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نقش استروئید‌های خوراکی آغاز شده توسط بیمار و والدین برای حملات آسم

Appendices

Appendix 1. Sources and search methods for Cochrane Airways Group's Specialised Register (CAGR)

Electronic searches: core databases

Database

Frequency of search

CENTRAL (Cochrane Library)

Monthly

MEDLINE (Ovid)

Weekly

Embase (Ovid)

Weekly

PsycINFO (Ovid)

Monthly

CINAHL (EBSCO)

Monthly

AMED (‐Ovid?)

Monthly

Handsearches: core respiratory conference abstracts

Conference

Years searched

American Academy of Allergy, Asthma and Immunology (AAAAI)

2001 onwards

American Thoracic Society (ATS)

2001 onwards

Asia Pacific Society of Respirology (APSR)

2004 onwards

British Thoracic Society Winter Meeting (BTS)

2000 onwards

Chest Meeting

2003 onwards

European Respiratory Society (ERS)

1992, 1994, 2000 onwards

International Primary Care Respiratory Group Congress (IPCRG)

2002 onwards

Thoracic Society of Australia and New Zealand (TSANZ)

1999 onwards

MEDLINE search strategy used to identify trials for the CAGR

Asthma search

1. exp Asthma/

2. asthma$.mp.

3. (antiasthma$ or anti‐asthma$).mp.

4. Respiratory Sounds/

5. wheez$.mp.

6. Bronchial Spasm/

7. bronchospas$.mp.

8. (bronch$ adj3 spasm$).mp.

9. bronchoconstrict$.mp.

10. exp Bronchoconstriction/

11. (bronch$ adj3 constrict$).mp.

12. Bronchial Hyperreactivity/

13. Respiratory Hypersensitivity/

14. ((bronchial$ or respiratory or airway$ or lung$) adj3 (hypersensitiv$ or hyperreactiv$ or allerg$ or insufficiency)).mp.

15. ((dust or mite$) adj3 (allerg$ or hypersensitiv$)).mp.

16. or/1‐15

Filter to identify randomised controlled trials (RCTs)

1. exp "clinical trial [publication type]"/

2. (randomized or randomised).ab,ti.

3. placebo.ab,ti.

4. dt.fs.

5. randomly.ab,ti.

6. trial.ab,ti.

7. groups.ab,ti.

8. or/1‐7

9. Animals/

10. Humans/

11. 9 not (9 and 10)

12. 8 not 11

The MEDLINE strategy and RCT filter are adapted to identify trials in other electronic databases.

Appendix 2. Search strategy to identify relevant trials from the CAGR

#1 AST:MISC1

#2 MeSH DESCRIPTOR Asthma Explode All

#3 asthma*:ti,ab

#4 #1 or #2 or #3

#5 prednis*

#6 methylprednis*

#7 dexamethasone

#8 cortisone

#9 hydrocortisone*

#10 medrol

#11 solumedrol

#12 solu‐medrol

#13 betamethasone

#14 triamcinolone

#15 (oral* or systemic*) near3 (steroid* or corticosteroid* or glucocorticoid*)

#16 OCS:ti,ab

#17 #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16

#18 MeSH DESCRIPTOR Patient Participation

#19 MeSH DESCRIPTOR Decision Making

#20 (patient* or parent* or caregiver* or career*) NEAR (initiat* or suggest* or instigat* or originat* or request* or propose* or encourage* or advocate*)

#21 self‐refer* or self NEXT refer*

#22 #18 or #19 or #20 or #21

#23 #4 AND #17 AND #22

#24 (#23) AND (INREGISTER)

(Note: in search line #1, MISC1 denotes the field in the record where the reference has been coded for condition, in this case, asthma)

Study flow diagram.
Figuras y tablas -
Figure 1

Study flow diagram.

Summary of findings for the main comparison. Summary of findings: patient‐initiated steroids

Patient‐initiated steroids compared with placebo/normal care/alternative active treatment for asthma

Patient or population: adults aged 18 years or older with asthma

Settings: outpatient

Intervention: patient‐initiated oral corticosteroids

Comparison: placebo/normal care/alternative active treatment

Outcomes

Number of participants
(studies)

Comments

Hospital admissions for asthma

0 (0 studies)

No studies met the inclusion criteria for this review

Asthma control (validated scales)

0 (0 studies)

Serious adverse events (all cause)

0 (0 studies)

Unscheduled visit to a healthcare provider

0 (0 studies)

Health‐related quality of life (validated scales)

0 (0 studies)

Days lost of study/work

0 (0 studies)

Adverse events (all cause)

0 (0 studies)

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very low quality: We are very uncertain about the estimate

Figuras y tablas -
Summary of findings for the main comparison. Summary of findings: patient‐initiated steroids
Summary of findings 2. Summary of findings: parent‐initiated steroids

Parent‐initiated steroids compared with placebo/normal care/alternative active treatment for asthma

Patient or population: children aged 5 years or older with asthma

Settings: outpatient

Intervention: parent‐initiated oral corticosteroids

Comparison: placebo/normal care/alternative active treatment

Outcomes

Number of participants
(studies)

Comments

Hospital admissions for asthma

0 (0 studies)

No studies met the inclusion criteria for this review

Asthma control (validated scales)

0 (0 studies)

Serious adverse events (all cause)

0 (0 studies)

Unscheduled visit to a healthcare provider

0 (0 studies)

Health‐related quality of life (validated scales)

0 (0 studies)

Days off school

0 (0 studies)

Adverse events (all cause)

0 (0 studies)

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very low quality: We are very uncertain about the estimate

Figuras y tablas -
Summary of findings 2. Summary of findings: parent‐initiated steroids