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Appendices

Appendix 1. MEDLINE search strategy

1. "absenteeism"[tw]

2. "sick days"[tw]

3. "illness days"[tw]

4. "sick listed"[tw]

5. ("long term"[tw] OR "absence"[tw] OR "leave"[tw]) AND ("disability"[tw] OR "sickness"[tw] OR "sick"[tw])

6. ("benefit"[tw] OR "benefits"[tw] OR "pension"[tw] OR "pensions"[tw]) AND ("claimant"[tw] OR "claimants"[tw] OR "claim"[tw] OR "claims"[tw])

7. "work disablement"[tw]

8. "work disability"[tw]

9. "working disability"[tw]

10. "work absence"[tw]

11. ("injured"[tw] OR "injury"[tw] OR "accident"[tw] OR "sickness"[tw] OR "sick"[tw] OR "disability"[tw] OR "disabled"[tw] OR "disablement"[tw] OR "invalid"[tw] OR "invalidity"[tw] OR "absent"[tw] OR "absence"[tw]) AND ("worker"[tw] OR "workers"[tw] OR "employee"[tw] OR "employees"[tw])

12. ("sickness"[tw] OR "disability"[tw] OR "disabled"[tw] OR "disablement"[tw] OR "invalid"[tw] OR "invalidity"[tw] OR "absent"[tw] OR "absence"[tw] OR "out of work"[tw] OR "social security"[tw] OR "social insurance"[tw]) AND ("benefit"[tw] OR "benefits"[tw] OR "beneficiaries"[tw] OR "beneficiary"[tw] OR "claimant"[tw] OR "claimants"[tw] OR "claim"[tw] OR "claims"[tw] OR "pension"[tw] OR "pensions"[tw] OR "pensioners"[tw] OR "pensioner"[tw] OR "compensation"[tw] OR "compensations"[tw])

13. "Insurance, disability"[tw]

14. "disability insurance"[tw]

15. ("workman's"[tw] OR "workman"[tw] OR "workmans"[tw] OR "workmen's"[tw] OR "workmen"[tw] OR "workmens"[tw] OR "worker's"[tw] OR "worker"[tw] OR "workers"[tw]) AND ("compensation"[tw] OR "compensations"[tw])

16. "case management"[tw]

17. "case manager"[tw]

18. "absence management"[tw]

19. "assertive community treatment"[tw]

20. "management programme"[tw]

21. "management program"[tw]

22. ("project"[tw] OR "programme"[tw] OR "program"[tw] OR "model"[tw] OR "interview"[tw] OR "interviews"[tw] OR "plan"[tw] OR "measure"[tw] OR "measures"[tw] OR "intervention"[tw] OR "interventions"[tw] OR "rehabilitation"[tw] OR "management"[tw]) AND ("co ordinator"[tw] OR "coordinator"[tw] OR "coordination"[tw] OR "co ordination"[tw] OR "coordinated"[tw] OR "co ordinated"[tw] OR "multidisciplinary"[tw] OR "multi disciplinary"[tw] OR "multi professional"[tw] OR "multiprofessional"[tw] OR "multimodal"[tw] OR "multi modal"[tw] OR "integrated"[tw] OR "patient centred"[tw] OR "patient focused"[tw] OR "individual"[tw] OR "individually"[tw] OR "face to face"[tw] OR "one on one"[tw] OR "in person"[tw] OR "personal"[tw] OR "personally"[tw] OR "customized"[tw] OR "customised"[tw] OR "tailored"[tw] OR "on the job"[tw] OR "work focused"[tw] OR "work related"[tw] OR "workplace"[tw] OR "work location"[tw] OR "work‐site"[tw] OR "work place"[tw] OR "job site"[tw] OR "worksite"[tw] OR "occupational"[tw] OR "vocational"[tw] OR "return to work"[tw] OR "return to work" [mesh] OR "counselling"[tw] OR "reintegration"[tw])

23. "rehabilitation"[tw] AND ("project"[tw] OR "programme"[tw] OR "program"[tw] OR "plan"[tw] OR "model"[tw] OR "measure"[tw] OR "measures"[tw] OR "intervention"[tw] OR "interview"[tw] OR "interviews"[tw] OR "intervention"[tw] OR "interventions"[tw] OR "management"[tw])

24. "randomized controlled trial"[pt]

25. "controlled clinical trial"[pt]

26. "randomized"[tiab]

27. "randomised"[tiab]

28. "randomly"[tiab]

29. "trial"[ti]

30. "clinical trials as topic"[mesh: noexp]

31. OR / 1 ‐ 15

32. OR / 16 ‐ 23

33. OR / 24 ‐ 30

34. AND / 31 – 33

Appendix 2. EMBASE search strategy

(("absenteeism" OR "sick days" OR "illness days" OR "sick listed" OR (("long term" OR "absence" OR "leave" ) NEAR/3 ("disability" OR "sickness" OR "sick")) OR (("benefit" OR "benefits" OR "pension" OR "pensions") AND ("claimant" OR "claimants" OR "claim" OR "claims")) OR "work disablement" OR "work disability" OR "working disability" OR "work absence" OR (("injured" OR "injury" OR "accident" OR "sickness" OR "sick" OR "disability" OR "disabled" OR "disablement" OR "invalid" OR "invalidity" OR "absent" OR "absence") AND ("worker" OR "workers" OR "employee" OR "employees")) OR (("sickness" OR "disability" OR "disabled" OR "disablement" OR "invalid" OR "invalidity" OR "absent" OR "absence" OR "out of work" OR "social security" OR "social insurance") NEAR/3 ("benefit" OR "benefits" OR "beneficiaries" OR "beneficiary" OR "claimant" OR "claimants" OR "claim" OR "claims" OR "pension" OR "pensions" OR "pensioners" OR "pensioner" OR "compensation" OR "compensations")) OR "Insurance, disability" OR "disability insurance" OR (("workman?s" OR "workman" OR "workmans" OR "workmen?s" OR "workmen" OR "workmens" OR "worker?s" OR "worker" OR "workers") Near/3 ("compensation" OR "compensations"))) AND ("case management" OR "case anager" OR "absence management" OR "assertive community treatment" OR "management programme" OR "management program" OR (("project" OR "programme" OR "program" OR "model" OR "interview" OR "interviews" OR "plan" OR "measure" OR "measures" OR "intervention" OR "interventions" OR "rehabilitation" OR "management") NEAR/3 ("co ordinator" OR "coordinator" OR "coordination" OR "co ordination" OR "coordinated" OR "co ordinated" OR "multidisciplinary" OR "multi disciplinary" OR "multi professional" OR "multiprofessional" OR "multimodal" OR "multi modal" OR "integrated" OR "patient centred" OR "patient focused" OR "individual" OR "individually" OR "face to face" OR "one on one" OR "in person" OR "personal" OR "personally" OR "customized" OR "customised" OR "tailored" OR "on the job" OR "work focused" OR "work related" OR "workplace" OR "work location" OR "work‐site" OR "work place" OR "job site" OR "worksite" OR "occupational" OR "vocational" OR "return to work" OR "counselling" OR "reintegration")) OR (("project" OR "programme" OR "program" OR "plan" OR "model" OR "measure" OR "measures" OR "intervention" OR "interview" OR "interviews" OR "intervention" OR "interventions" OR "management") NEAR/3 "rehabilitation"))):ti:ab:de AND ([controlled clinical trial]/lim OR [randomized controlled trial]/lim OR "randomized":ti:ab OR "randomly":ti:ab OR "trial":ti OR "controlled clinical trial":de OR "single blind procedure":de OR "double blind procedure":de OR "triple blind procedure":de OR (doubl* next blind*):ti:ab OR (singl* next blind*):ti:ab OR (assign*):ti:ab OR (allocate*):ti:ab OR (volunteer*):ti:ab) AND [embase]/lim

Appendix 3. CINAHL search strategy

TX (("absenteeism" OR "sick days" OR "illness days" OR "sick listed" OR (("long term" OR "absence" OR "leave") AND ("disability" OR "sickness" OR "sick")) OR (("benefit" OR "benefits" OR "pension" OR "pensions") AND ("claimant" OR "claimants" OR "claim" OR "claims")) OR "work disablement" OR "work disability" OR "working disability" OR "work absence" OR (("injured" OR "injury" OR "accident" OR "sickness" OR "sick" OR "disability" OR "disabled" OR "disablement" OR "invalid" OR "invalidity" OR "absent" OR "absence") AND ("worker" OR "workers" OR "employee" OR "employees")) OR (("sickness" OR "disability" OR "disabled" OR "disablement" OR "invalid" OR "invalidity" OR "absent" OR "absence" OR "out of work" OR "social security" OR "social insurance") AND ("benefit" OR "benefits" OR "beneficiaries" OR "beneficiary" OR "claimant" OR "claimants" OR "claim" OR "claims" OR "pension" OR "pensions" OR "pensioners" OR "pensioner" OR "compensation" OR "compensations")) OR "Insurance, disability" OR "disability insurance" OR (("workman?s" OR "workman" OR "workmans" OR "workmen?s" OR "workmen" OR "workmens" OR "worker?s" OR "worker" OR "workers") AND ("compensation" OR "compensations"))) AND ("case management" OR "case manager" OR "absence management" OR "assertive community Treatment" OR "management programme" OR "management program" OR (("project" OR "programme" OR "program" OR "model" OR "interview" OR "interviews" OR "plan" O "measure" OR "measures" OR "intervention" OR "interventions" OR "rehabilitation" OR "management") AND ("co ordinator" OR "coordinator" OR "coordination" OR "co ordination" OR "coordinated" OR "co ordinated" OR "multidisciplinary" OR "multi disciplinary" OR "multi professional" OR "multiprofessional" OR "multimodal" OR "multi modal" OR "integrated" OR "patient centred" OR "patient focused" OR "individual" OR "individually" OR "face to face" OR "one on one" OR "in person" OR "personal" OR "personally" OR "customized" OR "customised" OR "tailored" OR "on the job" OR "work focused" OR "work related" OR "workplace" OR "work location" OR "work‐site" OR "work place" OR "job site" OR "worksite" OR "occupational" OR "vocational" OR "return to work" OR "counselling" OR "reintegration")) OR (("project" OR "programme" OR "program" OR "plan" OR "model" OR "measure" OR "measures" OR "intervention" OR "interview" OR "interviews" OR "intervention" OR "interventions" OR "management" ) AND "rehabilitation"))) AND (TI (randomly OR randomi?ed OR trial) OR AB (randomly OR randomi?ed))

Appendix 4. PsycINFO search strategy

(("absenteeism" OR "sick days" OR "illness days" OR "sick listed" OR (("long term" OR "absence" OR "leave" ) ADJ3 ("disability" OR "sickness" OR "sick")) OR (("benefit" OR "benefits" OR "pension" OR "pensions") AND ("claimant" OR "claimants" OR "claim" OR "claims")) OR "work disablement" OR "work disability" OR "working disability" OR "work absence" OR (("injured" OR "injury" OR "accident" OR "sickness" OR "sick" OR "disability" OR "disabled" OR "disablement" OR "invalid" OR "invalidity" OR "absent" OR "absence") AND ("worker" OR "workers" OR "employee" OR "employees")) OR (("sickness" OR "disability" OR "disabled" OR "disablement" OR "invalid" OR "invalidity" OR "absent" OR "absence" OR "out of work" OR "social security" OR "social insurance") ADJ3 ("benefit" OR "benefits" OR "beneficiaries" OR "beneficiary" OR "claimant" OR "claimants" OR "claim" OR "claims" OR "pension" OR "pensions" OR "pensioners" OR "pensioner" OR "compensation" OR "compensations")) OR "Insurance, disability" OR "disability insurance" OR (("workman?s" OR "workman" OR "workmans" OR "workmen?s" OR "workmen" OR "workmens" OR "worker?s" OR "worker" OR "workers") Adj3 ("compensation" OR "compensations"))) AND ("case management" OR "case manager" OR "absence management" OR "assertive community Treatment" OR "management programme" OR "management program" OR (("project" OR "programme" OR "program" OR "model" OR "interview" OR "interviews" OR "plan" OR "measure" OR "measures" OR "intervention" OR "interventions" OR "rehabilitation" OR "management") ADJ3 ("co ordinator" OR "coordinator" OR "coordination" OR "co ordination" OR "coordinated" OR "co ordinated" OR "multidisciplinary" OR "multi disciplinary" OR "multi professional" OR "multiprofessional" OR "multimodal" OR "multi modal" OR "integrated" OR "patient centred" OR "patient focused" OR "individual" OR "individually" OR "face to face" OR "one on one" OR "in person" OR "personal" OR "personally" OR "customized" OR "customised" OR "tailored" OR "on the job" OR "work focused" OR "work related" OR "workplace" OR "work location" OR "work‐site" OR "work place" OR "job site" OR "worksite" OR "occupational" OR "vocational" OR "return to work" OR "counselling" OR "reintegration")) OR (("project" OR "programme" OR "program" OR "plan" OR "model" OR "measure" OR "measures" OR "intervention" OR "interview" OR "interviews" OR "intervention" OR "interventions" OR "management") ADJ3 "rehabilitation"))).tw. AND ("random*".ti,ab. OR "trial".ti.)

Appendix 5. CENTRAL search strategy

("Absenteeism" OR "sick leave" OR "sick absence" OR "sickness absence" OR "sick listed" OR ("long term" AND ("sickness" OR "sick")) OR "sickness benefit" OR "sickness benefits" OR (("benefit" OR "benefits" OR "pension" OR "pensions") AND ("claimant" OR "claimants" OR "claim" OR "claims")) OR "work disablement" OR "working disablement" OR "work disability" OR "working disability" OR (("injured" OR "injury" OR "accident" OR "sickness" OR "sick" OR "disability" OR "disabled" OR "disablement" OR "invalid" OR "invalidity" OR "absent" OR "absence" ) AND ("worker" OR "workers" OR "employee" OR "employees")) OR (("disability" OR "disabled" OR "disablement" OR "invalid" OR "invalidity" OR "absent" OR "absence" OR "out of work" OR "Social Security" OR "Insurance OR Disability" ) AND ("benefit" OR "benefits" OR "beneficiaries" OR "beneficiary" OR "claimant" OR "claimants" OR "claim" OR "claims" OR "pension" OR "pensions" OR "pensioners" OR "pensioner"))) AND ("case management" OR "case management" OR "case manager" OR "absence management" OR "assertive community Treatment" OR "management programmme" OR "management program" OR (("project" OR "programme" OR "program" OR "Model" OR "interview" OR "interviews" OR "plan" OR "measure" OR "measures" OR "intervention" OR "interventions" OR "rehabilitation" OR "rehabilitation" OR "management") AND ("co ordinator" OR "coordinator" OR "coordination" OR "co ordination" OR "coordinated" OR "co ordinated" OR "multidisciplinary" OR "multi disciplinary" OR "multi professional" OR "multiprofessional" OR "multimodal" OR "multi modal" OR "integrated" OR "patient centred" OR "patient focused" OR "individual" OR "individually" OR "face to face" OR "one on one" OR "in person" OR "personal" OR "personally" OR "customized" OR "customised" OR "tailored" OR "on the job" OR "work focused" OR "work related" OR "workplace" OR "occupational" OR "vocational" OR "return to work" OR "counselling" OR "reintegration")) OR (("project" OR "programme" OR "program" OR "plan" OR "Model" OR "measure" OR "measures" OR "intervention" OR "interview" OR "interviews" OR intervention OR interventions OR "management") AND "rehabilitation"))

PRISMA Study flow diagram
Figuras y tablas -
Figure 1

PRISMA Study flow diagram

Risk of bias graph: review author's judgements about each risk of bias item presented as percentages across all included studies.
Figuras y tablas -
Figure 2

Risk of bias graph: review author's judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 3

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Forest plot of comparison: time to return to work. RTWCP = return‐to‐work coordination programmes
Figuras y tablas -
Figure 4

Forest plot of comparison: time to return to work. RTWCP = return‐to‐work coordination programmes

Forest plot of comparison: cumulative sickness absence in work days. RTWCP = return‐to‐work coordination programmes
Figuras y tablas -
Figure 5

Forest plot of comparison: cumulative sickness absence in work days. RTWCP = return‐to‐work coordination programmes

Forest plot of comparison: proportion at work at end of the follow‐up. RTWCP = return‐to‐work coordination programmes
Figuras y tablas -
Figure 6

Forest plot of comparison: proportion at work at end of the follow‐up. RTWCP = return‐to‐work coordination programmes

Forest plot of comparison: proportion who had ever returned to work. RTWCP = return‐to‐work coordination programmes
Figuras y tablas -
Figure 7

Forest plot of comparison: proportion who had ever returned to work. RTWCP = return‐to‐work coordination programmes

Comparison 1 Return‐to‐work outcomes, Outcome 1 Time to return to work.
Figuras y tablas -
Analysis 1.1

Comparison 1 Return‐to‐work outcomes, Outcome 1 Time to return to work.

Comparison 1 Return‐to‐work outcomes, Outcome 2 Time to return to work, sensitivity analysis (low risk of bias studies only).
Figuras y tablas -
Analysis 1.2

Comparison 1 Return‐to‐work outcomes, Outcome 2 Time to return to work, sensitivity analysis (low risk of bias studies only).

Comparison 1 Return‐to‐work outcomes, Outcome 3 Cumulative sickness absence in work days.
Figuras y tablas -
Analysis 1.3

Comparison 1 Return‐to‐work outcomes, Outcome 3 Cumulative sickness absence in work days.

Comparison 1 Return‐to‐work outcomes, Outcome 4 Proportion at work at end of the follow‐up.
Figuras y tablas -
Analysis 1.4

Comparison 1 Return‐to‐work outcomes, Outcome 4 Proportion at work at end of the follow‐up.

Comparison 1 Return‐to‐work outcomes, Outcome 5 Proportion at work at end of the follow‐up, sensitivity analysis (low risk of bias studies only).
Figuras y tablas -
Analysis 1.5

Comparison 1 Return‐to‐work outcomes, Outcome 5 Proportion at work at end of the follow‐up, sensitivity analysis (low risk of bias studies only).

Comparison 1 Return‐to‐work outcomes, Outcome 6 Proportion who had ever returned to work.
Figuras y tablas -
Analysis 1.6

Comparison 1 Return‐to‐work outcomes, Outcome 6 Proportion who had ever returned to work.

Comparison 1 Return‐to‐work outcomes, Outcome 7 Proportion who had ever returned to work, sensitivity analysis (low risk of bias studies only).
Figuras y tablas -
Analysis 1.7

Comparison 1 Return‐to‐work outcomes, Outcome 7 Proportion who had ever returned to work, sensitivity analysis (low risk of bias studies only).

Comparison 2 Patient‐reported outcomes, Outcome 1 Pain ‐ scale 0 to 100 (higher score indicates improvement) ‐ MID 10.0.
Figuras y tablas -
Analysis 2.1

Comparison 2 Patient‐reported outcomes, Outcome 1 Pain ‐ scale 0 to 100 (higher score indicates improvement) ‐ MID 10.0.

Comparison 2 Patient‐reported outcomes, Outcome 2 Pain ‐ pooled RDs of workers with an improvement greater than the MID of 10.0.
Figuras y tablas -
Analysis 2.2

Comparison 2 Patient‐reported outcomes, Outcome 2 Pain ‐ pooled RDs of workers with an improvement greater than the MID of 10.0.

Comparison 2 Patient‐reported outcomes, Outcome 3 Overall function ‐ scale 0 to 100 (higher score indicates improvement) ‐ MID 10.0.
Figuras y tablas -
Analysis 2.3

Comparison 2 Patient‐reported outcomes, Outcome 3 Overall function ‐ scale 0 to 100 (higher score indicates improvement) ‐ MID 10.0.

Comparison 2 Patient‐reported outcomes, Outcome 4 Overall function ‐ pooled RDs of workers with an improvement greater than the MID of 10.0.
Figuras y tablas -
Analysis 2.4

Comparison 2 Patient‐reported outcomes, Outcome 4 Overall function ‐ pooled RDs of workers with an improvement greater than the MID of 10.0.

Comparison 2 Patient‐reported outcomes, Outcome 5 Physical function ‐ scale 0 to 100 (higher score indicates improvement) ‐ MID 8.4.
Figuras y tablas -
Analysis 2.5

Comparison 2 Patient‐reported outcomes, Outcome 5 Physical function ‐ scale 0 to 100 (higher score indicates improvement) ‐ MID 8.4.

Comparison 2 Patient‐reported outcomes, Outcome 6 Physical function ‐ pooled RDs of workers with an improvement greater than the MID of 8.4.
Figuras y tablas -
Analysis 2.6

Comparison 2 Patient‐reported outcomes, Outcome 6 Physical function ‐ pooled RDs of workers with an improvement greater than the MID of 8.4.

Comparison 2 Patient‐reported outcomes, Outcome 7 Social function ‐ scale to 0 to 100 (higher score indicates improvement) ‐ MID 11.7.
Figuras y tablas -
Analysis 2.7

Comparison 2 Patient‐reported outcomes, Outcome 7 Social function ‐ scale to 0 to 100 (higher score indicates improvement) ‐ MID 11.7.

Comparison 2 Patient‐reported outcomes, Outcome 8 Social function ‐ pooled RDs of workers with an improvement greater than the MID of 11.7.
Figuras y tablas -
Analysis 2.8

Comparison 2 Patient‐reported outcomes, Outcome 8 Social function ‐ pooled RDs of workers with an improvement greater than the MID of 11.7.

Comparison 2 Patient‐reported outcomes, Outcome 9 Mental function ‐ scale to 0 to 100 (higher score indicates improvement) ‐ MID 7.3.
Figuras y tablas -
Analysis 2.9

Comparison 2 Patient‐reported outcomes, Outcome 9 Mental function ‐ scale to 0 to 100 (higher score indicates improvement) ‐ MID 7.3.

Comparison 2 Patient‐reported outcomes, Outcome 10 Mental function ‐ pooled RDs of workers with an improvement greater than the MID of 7.3.
Figuras y tablas -
Analysis 2.10

Comparison 2 Patient‐reported outcomes, Outcome 10 Mental function ‐ pooled RDs of workers with an improvement greater than the MID of 7.3.

Comparison 2 Patient‐reported outcomes, Outcome 11 Depression ‐ scale 0 to 27 (higher score indicates deterioration) ‐ MID 5.0.
Figuras y tablas -
Analysis 2.11

Comparison 2 Patient‐reported outcomes, Outcome 11 Depression ‐ scale 0 to 27 (higher score indicates deterioration) ‐ MID 5.0.

Comparison 2 Patient‐reported outcomes, Outcome 12 Depression ‐ pooled RDs of workers with an improvement greater than the MID of 5.0.
Figuras y tablas -
Analysis 2.12

Comparison 2 Patient‐reported outcomes, Outcome 12 Depression ‐ pooled RDs of workers with an improvement greater than the MID of 5.0.

Comparison 2 Patient‐reported outcomes, Outcome 13 Anxiety ‐ scale 0 to 21 (higher score indicates deterioration) ‐ MID 4.0.
Figuras y tablas -
Analysis 2.13

Comparison 2 Patient‐reported outcomes, Outcome 13 Anxiety ‐ scale 0 to 21 (higher score indicates deterioration) ‐ MID 4.0.

Comparison 2 Patient‐reported outcomes, Outcome 14 Anxiety ‐ pooled RDs of workers with an improvement greater than the MID of 4.0.
Figuras y tablas -
Analysis 2.14

Comparison 2 Patient‐reported outcomes, Outcome 14 Anxiety ‐ pooled RDs of workers with an improvement greater than the MID of 4.0.

Summary of findings for the main comparison. Return to work coordination programmes compared to usual practice for improving return to work in workers on sick leave

Return to work coordination programmes compared to usual practice for improving return to work in workers on sick leave

Patient or population: workers on sick leave
Intervention: return‐to‐work coordination programmes
Comparison: usual practice

Outcomes

Anticipated absolute effects* (95% CI)

Relative effect
(95% CI)

№ of participants
(studies)

Quality of the evidence
(GRADE)

Risk with usual practice

Risk with return‐to‐work coordination programmes

Time to return to work ‐

short‐term
follow‐up: 6 months

HR 1.32
(0.93 to 1.88)

161
(2 RCTs)

⊕⊕⊝⊝
Lowa,b

Time to return to work ‐

long‐term
follow‐up: 12 months

HR 1.25
(0.95 to 1.66)

1935
(6 RCTs)

⊕⊕⊝⊝
Lowb,c

Time to return to work ‐ very long‐term
follow‐up: more than 12 months

HR 0.93
(0.74 to 1.17)

474
(2 RCTs)

⊕⊕⊝⊝
Lowa,b

Cumulative sickness absence in work days ‐ short‐term
follow‐up: 6 months

The mean cumulative sickness absence was 79.14 work days

The mean cumulative
sickness absence in the
intervention group was 16.18 work days lower
(32.42 lower to 0.06 higher)

113
(1 RCT)

⊕⊕⊕⊝
Moderateb

Cumulative sickness absence in work days ‐

long‐term
follow‐up: 12 months

The mean cumulative sickness absence was 144 work days

The mean cumulative
sickness absence in the
intervention group was 14.84 work days lower
(38.56 lower to 8.88 higher)

1339
(6 RCTs)

⊕⊕⊝⊝
Lowb,c

Cumulative sickness absence in work days ‐

very long‐term
follow‐up: more than 12 months

The mean cumulative sickness absence was 466 work days

The mean cumulative
sickness absence in the
intervention group was 7 work days higher
(15.17 lower to 29.17 higher)

8052
(1 RCT)

⊕⊕⊕⊝
Moderateb

Proportion at work at end of the follow‐up ‐ short‐term
follow‐up: 6 months

53 per 100

56 per 100
(46 to 69)

RR 1.06
(0.86 to 1.30)

1388
(5 RCTs)

⊕⊕⊝⊝
Lowa,b

Proportion at work at end of the follow‐up ‐

long‐term
follow‐up: 12 months

60 per 100

64 per 100
(59 to 69)

RR 1.06
(0.99 to 1.15)

3061
(5 RCTs)

⊕⊕⊝⊝
Lowa,b

Proportion at work at end of the follow‐up ‐

very long‐term
follow‐up: more than 12 months

53 per 100

49 per 100
(43 to 56)

RR 0.94
(0.82 to 1.07)

815
(2 RCTs)

⊕⊕⊝⊝
Lowa,b

Proportion who had ever returned to work ‐

short‐term
follow‐up: 6 months

57 per 100

49 per 100
(36 to 68)

RR 0.87
(0.63 to 1.19)

675
(4 RCTs)

⊕⊝⊝⊝
Very lowa,b,c

Proportion who had ever returned to work ‐ long‐term
follow‐up: 12 months

69 per 100

71 per 100
(67 to 75)

RR 1.03
(0.97 to 1.09)

3822
(8 RCTs)

⊕⊕⊕⊝
Moderateb

Proportion who had ever returned to work ‐

very long‐term
follow‐up: more than 12 months

75 per 100

71 per 100
(66 to 77)

RR 0.95
(0.88 to 1.02)

938
(3 RCTs)

⊕⊕⊝⊝
Lowa,b

*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; RR: risk ratio; OR: odds ratio.

GRADE Working Group grades of evidence
High quality: we are very confident that the true effect lies close to that of the estimate of the effect.
Moderate quality: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low quality: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
Very low quality: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

a Downgraded 1 level for risk of bias (attrition bias, reporting bias).
b Downgraded 1 level for imprecision (confidence interval encloses negative and positive effect or population size less than 400).
c Downgraded 1 level for inconsistency (substantial heterogeneity).

Figuras y tablas -
Summary of findings for the main comparison. Return to work coordination programmes compared to usual practice for improving return to work in workers on sick leave
Table 1. Involved disciplines in the intervention groups

Occupational or rehabilitation physician

General practitioner

(Occupational) physiotherapist

Psychologist, psychiatrist, psychotherapist

Occupational therapist

Social worker

Chiropractor

Other

Bültmann 2009

X

X

X

X

X

Davey 1994

X

X

X

X

Donceel 1999

X (social insurance physician)

X

Other healthcare personnel, social insurance agent

Feuerstein 2003

“[E].g. supervisor, injury compensation specialist, medical providers, claims examiner”

Jensen 2012

X

X

X

X

X

Lambeek 2010

X

X

X

Medical specialist

Lindh 1997

X

X

X

X

X

Nurse, vocational counsellor

Myhre 2014

X

X

Case worker, medical specialist, group discussions, lecturer

Purdon 2006

X

X

X

Podiatrists, osteopaths and dieticians

Rossignol 2000

X

X

X

Scholz 2015

X (insurance physician)

X

X

X

Outpatient care provider, inpatient care provider, other care provider

Stapelfeldt 2011

X

X

X

X

X

Van der Feltz‐Cornelis 2010

X

X

X

Volker 2015

X

X

X

Web‐based eHealth Modules

X = involved discipline

Figuras y tablas -
Table 1. Involved disciplines in the intervention groups
Comparison 1. Return‐to‐work outcomes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Time to return to work Show forest plot

9

Hazard Ratio (Random, 95% CI)

Subtotals only

1.1 Short‐term, follow‐up 6 months

2

161

Hazard Ratio (Random, 95% CI)

1.32 [0.93, 1.88]

1.2 Long‐term, follow‐up 12 months

6

1935

Hazard Ratio (Random, 95% CI)

1.25 [0.95, 1.66]

1.3 Very long‐term, follow‐up longer than 12 months

2

474

Hazard Ratio (Random, 95% CI)

0.93 [0.74, 1.17]

2 Time to return to work, sensitivity analysis (low risk of bias studies only) Show forest plot

7

Hazard Ratio (Random, 95% CI)

Subtotals only

2.1 Short‐term, follow‐up 6 months

1

110

Hazard Ratio (Random, 95% CI)

1.17 [0.76, 1.79]

2.2 Long‐term, follow‐up 12 months

6

1935

Hazard Ratio (Random, 95% CI)

1.25 [0.95, 1.66]

2.3 Very long‐term, follow‐up longer than 12 months

1

351

Hazard Ratio (Random, 95% CI)

0.86 [0.68, 1.09]

3 Cumulative sickness absence in work days Show forest plot

7

Mean Difference (IV, Random, 95% CI)

Subtotals only

3.1 Short‐term, follow‐up 6 months

1

113

Mean Difference (IV, Random, 95% CI)

‐16.18 [‐32.42, 0.06]

3.2 Long‐term, follow‐up 12 months

6

1339

Mean Difference (IV, Random, 95% CI)

‐14.84 [‐38.56, 8.88]

3.3 Very long‐term, follow‐up longer than 12 months

1

8052

Mean Difference (IV, Random, 95% CI)

7.0 [‐15.17, 29.17]

4 Proportion at work at end of the follow‐up Show forest plot

7

Risk Ratio (IV, Random, 95% CI)

Subtotals only

4.1 Short‐term, follow‐up 6 months

5

1388

Risk Ratio (IV, Random, 95% CI)

1.06 [0.86, 1.30]

4.2 Long‐term, follow‐up 12 months

5

3061

Risk Ratio (IV, Random, 95% CI)

1.06 [0.99, 1.15]

4.3 Very long‐term, follow‐up longer than 12 months

2

815

Risk Ratio (IV, Random, 95% CI)

0.94 [0.82, 1.07]

5 Proportion at work at end of the follow‐up, sensitivity analysis (low risk of bias studies only) Show forest plot

4

Risk Ratio (IV, Random, 95% CI)

Subtotals only

5.1 Short‐term, follow‐up 6 months

3

873

Risk Ratio (IV, Random, 95% CI)

1.20 [1.10, 1.30]

5.2 Long‐term, follow‐up 12 months

3

1174

Risk Ratio (IV, Random, 95% CI)

1.08 [0.94, 1.23]

5.3 Very long‐term, follow‐up longer than 12 months

1

351

Risk Ratio (IV, Random, 95% CI)

0.95 [0.80, 1.13]

6 Proportion who had ever returned to work Show forest plot

12

Risk Ratio (IV, Random, 95% CI)

Subtotals only

6.1 Short‐term, follow‐up 6 months

4

675

Risk Ratio (IV, Random, 95% CI)

0.87 [0.63, 1.19]

6.2 Long‐term, follow‐up 12 months

8

3822

Risk Ratio (IV, Random, 95% CI)

1.03 [0.97, 1.09]

6.3 Very long‐term, follow‐up longer than 12 months

3

938

Risk Ratio (IV, Random, 95% CI)

0.95 [0.88, 1.02]

7 Proportion who had ever returned to work, sensitivity analysis (low risk of bias studies only) Show forest plot

8

Risk Ratio (IV, Random, 95% CI)

Subtotals only

7.1 Short‐term, follow‐up 6 months

2

160

Risk Ratio (IV, Random, 95% CI)

1.06 [0.86, 1.31]

7.2 Long‐term, follow‐up 12 months

6

1935

Risk Ratio (IV, Random, 95% CI)

1.04 [0.96, 1.11]

7.3 Very long‐term, follow‐up longer than 12 months

1

351

Risk Ratio (IV, Random, 95% CI)

0.97 [0.87, 1.08]

Figuras y tablas -
Comparison 1. Return‐to‐work outcomes
Comparison 2. Patient‐reported outcomes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pain ‐ scale 0 to 100 (higher score indicates improvement) ‐ MID 10.0 Show forest plot

7

Mean Difference (IV, Random, 95% CI)

Subtotals only

1.1 Short‐term, follow‐up 6 months

4

427

Mean Difference (IV, Random, 95% CI)

‐4.76 [‐14.89, 5.36]

1.2 Long‐term, follow‐up 12 months

6

2319

Mean Difference (IV, Random, 95% CI)

‐2.98 [‐5.33, ‐0.63]

1.3 Very long‐term, longer than 12 months

1

80

Mean Difference (IV, Random, 95% CI)

‐7.20 [‐15.76, 1.36]

2 Pain ‐ pooled RDs of workers with an improvement greater than the MID of 10.0 Show forest plot

7

Risk Difference (Random, 95% CI)

Subtotals only

2.1 Short‐term, follow‐up 6 months

4

Risk Difference (Random, 95% CI)

‐0.03 [‐0.11, 0.05]

2.2 Long‐term, follow‐up 12 months

6

Risk Difference (Random, 95% CI)

‐0.03 [‐0.06, ‐0.00]

2.3 Very long‐term, longer than 12 months

1

Risk Difference (Random, 95% CI)

‐0.02 [‐0.11, 0.07]

3 Overall function ‐ scale 0 to 100 (higher score indicates improvement) ‐ MID 10.0 Show forest plot

6

Mean Difference (IV, Random, 95% CI)

Subtotals only

3.1 Short‐term, follow‐up 6 months

3

295

Mean Difference (IV, Random, 95% CI)

8.13 [3.95, 12.32]

3.2 Long‐term, follow‐up 12 months

5

2235

Mean Difference (IV, Random, 95% CI)

2.74 [‐0.15, 5.64]

4 Overall function ‐ pooled RDs of workers with an improvement greater than the MID of 10.0 Show forest plot

6

Risk Difference (Random, 95% CI)

Subtotals only

4.1 Short‐term, follow‐up, 6 months

3

Risk Difference (Random, 95% CI)

0.16 [‐0.04, 0.37]

4.2 Long‐term, follow‐up 12 months

5

Risk Difference (Random, 95% CI)

0.00 [‐0.09, 0.09]

5 Physical function ‐ scale 0 to 100 (higher score indicates improvement) ‐ MID 8.4 Show forest plot

5

Mean Difference (IV, Random, 95% CI)

Subtotals only

5.1 Short‐term, follow‐up 6 months

3

336

Mean Difference (IV, Random, 95% CI)

3.47 [‐3.26, 10.20]

5.2 Long‐term, follow‐up 12 months

4

1860

Mean Difference (IV, Random, 95% CI)

2.19 [‐2.29, 6.67]

5.3 Very long‐term, follow‐up longer than 12 months

1

78

Mean Difference (IV, Random, 95% CI)

1.85 [‐2.25, 5.95]

6 Physical function ‐ pooled RDs of workers with an improvement greater than the MID of 8.4 Show forest plot

5

Risk Difference (Random, 95% CI)

Subtotals only

6.1 Short‐term, follow‐up 6 months

3

Risk Difference (Random, 95% CI)

0.03 [‐0.07, 0.13]

6.2 Long‐term, follow‐up 12 months

4

Risk Difference (Random, 95% CI)

0.01 [‐0.02, 0.03]

6.3 Very long‐term, follow‐up longer than 12 months

1

Risk Difference (Random, 95% CI)

0.0 [‐0.02, 0.02]

7 Social function ‐ scale to 0 to 100 (higher score indicates improvement) ‐ MID 11.7 Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Subtotals only

7.1 Long‐term, follow‐up 12 months

2

1636

Mean Difference (IV, Random, 95% CI)

2.84 [‐0.09, 5.77]

8 Social function ‐ pooled RDs of workers with an improvement greater than the MID of 11.7 Show forest plot

2

Risk Difference (Random, 95% CI)

Subtotals only

8.1 Long‐term, follow‐up 12 months

2

Risk Difference (Random, 95% CI)

0.01 [‐0.02, 0.04]

9 Mental function ‐ scale to 0 to 100 (higher score indicates improvement) ‐ MID 7.3 Show forest plot

3

Mean Difference (IV, Random, 95% CI)

Subtotals only

9.1 Short‐term, follow‐up 6 months

1

125

Mean Difference (IV, Random, 95% CI)

1.85 [‐2.67, 6.37]

9.2 Long‐term, follow‐up 12 months

3

1737

Mean Difference (IV, Random, 95% CI)

3.14 [1.16, 5.11]

9.3 Very long‐term, follow‐up longer than 12 months

1

78

Mean Difference (IV, Random, 95% CI)

6.09 [0.56, 11.63]

10 Mental function ‐ pooled RDs of workers with an improvement greater than the MID of 7.3 Show forest plot

3

Risk Difference (Random, 95% CI)

Subtotals only

10.1 Short‐term, follow‐up 6 months

1

Risk Difference (Random, 95% CI)

0.0 [‐0.01, 0.01]

10.2 Long‐term, follow‐up 12 months

3

Risk Difference (Random, 95% CI)

0.00 [‐0.01, 0.01]

10.3 Very long‐term, follow‐up longer than 12 months

1

Risk Difference (Random, 95% CI)

0.0 [‐0.01, 0.01]

11 Depression ‐ scale 0 to 27 (higher score indicates deterioration) ‐ MID 5.0 Show forest plot

4

Mean Difference (IV, Random, 95% CI)

Subtotals only

11.1 Short‐term, follow‐up 6 months

3

252

Mean Difference (IV, Random, 95% CI)

0.37 [‐2.81, 3.55]

11.2 Long‐term, follow‐up 12 months

2

420

Mean Difference (IV, Random, 95% CI)

‐0.00 [‐1.07, 1.07]

12 Depression ‐ pooled RDs of workers with an improvement greater than the MID of 5.0 Show forest plot

4

Risk Difference (Random, 95% CI)

Subtotals only

12.1 Short‐term, follow‐up 6 months

3

Risk Difference (Random, 95% CI)

0.03 [‐0.07, 0.12]

12.2 Long‐term, follow‐up 12 months

2

Risk Difference (Random, 95% CI)

0.01 [‐0.04, 0.06]

13 Anxiety ‐ scale 0 to 21 (higher score indicates deterioration) ‐ MID 4.0 Show forest plot

3

Mean Difference (IV, Random, 95% CI)

Subtotals only

13.1 Short‐term, follow‐up 6 months

2

208

Mean Difference (IV, Random, 95% CI)

‐0.02 [‐3.24, 3.21]

13.2 Long‐term, follow‐up 12 months

2

420

Mean Difference (IV, Random, 95% CI)

0.97 [‐0.17, 2.12]

14 Anxiety ‐ pooled RDs of workers with an improvement greater than the MID of 4.0 Show forest plot

3

Risk Difference (Random, 95% CI)

Subtotals only

14.1 Short‐term, follow‐up 6 months

2

Risk Difference (Random, 95% CI)

‐0.01 [‐0.08, 0.07]

14.2 Long‐term, follow‐up 12 months

2

Risk Difference (Random, 95% CI)

0.02 [‐0.03, 0.08]

Figuras y tablas -
Comparison 2. Patient‐reported outcomes