Appendix 1. MEDLINE search strategy

We based this strategy on the Cochrane Highly Sensitive Search Strategy for identifying randomized trials (Lefebvre 2011).

1. exp Diazepam/ or (diazepam or methyldiazepinone or valium).tw.

2. exp Epilepsy/

3. exp Seizures/

4. (epilep$ or seizure$ or convuls$).tw.

5. 2 or 3 or 4

6. exp Pre‐Eclampsia/ or exp Eclampsia/

7. 5 not 6

8. (randomized controlled trial or controlled clinical trial).pt. or (randomized or placebo or randomly).ab.

9. clinical trials as topic.sh.

10. trial.ti.

11. 8 or 9 or 10

12. exp animals/ not humans.sh.

13. 11 not 12

14. 1 and 7 and 13

15. ("alcohol withdrawal" or "febrile seizure$" or "febrile convulsion$" or malaria or pharmacokinetic$).ti.

16. 14 not 15

17. ((adjunct$ or "add‐on" or "add on" or adjuvant$ or combination$ or polytherap$) not (monotherap$ or alone or singl$)).ti.

18. 16 not 17