasotec OR Zestril)
(renin inhibitor* OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (angiotensin receptor antagonist* OR angiotensin receptor blocker* OR arb OR arbs OR bitesartan)
(renin inhibitor* OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (azilsartan OR candesartan OR elisartan OR embusartan OR eprosartan OR forasartan OR irbesartan OR KT3‐671)
(renin inhibitor* OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (losartan or milfasartan or olmesartan or saprisartan or tasosartan or telmisartan or valsartan or zolasartan)
Appendix 6. WHO International Clinical Trials Registry Platform search strategy
Condition: hypertens
Recruitment status: All
Interventions:
(renin inhibitor OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (angiotensin converting enzyme inhibit OR ace inhibit OR alacepril OR benazepril OR captopril OR enalapril)
(renin inhibitor OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (perindopril OR pivopril OR quinapril OR ramipril OR rentiapril OR saralasin OR s nitrosocaptopril)
(renin inhibitor OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (spirapril OR temocapril OR teprotide OR trandolapril OR utibapril OR zabicipril OR zofenopril OR Aceon)
(renin inhibitor OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (Accupril OR Altace OR Capoten OR Lotensin OR Mavik OR Monopril OR Prinivil OR Univas OR Vasotec OR Zestril)
(renin inhibitor OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (angiotensin receptor antagonist OR angiotensin receptor blocker OR arb OR arbs OR bitesartan)
(renin inhibitor OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (azilsartan OR candesartan OR elisartan OR embusartan OR eprosartan OR forasartan OR irbesartan OR KT3‐671)
(renin inhibitor OR aliskiren OR ciprokiren OR ditekiren OR enalkiren OR remikiren OR rasilez OR tekturna OR terlakiren OR zankiren) AND (losartan OR milfasartan OR olmesartan OR saprisartan OR tasosartan OR telmisartan OR valsartan OR zolasartan)
