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Identification of potentially eligible reports for the original review in 2014.

Figuras y tablas -
Figure 1

Identification of potentially eligible reports for the original review in 2014.

Identification of potentially eligible reports for the first review update in 2015.

Figuras y tablas -
Figure 2

Identification of potentially eligible reports for the first review update in 2015.

Identification of potentially eligible reports for the second review update in 2021.

Figuras y tablas -
Figure 3

Identification of potentially eligible reports for the second review update in 2021.

Summary of findings 1. Summary of findings

Extracorporeal photopheresis (ECP) compared with alternative treatment for chronic graft‐versus‐host disease

Patient or population: children and adolescents with chronic graft‐versus‐host disease after haematopoietic stem cell transplantation

Settings: paediatric hospitals worldwide

Intervention: ECP alone or in combination with standard treatment

Comparison: alternative treatment alone

Outcomes

Anticipated absolute effects* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Risk without ECP

Risk with ECP

Response

not estimable

not estimable

not estimable

0 participants (0 studies)

not applicable

 

Overall survival

not estimable

not estimable

not estimable

0 participants (0 studies)

not applicable

 

Failure‐free survival

not estimable

not estimable

not estimable

0 participants (0 studies)

not applicable

 

Adverse events

not estimable

not estimable

not estimable

0 participants (0 studies)

not applicable

 

Quality of life

not estimable

not estimable

not estimable

0 participants (0 studies)

not applicable

 

Cost of intervention per month

not estimable

not estimable

not estimable

0 participants (0 studies)

not applicable

 

*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% confidence interval).
CI: Confidence interval; RCTs: randomised controlled trials.

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

Figuras y tablas -
Summary of findings 1. Summary of findings