Supplémentation en coenzyme Q10 dans la prévention primaire des cardiopathies
Appendices
Appendix 1. Search strategies November 2013
CENTRAL, DARE, HTA, NEED on The Cochrane Library
#1 MeSH descriptor: [Cardiovascular Diseases] explode all trees
#2 cardio*
#3 cardia*
#4 heart*
#5 coronary*
#6 angina*
#7 ventric*
#8 myocard*
#9 pericard*
#10 isch?em*
#11 emboli*
#12 arrhythmi*
#13 thrombo*
#14 atrial next fibrillat*
#15 tachycardi*
#16 endocardi*
#17 (sick next sinus)
#18 MeSH descriptor: [Stroke] explode all trees
#19 (stroke or stokes)
#20 cerebrovasc*
#21 cerebral next vascular
#22 apoplexy
#23 (brain near/2 accident*)
#24 ((brain* or cerebral or lacunar) near/2 infarct*)
#25 MeSH descriptor: [Hypertension] explode all trees
#26 hypertensi*
#27 (peripheral next arter* next disease*)
#28 ((high or increased or elevated) near/2 blood pressure)
#29 MeSH descriptor: [Hyperlipidemias] explode all trees
#30 hyperlipid*
#31 hyperlip?emia*
#32 hypercholesterol*
#33 hypercholester?emia*
#34 hyperlipoprotein?emia*
#35 hypertriglycerid?emia*
#36 MeSH descriptor: [Arteriosclerosis] explode all trees
#37 MeSH descriptor: [Cholesterol] explode all trees
#38 cholesterol
#39 "coronary risk factor*"
#40 MeSH descriptor: [Blood Pressure] this term only
#41 "blood pressure"
#42 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28 or #29 or #30 or #31 or #32 or #33 or #34 or #35 or #36 or #37 or #38 or #39 or #40 or #41
#43 MeSH descriptor: [Ubiquinone] this term only
#44 ubiquinone
#45 ubiquinol‐10
#46 ubidecarenone
#47 "Coenzyme Q"
#48 "coenzyme Q10"
#49 CoQ10
#50 caomet
#51 decorenone
#52 mitocor
#53 neuquinone
#54 "quinone q 10"
#55 ubimaior
#56 ubiten
#57 #43 or #44 or #45 or #46 or #47 or #48 or #49 or #50 or #51 or #52 or #53 or #54 or #55 or #56
#58 #42 and #57
MEDLINE OVID
1. exp Cardiovascular Diseases/
2. cardio*.tw.
3. cardia*.tw.
4. heart*.tw.
5. coronary*.tw.
6. angina*.tw.
7. ventric*.tw.
8. myocard*.tw.
9. pericard*.tw.
10. isch?em*.tw.
11. emboli*.tw.
12. arrhythmi*.tw.
13. thrombo*.tw.
14. atrial fibrillat*.tw.
15. tachycardi*.tw.
16. endocardi*.tw.
17. (sick adj sinus).tw.
18. exp Stroke/
19. (stroke or stokes).tw.
20. cerebrovasc*.tw.
21. cerebral vascular.tw.
22. apoplexy.tw.
23. (brain adj2 accident*).tw.
24. ((brain* or cerebral or lacunar) adj2 infarct*).tw.
25. exp Hypertension/
26. hypertensi*.tw.
27. peripheral arter* disease*.tw.
28. ((high or increased or elevated) adj2 blood pressure).tw.
29. exp Hyperlipidemias/
30. hyperlipid*.tw.
31. hyperlip?emia*.tw.
32. hypercholesterol*.tw.
33. hypercholester?emia*.tw.
34. hyperlipoprotein?emia*.tw.
35. hypertriglycerid?emia*.tw.
36. exp Arteriosclerosis/
37. exp Cholesterol/
38. cholesterol.tw.
39. "coronary risk factor* ".tw.
40. Blood Pressure/
41. blood pressure.tw.
42. or/1‐41
43. coenzyme Q10.tw.
44. Ubiquinone/
45. Ubiquinone.tw.
46. Ubiquinol‐10.tw.
47. Ubidecarenone.tw.
48. Coenzyme Q.tw.
49. CoQ10.tw.
50. caomet.tw.
51. decorenone.tw.
52. mitocor.tw.
53. neuquinone.tw.
54. quinone q 10.tw.
55. ubimaior.tw.
56. ubiten.tw.
57. or/43‐56
58. 42 and 57
59. randomized controlled trial.pt.
60. controlled clinical trial.pt.
61. randomized.ab.
62. placebo.ab.
63. drug therapy.fs.
64. randomly.ab.
65. trial.ab.
66. groups.ab.
67. 59 or 60 or 61 or 62 or 63 or 64 or 65 or 66
68. exp animals/ not humans.sh.
69. 67 not 68
70. 58 and 69
EMBASE OVID
1. exp cardiovascular disease/
2. cardio*.tw.
3. cardia*.tw.
4. heart*.tw.
5. coronary*.tw.
6. angina*.tw.
7. ventric*.tw.
8. myocard*.tw.
9. pericard*.tw.
10. isch?em*.tw.
11. emboli*.tw.
12. arrhythmi*.tw.
13. thrombo*.tw.
14. atrial fibrillat*.tw.
15. tachycardi*.tw.
16. endocardi*.tw.
17. (sick adj sinus).tw.
18. exp cerebrovascular disease/
19. (stroke or stokes).tw.
20. cerebrovasc*.tw.
21. cerebral vascular.tw.
22. apoplexy.tw.
23. (brain adj2 accident*).tw.
24. ((brain* or cerebral or lacunar) adj2 infarct*).tw.
25. exp hypertension/
26. hypertensi*.tw.
27. peripheral arter* disease*.tw.
28. ((high or increased or elevated) adj2 blood pressure).tw.
29. exp hyperlipidemia/
30. hyperlipid*.tw.
31. hyperlip?emia*.tw.
32. hypercholesterol*.tw.
33. hypercholester?emia*.tw.
34. hyperlipoprotein?emia*.tw.
35. hypertriglycerid?emia*.tw.
36. exp Arteriosclerosis/
37. exp Cholesterol/
38. cholesterol.tw.
39. "coronary risk factor*".tw.
40. Blood Pressure/
41. blood pressure.tw.
42. or/1‐41
43. ubidecarenone/
44. coenzyme Q10.tw.
45. ubiquinone.tw.
46. ubiquinol‐10.tw.
47. ubidecarenone.tw.
48. Coenzyme Q.tw.
49. CoQ10.tw.
50. caomet.tw.
51. decorenone.tw.
52. mitocor.tw.
53. neuquinone.tw.
54. quinone q 10.tw.
55. ubimaior.tw.
56. ubiten.tw.
57. or/43‐56
58. 42 and 57
59. random$.tw.
60. factorial$.tw.
61. crossover$.tw.
62. cross over$.tw.
63. cross‐over$.tw.
64. placebo$.tw.
65. (doubl$ adj blind$).tw.
66. (singl$ adj blind$).tw.
67. assign$.tw.
68. allocat$.tw.
69. volunteer$.tw.
70. crossover procedure/
71. double blind procedure/
72. randomized controlled trial/
73. single blind procedure/
74. 59 or 60 or 61 or 62 or 63 or 64 or 65 or 66 or 67 or 68 or 69 or 70 or 71 or 72 or 73
75. (animal/ or nonhuman/) not human/
76. 74 not 75
77. 58 and 76
78. limit 77 to embase
Web of Science
#15 #14 AND #13
#14 TS=((random* or blind* or allocat* or assign* or trial* or placebo* or crossover* or cross‐over*))
#13 #12 AND #9
#12 #11 OR #10
#11 TS=(caomet or decorenone or mitocor or neuquinone or (quinone NEXT q NEXT 10) or ubimaior or ubiten)
#10 TS=((coenzyme NEXT Q10) or Ubiquinone or Ubiquinol‐10 or Ubidecarenone or (Coenzyme NEXT Q) or CoQ10)
#9 #8 OR #7 OR #6 OR #5 OR #4 OR #3 OR #2 OR #1
#8 TS=(arteriosclerosis or cholesterol or "coronary risk factor*" or "blood pressure")
#7 TS=(hyperlipid* or hyperlip?emia* or hypercholesterol* or hypercholester?emia* or hyperlipoprotein?emia* or hypertriglycerid?emia*)
#6 TS=(high near/2 "blood pressure" or increased near/2 "blood pressure" or elevated near/2 "blood pressure")
#5 TS=(brain* near/2 infarct or cerebral near/2 infarct or lacunar near/2 infarct* or hypertensi* or "peripheral arter* disease*")
#4 TS=("cerebral vascular" or apoplexy or brain near/2 accident*)
#3 TS=("atrial fibrillat*" or tachycardi* or endocardi* or "sick sinus" or stroke or stokes or cerebrovasc*)
#2 TS=(myocard* or pericard* or isch?em* or emboli* or arrhythmi* or thrombo*)
#1 TS=(cardio* or cardia* or heart* or coronary* or angina* or ventric*)
Appendix 2. Search strategies for trial registers
metaRegister of controlled trials (mRCT), Clinical trials.gov, the WHO International Clinical Trials Registry platform (ICTRP)
1. Coenzyme Q10
Study flow diagram.
'Risk of bias' graph: authors' judgements about each risk of bias item presented as percentages across all included studies.
'Risk of bias' summary: authors' judgements about each risk of bias item for each included study.
Comparison 1 CoQ10, Outcome 1 Systolic blood pressure.
Comparison 1 CoQ10, Outcome 2 Diastolic blood pressure.
Comparison 1 CoQ10, Outcome 3 Total cholesterol.
Comparison 1 CoQ10, Outcome 4 HDL‐cholesterol.
Comparison 1 CoQ10, Outcome 5 Triglycerides.
| Study | Country | Baseline CoQ10 level | Dose of CoQ10 level studied (mg/day) | Statin therapy | Duration of CoQ10 intervention |
| Italy | Plasma 1.20 mg/dL equivalent to 12,000 µg/L (intervention group) 1.08 mg/dL equivalent to 10,800 µg/L (control group) | 100 | Yes | 90 days | |
| Finland | Plasma 0.83 ± 0.04 µmol/L equivalent to 716.57 ± 34.53 µg/L (intervention group) 1.07 ± 0.10 µmol/L equivalent to 923.77 ± 86.33 µg/L (control group) | 200 | Yes | 3 months | |
| Seoul, Republic of Korea | Serum 0.63 ± 0.25 µg/ml equivalent to 630 ± 250 µg/L (intervention group) 0.65 ± 0.27 µg/ml equivalent to 650 ± 270 µg/L (control group) | 200 | No | 12 weeks | |
| Japan | Plasma 1.113 ± 0.444 µmol/L equivalent to 960.90 ± 383.32 µg/L (intervention group) 1.180 ± 0.282 µmol/L equivalent to 1018.74 ± 243.46 µg/L (control group) | 100 | Yes | 12 weeks | |
| Japan | Serum 0.704 ± 0.04 µg/ml equivalent to 704 ± 40µg/L (intervention group) 0.626 ± 0.05 µg/ml equivalent to 626 ± 50 µg/L (control group) | 100 | No | 12 weeks | |
| New Zealand | Plasma 1.3 (1.0 to 1.4) µmol/L equivalent to 1122.34 ± (863.34 to 1208.68) µg/L (intervention group) 1.4 (1.1 to 1.8) µmol/L equivalent to 1208.68 ± (949.67 to 1554.01) µg/L (control group) | 200 | Yes | 12 weeks | |
| Conversions: Molecular mass CoQ10 is 863.34 g | |||||
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Systolic blood pressure Show forest plot | 2 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 2 Diastolic blood pressure Show forest plot | 2 | 71 | Mean Difference (IV, Random, 95% CI) | ‐1.62 [‐5.20, 1.96] |
| 3 Total cholesterol Show forest plot | 1 | 51 | Mean Difference (IV, Fixed, 95% CI) | 0.30 [‐0.10, 0.70] |
| 4 HDL‐cholesterol Show forest plot | 1 | 51 | Mean Difference (IV, Fixed, 95% CI) | 0.02 [‐0.13, 0.17] |
| 5 Triglycerides Show forest plot | 1 | 51 | Mean Difference (IV, Fixed, 95% CI) | 0.05 [‐0.42, 0.52] |
