1

randomized controlled trial.pt.

2

controlled clinical trial.pt.

3

randomized.ab.

4

placebo.ab.

5

Clinical Trials as Topic/

6

randomly.ab.

7

trial.ti.

8

(crossover or cross‐over).tw.

9

Pragmatic Clinical Trials as Topic/

10

pragmatic clinical trial.pt.

11

or/1‐10

12

exp Breast Neoplasms/

13

(local$ adj6 advance$ adj6 (breast adj6 (neoplasm$ or cancer$ or carcinoma$ or tumo?r$))).tw.

14

(metasta$ adj6 (breast adj6 (neoplasm$ or cancer$ or carcinoma$ or tumo?r$))).tw.

15

or/12‐14

16

exp "Poly(ADP‐ribose) Polymerases"/

17

"Poly(ADP‐ribose) Polymerase inhibitor".tw.

18

(poly$ adj6 polymerase$ adj6 inhibit$).tw.

19

(poly$ adj6 ribose$ adj6 polymerase$ adj6 inhibit$).tw.

20

(poly$ adj6 ADP$ adj6 polymerase$ adj6 inhibit$).tw.

21

(PARP$ adj6 inhibit$).tw.

22

exp ADP Ribose Transferases/

23

(veliparib or ABT‐888).mp.

24

(olaparib or AZD‐2281).mp.

25

(rucaparib or AG014699 or PF‐01367338 or CO‐388).mp.

26

(niraparib or MK‐4827).mp.

27

(BMN 673 or E7449 or E7016 or ABT‐767 or BGB‐290).mp.

28

or/16‐27

29

and/11,15,28

30

animals/ not (humans/ and animals/)

31

29 not 30

32

limit 31 to yr="2008 ‐Current"

#1

random* OR factorial* OR crossover* OR cross NEXT/1 over* OR placebo* OR (doubl* AND blind*) OR (singl* AND blind*) OR assign* OR allocat* OR volunteer* OR 'crossover procedure'/exp OR 'double blind procedure'/exp OR 'randomized controlled trial'/exp OR 'single blind procedure'/exp

#2

'breast'/exp OR 'breast disease'/exp AND 'neoplasm'/exp OR 'breast tumor'/exp OR (breast* NEAR/5 neoplas*):ab,ti OR (breast*NEAR/5 cancer*):ab,ti OR (breast* NEAR/5 carcin*):ab,ti OR (breast* NEAR/5 tumo*):ab,ti OR (breast* NEAR/5 metasta*):ab,ti OR (breast* NEAR/5 malig*):ab,ti

#3

local* AND advance* AND breast NEAR/5 (cancer* OR carcinoma* OR neoplasm* OR tumour* OR tumor*)

#4

local* AND advance* NEAR/5 breast AND (cancer* OR carcinoma* OR neoplasm* OR tumour* OR tumor*)

#5

local* AND advance* NEAR/5 ('breast cancer' OR 'breast carcinoma' OR 'breast neoplasm' OR 'breast tumour' OR 'breast tumor')

#6

'locally advanced breast cancer' OR 'locally advanced breast carcinoma' OR 'locally advanced breast neoplasm' OR 'locally advanced breast tumour' OR 'locally advanced breast tumor'

#7

metasta* AND breast NEAR/5 (cancer* OR carcinoma* OR neoplasm* OR tumour* OR tumor*)

#8

metasta* NEAR/5 breast AND (cancer* OR carcinoma* OR neoplasm* OR tumour* OR tumor*)

#9

metasta* NEAR/5 ('breast cancer' OR 'breast carcinoma' OR 'breast neoplasm' OR 'breast tumour' OR 'breast tumor')

#10

'metastatic breast cancer'/exp OR 'metastatic breast cancer' OR 'metastatic breast carcinoma' OR 'metastatic breast neoplasm' OR 'metastatic breast tumour' OR 'metastatic breast tumor'

#11

#2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10

#12

'nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor'/exp

#13

poly AND 'adp ribose' AND poly* NEAR/6 inhibit* OR poly AND 'adp ribose' AND polymerase AND inhibitor

#14

parp* AND inhibit$ OR parp* NEAR/6 inhibit*

#15

'veliparib'/exp OR veliparib OR 'abt 888'

#16

'olaparib'/exp OR olaparib OR 'azd 2281'

#17

'rucaparib'/exp OR rucaparib OR ag014699 OR 'pf 01367338' OR 'co 388'

#18

'niraparib'/exp OR niraparib OR 'mk 4827'

#19

'talazoparib'/exp OR talazoparib OR bmn AND 673 OR 'bmn673' OR 'bmn 673'

#20

'e7449' OR 'e7016' OR 'abt‐767' OR 'bgb‐290'

#21

#12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20

#22

#1 AND #11 AND #21

#23

#22 AND [humans]/lim

#24

#23 AND [embase]/lim AND [2008‐2014]/py