1 Severity of somatic symptoms at end of treatment Show forest plot

10

1081

Std. Mean Difference (IV, Random, 95% CI)

‐0.34 [‐0.53, ‐0.16]

1.1 Cognitive behavioural therapy versus usual care or waiting list

6

593

Std. Mean Difference (IV, Random, 95% CI)

‐0.37 [‐0.69, ‐0.05]

1.2 Behavioural therapy versus usual care or waiting list

1

37

Std. Mean Difference (IV, Random, 95% CI)

‐0.22 [‐0.87, 0.43]

1.3 Third‐wave cognitive behavioural therapy versus usual care or waiting list

1

114

Std. Mean Difference (IV, Random, 95% CI)

‐0.31 [‐0.68, 0.06]

1.4 Psychodynamic therapy versus usual care or waiting list

1

252

Std. Mean Difference (IV, Random, 95% CI)

‐0.39 [‐0.64, ‐0.13]

1.5 Integrative therapies versus usual care or waiting list

1

85

Std. Mean Difference (IV, Random, 95% CI)

‐0.15 [‐0.69, 0.40]

2 Severity of somatic symptoms within 1 year after treatment Show forest plot

7

950

Std. Mean Difference (IV, Random, 95% CI)

‐0.24 [‐0.37, ‐0.11]

2.1 Cognitive behavioural therapy versus usual care or waiting list

4

496

Std. Mean Difference (IV, Random, 95% CI)

‐0.29 [‐0.49, ‐0.09]

2.2 Third‐wave cognitive behavioural therapy versus usual care or waiting list

1

107

Std. Mean Difference (IV, Random, 95% CI)

‐0.15 [‐0.53, 0.23]

2.3 Psychodynamic therapy versus usual care or waiting list

1

262

Std. Mean Difference (IV, Random, 95% CI)

‐0.20 [‐0.44, 0.05]

2.4 Integrative therapies versus usual care or waiting list

1

85

Std. Mean Difference (IV, Random, 95% CI)

‐0.15 [‐0.69, 0.40]

3 Severity of somatic symptoms > 1 year after treatment Show forest plot

2

228

Std. Mean Difference (IV, Random, 95% CI)

‐0.52 [‐0.80, ‐0.24]

3.1 Cognitive behavioural therapy versus usual care or waiting list

2

228

Std. Mean Difference (IV, Random, 95% CI)

‐0.52 [‐0.80, ‐0.24]

4 Acceptability Show forest plot

14

1644

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.88, 0.99]

4.1 Cognitive behavioural therapy versus usual care or waiting list

10

1037

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.85, 1.01]

4.2 Behavioural therapy versus usual care or waiting list

1

48

Risk Ratio (M‐H, Random, 95% CI)

0.9 [0.67, 1.21]

4.3 Third‐wave cognitive behavioural therapy versus usual care or waiting list

1

125

Risk Ratio (M‐H, Random, 95% CI)

0.85 [0.72, 1.00]

4.4 Psychodynamic therapy versus usual care or waiting list

1

328

Risk Ratio (M‐H, Random, 95% CI)

0.92 [0.88, 0.96]

4.5 Integrative therapies versus usual care or waiting list

1

106

Risk Ratio (M‐H, Random, 95% CI)

1.06 [0.81, 1.39]

5 Severity of anxiety symptoms at end of treatment ‐ participant rated Show forest plot

4

270

Std. Mean Difference (IV, Random, 95% CI)

0.06 [‐0.20, 0.32]

5.1 Cognitive behavioural therapy versus usual care or waiting list

3

185

Std. Mean Difference (IV, Random, 95% CI)

0.07 [‐0.22, 0.37]

5.2 Integrative therapies versus usual care or waiting list

1

85

Std. Mean Difference (IV, Random, 95% CI)

0.01 [‐0.53, 0.56]

6 Severity of anxiety symptoms at end of treatment ‐ clinician rated Show forest plot

3

320

Std. Mean Difference (IV, Random, 95% CI)

‐0.40 [‐0.63, ‐0.17]

6.1 Cognitive behavioural therapy versus usual care

2

284

Std. Mean Difference (IV, Random, 95% CI)

‐0.38 [‐0.63, ‐0.14]

6.2 Behavioural therapy versus usual care

1

36

Std. Mean Difference (IV, Random, 95% CI)

‐0.57 [‐1.24, 0.10]

7 Severity of anxiety symptoms within 1 year after treatment ‐ participant rated Show forest plot

2

134

Std. Mean Difference (IV, Random, 95% CI)

0.18 [‐0.22, 0.58]

7.1 Cognitive behavioural therapy versus usual care or waiting list

1

49

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.59, 0.59]

7.2 Integrative therapies versus usual care or waiting list

1

85

Std. Mean Difference (IV, Random, 95% CI)

0.33 [‐0.21, 0.88]

8 Severity of anxiety symptoms within 1 year after treatment ‐ clinician rated Show forest plot

2

251

Std. Mean Difference (IV, Random, 95% CI)

‐0.66 [‐1.15, ‐0.18]

9 Severity of anxiety symptoms > 1 year after treatment ‐ clinician rated Show forest plot

1

Std. Mean Difference (IV, Random, 95% CI)

Totals not selected

10 Severity of depressive symptoms at end of treatment ‐ participant rated Show forest plot

6

661

Std. Mean Difference (IV, Random, 95% CI)

‐0.03 [‐0.22, 0.16]

10.1 Cognitive behavioural therapy versus usual care or waiting list

4

325

Std. Mean Difference (IV, Random, 95% CI)

0.09 [‐0.13, 0.31]

10.2 Psychodynamic therapy versus usual care or waiting list

1

251

Std. Mean Difference (IV, Random, 95% CI)

‐0.30 [‐0.55, ‐0.04]

10.3 Integrative therapy versus usual care or waiting list

1

85

Std. Mean Difference (IV, Random, 95% CI)

0.10 [‐0.45, 0.64]

11 Severity of depressive symptoms at end of treatment ‐ clinician rated Show forest plot

3

316

Std. Mean Difference (IV, Random, 95% CI)

‐0.25 [‐0.48, ‐0.02]

11.1 Cognitive behavioural therapy versus usual care or waiting list

2

284

Std. Mean Difference (IV, Random, 95% CI)

‐0.25 [‐0.49, ‐0.01]

11.2 Behavioural therapy versus usual care or waiting list

1

32

Std. Mean Difference (IV, Random, 95% CI)

‐0.26 [‐0.96, 0.44]

12 Severity of depressive symptoms within 1 year after treatment ‐ participant rated Show forest plot

4

535

Std. Mean Difference (IV, Random, 95% CI)

0.04 [‐0.34, 0.42]

12.1 Cognitive behavioural therapy versus usual care or waiting list

2

189

Std. Mean Difference (IV, Random, 95% CI)

0.21 [‐0.07, 0.50]

12.2 Psychodynamic therapy versus usual care or waiting list

1

261

Std. Mean Difference (IV, Random, 95% CI)

‐0.35 [‐0.59, ‐0.10]

12.3 Integrative therapy versus usual care or waiting list

1

85

Std. Mean Difference (IV, Random, 95% CI)

0.31 [‐0.24, 0.85]

13 Severity of depressive symptoms within 1 year after treatment ‐ clinician rated Show forest plot

2

251

Std. Mean Difference (IV, Random, 95% CI)

‐0.55 [‐1.17, 0.07]

14 Severity of depressive symptoms > 1 year after treatment ‐ clinician rated Show forest plot

1

Std. Mean Difference (IV, Random, 95% CI)

Totals not selected

15 Dysfunctional cognitions, emotions and behaviours at end of treatment Show forest plot

3

440

Std. Mean Difference (IV, Random, 95% CI)

‐0.11 [‐0.37, 0.16]

15.1 Cognitive behavioural therapy versus usual care or waiting list

2

189

Std. Mean Difference (IV, Random, 95% CI)

‐0.15 [‐0.73, 0.44]

15.2 Psychodynamic therapy versus usual care or waiting list

1

251

Std. Mean Difference (IV, Random, 95% CI)

‐0.14 [‐0.39, 0.12]

16 Dysfunctional cognitions, emotions, and behaviours within 1 year after treatment Show forest plot

3

451

Std. Mean Difference (IV, Random, 95% CI)

‐0.16 [‐0.38, 0.07]

16.1 Cognitive behavioural therapy versus usual care or waiting list

2

189

Std. Mean Difference (IV, Random, 95% CI)

‐0.25 [‐0.79, 0.30]

16.2 Psychodynamic therapy versus usual care or waiting list

1

262

Std. Mean Difference (IV, Random, 95% CI)

‐0.13 [‐0.38, 0.11]

17 Adverse events Show forest plot

3

445

Risk Ratio (M‐H, Random, 95% CI)

1.31 [0.47, 3.66]

18 Treatment response at end of treatment Show forest plot

4

391

Risk Ratio (M‐H, Random, 95% CI)

3.30 [2.08, 5.21]

19 Treatment response within 1 year after treatment Show forest plot

3

332

Risk Ratio (M‐H, Random, 95% CI)

2.53 [1.25, 5.10]

20 Treatment response > 1 year after treatment Show forest plot

2

240

Risk Ratio (M‐H, Random, 95% CI)

10.31 [2.95, 36.02]

21 Functional disability and quality of life at end of treatment Show forest plot

7

730

Std. Mean Difference (IV, Random, 95% CI)

0.17 [0.03, 0.32]

21.1 Cognitive behavioural therapy versus usual care or waiting list

4

341

Std. Mean Difference (IV, Random, 95% CI)

0.15 [‐0.06, 0.37]

21.2 Behavioural therapy versus usual care or waiting list

1

34

Std. Mean Difference (IV, Random, 95% CI)

0.16 [‐0.51, 0.83]

21.3 Third‐wave cognitive behavioural therapy versus usual care or waiting list

1

111

Std. Mean Difference (IV, Random, 95% CI)

0.08 [‐0.29, 0.46]

21.4 Psychodynamic therapy versus usual care or waiting list

1

244

Std. Mean Difference (IV, Random, 95% CI)

0.24 [‐0.01, 0.50]

22 Functional disability and quality of life within 1 year after treatment Show forest plot

4

526

Std. Mean Difference (IV, Random, 95% CI)

0.16 [‐0.01, 0.33]

22.1 Cognitive behavioural therapy versus usual care or waiting list

2

168

Std. Mean Difference (IV, Random, 95% CI)

0.22 [‐0.08, 0.53]

22.2 Third‐wave cognitive behavioural therapy versus usual care or waiting list

1

107

Std. Mean Difference (IV, Random, 95% CI)

‐0.10 [‐0.48, 0.28]

22.3 Psychodynamic therapy versus usual care or waiting list

1

251

Std. Mean Difference (IV, Random, 95% CI)

0.23 [‐0.02, 0.48]

23 Functional disability and quality of life > 1 year of treatment Show forest plot

1

72

Std. Mean Difference (IV, Random, 95% CI)

0.36 [‐0.11, 0.82]

24 Healthcare use at end of treatment Show forest plot

2

117

Std. Mean Difference (IV, Random, 95% CI)

‐0.68 [‐1.06, ‐0.30]

25 Healthcare use within 1 year after treatment Show forest plot

4

532

Std. Mean Difference (IV, Random, 95% CI)

‐0.09 [‐0.31, 0.12]

25.1 Cognitive behavioural therapy versus usual care or waiting list

2

189

Std. Mean Difference (IV, Random, 95% CI)

‐0.27 [‐0.56, 0.02]

25.2 Integrative therapies versus usual care or waiting list

1

81

Std. Mean Difference (IV, Random, 95% CI)

0.13 [‐0.44, 0.69]

25.3 Psychodynamic therapy versus usual care or waiting list

1

262

Std. Mean Difference (IV, Random, 95% CI)

0.02 [‐0.23, 0.26]

1 Severity of somatic symptoms at end of treatment Show forest plot

5

624

Std. Mean Difference (IV, Random, 95% CI)

‐0.19 [‐0.43, 0.04]

1.1 Cognitive behavioural therapy versus enhanced care

3

307

Std. Mean Difference (IV, Random, 95% CI)

‐0.34 [‐0.71, 0.03]

1.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

106

Std. Mean Difference (IV, Random, 95% CI)

0.01 [‐0.38, 0.39]

1.3 Psychodynamic therapy versus enhanced care

1

211

Std. Mean Difference (IV, Random, 95% CI)

‐0.04 [‐0.31, 0.23]

2 Severity of somatic symptoms within 1 year after treatment Show forest plot

5

593

Std. Mean Difference (IV, Random, 95% CI)

‐0.21 [‐0.40, ‐0.02]

2.1 Cognitive behavioural therapy versus enhanced care

3

289

Std. Mean Difference (IV, Random, 95% CI)

‐0.30 [‐0.60, ‐0.00]

2.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

93

Std. Mean Difference (IV, Random, 95% CI)

0.05 [‐0.36, 0.46]

2.3 Psychodynamic therapy versus enhanced care

1

211

Std. Mean Difference (IV, Random, 95% CI)

‐0.20 [‐0.47, 0.07]

3 Severity of somatic symptoms > 1 year after treatment Show forest plot

2

172

Std. Mean Difference (IV, Random, 95% CI)

‐0.32 [‐0.73, 0.10]

3.1 Cognitive behavioural therapy versus enhanced care

1

82

Std. Mean Difference (IV, Random, 95% CI)

‐0.53 [‐0.98, ‐0.09]

3.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

90

Std. Mean Difference (IV, Random, 95% CI)

‐0.11 [‐0.53, 0.30]

4 Acceptability Show forest plot

5

679

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.87, 1.00]

4.1 Cognitive behavioural therapy versus enhanced care

3

349

Risk Ratio (M‐H, Random, 95% CI)

0.91 [0.82, 1.02]

4.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

119

Risk Ratio (M‐H, Random, 95% CI)

0.91 [0.82, 1.01]

4.3 Psychodynamic therapy versus enhanced care

1

211

Risk Ratio (M‐H, Random, 95% CI)

1.01 [0.89, 1.14]

5 Severity of anxiety or depressive symptoms (or both) at end of treatment Show forest plot

5

624

Std. Mean Difference (IV, Random, 95% CI)

‐0.14 [‐0.30, 0.02]

5.1 Cognitive behavioural therapy versus enhanced care

3

307

Std. Mean Difference (IV, Random, 95% CI)

‐0.17 [‐0.40, 0.05]

5.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

106

Std. Mean Difference (IV, Random, 95% CI)

‐0.05 [‐0.43, 0.33]

5.3 Psychodynamic therapy versus enhanced care

1

211

Std. Mean Difference (IV, Random, 95% CI)

‐0.13 [‐0.40, 0.14]

6 Severity of anxiety or depressive symptoms (or both) within 1 year after treatment Show forest plot

5

593

Std. Mean Difference (IV, Random, 95% CI)

‐0.13 [‐0.29, 0.03]

6.1 Cognitive behavioural therapy versus enhanced care

3

289

Std. Mean Difference (IV, Random, 95% CI)

‐0.17 [‐0.40, 0.06]

6.2 Third‐wave behavioural therapy versus enhanced care

1

93

Std. Mean Difference (IV, Random, 95% CI)

‐0.04 [‐0.45, 0.36]

6.3 Psychodynamic therapy versus enhanced care

1

211

Std. Mean Difference (IV, Random, 95% CI)

‐0.11 [‐0.38, 0.16]

7 Severity of anxiety or depressive symptoms (or both) > 1 year after treatment Show forest plot

2

184

Std. Mean Difference (IV, Random, 95% CI)

‐0.26 [‐0.55, 0.03]

7.1 Cognitive behavioural therapy versus enhanced care

1

94

Std. Mean Difference (IV, Random, 95% CI)

‐0.36 [‐0.77, 0.04]

7.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

90

Std. Mean Difference (IV, Random, 95% CI)

‐0.15 [‐0.56, 0.26]

8 Dysfunctional cognitions, emotions, and behaviours at end of treatment Show forest plot

4

499

Std. Mean Difference (IV, Random, 95% CI)

‐0.09 [‐0.29, 0.10]

8.1 Cognitive behavioural therapy versus enhanced care

2

182

Std. Mean Difference (IV, Random, 95% CI)

‐0.28 [‐0.57, 0.01]

8.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

106

Std. Mean Difference (IV, Random, 95% CI)

0.06 [‐0.32, 0.44]

8.3 Psychodynamic therapy versus enhanced care

1

211

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.27, 0.27]

9 Dysfunctional cognitions, emotions, and behaviours within 1 year after treatment Show forest plot

4

477

Std. Mean Difference (IV, Random, 95% CI)

‐0.24 [‐0.49, 0.00]

9.1 Cognitive behavioural therapy versus enhanced care

2

173

Std. Mean Difference (IV, Random, 95% CI)

‐0.45 [‐0.83, ‐0.07]

9.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

93

Std. Mean Difference (IV, Random, 95% CI)

‐0.03 [‐0.44, 0.38]

9.3 Psychodynamic therapy versus enhanced care

1

211

Std. Mean Difference (IV, Random, 95% CI)

‐0.13 [‐0.40, 0.14]

10 Dysfunctional cognitions, emotions, and behaviours > 1 year after treatment Show forest plot

2

184

Std. Mean Difference (IV, Random, 95% CI)

‐0.58 [‐1.27, 0.11]

10.1 Cognitive behavioural therapy versus enhanced care

1

94

Std. Mean Difference (IV, Random, 95% CI)

‐0.94 [‐1.36, ‐0.51]

10.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

90

Std. Mean Difference (IV, Random, 95% CI)

‐0.23 [‐0.64, 0.19]

11 Functional disability and quality of life at end of treatment Show forest plot

4

497

Std. Mean Difference (IV, Random, 95% CI)

0.13 [‐0.05, 0.30]

11.1 Cognitive behavioural therapy versus enhanced care

2

182

Std. Mean Difference (IV, Random, 95% CI)

0.21 [‐0.08, 0.51]

11.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

104

Std. Mean Difference (IV, Random, 95% CI)

0.07 [‐0.31, 0.46]

11.3 Psychodynamic therapy at end of treatment

1

211

Std. Mean Difference (IV, Random, 95% CI)

0.08 [‐0.19, 0.35]

12 Functional disability and quality of life within 1 year after treatment Show forest plot

4

476

Std. Mean Difference (IV, Random, 95% CI)

0.20 [0.02, 0.38]

12.1 Cognitive behavioural therapy versus enhanced care

2

173

Std. Mean Difference (IV, Random, 95% CI)

0.30 [0.00, 0.60]

12.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

92

Std. Mean Difference (IV, Random, 95% CI)

0.10 [‐0.31, 0.51]

12.3 Psychodynamic therapy versus enhanced care

1

211

Std. Mean Difference (IV, Random, 95% CI)

0.16 [‐0.11, 0.43]

13 Functional disability and quality of life > 1 year of treatment Show forest plot

2

184

Std. Mean Difference (IV, Random, 95% CI)

0.22 [‐0.16, 0.60]

13.1 Cognitive behavioural therapy versus enhanced care

1

94

Std. Mean Difference (IV, Random, 95% CI)

0.42 [0.01, 0.83]

13.2 Third‐wave cognitive behavioural therapy versus enhanced care

1

90

Std. Mean Difference (IV, Random, 95% CI)

0.03 [‐0.39, 0.44]

14 Healthcare use at end of treatment Show forest plot

2

334

Std. Mean Difference (IV, Random, 95% CI)

‐0.03 [‐0.33, 0.28]

14.1 Cognitive behavioural therapy versus enhanced care

1

123

Std. Mean Difference (IV, Random, 95% CI)

‐0.21 [‐0.56, 0.15]

14.2 Psychodynamic therapy versus enhanced care

1

211

Std. Mean Difference (IV, Random, 95% CI)

0.11 [‐0.16, 0.38]

15 Healthcare use within 1 year after treatment Show forest plot

2

319

Std. Mean Difference (IV, Random, 95% CI)

‐0.24 [‐0.46, ‐0.01]

15.1 Cognitive behavioural therapy versus enhanced care

1

108

Std. Mean Difference (IV, Random, 95% CI)

‐0.08 [‐0.46, 0.30]

15.2 Psychodynamic therapy versus enhanced care

1

211

Std. Mean Difference (IV, Random, 95% CI)

‐0.32 [‐0.59, ‐0.05]

1 Severity of somatic symptoms at end of treatment Show forest plot

1

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only

2 Acceptability Show forest plot

1

Risk Ratio (M‐H, Random, 95% CI)

Subtotals only

3 Severity of anxiety or depressive symptoms (or both) at end of treatment Show forest plot

1

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only

4 Functional disability and quality of life at end of treatment Show forest plot

1

Std. Mean Difference (IV, Random, 95% CI)

Subtotals only