Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia
Appendices
Appendix 1. CENTRAL search strategy
#1 MeSH descriptor: [Blood Platelets] explode all trees
#2 (platelet* or thrombocyte*):ti
#3 MeSH descriptor: [Platelet Transfusion] explode all trees
#4 MeSH descriptor: [Plateletpheresis] explode all trees
#5 ((platelet* or thrombocyte*) near/5 (prophyla* or transfus* or infus* or administ* or requir* or need* or product or products or component* or concentrate* or apheres* or pooled or single donor* or random donor*))
#6 thrombocyt?pheres* or plateletpheres*
#7 ((platelet* or thrombocyte*) near/5 (protocol* or trigger* or threshold* or schedul* or dose* or dosing or usage or utilisation or utilization))
#8 #1 or #2 or #3 or #4 or #5 or #6 or #7
#9 MeSH descriptor: [Spinal Puncture] this term only
#10 MeSH descriptor: [Anesthesia, Epidural] explode all trees
#11 MeSH descriptor: [Anesthesia, Spinal] this term only
#12 MeSH descriptor: [Injections, Spinal] explode all trees
#13 MeSH descriptor: [Myelography] this term only
#14 MeSH descriptor: [Nerve Block] explode all trees
#15 ((spine or spinal or intraspinal or dura* or intradural or epidural or lumbar* or intralumbar* or theca* or intrathecal or subarachnoid* or peridural* or caudal*) near/6 (punctur* or inject* or infus* or anesth* or anaesth* or needle* or tap* or block* or drug* or administ*))
#16 ((intrathecal or theca*) near/6 (treatment* or chemotherapy or antibiotic* or therapy or inject*))
#17 myelogra*
#18 #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17
#19 #8 and #18
Appendix 2. MEDLINE (OvidSP) search strategy
1. Spinal Puncture/
2. Anesthesia, Epidural/
3. Anesthesia Spinal/
4. exp Injections, Spinal/
5. Myelography/
6. exp Nerve Block/
7. ((spine or spinal or intraspinal or dura* or intradural or epidural or lumbar* or intralumbar* or theca* or intrathecal or subarachnoid* or peridural* or caudal*) adj6 (punctur* or inject* or infus* or anesth* or anaesth* or needle* or tap* or block* or drug* or administ*)).tw,kf.
8. ((intrathecal OR theca*) adj6 (treatment* OR chemotherapy OR antibiotic* OR therapy OR inject*)).tw,kf.
9. myelogra*.tw,kf.
10. or/1‐9
11. Platelet Transfusion/
12. Plateletpheresis/
13. Blood Platelets/
14. ((platelet* or thrombocyte*) adj5 (prophyla* or transfus* or infus* or administ* or requir* or need* or product* or component* or concentrate* or apheres* or pooled or single donor or random donor)).tw,kf.
15. (thrombocytopheres* or plateletpheres*).tw,kf.
16. ((platelet* or thrombocyte*) adj5 (protocol* or trigger* or threshold* or schedul* or dose* or dosing or usage or utili?ation)).tw,kf.
17. (platelet* or thrombocyte*).ti.
18. or/11‐17
19. 10 and 18
20. randomized controlled trial.pt.
21. controlled clinical trial.pt.
22. randomi*.tw,kf.
23. placebo.ab.
24. exp clinical trials as topic/
25. randomly.ab.
26. trial.tw.
27. groups.ab.
28. or/20‐27
29. 19 and 28
Appendix 3. EMBASE (OvidSP) search strategy
1. Lumbar Puncture/
2. Puncture/
3. exp Intraspinal Drug Administration/
4. exp Epidural Anesthesia/
5. Spinal Anesthesia/
6. Myelography/
7. exp Nerve Block/
8. ((spine or spinal or intraspinal or dura* or intradural or epidural or lumbar* or intralumbar* or theca* or intrathecal or subarachnoid* or peridural* or caudal*) adj6 (punctur* or inject* or infus* or anesth* or anaesth* or needle* or tap* or block* or drug* or administ*)).tw.
9. ((intrathecal OR theca*) adj6 (treatment* OR chemotherapy OR antibiotic* OR therapy)).tw.
10. myelogra*.tw.
11. or/1‐10
12. Thrombocyte Transfusion/
13. Thrombocytopheresis/
14. Thrombocyte/
15. ((platelet* or thrombocyte*) adj5 (prophyla* or transfus* or infus* or administ* or requir* or need* or product* or component* or concentrate* or apheres* or pooled or single donor or random donor)).tw.
16. (thrombocyt?pheres* or plateletpheres*).tw.
17. ((platelet* or thrombocyte*) adj5 (protocol* or trigger* or threshold* or schedul* or dose* or dosing or usage or utili?ation)).tw.
18. (platelet* or thrombocyte*).ti.
19. or/12‐18
20. 11 and 19
21. Randomized Controlled Trial/
22. Randomization/
23. Single Blind Procedure/
24. Double Blind Procedure/
25. Crossover Procedure/
26. Placebo/
27. exp Clinical Trial/
28. Prospective Study/
29. (randomi* or double‐blind* or single‐blind* or RCT*).tw.
30. (random* adj2 (allocat* or assign* or divid* or receiv*)).tw.
31. (crossover* or cross over* or cross‐over* or placebo*).tw.
32. ((treble or triple) adj blind*).tw.
33. or/21‐32
34. Case Study/
35. case report*.tw.
36. (note or editorial).pt.
37. or/34‐36
38. 33 not 37
39. 20 and 38
40. limit 39 to embase
Appendix 4. PubMed search strategy (epublications only)
#1 ((spine OR spinal OR intraspinal OR dura OR dural OR intradural OR epidural OR lumbar* OR intralumbar* OR theca* OR intrathecal OR subarachnoid* OR peridural* OR caudal*) AND (punctur* OR inject* OR infus* OR anesth* OR anaesth* OR needle* OR tap* OR block* OR drug* OR administ*))
#2 ((intrathecal OR theca*) AND (treatment* OR chemotherapy OR antibiotic* OR therapy OR inject*))
#3 myelogra*
#4 #1 OR #2 OR #3
#5 ((platelet* OR thrombocyte*) AND (prophyla* OR transfus* OR infus* OR administ* OR requir* OR need* OR product* OR component* OR concentrate* OR apheres* OR pooled OR single donor* OR random donor*))
#6 (thrombocytopheres* OR plateletpheres*)
#7 ((platelet* OR thrombocyte*) AND (protocol* OR trigger* OR threshold* OR schedul* OR dose* OR dosing OR usage OR utilisation OR utilization))
#8 platelet*[TI] OR thrombocyte*[TI]
#9 #5 OR #6 OR #7 OR #8
#10 #4 AND #9
#11 (random* OR blind* OR control group OR placebo OR controlled trial OR controlled study OR groups OR trials OR systematic review OR meta‐analysis OR metaanalysis OR literature search OR medline OR cochrane OR embase) AND (publisher[sb] OR inprocess[sb] OR pubmednotmedline[sb])
#12 #10 AND #11
Appendix 5. Transfusion Evidence Library search strategy
Search box: (lumbar OR spinal OR puncture OR injection OR needle OR epidural OR intradural OR dural OR intrathecal OR subarachnoid OR peridural OR caudal OR block OR anaesthetic OR anesthetic OR anesthesia OR anaesthesia OR drug OR tap OR administration OR procedure)
Filter: Platelets
Appendix 6. WHO ICTRP search strategy
(Title: lumbar OR spinal OR puncture OR injection OR epidural OR intradural OR dural OR peridural OR caudal OR intrathecal OR subarachnoid OR administration OR procedure)
AND
(Intervention: platelet OR platelets)
Appendix 7. Clinical.trials.gov search strategy
Search Terms: (lumbar puncture OR spinal injection OR epidural OR intradural OR dural OR peridural OR caudal OR intrathecal OR subarachnoid OR nerve block) AND (platelets OR platelet transfusion)
AND
Study Design: Intervention Studies
