ارزیابی پیش از بارداری خطر برای ابتلا به تالاسمی، بیماری سلول داسیشکل، فیبروز سیستیک و بیماری تای‐ساکس
Referencias
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منابع دیگر نسخههای منتشرشده این مرور
Characteristics of studies
Characteristics of excluded studies [ordered by study ID]
Ir a:
| Study | Reason for exclusion |
| Participants: couples planning to marry and applying for marriage licence Intervention: premarital screening programme for sickle cell and beta‐thalassemia Comparator: none Outcome: number confirmed sickle cell and beta thalassemia carriers, decision for marriage Design: observational, cross‐sectional study Excluded due to non‐RCT design | |
| Participants: adults 18 ‐ 45 years Intervention: genetic carrier testing for cystic fibrosis Comparator: none Outcome: anxiety Design: observational, before and after intervention study Excluded due to non‐RCT study design | |
| Participants: infertile couples undergoing cystic fibrosis screening as part of assisted reproduction process Intervention: genetic counselling via computer program Comparator: standard care genetic counselling session Outcome: knowledge Design: RCT Excluded because intervention was method of delivering genetic counselling and not preconception genetic carrier testing or screening compared to standard care | |
| Participants: relatives of people with cystic fibrosis Intervention: home‐based pretest education from pamphlet with genetic test Comparator: clinic based pretest education via genetic counselling with genetic test Outcome: anxiety, knowledge, satisfaction, reproductive intent Design: RCT Excluded because intervention was method of delivering genetic counselling and not preconception genetic carrier testing or screening compared to standard care | |
| Participants: carriers of Tay‐Sachs disease identified prospectively or retrospectively during population screening Intervention: genetic carrier population screening Comparator: none Outcomes: knowledge, attitudes, anxiety, concerns, satisfaction Design: observational, cross‐sectional Excluded due to non‐RCT study design | |
| Participants: non‐pregnant adults visiting clinical and non‐clinical sites Intervention: genetic carrier testing for cystic fibrosis Comparator: none Outcome: attitudes, beliefs Design: observational, before and after intervention design Excluded due to non‐RCT study design | |
| Participants: adults carriers of beta‐thalassaemia 18 ‐ 65 years in a HMO Intervention: genetic counselling through video Comparator: conventional counselling by trained physician Outcome: knowledge, sexual activity, mood change, behaviour, anxiety Design: RCT Excluded because intervention is not preconception genetic carrier testing or screening | |
| Participants: adults of Ashkenazi Jewish background in prenatal and preconception settings Intervention: genetic carrier screening and education programme for Tay‐Sachs disease Comparator: none Outcome: knowledge, concern, attitudes, perceptions of genetic risk Design: observational, before and after intervention Excluded due to non‐RCT study design | |
| Participants: adults aged 20 ‐ 35 years invited through Municipal Health Service or General Practitioner Intervention: genetic carrier screening for cystic fibrosis Comparator: none Outcome: knowledge, attitudes, understanding, satisfaction, psychological well‐being, uptake, worry, reproductive intentions, sharing of information Design: observational, before and after intervention Excluded due to non‐RCT study design | |
| Participants: adults 18 ‐ 50 years in a primary care setting Intervention: genetic carrier testing and counselling for cystic fibrosis Comparator: none Outcome: anxiety, knowledge Design: observational, before and after intervention Excluded due to non‐RCT study design | |
| Participants: adults 16 ‐ 45 years in one primary care practice in South Wales Intervention: genetic carrier testing for cystic fibrosis Comparator: none Outcome: knowledge, anxiety Design: observational, before and after intervention Excluded due to non‐RCT study design | |
| Participants: adults 18 ‐ 44 years in a HMO Intervention: invitation offering cystic fibrosis carrier screening and information giving either by personal education on‐site or by mailed brochure Comparator: none Outcome: attitudes, tolerance, utilization Design: observational, before and after intervention Excluded due to non‐RCT study design | |
| Participants: Parents of infants with positive newborn screening results for cystic fibrosis and one identified CFTR mutation Intervention: Genetic counselling plus four‐minute video on cystic fibrosis Comparator: Genetic counselling only Outcome: Knowledge: understanding of carrier status, autosomal recessive inheritance, the newborn screening process, and symptoms of CF Design: RCT Excluded due to intervention was method of delivering genetic counselling and education and not preconception genetic carrier testing or screening | |
| Participants: adults 16 ‐ 44 years from primary care practices and family planning clinics Intervention: genetic carrier testing for cystic fibrosis Comparator: none Outcome: anxiety, response to positive results, knowledge, reproductive intentions, behaviour Design: observational, before and after intervention Excluded due to non‐RCT study design | |
| Participants: adults 18 ‐ 35 years with sickle cell disease or sickle cell trait from clinics and community settings Intervention: web‐based multimedia educational intervention Comparator: usual care information e‐book Outcome: knowledge, reproductive intent and behaviour Design: randomised controlled trial Excluded because intervention was the delivery of education and not preconception genetic carrier testing or screening |
HMO: health maintenance organisation
RCT: randomised controlled trial
Characteristics of ongoing studies [ordered by study ID]
Ir a:
| Trial name or title | Design of a randomised controlled trial for genomic carrier screening in healthy patients seeking preconception genetic testing |
| Methods | Randomised controlled trial |
| Participants | Women who received carrier screening for cystic fibrosis |
| Interventions | Genome sequencing |
| Outcomes | Patient‐reported outcomes (PROs), economic outcomes |
| Starting date | 2017 |
| Contact information | Centre for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave. USA |
| Notes |
Study flow diagram
