Term

Definition

Complement‐dependent cytotoxicity (CDC)

Binding of the antibody recruits complement proteins, which punch holes in the cell membrane, flooding the cell and leading to celllysis.

Apoptosis

Binding of the antibody signals the cell to self‐destruct.

Antibody‐dependent cell‐mediated cytotoxicity (ADCC)

Natural killer cells, T cells, and macrophages are involved in recognizing and killing antibody‐labelled target cells, leading to celllysis.

No.

PubMed

Embase

LILACS

#1

Hemophilia

Hemophilia

Hemophilia/Haemophilia

#2

"Hemophilia A/drug therapy"[Mesh]

'hemophilia'/exp

Hemophilia/Haemophilia

#3

"Hemophilia B/drug therapy"[Mesh]

'rituximab'/exp

Ritux$

#4

"rituximab" [Supplementary Concept]

Ritux*

rituximab

#5

Ritux*

'mabthera'/exp

#1 OR #2

#6

Mabthera

mabthera

#3 OR #4

#7

"Antibodies, Monoclonal, Murine‐Derived/therapeutic use"[Mesh]

Antibodies

#5 AND #6

#8

#1‐#3/OR

Monoclonal

#9

#4‐#7/OR

Murine‐Derived

#10

#8 AND #9

#1 OR #2

#11

#3‐#6/OR

#12

#7‐#9/AND

#13

#11 OR #12

#14

#10 AND #13