Transfuzija trombocita prije lumbalne punkcije ili epiduralne anestezije za sprječavanje komplikacija kod osoba s trombocitopenijom
Appendices
Appendix 1. CENTRAL search strategy
#1 MeSH descriptor: [Blood Platelets] explode all trees
#2 (platelet* or thrombocyte*):ti
#3 MeSH descriptor: [Platelet Transfusion] explode all trees
#4 MeSH descriptor: [Plateletpheresis] explode all trees
#5 ((platelet* or thrombocyte*) near/5 (prophyla* or transfus* or infus* or administ* or requir* or need* or product or products or component* or concentrate* or apheres* or pooled or single donor* or random donor*))
#6 thrombocyt?pheres* or plateletpheres*
#7 ((platelet* or thrombocyte*) near/5 (protocol* or trigger* or threshold* or schedul* or dose* or dosing or usage or utilisation or utilization))
#8 #1 or #2 or #3 or #4 or #5 or #6 or #7
#9 MeSH descriptor: [Spinal Puncture] this term only
#10 MeSH descriptor: [Anesthesia, Epidural] explode all trees
#11 MeSH descriptor: [Anesthesia, Spinal] this term only
#12 MeSH descriptor: [Injections, Spinal] explode all trees
#13 MeSH descriptor: [Myelography] this term only
#14 MeSH descriptor: [Nerve Block] explode all trees
#15 ((spine or spinal or intraspinal or dura* or intradural or epidural or lumbar* or intralumbar* or theca* or intrathecal or subarachnoid* or peridural* or caudal*) near/6 (punctur* or inject* or infus* or anesth* or anaesth* or needle* or tap* or block* or drug* or administ*))
#16 ((intrathecal or theca*) near/6 (treatment* or chemotherapy or antibiotic* or therapy or inject*))
#17 myelogra*
#18 #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17
#19 #8 and #18
Appendix 2. MEDLINE (OvidSP) search strategy
1. Spinal Puncture/
2. Anesthesia, Epidural/
3. Anesthesia Spinal/
4. exp Injections, Spinal/
5. Myelography/
6. exp Nerve Block/
7. ((spine or spinal or intraspinal or dura* or intradural or epidural or lumbar* or intralumbar* or theca* or intrathecal or subarachnoid* or peridural* or caudal*) adj6 (punctur* or inject* or infus* or anesth* or anaesth* or needle* or tap* or block* or drug* or administ*)).tw,kf.
8. ((intrathecal or theca*) adj6 (treatment* or chemotherapy or antibiotic* or therapy or inject*)).tw,kf.
9. myelogra*.tw,kf.
10. or/1‐9
11. Platelet Transfusion/
12. Plateletpheresis/
13. Blood Platelets/
14. ((platelet* or thrombocyte*) adj5 (prophyla* or transfus* or infus* or administ* or requir* or need* or product* or component* or concentrate* or apheres* or pooled or single donor or random donor)).tw,kf.
15. (thrombocytopheres* or plateletpheres*).tw,kf.
16. ((platelet* or thrombocyte*) adj5 (protocol* or trigger* or threshold* or schedul* or dose* or dosing or usage or utili?ation)).tw,kf.
17. (platelet* or thrombocyte*).ti.
18. or/11‐17
19. 10 and 18
Appendix 3. Embase (OvidSP) search strategy
1. Lumbar Puncture/
2. Puncture/
3. exp Intraspinal Drug Administration/
4. exp Epidural Anesthesia/
5. Spinal Anesthesia/
6. Myelography/
7. exp Nerve Block/
8. ((spine or spinal or intraspinal or dura* or intradural or epidural or lumbar* or intralumbar* or theca* or intrathecal or subarachnoid* or peridural* or caudal*) adj6 (punctur* or inject* or infus* or anesth* or anaesth* or needle* or tap* or block* or drug* or administ*)).tw.
9. ((intrathecal or theca*) adj6 (treatment* or chemotherapy or antibiotic* or therapy or inject*)).tw.
10. myelogra*.tw.
11. or/1‐10
12. Thrombocyte Transfusion/
13. Thrombocytopheresis/
14. Thrombocyte/ and transfus*.mp.
15. *Thrombocyte/
16. ((platelet* or thrombocyte*) adj5 (prophyla* or transfus* or infus* or administ* or requir* or need* or product* or component* or concentrate* or apheres* or pooled or single donor or random donor)).tw,kf.
17. (thrombocytopheres* or plateletpheres*).tw,kf.
18. ((platelet* or thrombocyte*) adj5 (protocol* or trigger* or threshold* or schedul* or dose* or dosing or usage or utili?ation)).tw,kf.
19. (platelet* or thrombocyte*).ti.
20. or/12‐19
21. 11 and 20
Appendix 4. PubMed search strategy (e‐publications only)
#1 ((spine OR spinal OR intraspinal OR dura OR dural OR intradural OR epidural OR lumbar* OR intralumbar* OR theca* OR intrathecal OR subarachnoid* OR peridural* OR caudal*) AND (punctur* OR inject* OR infus* OR anesth* OR anaesth* OR needle* OR tap* OR block* OR drug* OR administ*))
#2 ((intrathecal OR theca*) AND (treatment* OR chemotherapy OR antibiotic* OR therapy OR inject*))
#3 myelogra*
#4 #1 OR #2 OR #3
#5 ((platelet* OR thrombocyte*) AND (prophyla* OR transfus* OR infus* OR administ* OR requir* OR need* OR product* OR component* OR concentrate* OR apheres* OR pooled OR single donor* OR random donor*))
#6 (thrombocytopheres* OR plateletpheres*)
#7 ((platelet* OR thrombocyte*) AND (protocol* OR trigger* OR threshold* OR schedul* OR dose* OR dosing OR usage OR utilisation OR utilization))
#8 platelet*[TI] OR thrombocyte*[TI]
#9 #5 OR #6 OR #7 OR #8
#10 #4 AND #9
#11 (publisher[sb] OR inprocess[sb] OR pubmednotmedline[sb])
#12 #10 AND #11
Appendix 5. Transfusion Evidence Library search strategy
Search box: (lumbar OR spinal OR puncture OR injection OR needle OR epidural OR intradural OR dural OR peridural OR caudal OR intrathecal OR subarachnoid OR block OR anaesthetic OR anesthetic OR anesthesia OR anaesthesia OR drug OR tap OR administration OR procedure)
Filter: Platelets
Appendix 6. WHO ICTRP search strategy
(Title: lumbar OR spinal OR puncture OR injection OR epidural OR intradural OR dural OR peridural OR caudal OR intrathecal OR subarachnoid OR administration OR procedure) AND
(Intervention: platelet OR platelets)
Appendix 7. ClinicalTrials.gov search strategy
Search Terms: (lumbar puncture OR spinal injection OR epidural OR intradural OR dural OR peridural OR caudal OR intrathecal OR subarachnoid OR nerve block) AND (platelets OR platelet transfusion)
Study Design: All Studies
Study flow diagram.
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
| Platelet transfusion compared with no platelet transfusion for lumbar puncture procedures | ||||||
| Patient or population: People with thrombocytopenia Intervention: Platelet transfusion Comparison: No platelet transfusion | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect | No. of participants | Quality of the evidence | Comments | |
| Assumed risk | Corresponding risk | |||||
| No platelet transfusions | Platelet transfusion | |||||
| Major procedure‐related bleeding within 24 hours of the procedure | No cases of major bleeding | Not estimated | 150 (2 studies) | ⊕⊝⊝⊝ Very low 1, 2 | ||
| All‐cause mortality up to 30 days after the procedure | ‐ | ‐ | ‐ | ‐ | ‐ | Not reported |
| Transfusion‐related complications within 24 hours of the procedure | ‐ | ‐ | ‐ | ‐ | ‐ | Not reported |
| Procedure‐related (lumbar puncture or epidural anaesthetic) complications within 7 days of the procedure | No serious adverse events | Not estimated | 21 (1 study) | ⊕⊝⊝⊝ Very low1, 2 | ||
| Quality of life (as defined by the individual studies) | ‐ | ‐ | ‐ | ‐ | ‐ | Not reported |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). | ||||||
| GRADE Working Group grades of evidence | ||||||
| 1Downgraded one level due to imprecision (low event rate). No events occurred. | ||||||
