Liječenje postoperativne boli blokom perifernih živaca nakon velike operacije koljena
Appendices
Appendix 1. Search strategies
CENTRAL (Cochrane Library)
#1MeSH descriptor: [Arthroplasty, Replacement, Knee] explode all trees
#2MeSH descriptor: [Knee Prosthesis] explode all trees
#3MeSH descriptor: [Anterior Cruciate Ligament Reconstruction] explode all trees
#4knee*:it,ab,kw (Word variations have been searched)
#5#1 or #2 or #3 or #4
#6MeSH descriptor: [Pain, Postoperative] explode all trees
#7MeSH descriptor: [Analgesia] explode all trees
#8MeSH descriptor: [Pain Management] explode all trees
#9MeSH descriptor: [Analgesia, Patient‐Controlled] explode all trees
#10((postoperat* or post‐operat* or "after operat*" or "follow* operat*" or postsurg* or post‐surg* or "after surg*" or "follow* surg*") near/6 (pain* or analgesi*)):ti,ab,kw (Word variations have been searched)
#11#6 or #7 or #8 or #9 or #10
#12MeSH descriptor: [Nerve Block] explode all trees
#13("nerve near/3 block*" or chemodenervation or "chemical near/1 neurolys?s"):ti,ab,kw (Word variations have been searched)
#14#12 or #13
#15#5 and #11 and #14
MEDLINE & MEDLINE in Process (OVID)
1. exp arthroplasty, replacement, knee/
2. exp knee prosthesis/
3. exp anterior cruciate ligament reconstruction/
4. knee*.mp.
5. or/1‐4
6. exp pain, postoperative/
7. exp analgesia/
8. exp pain management/
9. exp analgesia, patient‐controlled/
10. ((postoperat* or post‐operat* or "after operat*" or "follow* operat*" or postsurg* or post‐surg* or "after surg*" or "follow* surg*") adj6 (pain* or analgesi*)).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]
11. 7 or 8 or 9 or 10
12. exp nerve block/
13. ("nerve adj3 block*" or chemodenervation or "chemical adj1 neurolys?s").mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier]
14. 12 or 13
15. 5 and 11 and 14
16. randomized controlled trial.pt.
17. controlled clinical trial.pt.
18. randomized.ab.
19. placebo.ab.
20. drug therapy.fs.
21. randomly.ab.
22. trial.ab.
23. or/16‐22
24. exp animals/ not humans.sh.
25. 23 not 24
26. 15 and 25
EMBASE (OVID)
1. exp knee arthroplasty/
2. exp knee prosthesis/
3. exp anterior cruciate ligament reconstruction/
4. knee*.mp.
5. or/1‐4
6. exp postoperative pain/
7. exp analgesia/
8. exp patient controlled analgesia/
9. ((postoperat* or post‐operat* or "after operat*" or "follow* operat*" or postsurg* or post‐surg* or "after surg*" or "follow* surg*") adj6 (pain* or analgesi*)).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword]
10. 7 or 8 or 9
11. exp nerve block/
12. ("nerve adj3 block*" or chemodenervation or "chemical adj1 neurolys?s").mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword]
13. 11 or 12
14. 5 and 10 and 13
15. random$.tw.
16. factorial$.tw.
17. crossover$.tw.
18. cross over$.tw.
19. cross‐over$.tw.
20. placebo$.tw.
21. (doubl$ adj blind$).tw.
22. (singl$ adj blind$).tw.
23. assign$.tw.
24. allocat$.tw.
25. volunteer$.tw.
26. Crossover Procedure/
27. double‐blind procedure.tw.
28. Randomized Controlled Trial/
29. Single Blind Procedure/
30. or/15‐29
31. (animal/ or nonhuman/) not human/
32. 30 not 31
33. 14 and 32
Study flow diagram.
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 1 Pain intensity at rest (0 ‐ 23 hours postoperatively).
Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 2 Pain intensity at rest (24 ‐ 47 hours postoperatively).
Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 3 Pain intensity at rest (48 ‐ 72 hours postoperatively).
Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 4 Pain intensity on movement (0 ‐ 23 hours postoperatively).
Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 5 Pain intensity on movement (24 ‐ 47 hours postoperatively).
Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 6 Pain intensity on movement (48 ‐ 72 hours postoperatively).
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Pain intensity at rest (0 ‐ 23 hours postoperatively) Show forest plot | 7 | 390 | Mean Difference (IV, Random, 95% CI) | ‐11.85 [‐20.45, ‐3.25] |
| 1.1 Total knee arthroplasty | 3 | 183 | Mean Difference (IV, Random, 95% CI) | ‐19.50 [‐35.01, ‐3.99] |
| 1.2 Anterior cruciate ligament reconstruction | 3 | 167 | Mean Difference (IV, Random, 95% CI) | ‐2.82 [‐8.03, 2.38] |
| 1.3 Partial menisectomy arthroscopically | 1 | 40 | Mean Difference (IV, Random, 95% CI) | ‐15.60 [‐22.84, ‐8.36] |
| 2 Pain intensity at rest (24 ‐ 47 hours postoperatively) Show forest plot | 6 | 320 | Mean Difference (IV, Random, 95% CI) | ‐12.92 [‐19.82, ‐6.02] |
| 2.1 Total knee arthroplasty | 4 | 224 | Mean Difference (IV, Random, 95% CI) | ‐15.05 [‐24.11, ‐5.98] |
| 2.2 Anterior cruciate ligament reconstruction | 1 | 56 | Mean Difference (IV, Random, 95% CI) | ‐0.10 [‐11.59, 11.39] |
| 2.3 Partial menisectomy arthroscopically | 1 | 40 | Mean Difference (IV, Random, 95% CI) | ‐15.50 [‐22.27, ‐8.73] |
| 3 Pain intensity at rest (48 ‐ 72 hours postoperatively) Show forest plot | 4 | 210 | Mean Difference (IV, Random, 95% CI) | ‐9.72 [‐16.75, ‐2.70] |
| 3.1 Total knee arthroplasty | 3 | 154 | Mean Difference (IV, Random, 95% CI) | ‐13.73 [‐18.21, ‐9.26] |
| 3.2 Anterior cruciate ligament reconstruction | 1 | 56 | Mean Difference (IV, Random, 95% CI) | ‐0.5 [‐10.60, 9.60] |
| 4 Pain intensity on movement (0 ‐ 23 hours postoperatively) Show forest plot | 5 | 304 | Mean Difference (IV, Random, 95% CI) | ‐6.95 [‐15.92, 2.01] |
| 4.1 Total knee arthroplasty | 2 | 153 | Mean Difference (IV, Random, 95% CI) | ‐12.93 [‐26.62, 0.75] |
| 4.2 Anterior cruciate ligament reconstruction | 2 | 111 | Mean Difference (IV, Random, 95% CI) | 0.10 [‐7.49, 7.70] |
| 4.3 Partial menisectomy arthroscopically | 1 | 40 | Mean Difference (IV, Random, 95% CI) | ‐7.5 [‐19.91, 4.91] |
| 5 Pain intensity on movement (24 ‐ 47 hours postoperatively) Show forest plot | 3 | 182 | Mean Difference (IV, Random, 95% CI) | ‐8.87 [‐27.77, 10.03] |
| 6 Pain intensity on movement (48 ‐ 72 hours postoperatively) Show forest plot | 2 | 112 | Mean Difference (IV, Fixed, 95% CI) | ‐6.19 [‐11.76, ‐0.62] |
