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Cochrane Database of Systematic Reviews

Fibrin‐based haemostatic agents for reducing blood loss in adult liver resection

Esta versión no es la más reciente

ver la versión actual 08 agosto 2023

Información

DOI:
https://doi.org/10.1002/14651858.CD010872Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 12 diciembre 2013see what's new
Tipo:
  1. Intervention
Etapa:
  1. Protocol
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Hepatobiliar

Copyright:
  1. Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Contraer

Autores

  • Aimen O Amera

    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

    These authors contributed equally to this work.

  • Colin H Wilsona

    Correspondencia a: Institute of Transplantation, The Freeman Hospital, Newcastle upon Tyne, UK

    [email protected]

    [email protected]

    These authors contributed equally to this work.

  • Steven A White

    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

  • Derek M Manas

    Institute of Transplantation, The Freeman Hospital, Newcastle upon Tyne, UK

Contributions of authors

AO Amer conceived and designed the review protocol. CH Wilson is the co‐author of this review protocol. Both authors have made equal contributions to designing and writing the protocol, and the pro‐formas for trial selection and data extraction. SA White and DM Manas have both provided advise on the design and writing of the protocol. All authors approved of the final protocol version.

Sources of support

Internal sources

  • Institute of Transplantation, The Freeman Hospital, Newcastle upon Tyne, UK.

External sources

  • The Editorial Team Office, The Cochrane Hepato‐Biliary Group, Copenhagen, Denmark.

Declarations of interest

None declared.

Acknowledgements

Peer reviewers: Sebastian Hinz, Germany; Janus C Jakobsen, Denmark.
Contact editor: Ronald L Koretz, USA.

Version history

Published

Title

Stage

Authors

Version

2023 Aug 08

Fibrin‐based haemostatic agents for reducing blood loss in adult liver resection

Review

Abdullah K Malik, Aimen O Amer, Samuel J Tingle, Emily R Thompson, Steven A White, Derek M Manas, Colin Wilson

https://doi.org/10.1002/14651858.CD010872.pub2

2013 Dec 12

Fibrin‐based haemostatic agents for reducing blood loss in adult liver resection

Protocol

Aimen O Amer, Colin H Wilson, Steven A White, Derek M Manas

https://doi.org/10.1002/14651858.CD010872

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Table 1. Surgical and anaesthetic techniques used to minimise intraoperative blood loss and maintain haemostasis in liver surgery*

Anaesthetic techniques

Surgical techniques

Surgical instruments

Lowering venous pressure

Anatomical dissection

CUSA1

Autologous transfusion

Hepatic inflow occlusion

RFA2 needle dissection

Antifibrinolytic agents

Ischaemic preconditioning

Monopolar Dissecting Sealer3

 

Total vascular exclusion

Water jet dissection4

 

In situ hypothermic perfusion

Argon beam coagulation

Harmonic scalpel5

*Adapted from Berrevoet 2007.
1Cavitron ultrasonic surgical aspirator.
2Radiofrequency ablation.
3Saline‐linked radiofrequency sealer (TissueLink Medical Inc.).
4Laminar liquid jet dissection.
5Vibration‐powered coagulation and cutting device (Ethicon Endo‐Surgery).

Figuras y tablas -
Table 1. Surgical and anaesthetic techniques used to minimise intraoperative blood loss and maintain haemostasis in liver surgery*
Ir a la tabla del protocolo
Table 2. Examples of fibrin‐based haemostatic agents and their main components

Product name

Fibrinogen concentration (mg/mL)

Thrombin concentration (IU/mL)

Factor XIII concentration (U/mL)

Antifibrinolytic agent

Beriplast®P (CSL Behring, Germany)

90

500

60

Bovine aprotinin: 1000 KIU/mL

Biocol® (LFB, France)

127

558

11

Bovine aprotinin: 3000 KIU/mL

Bolheal® (Kaketsuken Pharmaceutical, Japan)

80

250

75

Bovine aprotinin: 1000 KIU/mL

Evicel® ‐ formerly Crosseal® (Omrix Biopharmaceuticals, Israel)

70

1000

None

None

Quixil® (Omrix Biopharmaceuticals, Israel)

50

1000

None

Tranexamic acid: 85 to 105 mg/mL

Tachosil® (Nycomed, Switzerland)

5.5*

2.0**

None

None

Tisseel® (Baxter, Austria)

90

500

30

Bovine aprotinin: 3000 KIU/mL

*mg/cm2.
**IU/cm2.
IU: international units.
KIU: kallikrein inhibitor units.

Figuras y tablas -
Table 2. Examples of fibrin‐based haemostatic agents and their main components
Ir a la tabla del protocolo