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Surgical interventions for the prevention or treatment of lymphoedema after breast cancer treatment

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Appendices

Appendix 1. CENTRAL

  1. MeSH descriptor: [Breast Neoplasms] explode all trees

  2. breast near cancer*

  3. breast near neoplasm*

  4. breast near carcinoma*

  5. breast near tumour*

  6. breast near tumor*

  7. #1 or #2 or #3 or #4 or #5 or #6

  8. MeSH descriptor: [Lymphedema] explode all trees

  9. lymphoedema or lymphedema

  10. breast cancer associated lymphoedema

  11. breast cancer near/5 (lymphoedema or lymphedema)

  12. #9 or #10 or #11

  13. MeSH descriptor: [Lipectomy] explode all trees

  14. liposuction

  15. lymph node transfer

  16. lymph node near/5 transfer

  17. MeSH descriptor: [Anastomosis, Surgical] explode all trees

  18. lymphaticovenular anastomosis

  19. LVA

  20. Lympathico‐lymphatic bypass

  21. Lympathico‐lymphatic near/5 bypass

  22. microsurgical lymphatic reconstruction

  23. lymphatic near/5 reconstruction

  24. microsurgical near/5 lymphatic reconstruction

  25. microsurgical near/5 lymphatic

  26. Anastamotic reconstruction or Anastomotic reconstruction

  27. surg* prevent* near/5 (lymphoedema or lymphedema)

  28. surg* treat* near/5 (lymphoedema or lymphedema)

  29. #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28

  30. #7 and #12 and #29

Appendix 2. MEDLINE

1

randomized controlled trial.pt.

2

controlled clinical trial.pt.

3

randomized.ab.

4

placebo.ab.

5

clinical trials as topic.sh.

6

randomly.ab.

7

trial.ab.

8

groups.ab.

9

1 or 2 or 3 or 4 or 5 or 6 or 7 or 8

10

exp Breast Neoplasms/

11

(breast adj6 cancer$).mp.

12

(breast adj6 neoplasm$).mp.

13

(breast adj6 carcinoma$).mp.

14

(breast adj6 tumour$).mp.

15

(breast adj6 tumor$).mp.

16

10 or 11 or 12 or 13 or 14 or 15

17

exp Lymphedema/

18

lymphedema.mp. OR upper‐limb lymphedema.mp

19

lymphoedema.mp. OR upper‐limb lymphoedema.mp

20

breast cancer associated lymphoedema.mp.

21

breast cancer associated lymphedema.mp.

22

(breast cancer adj6 (lymphoedema or lymphedema)).mp.

23

17 or 18 or 19 or 20 or 21 or 22

24

exp Lipectomy/

25

liposuction.mp.

26

lymph node transfer.mp.

27

(lymph node adj5 transfer).mp.

28

exp Anastomosis, Surgical/

29

lymphaticovenular anastomosis.mp. OR lymphaticovenous anastomosis.mp

30

LVA.mp. OR LYMPHA.mp

31

Lympathico‐lymphatic bypass.mp. OR axillary clearance.mp OR axillary dissection.mp OR axillary lymphadenectomy.mp OR lymph node flap.mp

32

(Lympathico‐lymphatic adj5 bypass).mp.

33

microsurgical lymphatic reconstruction.mp.

34

(lymphatic adj5 reconstruction).mp.

35

(microsurgical adj5 lymphatic reconstruction).mp.

36

(microsurgical adj5 lymphatic).mp.

37

Anastamotic reconstruction.mp.

38

(surg* prevent* adj5 (lymphoedema or lymphedema)).mp.

39

(surg* treat* adj5 (lymphoedema or lymphedema)).mp.

40

24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39

41

9 and 16 and 23 and 40

42

Animals/ not Humans/

43

41 not 42

Appendix 3. EMBASE

  1. 'randomized controlled trial'/syn OR randomi* NEXT/10 controlled OR 'randomization'/syn OR 'random allocation' OR 'double blind procedure'/syn OR (single OR double OR tripl* OR trebl*) NEXT/1 (blind* OR mask*) OR 'clinical trial'/syn OR 'clinical trials' OR'multicenter study'/syn OR (multicentre OR multicenter) NEXT/1 stud* OR randomly:ab,ti OR trial:ab,ti OR groups:ab,ti

  2. 'breast'/exp OR 'breast disease'/exp AND 'neoplasm'/exp OR 'breast tumor'/exp OR (breast* NEAR/5 neoplas*):ab,ti OR (breast* NEAR/5cancer*):ab,ti OR (breast* NEAR/5 carcin*):ab,ti OR (breast* NEAR/5 tumo*):ab,ti OR (breast* NEAR/5 metasta*):ab,ti OR (breast* NEAR/5malig*):ab,ti

  3. 'lymphoedema'/exp OR lymphoedema OR 'upper‐limb lymphoedema'

  4. 'lymphedema'/exp OR lymphedema OR 'upper‐limb lymphedema'

  5. 'breast cancer associated lymphoedema'

  6. 'breast cancer associated lymphedema'

  7. 'breast cancer' NEAR/5 (lymphoedema OR lymphedema)

  8. #3 OR #4 OR #5 OR #6 OR #7

  9. 'lipectomy'/exp OR lipectomy

  10. 'liposuction'/exp OR liposuction

  11. 'lymph node transfer'

  12. 'lymph node' NEAR/5 transfer

  13. lva OR lympha

  14. 'lymphaticovenular anastomosis' OR 'lymphaticovenous anastomosis'

  15. 'lympathico‐lymphatic bypass' OR 'axillary clearance' OR 'axillary dissection' OR 'axillary lymphadenectomy' OR 'lymph node flap'

  16. 'lympathico‐lymphatic' NEAR/5 bypass

  17. 'microsurgical lymphatic reconstruction'

  18. lymphatic NEAR/5 reconstruction

  19. microsurgical NEAR/5 'lymphatic reconstruction'

  20. microsurgical NEAR/5 lymphatic

  21. 'anastamotic reconstruction'

  22. 'anastomotic reconstruction'

  23. 'surgical prevention' NEAR/5 (lymphoedema OR lymphedema)

  24. 'surgical treatment' NEAR/5 (lymphoedema OR lymphedema)

  25. 'surgical treatments' NEAR/5 (lymphoedema OR lymphedema)

  26. #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25

  27. #1 AND #2 AND #8 AND #26

  28. #27 NOT ([animals]/lim NOT [humans]/lim)

  29. #28 AND [embase]/lim

Appendix 4. CINAHL

S1. (MH "Clinical Trials+")

S2. PT Clinical trial

S3. TX clinic* n1 trial*

S4. TX ( (singl* n1 blind*) or (singl* n1 mask*) ) or TX ( (doubl* n1 blind*) or (doubl* n1 mask*) ) or TX ( (tripl* n1 blind*) or (tripl* n1 mask*) ) or TX ( (trebl* n1 blind*) or (trebl* n1 mask*) )

S5. TX randomi* control* trial*

S6. (MH "Random Assignment")

S7. TX random* allocat*

S8. TX placebo*

S9. (MH "Placebos")

S10. (MH "Quantitative Studies")

S11. TX allocat* random*

S12. S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11

S13. (MH "Breast Neoplasms+")

S14. TX breast cancer*

S15. TX breast tumour*

S16. TX breast tumor*

S17. TX breast carcinoma*

S18. S12 OR S13 OR S14 OR S15 OR S16 OR S17

S19. (MH "Lymphedema+")

S20. "lymphedema" OR TX upper‐limb lymphedema*

S21. "lymphoedema" OR TX upper‐limb lymphoedema*

S22. TX breast cancer associated lymphoedema

S23. TX breast cancer associated lymphedema

S24. S19 OR S20 OR S21 OR S22 OR S23

S25. (MH "Lipectomy+")

S26. "liposuction"

S27. TX lymphaticovenular anastomosis

S28. "LVA" OR "LYMPHA" OR TX LVA OR TX LYMPHA

S29. TX Lympathico‐lymphatic bypass

S30. TX microsurgical lymphatic reconstruction* OR TX axillary clearance OR TX axillary lymphadenectomy OR TX axillary dissection OR "axillary clearance" OR "axillary lymphadenectomy" OR "axillary clearance"

S31. TX Anastamotic reconstruction* OR TX Anastomotic reconstruction*

S32. TX (lymph node* n5 transfer)

S33. TX (Lympathico‐lymphatic n5 bypass)

S34. TX (lymphatic n5 reconstruction)

S35. TX (microsurgical n5 lymphatic reconstruction*)

S36. TX (microsurgical n5 lymphatic)

S37. TX (surg* prevent* n5 (lymphoedema or lymphedema))

S38. TX (surg* treatment* n5 (lymphoedema or lymphedema))

S39. S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38

S40. S12 AND S18 AND S24 AND S39

Appendix 5. WHO ICTRP

Basic searches:

1. Lymphoedema AND liposuction

2. Lymphoedema AND lymph node transfer

3. Lymphoedema AND lymphaticovenular anastomosis

4. Lymphoedema AND LVA

5. Lymphoedema AND Lympathico‐lymphatic bypass

6. Lymphoedema AND microsurgical lymphatic reconstruction

7. Lymphoedema AND Anastomotic reconstruction

8. Lymphoedema AND Anastamotic reconstruction

9. Lymphoedema AND axillary dissection

10. Lymphoedema AND axillary lymphadenectomy

11. Lymphoedema AND axillary clearance

12. Lymphoedema AND LYMPHA

13. Lymphoedema AND lymph node flap

14. Lymphoedema AND lymphaticovenous anastomsis

Advanced searches:

1. Condition: lymphoedema

Intervention: liposuction OR lymph node transfer OR lymphaticovenular anastomosis OR LVA OR Lympathico‐lymphatic bypass OR microsurgical lymphatic reconstruction OR Anastomotic reconstruction OR Anastamotic reconstruction OR lymphatic surgery OR lymphatic reconstruction OR surgical intervention OR lymphatic bypass OR axillary clearance OR axillary dissection OR axillary lymphadenectomy OR LYMPHA OR Lymph node flap OR lymphaticovenous anastomosis

Recruitment Status: ALL

Appendix 6. ClinicalTrials.gov

Basic searches:

1. Lymphoedema AND liposuction

2. Lymphoedema AND lymph node transfer

3. Lymphoedema AND lymphaticovenular anastomosis

4. Lymphoedema AND LVA

5. Lymphoedema AND Lympathico‐lymphatic bypass

6. Lymphoedema AND microsurgical lymphatic reconstruction

7. Lymphoedema AND Anastomotic reconstruction

8. Lymphoedema AND Anastamotic reconstruction

9. Lymphoedema AND axillary dissection

10. Lymphoedema AND axillary lymphadenectomy

11. Lymphoedema AND axillary clearance

12. Lymphoedema AND LYMPHA

13. Lymphoedema AND lymph node flap

14. Lymphoedema AND lymphaticovenous anastomsis

Advanced searches:

1. Condition: breast cancer AND lymphoedema

Intervention: liposuction OR lymph node transfer OR lymphaticovenular anastomosis OR LVA OR Lympathico‐lymphatic bypass OR microsurgical lymphatic reconstruction OR Anastomotic reconstruction OR Anastamotic reconstruction OR lymphatic surgery OR lymphatic reconstruction OR surgical intervention OR lymphatic bypass OR axillary clearance OR axillary dissection OR axillary lymphadenectomy OR LYMPHA OR Lymph node flap OR lymphaticovenous anastomosis

Recruitment: All studies

Study Results: All studies

Study Type: All studies

Gender: All studies