Co‐enzyme Q10 supplementation for the primary prevention of cardiovascular disease

Scolaris Content Display Scolaris Content Display

Ir a:

Figure 1

Study flow diagram.

Figure 2

'Risk of bias' graph: authors' judgements about each risk of bias item presented as percentages across all included studies.

Figure 3

'Risk of bias' summary: authors' judgements about each risk of bias item for each included study.

Analysis 1.1

Comparison 1 CoQ10, Outcome 1 Systolic blood pressure.

Analysis 1.2

Comparison 1 CoQ10, Outcome 2 Diastolic blood pressure.

Analysis 1.3

Comparison 1 CoQ10, Outcome 3 Total cholesterol.

Analysis 1.4

Comparison 1 CoQ10, Outcome 4 HDL‐cholesterol.

Analysis 1.5

Comparison 1 CoQ10, Outcome 5 Triglycerides.

Table 1. Country, baseline CoQ10 levels and dose of CoQ10 supplementation

Study	Country	Baseline CoQ10 level	Dose of CoQ10 level studied (mg/day)	Statin therapy	Duration of CoQ10 intervention
Bargossi 1994	Italy	Plasma 1.20 mg/dL equivalent to 12,000 µg/L (intervention group) 1.08 mg/dL equivalent to 10,800 µg/L (control group)	100	Yes	90 days
Kaikkonen 2000	Finland	Plasma 0.83 ± 0.04 µmol/L equivalent to 716.57 ± 34.53 µg/L (intervention group) 1.07 ± 0.10 µmol/L equivalent to 923.77 ± 86.33 µg/L (control group)	200	Yes	3 months
Lee 2011	Seoul, Republic of Korea	Serum 0.63 ± 0.25 µg/ml equivalent to 630 ± 250 µg/L (intervention group) 0.65 ± 0.27 µg/ml equivalent to 650 ± 270 µg/L (control group)	200	No	12 weeks
Mabuchi 2007	Japan	Plasma 1.113 ± 0.444 µmol/L equivalent to 960.90 ± 383.32 µg/L (intervention group) 1.180 ± 0.282 µmol/L equivalent to 1018.74 ± 243.46 µg/L (control group)	100	Yes	12 weeks
Yamagami 1986	Japan	Serum 0.704 ± 0.04 µg/ml equivalent to 704 ± 40µg/L (intervention group) 0.626 ± 0.05 µg/ml equivalent to 626 ± 50 µg/L (control group)	100	No	12 weeks
Young 2007	New Zealand	Plasma 1.3 (1.0 to 1.4) µmol/L equivalent to 1122.34 ± (863.34 to 1208.68) µg/L (intervention group) 1.4 (1.1 to 1.8) µmol/L equivalent to 1208.68 ± (949.67 to 1554.01) µg/L (control group)	200	Yes	12 weeks
Conversions: Mass (g) = N^o moles(n) x molecular mass (gmol^‐1) Molecular mass CoQ10 is 863.34 g

Table 1. Country, baseline CoQ10 levels and dose of CoQ10 supplementation

Comparison 1. CoQ10

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Systolic blood pressure Show forest plot	2		Mean Difference (IV, Fixed, 95% CI)	Totals not selected

2 Diastolic blood pressure Show forest plot	2	71	Mean Difference (IV, Random, 95% CI)	‐1.62 [‐5.20, 1.96]

3 Total cholesterol Show forest plot	1	51	Mean Difference (IV, Fixed, 95% CI)	0.30 [‐0.10, 0.70]

4 HDL‐cholesterol Show forest plot	1	51	Mean Difference (IV, Fixed, 95% CI)	0.02 [‐0.13, 0.17]

5 Triglycerides Show forest plot	1	51	Mean Difference (IV, Fixed, 95% CI)	0.05 [‐0.42, 0.52]

Comparison 1. CoQ10