Scolaris Content Display Scolaris Content Display

Unterstützende Interventionen zur Verbesserung der Nahrungsaufnahme von mangelernährten oder Mangelernährungs‐gefährdeten Erwachsenen

Appendices

Appendix 1. Search strategies (inception to March 2013)

Cochrane Library

#1 food* OR meal* OR snack* OR drink* OR feed*: ti,ab
#2 nutri* OR diet*: ti,ab
#3 dining*: ti,ab
#4 screening OR monitoring: ti,ab
#5 documentation OR communication: ti,ab
#6 time* OR timing OR pattern OR style OR arrangement* OR environment*: ti,ab
#7 staff* OR train*: ti,ab
#8 nurs*: ti,ab
#9 healthcare OR health care: ti,ab
#10 cater*: ti,ab
#11 flavo?r* OR taste: ti,ab
#12 content OR composition OR density: ti,ab
#13 appear* OR presentation:ti,ab
#14 size OR portion OR amount: ti,ab
#15 protected meal*: ti,ab
#16 red tray*: ti,ab
#17 fortif*:ti,ab
#18 supplement*: ti,ab
#19 ((supportive OR nutrition* OR diet*) NEAR/3 intervention):ti,ab
#20 (assist* OR help* OR support*):ti,ab
#21 (add* OR extra):ti,ab
#22 (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv*   OR reduc* OR target*):ti,ab
#23 (food* OR meal* OR snack* OR drink* OR feed*) NEAR/3 ((time* OR timing OR pattern OR style OR arrangement* OR environment*) OR (flavour* OR flavor* OR taste) OR         (content OR composition OR density) OR (appear* OR presentation) OR (size OR portion OR amount) OR (fortif*) OR (supplement*) OR (assist* OR help* OR support*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)):ti,ab
#24 (nutri* OR diet*) NEAR/4 ((content OR composition OR density) OR (fortif*) OR (supplement*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif*           OR increas* OR decreas* OR improv* OR reduc* OR target*)):ti,ab
#25 dining* NEAR/4 ((time* OR timing OR pattern OR style OR arrangement* OR environment*) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)):ti,ab
#26 (screening OR monitoring) NEAR/4 ((nutri* OR diet*) OR (assist* OR help* OR support*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)):ti,ab
#27 (documentation OR communication) NEAR/4 (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*):ti,ab
#28 (staff* OR train*) NEAR/4 ((nurs*) OR (healthcare OR health care) OR (cater*) OR (assist* OR help* OR support*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)):ti,ab
#29 supplement* NEAR/5 (add* OR extra):ti,ab
#30 (assist* OR help* OR support*) NEAR/4 ((nurs*) OR (healthcare OR health care) OR (cater*)):ti,ab
#31 (#15 OR #16 OR #19)
#32 (#23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31)
#33 (low BMI OR low body mass index):ti,ab
#34 (low weight OR underweight OR under‐weight):ti,ab
#35 (maln*):ti,ab
#36 (nutritional risk OR (risk NEAR/4 maln*)):ti,ab
#37 (poor nutr* OR undernourish* OR under‐nourish*):ti,ab
#38 ((poor OR inadequate OR suboptimal) NEAR/5 intake*):ti,ab
#39 (institutionali?ed):ti,ab
#40 (elderly):ti,ab
#41 (homebound OR home‐bound OR housebound OR house‐bound):ti,ab
#42 ((extended OR longterm OR long‐term OR community) NEAR/1 care):ti,ab
#43 ((nursing OR care OR residential) NEAR/1 home):ti,ab
#44 (inpatient* OR hospitali?* OR hospital patient*):ti,ab
#45 exp Nutritional Status/
#46 exp Nutrition Disorders/
#47 exp Nutrition Assessment/
#48 exp Nutritional Support/
#49 exp Nutrition Policy/
#50 exp Malnutrition/
#51 diet/
#52 dietetics/
#53 hospital food service/
#54 energy intake/
#55 fortified food/
#56 #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 OR #44 OR #45 OR #46 OR #47 OR #48 OR #49 OR #50 OR #51 OR #52 OR #53 OR #54 OR #55
#57 32 AND 56
#58 exp Pregnancy/
#59 pregnan*:kw,ti
#60 #58 OR #59
#61 #57 NOT #60
#62 (child* OR infant OR paediatric OR pediatric):kw,ti
#63 #61 NOT #62
#64 (animal OR rat OR mouse OR guinea pig OR primate OR monkey OR cat OR dog):kw,ti
#65 #63 NOT #64

MEDLINE + OLDMEDLINE

#1  (food* OR meal* OR snack* OR drink* OR feed*).ab,ti.
#2  (nutri* OR diet*).ab,ti.
#3 "dining*".ab,ti.
#4  (screening OR monitoring).ab,ti.
#5 (documentation OR communication).ab,ti.
#6  (time* OR timing OR pattern OR style OR arrangement* OR environment).ab,ti.
#7 (staff* OR train*).ab,ti.
#8  "nurs*".ab,ti.
#9   (healthcare OR health care).ab,ti.
#10 "cater*".ab,ti.
#11 (flavo?r* OR taste).ab,ti.
#12  (content OR composition OR density).ab,ti.
#13  (appear* OR presentation).ab,ti.
#14 (size OR portion OR amount).ab,ti.
#15  "protected meal*".ab,ti.
#16  "red tray*".ab,ti.
#17 "fortif*".ab,ti.
#18  "supplement*".ab,ti.
#19  ((supportive OR nutrition* OR diet*) ADJ3 intervention).ab,ti.
#20  (assist* OR help* OR support*).ab,ti.
#21  (add* OR extra).ab,ti.
#22  (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*).ab,ti.
#23  1 ADJ3 (6 OR 11 OR 12 OR 13 OR 14 OR 17 OR 18 OR 20 OR 21 OR 22)
#24 2 ADJ4 (12 OR 17 OR 18 OR 21 OR 22)
#25  3 ADJ4 (6 OR 22)
#26  4 ADJ4 (2 OR 21 OR 22)
#27  5 ADJ4 22
#28  7 ADJ4 (8 OR 9 OR 10 OR 20 OR 21 OR 22)
#29  18 ADJ5 21
#30  20 ADJ4 (8 OR 9 OR 10)
#31  15 OR 16 OR 19
#32  23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31
#33  (low bmi OR low body mass index).ab,ti.
#34  (low weight OR underweight OR under‐weight).ab,ti.
#35  "maln*".ab,ti.
#36  (nutritional risk OR (risk ADJ4 maln*)).ab,ti.
#37  (poor nutr* OR undernourish* OR under‐nourish*).ab,ti.
#38  ((poor OR inadequate OR suboptimal) adj5 intake*).ab,ti.
#39  institutionali?ed.ab,ti.
#40  elderly.ab,ti.
#41  (homebound OR home‐bound OR housebound OR house‐bound).ab,ti.
#42  ((extended OR longterm OR long‐term OR community) ADJ1 care).ab,ti.
#43  ((nursing OR care OR residential) ADJ1 home).ab,ti.
#44  (inpatient* OR hospitali?* OR hospital patient*).ab,ti.
#45  exp Nutritional Status/
#46  exp Nutrition Disorders/dh, th [Diet Therapy, Therapy]
#47  nutrition assessment.sh.
#48  nutritional support.sh.
#49  nutrition policy.sh.
#50  exp Malnutrition/dh, th [Diet Therapy, Therapy]
#51  *diet/
#52  *dietetics/
#53  *food service, hospital/
#54  *energy intake/
#55  *food, fortified/
#56  33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44 OR 45 OR 46 OR 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55
#57  32 AND 56
#58  randomized controlled trial.pt.
#59  controlled clinical trial.pt.
#60  randomi?ed.ab.
#61  placebo.ab.
#62  clinical trials as topic.sh.
#63  randomly.ab.
#64  trial.ti.
#65  58 OR 59 OR 60 OR 61 OR 62 OR 63 OR 64
#66  meta‐analysis.pt
#67  exp technology assessment, biomedical/
#68  exp meta‐analysis/
#69  exp meta‐analysis as topic/
#70  hta.tw, ot.
#71  (health technology ADJ6 assessment$).tw,ot.
#72 (meta analy$ OR metaanaly$ or meta?analy$).tw,ot.
#73 ((review$ OR search$) ADJ10 (literature$ OR medical database$ OR medline OR pubmed OR embase OR cochrane OR cinahl OR psycinfo OR psyclit OR healthstar OR biosis OR current content$ OR systemat$)).tw,ot.
#74 66 OR 67 OR 68 OR 69 OR 70 OR 71 OR 72 OR 73
#75  65 OR 74
#76 (comment OR editorial OR historical‐article).pt.
#77  75 NOT 76
#78 57 AND 77
#79  (animals NOT (animals AND humans)).sh.
#80 78 NOT 79
#81 exp Pregnancy/
#82  pregnan*.tw,ot.
#83 81 OR 82
#84  80 NOT 83
#85  limit 84 to "all adult (19 plus years)"

MEDLINE in‐process & other non‐indexed citations

#1  (food* OR meal* OR snack* OR drink* OR feed*).ab,ti.
#2  (nutri* OR diet*).ab,ti.
#3  "dining*".ab,ti.
#4  (screening OR monitoring).ab,ti.
#5  (documentation OR communication).ab,ti.
#6  (time* OR timing OR pattern OR style OR arrangement* OR environment).ab,ti.
#7  (staff* OR train*).ab,ti.
#8  "nurs*".ab,ti.
#9   (healthcare OR health care).ab,ti.
#10  "cater*".ab,ti.
#11  (flavo?r* OR taste).ab,ti.
#12  (content OR composition OR density).ab,ti.
#13  (appear* OR presentation).ab,ti.
#14  (size OR portion OR amount).ab,ti.
#15  "protected meal*".ab,ti.
#16  "red tray*".ab,ti.
#17  "fortif*".ab,ti.
#18  "supplement*".ab,ti.
#19  ((supportive OR nutrition* OR diet*) ADJ3 intervention).ab,ti.
#20  (assist* OR help* OR support*).ab,ti.
#21  (add* OR extra).ab,ti.
#22  (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*).ab,ti.
#23  1 ADJ3 (6 OR 11 OR 12 OR 13 OR 14 OR 17 OR 18 OR 20 OR 21 OR 22)
#24  2 ADJ4 (12 OR 17 OR 18 OR 21 OR 22)
#25  3 ADJ4 (6 OR 22)
#26  4 ADJ4 (2 OR 21 OR 22)
#27  5 ADJ4 22
#28  7 ADJ4 (8 OR 9 OR 10 OR 20 OR 21 OR 22)
#29  18 ADJ5 21
#30  20 ADJ4 (8 OR 9 OR 10)
#31  15 OR 16 OR 19
#32  23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31
#33  (low bmi OR low body mass index).ab,ti.
#34  (low weight OR underweight OR under‐weight).ab,ti.
#35  "maln*".ab,ti.
#36  (nutritional risk OR (risk ADJ4 maln*)).ab,ti.
#37  (poor nutr* OR undernourish* OR under‐nourish*).ab,ti.
#38  ((poor OR inadequate OR suboptimal) adj5 intake*).ab,ti.
#39  institutionali?ed.ab,ti.
#40  elderly.ab,ti.
#41  (homebound OR home‐bound OR housebound OR house‐bound).ab,ti.
#42  ((extended OR longterm OR long‐term OR community) ADJ1 care).ab,ti.
#43  ((nursing OR care OR residential) ADJ1 home).ab,ti.
#44  (inpatient* OR hospitali?* OR hospital patient*).ab,ti.
#45  33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44
#46  32 AND 45
#47  (random* OR rct*).tw,ot.
#48  “single blind*”.tw, ot.
#49  “double blind*”.tw, ot.
#50  ((triple OR treble) AND blind*).tw,ot.
#51  ((control* AND trial*) OR (clinical ADJ4 trial*) OR trial*).tw,ot.
#52  (systematic* review*).tw,ot.
#53  hta.tw, ot.
#54  (health technology ADJ6 assessment$).tw,ot.
#55  (meta analy$ OR metaanaly$ or meta?analy$).tw,ot.
#56  ((review$ OR search$) ADJ10 (literature$ OR medical database$ OR medline OR pubmed OR embase OR cochrane OR cinahl OR psycinfo OR psyclit OR healthstar OR biosis OR current content$ OR systemat$)).tw,ot.
#57  47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55 OR 56
#58  (comment OR editorial OR historical‐article).pt.
#59  57 NOT 58
#60  46 AND 59
#61  pregnan*.tw,ot.
#62  60 NOT 61

Embase + Embase classic

#1  (food* OR meal* OR snack* OR drink* OR feed*).ab,ti.
#2  (nutri* OR diet*).ab,ti.
#3   "dining*".ab,ti.
#4  (screening OR monitoring).ab,ti.
#5  (documentation OR communication).ab,ti.
#6  (time* OR timing OR pattern OR style OR arrangement* OR environment).ab,ti.
#7  (staff* OR train*).ab,ti.
#8  "nurs*".ab,ti.
#9  (healthcare OR health care).ab,ti.
#10  "cater*".ab,ti.
#11  (flavo?r* OR taste).ab,ti.
#12  (content OR composition OR density).ab,ti.
#13  (appear* OR presentation).ab,ti.
#14  (size OR portion OR amount).ab,ti.
#15  "protected meal*".ab,ti.
#16  "red tray*".ab,ti.
#17  "fortif*".ab,ti.
#18  "supplement*".ab,ti.
#19  ((supportive OR nutrition* OR diet*) ADJ3 intervention).ab,ti.
#20  (assist* OR help* OR support*).ab,ti.
#21  (add* OR extra).ab,ti.
#22  (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv*   OR reduc* OR target*).ab,ti.
#23  1 ADJ3 (6 OR 11 OR 12 OR 13 OR 14 OR 17 OR 18 OR 20 OR 21 OR 22)
#24  2 ADJ4 (12 OR 17 OR 18 OR 21 OR 22)
#25  3 ADJ4 (6 OR 22)
#26  4 ADJ4 (2 OR 21 OR 22)
#27  5 ADJ4 22
#28  7 ADJ4 (8 OR 9 OR 10 OR 20 OR 21 OR 22)
#29  18 ADJ5 21
#30  20 ADJ4 (8 OR 9 OR 10)
#31  15 OR 16 OR 19
#32  23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31
#33  (low bmi OR low body mass index).ab,ti.
#34  (low weight OR underweight OR under‐weight).ab,ti.
#35  "maln*".ab,ti.
#36  (nutritional risk OR (risk ADJ4 maln*)).ab,ti.
#37  (poor nutr* OR undernourish* OR under‐nourish*).ab,ti.
#38  ((poor OR inadequate OR suboptimal) adj5 intake*).ab,ti.
#39  institutionali?ed.ab,ti.
#40  elderly.ab,ti.
#41  (homebound OR home‐bound OR housebound OR house‐bound).ab,ti.
#42  ((extended OR longterm OR long‐term OR community) ADJ1 care).ab,ti.
#43  ((nursing OR care OR residential) ADJ1 home).ab,ti.
#44  (inpatient* OR hospitali?* OR hospital patient*).ab,ti.
#45  exp Nutritional Status/
#46  exp Nutritional Disorder/dh, th [Therapy]
#47  nutrition assessment.sh.
#48  nutritional support.sh.
#49  health care policy.sh.
#50  exp Malnutrition/dh, th [Therapy]
#51  *diet/
#52  *dietetics/
#53  *food service, hospital/
#54  *energy intake/
#55  *food, fortified/
#56   33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44 OR 45 OR 46 OR 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55
#57  32 AND 56
#58  (random* OR rct*).tw,ot.
#59  “single blind*”.tw, ot.
#60  “double blind*”.tw, ot.
#61  ((triple OR treble) AND blind*).tw,ot.
#62  ((control* AND trial*) OR (clinical ADJ4 trial*) OR trial*).tw,ot.
#63  (systematic* review*).tw,ot.
#64  hta.tw, ot.
#65  (health technology ADJ6 assessment$).tw,ot.
#66  (meta analy$ OR metaanaly$ or meta?analy$).tw,ot.
#67  ((review$ OR search$) ADJ10 (literature$ OR medical database$ OR medline OR pubmed OR embase OR cochrane OR cinahl OR psycinfo OR psyclit OR healthstar OR biosis OR current content$ OR systemat$)).tw,ot.
#68  58 OR 59 OR 60 OR 61 OR 62 OR 63 OR 64 OR 65 OR 66 OR 67
#69  (comment OR editorial OR historical‐article).pt.
#70  68 NOT 69
#71  57 AND 70
#72  exp Pregnancy/
#73  pregnan*.tw,ot.
#74  72 OR 73
#75  71 NOT 74
#76  limit 75 to (human and (adult <18 to 64 years> or aged <65+ years>))

AMED

#1  (food* OR meal* OR snack* OR drink* OR feed*).ti,ab
#2  (nutri* OR diet*).ti,ab
#3   "dining*".ti,ab
#4   screening OR monitoring).ti,ab
#5   documentation OR communication).ti,ab
#6   time* OR timing OR pattern OR style OR arrangement* OR environment).ti,ab
#7   staff* OR train*).ti,ab
#8   nurs*".ti,ab
#9   healthcare OR “health care”).ti,ab
#10 cater*".ti,ab
#11  flavo?r* OR taste).ti,ab
#12  content OR composition OR density).ti,ab
#13  appear* OR presentation).ti,ab
#14  size OR portion OR amount).ti,ab
#15  protected meal*".ti,ab
#16  red tray*".ti,ab
#17  fortif*".ti,ab
#18  "supplement*".ti,ab
#19  ((supportive OR nutrition* OR diet*) ADJ3 intervention).ti,ab
#20  (assist* OR help* OR support*).ti,ab
#21  (add* OR extra).ti,ab
#22  alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*).ti,ab
#23  1 DJ3 (6 OR 11 OR 12 OR 13 OR 14 OR 17 OR 18 OR 20 OR 21 OR 22)
#24  2 ADJ4 (12 OR 17 OR 18 OR 21 OR 22)
#25  3 ADJ4 (6 OR 22)
#26  4 ADJ4 (2 OR 21 OR 22)
#27  5 ADJ4 22
#28  7 ADJ4 (8 OR 9 OR 10 OR 20 OR 21 OR 22)
#29  18 ADJ5 21
#30  20 ADJ4 (8 OR 9 OR 10)
#31  15 OR 16 OR 19
#32  23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31
#33  (“low bmi” OR “low body mass index”).ti,ab
#34  (“low weight” OR underweight OR under‐weight).ti,ab
#35  "maln*".ti,ab
#36  (“nutritional risk” OR (risk ADJ4 maln*)).ti,ab
#37  (“poor nutr*” OR undernourish* OR under‐nourish*).ti,ab
#38  ((poor OR inadequate OR suboptimal) ADJ5 intake*).ti,ab
#39  institutionali?ed.ti,ab
#40  elderly.ti,ab
#41  (homebound OR home‐bound OR housebound OR house‐bound).ti,ab
#42  ((extended OR longterm OR long‐term OR community) ADJ1 care).ti,ab
#43  ((nursing OR care OR residential) ADJ1 home).ti,ab
#44  (inpatient* OR hospitali?* OR hospital patient*).ti,ab
#45  33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44
#46  2 AND 45
#47  (random* OR rct*).ti,ab
#48  “single blind*”.ti,ab
#49  “double blind*”.ti,ab
#50  ((triple OR treble) AND blind*).ti,ab
#51  ((control* AND trial*) OR (clinical ADJ4 trial*) OR trial*).ti,ab
#52  (systematic* review*).ti,ab
#53  (“health technology” ADJ6 assessment$).ti,ab
#54  hta.ti,ab
#55  (“meta analy$” OR metaanaly$ or meta?analy$).ti,ab
#56  47 OR 48 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55
#57  46 AND 56
#58  (comment OR editorial OR historical‐article).pt.
#59  57 NOT 58
#60  (animal OR rat OR mouse OR guinea pig OR primate OR monkey OR cat OR dog).ti,ab
#61  9 NOT 60
#62  regnan*.ti,ab
#63  61 NOT 62
#64  (child* OR infant OR paediatric OR pediatric).ti,ab
#65  63 NOT 64

British Nursing Index

#1 (food* OR meal* OR snack* OR drink* OR feed*).ab,ti.
#2  (nutri* OR diet*).ab,ti.
#3  "dining*".ab,ti.
#4  (screening OR monitoring).ab,ti.
#5  (documentation OR communication).ab,ti.
#6  (time* OR timing OR pattern OR style OR arrangement* OR environment).ab,ti.
#7  (staff* OR train*).ab,ti.
#8  "nurs*".ab,ti.
#9  (healthcare OR health care).ab,ti.
#10  "cater*".ab,ti.
#11 (flavo?r* OR taste).ab,ti.
#12 (content OR composition OR density).ab,ti.
#13 (appear* OR presentation).ab,ti.
#14 (size OR portion OR amount).ab,ti.
#15 "protected meal*".ab,ti.
#16 "red tray*".ab,ti.
#17 "fortif*".ab,ti.
#18 "supplement*".ab,ti.
#19 ((supportive OR nutrition* OR diet*) ADJ3 intervention).ab,ti.
#20 (assist* OR help* OR support*).ab,ti.
#21 (add* OR extra).ab,ti.
#22 (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*).ab,ti.
#23 1 ADJ3 (6 OR 11 OR 12 OR 13 OR 14 OR 17 OR 18 OR 20 OR 21 OR 22)
#24 2 ADJ4 (12 OR 17 OR 18 OR 21 OR 22)
#25 3 ADJ4 (6 OR 22)
#26 4 ADJ4 (2 OR 21 OR 22)
#27 5 ADJ4 22
#28 7 ADJ4 (8 OR 9 OR 10 OR 20 OR 21 OR 22)
#29 18 ADJ5 21
#30 20 ADJ4 (8 OR 9 OR 10)
#31 15 OR 16 OR 19
#32 23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31
#33 (low bmi OR low body mass index).ab,ti.
#34 (low weight OR underweight OR under‐weight).ab,ti.
#35 "maln*".ab,ti.
#36 (nutritional risk OR (risk ADJ4 maln*)).ab,ti.
#37 (poor nutr* OR undernourish* OR under‐nourish*).ab,ti.
#38 ((poor OR inadequate OR suboptimal) adj5 intake*).ab,ti.
#39 institutionali?ed.ab,ti.
#40 elderly.ab,ti.
#41 homebound OR home‐bound OR housebound OR house‐bound).ab,ti.
#42 ((extended OR longterm OR long‐term OR community) ADJ1 care).ab,ti.
#43 ((nursing OR care OR residential) ADJ1 home).ab,ti.
#44 (inpatient* OR hospitali?* OR hospital patient*).ab,ti.
#45 33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44
#46 32 AND 45
#47 (random* OR rct*).tw,ot.
#48 “single blind*”.tw, ot.
#49 “double blind*”.tw, ot.
#50 ((triple OR treble) AND blind*).tw,ot.
#51 ((control* AND trial*) OR (clinical ADJ4 trial*) OR trial*).tw,ot.
#52 (systematic* review*).tw,ot.
#53 hta.tw, ot.
#54 (health technology ADJ6 assessment$).tw,ot.
#55 (meta analy$ OR metaanaly$ or meta?analy$).tw,ot.
#56  (review$ OR search$) ADJ10 (literature$ OR medical database$ OR medline OR pubmed OR embase OR cochrane OR cinahl OR psycinfo OR psyclit OR healthstar OR biosis OR current content$ OR systemat$)).tw,ot.
#57 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55 OR 56
#58 (comment or editorial or historical‐article).pt.
#59 57 NOT 58
#60 46 AND 59
#61 pregnan*.tw,ot.
#62 60 NOT 61

CINAHL

#1  (TI (food* OR meal* OR snack* OR drink* OR feed*)) OR (AB (food* OR meal* OR snack* OR drink* OR feed*))
#2  (TI (nutri* OR diet*)) OR (AB (nutri* OR diet*))
#3  (TI dining*) OR (AB dining*)
#4  (TI (screening OR monitoring)) OR (AB (screening OR monitoring))
#5  (TI (documentation OR communication)) OR (AB (documentation OR communication))
#6  (TI (time* OR timing OR pattern OR style OR arrangement* OR environment*)) OR (AB (time* OR timing OR pattern OR style OR arrangement* OR environment*))
#7  (TI (staff* OR train*)) OR (AB (staff* OR train*))
#8  (TI nurs*) OR (AB nurs*)
#9  (TI (healthcare OR health care)) OR (AB (healthcare OR health care))
#10 (TI cater*) OR (AB cater*)
#11 (TI (flavo?r* OR taste)) OR (AB (flavo?r* OR taste))
#12 (TI (content OR composition OR density)) OR (AB (content OR composition OR density))
#13 (TI (appear* OR presentation)) OR (AB (appear* OR presentation))
#14 (TI (size OR portion OR amount)) OR (AB (size OR portion OR amount)) 
#15 (TI (protected meal*)) OR (AB (protected meal*))
#16 (TI (red tray*)) OR (AB (protected meal*))
#17 (TI fortif*) OR (AB fortif*)
#18 (TI supplement*) OR (AB supplement*)
#19 (TI ((supportive OR nutrition* OR diet*) N3 intervention)) OR (AB ((supportive OR nutrition* OR diet*) N3 intervention))
#20 (TI (assist* OR help* OR support*)) OR (AB (assist* OR help* OR support*))
#21 (TI (add* OR extra)) OR (AB (add* OR extra))
#22 (TI (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)) OR (AB (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))
#23 (TI (food* OR meal* OR snack* OR drink* OR feed*) N3 ((time* OR timing OR pattern OR style OR arrangement* OR environment*) OR (flavour* OR flavor* OR taste) OR (content OR composition OR density) OR (appear* OR presentation) OR (size OR portion OR amount) OR (fortif*) OR (supplement*) OR (assist* OR help* OR support*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))) OR (AB (food* OR meal* OR snack* OR drink* OR feed*) N3 ((time* OR timing OR pattern OR style OR arrangement* OR environment*) OR (flavour* OR flavor* OR taste) OR (content OR composition OR density) OR (appear* OR presentation) OR (size OR portion OR amount) OR (fortif*) OR (supplement*) OR (assist* OR help* OR support*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)))
#24 (TI (nutri* OR diet*) N4 ((content OR composition OR density) OR (fortif*) OR (supplement*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))) OR (AB (nutri* OR diet*) N4 ((content OR composition OR density) OR (fortif*) OR (supplement*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)))
#25 (TI dining* N4 ((time* OR timing OR pattern OR style OR arrangement* OR environment*) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))) OR (AB dining* N4 ((time* OR timing OR pattern OR style OR arrangement* OR environment*) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)))
#26 (TI (screening OR monitoring) N4 ((nutri* OR diet*) OR (assist* OR help* OR support*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))) OR (AB (screening OR monitoring) N4 ((nutri* OR diet*) OR (assist* OR help* OR support*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)))
#27 (TI (documentation OR communication) N4 ((alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))) OR (AB (documentation OR communication) N4 ((alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)))
#28 (TI (staff* OR train*) N4 ((nurs*) OR (healthcare OR health care) OR (cater*) OR (assist* OR help* OR support*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))) OR (AB (staff* OR train*) N4 ((nurs*) OR (healthcare OR health care) OR (cater*) OR (assist* OR help* OR support*) OR (add* OR extra) OR (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*)))
#29 (TI (supplement* N5 (add* OR extra))) OR (AB (supplement* N5 (add* OR extra)))
#30 (TI (assist* OR help* OR support*) N4 ((nurs*) OR (healthcare OR health care) OR (cater*))) OR (AB (assist* OR help* OR support*) N4 ((nurs*) OR (healthcare OR health care) OR (cater*)))
#31 (S15 OR S16 OR S19)
#32 S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31
#33 (TI (low BMI OR low body mass index)) OR (AB (low BMI OR low body mass index))
#34 (TI (low weight OR underweight OR under‐weight)) OR (AB (low weight OR underweight OR under‐weight))
#35 (TI maln*) OR (AB maln*)
#36 (TI (nutritional risk OR (risk N4 maln*))) OR (AB (nutritional risk OR (risk N4 maln*)))
#37 (TI (poor nutr* OR undernourish* OR under‐nourish*)) OR (AB (poor nutr* OR undernourish* OR under‐nourish*))
#38 TI (poor OR inadequate OR suboptimal) N5 intake*) OR (AB (poor OR inadequate OR suboptimal) N5 intake*)
#39 (TI (institutionali?ed)) OR (AB (institutionali?ed))
#40 (TI elderly) OR (AB elderly)
#41 (TI (homebound OR home‐bound OR housebound OR house‐bound)) OR (AB (homebound OR home‐bound OR housebound OR house‐bound))
#42 (TI ((extended OR longterm OR long‐term OR community) N1 care)) OR (AB ((extended OR longterm OR long‐term OR community) N1 care))
#43 (TI ((nursing OR care OR residential) N1 home)) OR (AB ((nursing OR care OR residential) N1 home))
#44 (TI (inpatient* OR hospitali?* OR hospital patient*)) OR (AB (inpatient* OR hospitali?* OR hospital patient*))
#45 SU Nutritional Status
#46 SU Nutrition Disorders
#47 SU Nutritional Assessment
#48 SU Nutritional Support
#49 SU Nutrition Policy
#50 SU Malnutrition
#51 SU Diet
#52 SU Dietetics
#53 SU Hospital Food Service
#54 SU Energy Intake
#55 SU Fortified Food
#56 S33 OR S34 OR S35 OR S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 OR S43 OR S44 OR S45 OR S46 OR S47 OR S48 OR S49 OR S50 OR S51 OR S52 OR S53 OR S54 OR S55
#57 S32 AND S56
#58 (TI (random* OR rct*)) OR (TX (random* OR rct*))
#59 (TI single blind*) OR (TX single blind*)
#60 (TI double blind*) OR (TX double blind*)
#61 (TI ((triple OR treble) AND blind*)) OR (TX ((triple OR treble) AND blind*))
#62 (TI ((control* AND trial*) OR (clinical N4 trial*) OR trial*)) OR (TX ((control* AND trial*) OR (clinical N4 trial*) OR trial*))
#63 (TI systematic* review*) OR (TX systematic* review*)
#64 (TI hta) OR (TX hta)
#65 (TI (health technology N6 assessment*)) OR (TX (health technology N6 assessment*)) 
#66 (TI (meta analy* OR metaanaly* or meta?analy*)) OR (TX (meta  analy* OR metaanaly* or meta?analy*))
#67 (TI ((review* OR search*) N10 (literature* OR medical database* OR medline OR pubmed OR embase OR cochrane OR cinahl OR psycinfo OR psyclit OR healthstar OR biosis OR current content* OR systemat*))) OR (TX ((review* OR search*) N10 (literature* OR medical database* OR medline OR pubmed OR embase OR cochrane OR cinahl OR psycinfo OR psyclit OR healthstar OR biosis OR current content* OR systemat*)))
#68 S58 OR S59 OR S60 OR S61 OR S62 OR S63 OR S64 OR S65 OR  S66 OR S67
#69 PT (comment OR editorial OR historical‐article)
#70 S68 NOT S69
#71 SU Pregnancy
#72 (TI pregnan*) OR (TX pregnan*)
#73 S71 OR S72
#74 S70 NOT S73
#75 S57 AND S74
Limiters ‐ Human; Age Groups: Adult: 19‐44 years, Aged: 65+ years

SCOPUS

#1
((TITLE‐ABS‐KEY((food* W/3 time*) OR (food* W/3 timing) OR (food* W/3 pattern) OR (food* W/3 style) OR (food* W/3 arrangement*)OR (food*W/3 environment) OR (food* W/3 flavour) OR (food* W/3 taste) OR (food* W/3 content) OR (food* W/3 composition) OR (food* W/3 density) OR (food* W/3 appear*) OR (food* W/3 presentation) OR (food* W/3 size) OR (food* W/3 portion) OR (food* W/3 amount) OR (food* W/3 fortifi*) OR (food* W/3 supplement*) OR (food* W/3 assist*) OR (food* W/3 help*) OR (food* W/3 support*) OR (food* W/3 add*) OR (food* W/3 extra) OR (food* W/3 alter*) OR (food* W/3 chang*) OR (food* W/3 new) OR (food* W/3 enhance*) OR (food* W/3 modif*) OR (food* W/3 increas*) OR (food W/3 decreas*) OR (food* W/3 improv*) OR (food* W/3 reduc*) OR (food* W/3 target*))) OR (TITLE‐ABS‐KEY((meal* W/3 time*) OR (meal* W/3 timing) OR (meal* W/3 pattern) OR (meal* W/3 style) OR (meal* W/3 arrangement*)OR (meal*W/3 environment) OR (meal* W/3 flavour) OR (meal* W/3 taste) OR (meal* W/3 content) OR (meal* W/3 composition) OR (meal* W/3 density) OR (meal* W/3 appear*) OR (meal* W/3 presentation) OR (meal* W/3 size) OR (meal* W/3 portion) OR (meal* W/3 amount) OR (meal* W/3 fortifi*) OR (meal* W/3 supplement*) OR (meal* W/3 assist*) OR (meal* W/3 help*) OR (meal* W/3 support*) OR (meal* W/3 add*) OR (meal* W/3 extra) OR (meal* W/3 alter*) OR (meal* W/3 chang*) OR (meal* W/3 new) OR (meal* W/3 enhance*) OR (meal* W/3 modif*) OR (meal* W/3 increas*) OR (food W/3 decreas*) OR (meal* W/3 improv*) OR (meal* W/3 reduc*) OR (meal* W/3 target*))) OR (TITLE‐ABS‐KEY((snack* W/3 time*) OR (snack* W/3 timing) OR (snack* W/3 pattern) OR (snack* W/3 style) OR (snack* W/3 arrangement*)OR (snack*W/3 environment) OR (snack* W/3 flavour) OR (snack* W/3 taste) OR (snack* W/3 content) OR (snack* W/3 composition) OR (snack* W/3 density) OR (snack* W/3 appear*) OR (snack* W/3 presentation) OR (snack* W/3 size) OR (snack* W/3 portion) OR (snack* W/3 amount) OR (snack* W/3 fortifi*) OR (snack* W/3 supplement*) OR (snack* W/3 assist*) OR (snack* W/3 help*) OR (snack* W/3 support*) OR (snack* W/3 add*) OR (snack* W/3 extra) OR (snack* W/3 alter*) OR (snack* W/3 chang*) OR (snack* W/3 new) OR (snack* W/3 enhance*) OR (snack* W/3 modif*) OR (snack* W/3 increas*) OR (food W/3 decreas*) OR (snack* W/3 improv*) OR (snack* W/3 reduc*) OR (snack* W/3 target*))) OR (TITLE‐ABS‐KEY((drink* W/3 time*) OR (drink* W/3 timing) OR (drink* W/3 pattern) OR (drink* W/3 style) OR (drink* W/3 arrangement*)OR (drink*W/3 environment) OR (drink* W/3 flavour) OR (drink* W/3 taste) OR (drink* W/3 content) OR (drink* W/3 composition) OR (drink* W/3 density) OR (drink* W/3 appear*) OR (drink* W/3 presentation) OR (drink* W/3 size) OR (drink* W/3 portion) OR (drink* W/3 amount) OR (drink* W/3 fortifi*) OR (drink* W/3 supplement*) OR (drink* W/3 assist*) OR (drink* W/3 help*) OR (drink* W/3 support*) OR (drink* W/3 add*) OR (drink* W/3 extra) OR (drink* W/3 alter*) OR (drink* W/3 chang*) OR (drink* W/3 new) OR (drink* W/3 enhance*) OR (drink* W/3 modif*) OR (drink* W/3 increas*) OR (food W/3 decreas*) OR (drink* W/3 improv*) OR (drink* W/3 reduc*) OR (drink* W/3 target*))) OR (TITLE‐ABS‐KEY((feed* W/3 time*) OR (feed* W/3 timing) OR (feed* W/3 pattern) OR (feed* W/3 style) OR (feed* W/3 arrangement*) OR (feed* W/3 environment) OR (feed* W/3 flavour) OR (feed* W/3 taste) OR (feed* W/3 content) OR (feed* W/3 composition) OR (feed* W/3 density) OR (feed* W/3 appear*) OR (feed* W/3 presentation) OR (feed* W/3 size) OR(feed* W/3 portion) OR(feed* W/3 amount) OR(feed* W/3 fortifi*) OR (feed* W/3 supplement*) OR (feed* W/3 assist*) OR(feed* W/3 help*) OR (feed* W/3 support*) OR (feed* W/3 add*) OR (feed* W/3 extra) OR (feed* W/3 alter*) OR(feed* W/3 chang*) OR (feed* W/3 new) OR (feed* W/3 enhance*) OR (feed* W/3 modif*) OR (feed* W/3 increas*) OR (food W/3 decreas*) OR (feed* W/3 improv*) OR (feed* W/3 reduc*) OR (feed* W/3 target*))))
#2
OR ((TITLE‐ABS‐KEY((nutri* W/3 content) OR (nutri* W/3 composition)OR (nutri* W/3 density))) OR (TITLE‐ABS‐KEY((diet* W/3 content) OR (diet* W/3 composition)OR (diet* W/3 density))) OR (TITLE‐ABS‐KEY(nutri* W/3 fortifi*)) OR (TITLE‐ABS‐KEY(diet* W/3 fortifi*)) OR (TITLE‐ABS‐KEY(nutri* W/3 supplement*)) OR (TITLE‐ABS‐KEY(diet* W/3 supplement*)) OR (TITLE‐ABS‐KEY(nutri* W/3 add*) OR (nutri* W/3 extra)) OR (TITLE‐ABS‐KEY((diet* W/3 add*) OR (diet* W/3 extra))))
#3
OR ((TITLE‐ABS‐KEY((dining* W/3 time*) OR (dining* W/3 timing) OR (dining* W/3 pattern) OR (dining* W/3 style) OR (dining* W/3 arrangement*)OR (dining* W/3 environment))) OR (TITLE‐ABS‐KEY((dining* W/3 alter*) OR (dining* W/3 chang*) OR (dining* W/3 new) OR (dining* W/3 enhance*) OR (dining* W/3 modif*) OR (dining*W/3 increas*) OR (food W/3 decreas*) OR (dining* W/3 improv*) OR (dining* W/3 reduc*) OR (dining* W/3 target*))))
#4
OR ((TITLE‐ABS‐KEY((screening W/3 nutri*) OR (screening W/3 diet*))) OR (TITLE‐ABS‐KEY((monitoring W/3 nutri*) OR (monitoring W/3 diet*))) OR (TITLE‐ABS‐KEY((screening W/3 add*) OR (screening W/3 extra))) OR (TITLE‐ABS‐KEY((monitoring W/3 add*) OR (monitoring W/3 extra))) OR (TITLE‐ABS‐KEY((screeningW/3 alter*) OR (screening W/3 chang*) OR (screening W/3 new) OR (screening W/3 enhance*) OR (screeningW/3 modif*) OR (screening W/3 increas*) OR (food W/3 decreas*) OR (screening W/3 improv*) OR (screening W/3 reduc*) OR (screening W/3 target*))) OR (TITLE‐ABS‐KEY((monitoring W/3 alter*)OR (monitoringW/3 chang*)OR (monitoringW/3 new)OR (monitoringW/3 enhance*)OR (monitoringW/3 modif*)OR (monitoringW/3 increas*)OR (foodW/3 decreas*)OR (monitoringW/3 improv*)OR (monitoringW/3 reduc*)OR (monitoringW/3 target*))))
#5
OR ((TITLE‐ABS‐KEY((documentation W/3 alter*) OR (documentation W/3 chang*) OR (documentation W/3 new) OR (documentation W/3 enhance*) OR (documentation W/3 modif*) OR (documentation W/3 increas*) OR (food W/3 decreas*) OR (documentation W/3 improv*)OR (documentation W/3 reduc*)OR (documentation W/3 target*))) OR (TITLE‐ABS‐KEY((communication W/3 alter*)OR (communicationW/3 chang*) OR (communication W/3 new) OR (communication W/3 enhance*) OR (communication W/3 modif*) OR (communication W/3 increas*) OR (food W/3 decreas*) OR (communication W/3 improv*) OR (communication W/3 reduc*) OR (communication W/3 target*))))
#6
OR ((TITLE‐ABS‐KEY((staff* W/3 nurs*)OR (train* W/3 nurs*))) OR (TITLE‐ABS‐KEY((staff* W/3 healthcare)OR (train*W/3 healthcare)OR (staff* W/3 health care) OR (train* W/3 healthcare))) OR (TITLE‐ABS‐KEY(staff* W/3 cater*)) OR (TITLE‐ABS‐KEY((staff* W/3 assist*) OR (train* W/3 assist) OR (staff* W/3 help*) OR (train* W/3 help*) OR (staff* W/3 support*) OR (train*W/3 support*) OR (staff* W/3 add*) OR (train* W/3 add*) OR (staff* W/3 extra) OR (train* W/3 extra))) OR (TITLE‐ABS‐KEY((staff* W/3 alter*) OR (staff* W/3 chang*) OR (staff* W/3 new) OR (staff* W/3 enhance*)OR (staff* W/3 modif*)OR (staff* W/3 increas*)OR (food W/3 decreas*)OR (staff* W/3 improv*)OR (staff* W/3 reduc*)OR (staff* W/3 target*))) OR (TITLE‐ABS‐KEY((train* W/3 alter*) OR (train* W/3 chang*) OR (train* W/3 new) OR (train* W/3 enhance*)OR (train* W/3 modif*)OR (train* W/3 increas*)OR (food W/3 decreas*)OR (train* W/3 improv*)OR (train* W/3 reduc*)OR (train* W/3 target*))))
#7
OR (TITLE‐ABS‐KEY((supplement* W/3 add*) OR (supplement* W/3 extra)))))
#8
(((((((TITLE‐ABS‐KEY((assist* W/3 nurs*) OR (assist* W/3 healthcare) OR (assist* W/3 healthcare) OR(assist* W/3 cater*))) OR (TITLE‐ABS‐KEY((help* W/3 nurs*) OR (help* W/3 healthcare)OR (help* W/3 health care) OR (help* W/3 cater*))) OR (TITLE‐ABS‐KEY((support* W/3 nurs*) OR (support* W/3 healthcare) OR (support* W/3 health care) OR (support* W/3 cater*))))
#9
OR (TITLE‐ABS‐KEY(("protected meal" OR "red tray")) OR ((supportive W/3 intervention) OR (nutrition* W/3intervention) OR (diet* W/3intervention)))
#10
#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9
#11
OR (TITLE‐ABS‐KEY("low BMI" OR "low body mass index"))
#12
OR (TITLE‐ABS‐KEY("low weight" OR underweightOR "under‐weight"))
#13
OR (TITLE‐ABS‐KEY(maln*))
#14
OR (TITLE‐ABS‐KEY(("nutritional risk") OR (risk W/3 maln*)))
#15
OR (TITLE‐ABS‐KEY("poor nutr*"OR undernourish* OR "under‐nourish*"))
#16
OR (TITLE‐ABS‐KEY((poor W/3 intake*) OR (inadequateW/3 intake*) OR (suboptimal W/3 intake*)))
#17
OR (TITLE‐ABS‐KEY(institutionali?ed OR elderly))
#18
OR (TITLE‐ABS‐KEY(homebound OR "home bound" OR housebound OR "house bound"))
#19
OR (ABS((extended W/1care) OR(longterm W/1care) OR("long term" W/1 care)  OR (community W/1 care)))
#20
OR (ABS((nursing W/1 home)OR (care W/3 home)  OR (residential W/3 home)))
#21
OR (ABS(inpatient* OR hospitali?* OR "hospital patient*"))
#22
OR (ABS("nutritional status" OR "nutrition disorder*" OR "nutrition assessment*" OR "nutritional support*" OR "nutrition policy"))
#23
OR (ABS(diet* OR "food service" OR "energy intake" OR "fortified food"))
#24
#11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17
#25
#18 OR #19 OR #20 OR #21 OR #22 OR #23
#26
#24 OR #25
#27
#10 AND #26
#28
((ABS("controlled trial*" OR "controlled clinical trial*" OR "clinical trial*")) OR (ABS(random* ORplacebo)) OR (ABS("meta‐analys*" OR metaanalys* OR hta OR "health technology assessment")) OR (ABS(literature* OR "medical database*" OR medline OR pubmed OR embase OR cochrane OR cinahl OR psycinfo OR psyclit OR healthstar OR biosis OR "current content*" OR "systematic review*")))
#29
#27 AND #28
#30
(ABS(adult*))
#31
#29 AND #30
#32
(ABS(pregnan*))
#33
#31 AND NOT #32
#34
(ABS(animal*))
#35
#33 AND NOT #34

ISI Web of Science

#1  TS=((food* OR meal* OR snack* OR drink* OR feed*) NEAR/3 (time* OR timing OR pattern OR style OR arrangement* OR environment OR flavor OR taste OR content OR composition OR density OR appear* OR presentation OR size OR portion OR amount OR fortifi* OR supplement* OR assist* OR help* OR support* OR add* OR extra OR alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))
# 2  TS=((nutri* OR diet*) NEAR/3 (content OR composition OR density OR fortfi* OR supplement* OR add* OR extra OR alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target))
# 3 TS=((dining*) NEAR/3 (time* OR timing OR pattern OR style OR arrangement* OR environment OR alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))
# 4  TS=((screening OR monitoring) NEAR/3 (nutri* OR diet* OR add* OR extra OR alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))
# 5  TS=((documentation OR communication) NEAR/3 (alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))
# 6  TS=((staff* OR train*) NEAR/3 (nurs* OR healthcare OR "health care" OR cater* OR assist* OR help* OR support* OR add* OR extra OR alter* OR chang* OR new OR enhance* OR modif* OR increas* OR decreas* OR improv* OR reduc* OR target*))
# 7  TS=((supplement*) NEAR/6 (add* OR extra))
# 8 TS=((assist* OR help* OR support*) NEAR/3 (nurs* OR healthcare OR    "health care" OR cater*))
# 9  TS=(("protected meal" OR "red tray") OR ((supportive OR nutrition* OR diet*) NEAR/3 intervention*))
# 10 #9 OR #8 OR #7 OR #6 OR #5 OR #4 OR #3 OR #2 OR #1
# 11 TS=(("low bmi" OR "low body mass index"))
# 12 TS=(("low weight" OR underweight OR "under‐weight"))
# 13 TS=(maln*)
# 14 TS=("nutritional risk" OR (risk NEAR/3 maln*))
# 15 TS=(("poor nutr*" OR undernourish* OR "under nourish*"))
# 16 TS=((poor OR inadequate OR suboptimal) NEAR/6 intake*)
# 17 TS=((institutionali?ed OR elderly))
# 18 TS=((homebound OR "home bound" OR housebound OR "house bound"))
# 19 TS=((extended OR longterm OR "long term" OR community) NEAR/1 care)
# 20 TS=((nursing OR care OR residential) NEAR/1 home)
# 21 TS=((inpatient* OR hospitali?* OR "hospital patient*"))
# 22 TS=(nutritional status)
# 23 TS=(nutrition disorder*)
# 24 TS=(("nutrition assessment*" OR "nutritional support*"OR "nutrition policy"))
# 25 TS=((diet* OR "food service" OR "energy intake" OR "fortified food"))
# 26 #25 OR #24 OR #23 OR #22 OR #21 OR #20 OR #19 OR #18 OR #17 OR #16 OR #15 OR #14 OR #13 OR #12 OR #11
# 27 #26 AND #10
# 28 TS=("controlled trial*" OR "controlled clinical trial*" OR "clinical trial*")
# 29 TS=(random* OR placebo)
# 30 TS=("meta‐analys*" OR metaanalys* OR hta OR "health technology assessment")
# 31 TS=((literature* OR "medical database*" OR medline OR pubmed OR embase OR cochrane OR cinahl OR psycinfo OR psyclit OR healthstar OR biosis OR "current content*" OR "systematic review*"))
# 32 #31 OR #30 OR #29 OR #28
# 33 #32 AND #27
# 34 TS=(adult*)
# 35 #34 AND #33
# 36 TS=(pregnan*)
# 37 #35 NOT #36
# 38 TS=(animal*)
# 39 #37 NOT #38

Appendix 2. Search strategies (January 2013 to September 2016)

Cochrane Library (Wiley)

I: Population

1. [mh ^Stroke] or stroke:ti,ab

2. [mh ^"Alzheimer Disease"] or alzheimer:ti,ab

3. [mh ^Dementia] or dement*:ti,ab

4. [mh ^"Mild Cognitive Impairment"] or "cognitive impairment":ti,ab

5. [mh "Hip Fractures"] or ("hip fracture*" or "femoral neck fracture*"):ti,ab

6. [mh ^"Nursing Homes"] or [mh ^"Homes for the Aged"] or ("nursing home*"):ti,ab

7. (residents or residential):ti,ab

8. [mh ^"Aged"] or [mh ^"Aging"] or aged:ti,ab

9. [mh ^"Frail Elderly"] or (elder or elders or elderly):ti,ab

10. (older or geriatric):ti,ab

11. [mh ^"Inpatients"] or inpatients:ti,ab

12. [mh ^"Outpatients"] or outpatients:ti,ab

13. [mh ^"Institutionalization"] or institutionali*:ti,ab

14. [mh ^"Hospitalization"] or (hospitali?ed or hospitali?ation):ti,ab

15. {or #1‐#14}

II: Condition

16. [mh ^"Malnutrition"] or [mh ^"Protein‐Energy Malnutrition"]

17. (malnourish* or malnutrition):ti,ab

18. [mh ^"Nutrition Assessment"]

19. [mh ^"Nutritional Status"] or "nutritional status":ti,ab

20. [mh ^"Nutritional Requirements"]

21. [mh ^"Nutrition Disorders"]

22. [mh ^"Nutritional Support"]

23. ((nutritional or nutrition or nutritionally) near/2 risk):ti,ab

24. ((unintentional or risk) near/2 "weight loss"):ti,ab

25. (undernutrition or undernourished or hyponutrition):ti,ab

26. [mh ^"Elder Nutritional Physiological Phenomena"]

27. [mh ^"Energy Intake"]

28. [mh ^"Feeding Behavior"] or [mh ^"Feeding Methods"]

29. ("Mini Nutritional Assessment" or "Eating Behaviour Scale" or "Edinburgh Feeding Evaluation" or "Malnutrition Universal Screening Tool"):ti,ab

30. ((improve* or increase* or inadequate) near/3 ("nutrient intake" or "energy intake" or "dietary intake" or "food intake")):ti,ab

31. {or #16‐#30}

32. #15 and #31

33. #32 not (child* or infant* or pregnan*):ti,ab,kw

34. Publication Year from 2013 to 2016

MEDLINE (Ovid SP)

I: Population

1. Stroke/ or stroke.tw.

2. Alzheimer Disease/ or alzheimer.tw.

3. Dementia/ or dement*.tw.

4. Mild Cognitive Impairment/ or cognitive impairment.tw.

5. exp Hip Fractures/ or (hip fracture? or femoral neck fracture?).tw.

6. Nursing Homes/ or Homes for the Aged/ or (nursing home?).tw.

7. (residents or residential).tw.

8. Aged/ or Aging/ or aged.tw.

9. Frail Elderly/ or (elder or elders or elderly).tw.

10. (older or geriatric).tw.

11. Inpatients/ or inpatients.tw.

12. Outpatients/ or outpatients.tw.

13. Institutionalization/ or institutionali*.tw.

14. Hospitalization/ or (hospitali?ed or hospitali?ation).tw.

15. or/1‐14

II: Condition

16. Malnutrition/ or Protein‐Energy Malnutrition/

17. (malnourish* or malnutrition).tw.

18. Nutrition Assessment/

19. Nutritional Status/ or nutritional status.tw.

20. Nutritional Requirements/

21. Nutrition Disorders/

22. Nutritional Support/

23. ((nutritional or nutrition or nutritionally) adj2 risk).tw.

24. ((unintentional or risk) adj2 weight loss).tw.

25. (undernutrition or undernourished or hyponutrition).tw.

26. Elder Nutritional Physiological Phenomena/

27. Energy Intake/

28. Feeding Behavior/ or Feeding Methods/

29. (Mini Nutritional Assessment or Eating Behaviour Scale or Edinburgh Feeding Evaluation or Malnutrition Universal Screening Tool).tw.

30. ((improve* or increase? or inadequate) adj3 (nutrient intake or energy intake or dietary intake or food intake)).tw.

31. or/16‐30

32. 15 and 31

III. [Cochrane Handbook 2008 RCT filter ‐ sensitivity and precision max. version]

33. randomized controlled trial.pt.

34. controlled clinical trial.pt.

35. randomi?ed.ab.

36. placebo.ab.

37. clinical trials as topic/

38. randomly.ab.

39. trial.ti.

40. or/33‐39

41. exp animals/ not humans/

42. 40 not 41

43. 32 and 42

44. 43 not (child* or infant* or pregnan*).tw.

45. limit 44 to yr="2013‐Current"

ClinicalTrials.gov (Advanced search)

Search Terms: malnourished OR malnutrition OR undernourished OR undernutrition OR "under nutrition" OR "poor nutritional status" OR "nutritional risk" OR "inadequate nutrient intake"

Study Type: Interventional Studies

Age Group: Adult (18–65), Senior (66+)

WHO ICTRP (Standard search)

malnourished AND elder* OR

malnutrition AND elder* OR

undernourished AND elder* OR

undernutrition AND elder* OR

malnourished AND aged OR

malnutrition AND aged OR

undernourished AND aged OR

undernutrition AND aged OR

malnourished AND geriatric OR

malnutrition AND geriatric OR

undernourished AND geriatric OR

undernutrition AND geriatric

Appendix 3. Description of interventions

Intervention(s)

Type of intervention(s)a

Comparator(s)

Barton 2000

I1: portion size decreased by 20% but fortified to achieve overall daily energy provision increased by 200 kcal (randomised)

Modification of meal profile or pattern

Normal hospital menu (randomised group)

I2: normal hospital menu plus cooked breakfast (not randomised group)

Beck 2002

I1: homemade oral supplement (group A, not randomised)

Additional supplementation of meals

Usual diet

I2: homemade oral supplement (group B)

Bouillanne 2013

'Pulse diet': 78% of daily protein requirements provided at lunch (no change to energy and protein)

Modification of meal profile or pattern

'Spread diet': usual diet (daily protein requirements distributed between meals)

Bourdel‐Marchasson 2000

Oral supplementation in addition to standard diet

Additional supplementation of meals

Standard diet

Brouillette 1991

Osmotherapy (use of aromas to stimulate appetite) + activities

Changes to the feeding environment

Activities only

Castellanos 2009

I1: two breakfast and two lunch foods fortified to improve energy and protein content (hot cereal and juice breakfast, soup and side dish at lunch)

Modification of meal profile or pattern

Routine care, no meals enhanced

I2: two lunch foods only fortified versus normal menu

Chang 2005

Training in feeding skills (feeding skills training programme for nursing assistants)

Changes to the organisation of nutritional care

No training

Dennis 2005

Normal hospital diet plus oral nutritional supplements

Additional supplementation of meals

Normal hospital diet

Duncan 2006

Additional personal attention of a dietetic assistant e.g. checking personal food preferences, assisting with food choice, provision of appropriate feeding aids, feeding assistance and collecting information to aid nutritional assessment

Changes to the organisation of nutritional care

Routine care

Essed 2007

Food sprinkled with 1 g (+ 0.2 g) of intervention + maltodextrin carrier

I1: monosodium glutamate

Modification of meal profile or pattern

Maltodextrin (placebo)

I2: flavour

I3: monosodium glutamate + flavour

Essed 2009

Three foods (previously identified as preferred), i.e. mashed potato (0.2 g NaCl/100 g + 0.5% monosodium glutamate), mince meat (0.37 g NaCl/100 g + 2% monosodium glutamate and spinach (0.25 g NaCl/100 g + 2% monosodium glutamate)

Modification of meal profile or pattern

Usual hot meal

Faxen‐Irving 2011

A daily dose of 3 x 30 mL fat emulsion distributed at the same time as pharmaceutical prescriptions

Additional supplementation of meals

Standard care

Gaskill 2009

Nutrition education programme

Changes to the organisation of nutritional care

Usual care

Germain 2006

Re‐formed foods, thickened beverages and dietary supplements as necessary

Modification of meal profile or pattern

Traditional modified texture diet

Hankey 1993

Supplements in addition to their normal hospital diet

Additional supplementation of meals

Standard hospital food

Hickson 2004

Additional nutritional care from a trained health care assistant

Changes to the organisation of nutritional care

Usual care

Holyday 2012

Malnutrition care plan; screening, assessment and intervention tailored to individuals requirements (including texture modification, fortification, oral nutritional supplements, snacks, assistance)

Changes to the organisation of nutritional care

Usual care

Johansen 2004

Nutrition team (dietitian + nurse)

Changes to the organisation of nutritional care

Usual care

Kraft 2012

Oral nutritional supplements + monitoring using telemedicine

Changes to the organisation of nutritional care

Usual care

Kretser 2003

Modified meals on wheels system (21 meals + 14 snacks) and daily phone call

Congregate and home meal delivery systems

Traditional meals on wheels (one hot meal delivered five days a week at lunch)

Larsson 1990

Oral nutritional supplements plus normal hospital diet

Additional supplementation of meals

Normal hospital diet

Leslie 2012

Energy enriched usual meals

Modification of meal profile or pattern

Usual care

Lin 2010

I1: spaced‐retrieval ‐ a method to enhance learning, retention and recall of information

Changes to the organisation of nutritional care

Usual care

I2: Montessori intervention ‐ a method capable of stopping or reducing residents problem behaviours

Lin 2011

Montessori intervention ‐ designed to manage eating difficulties

Changes to the organisation of nutritional care

Usual care

Mathey 2001a

Improved meal ambiance comprising improvements to physical environment, meal service and organisation of assistance

Changes to the feeding environment

Usual care

Mathey 2001b

Creating a better ambience during food consumption

Changes to the feeding environment

Usual care

Munk 2014

Energy and protein enriched foods provided in addition to the hospital food via an a la carte menu

Modification of meal profile or pattern

Usual care

Nijs 2006

Family‐style meals comprising table dressing, food service, staff protocols, residents protocol and a meal‐time protocol, meal choice at the time of meal

Changes to the feeding environment

Individual pre‐plated meal service, meal chosen 2 weeks in advance.

Olofsson 2007

Multi‐component intervention (including nutrition)

Changes to the organisation of nutritional care

Usual care

Pivi 2011

I1: nutrition education for caregivers and participants

Changes to the organisation of nutritional care

Usual care

I2: oral nutritional supplements (two cartons daily for six months)

Potter 2001

Oral nutritional supplement + normal hospital diet

Additional supplementation of meals

Normal hospital diet

Remsburg 2001

Buffet style dining programme for supper only

Changes to the feeding environment

Usual care, tray‐style meal served by nursing home staff

Salva 2011

Teaching and training intervention to improve nutrition care

Changes to the organisation of nutritional care

Usual care

Silver 2008

Home‐delivered fortified lunch once weekly for 7 months

Modification of meal profile or pattern

Home delivered usual lunch once weekly for 7 months

Simmons 2008

Mealtime feeding assistance and/or between meal snacks

Additional supplementation of meals

Usual care

Simmons 2010

I1: snacks between meal snacks

Additional supplementation of meals

Usual care

Smolliner 2008

I2: oral nutritional supplements

Protein and energy‐enriched soups and sauces and two additional snacks high in protein and energy

Modification of meal profile or pattern

Usual diet

Splett 2003

Medical nutrition therapy (protocol‐driven nutritional assessment and intervention activities carried by dietitians)

Changes to the organisation of nutritional care

Usual care by dietitians

Taylor 2006

5‐meal menu pattern with energy content similar to existing 3‐meal menu

Modification of meal profile or pattern

3‐meal menu (usual care)

Van den Berg 2015

I1: offered 125 mL ONS twice daily with medication rounds

Additional supplementation of meals

Usual care (125 mL ONS offered in between meals)

I2: offered 62 mL ONS four times daily with medication rounds

Van Ort 1995

I2: offered 62 mL ONS daily with medication rounds

Changes to the feeding environment

Usual care

aNumbers refer to intervention sub‐categories: (1) changes to the organisation of nutritional care, (2) changes to the feeding environment, (3) modification of meal profile or pattern, (4) additional supplementation of meals, (5) congregate and home meal delivery systems ‐ see Table 1

C: comparator; I: intervention; ONS: oral nutritional supplement

Appendix 4. Baseline characteristics (I)

Intervention(s) and comparator(s)

Participants
(N)

Description of participants
(trial design)

Country

Setting

Sex
N (female %)

Age
mean years (SD)/range)

Barton 2000

I1: reduced portion fortified menu

13

Elderly hospitalised individuals

(cross‐over RCT)

UK

Elderly rehab ward

6 (46)

77 (8)

I2: normal menu plus cooked breakfast

8 (non‐randomised)

5 (63) (non‐randomised)

78 (9) (non‐randomised)

C: normal hospital menu

14

11 (79)

75 (11)

Beck 2002

I1: homemade oral supplement

36

Nursing home residents > 65 years

(parallel RCT)

Denmark

Residential care home

22 (61)

81 (76‐86)

I2: homemade oral supplement (B)

C: usual diet

Bouillanne 2013

I: pulse diet (78% protein at lunch)

66

Hospitalised elderly individuals
(parallel RCT)

France

Intermediate care unit

46 (70)

84.1 (6)

C: usual diet (protein distributed between meals)

85.7 (6.3)

Bourdel‐Marchasson 2000

I: oral supplementation + standard diet

295

Critically ill elderly participants

(cluster‐RCT)

France

Hospital wards & geriatric units

199 (67.5)

83.6 (7.3)

C: standard diet

377

238 (63.1)

83.0 (7.1)

Brouillette 1991

I: osmotherapy + activities

10

Nursing home residents
(parallel RCT)

USA

Residential care home

14 (88) of those that completed the trial

80 (6.4)

C: activities only

10

87 (6.8)

Castellanos 2009

I1: fortified breakfast and lunch menu

39

Nursing home residents

(cross‐over RCT)

USA

Residential care home

23/33 finishing (70)

87.3 (8.6)

I2: fortified lunch menu

39

C: usual menu

39

Chang 2005

I: training in feeding skills

20

Nursing assistants and nursing home residents with dementia
(cluster RCT)

Taiwan

Residential care home

C: no training

16

Dennis 2005

I: nutritional supplement + normal hospital diet

2016

Participants with recent stroke
(parallel RCT)

15 different countries

Hospital

945 (47)

71 (12)

C: normal hospital diet

2007

929 (46)

71 (13)

Duncan 2006

I. dietetic assistant

153

Women > 65 years admitted with acute hip fracture
(parallel RCT)

UK

Acute trauma ward

318 (100)

83.6

C: usual care

165

83.5

Essed 2007

I1: monosodium glutamate

19

Residents of nursing home ≥ 65 years

(factorial RCT)

Netherlands

Residential care home

58 (70)

84.9 (5.7)

I2: flavour

19

85.4 (6.7)

I3: monosodium glutamate + flavour

22

84.9 (6.2)

C: maltodextrin

23

85.6 (8.5)

Essed 2009

I: monosodium glutamate + NaCl

53

Nursing home residents > 65 years

(cross‐over RCT)

Netherlands

Residential care home

40 (76)

85.8 (6.2)

C: usual hot meal

53

Faxen‐Irving 2011

I: 3 x 30 mL of fat emulsion daily

34

Recently admitted geriatric persons > 65 years
(parallel RCT)

Sweden

Geriatric acute ward

(61)

82.7 (7.5) ‐ data from those who completed the trial only (N = 24)

C: usual care

37

(49)

85.1 (6.7) ‐ data from those who completed the trial only (N = 27)

Gaskill 2009

I: nutrition education programme

352

Nursing home residents
(cluster‐RCT)

Australia

Residential care home

245 (70)

84.2 (8.7)

C: usual care

Germain 2006

I: re‐formed foods

8

Frail institutionalised elderly people with dysphagia
(parallel RCT)

Canada

Residential care home

5 (63)

82.5 (4.4)

C: usual diet

9

5 (56)

84.6 (3.8)

Hankey 1993

I: oral nutritional supplement

7

Frail elderly persons in continuing care
(parallel RCT)

UK

Hospital

11 (79)

81 (1.6)

C: standard hospital diet

7

Hickson 2004

I: feeding assistance

292

Acutely ill elderly inpatients
(parallel RCT)

UK

Elderly medicine ward

200 (69)

82 (76 ‐ 86)

C: usual care

300

173 (58)

82 (77 ‐ 87)

Holyday 2012

I: malnutrition care plan

71

Acutely ill elderly inpatients
(parallel RCT)

Australia

Acute geriatric medicine ward

43 (61)

83.7 (6.7)

C: usual care

72

39 (54)

83.4 (7.6)

Johanssen 2004

I: nutrition team

108

Nutritional risk score 2000 > 3 on admission to hospital
(parallel RCT)

Denmark

Hospital, three different levels

54 (50)

62 (1.6)

C: usual care

104

56 (54)

62.4 (1.7)

Kraft 2012

I: ONS + telemedicine monitoring

13

Malnourished geriatric home‐dwelling persons
(parallel RCT)

Germany

Hospital discharge and tele‐medicine monitoring

7 (54)

80.7 (5.6)

C: usual care

13

9 (69)

78.8 (8.8)

Kretser 2003

I: modified meals on wheels

102

Homebound older adults at nutritional risk
(parallel RCT)

USA

Home care

70 (69)

(60‐90)

C: traditional meals on wheels

101

74 (73)

Larsson 1990

I: ONS plus normal hospital diet

435

Older people admitted to a long‐term medical care clinic
(parallel RCT)

Sweden

Hospital

Unclear ‐ varies between papers, authors to be contacted

80.1 (8.5)

C: normal hospital diet

Leslie 2012

I: energy enriched meals

22

People living in residential care homes

(cluster‐RCT)

UK

Residential care home

36 (88%)

90.9 (77‐105)

C; usual care

19

90.3 (70‐100)

Lin 2010

I1: spaced‐retrieval

32

Residents with dementia
(cluster‐RCT)

Taiwan

Residential care home

18 (56)

76.7 (6.1)

I2: Montessori

29

12 (41)

82.9 (6.0)

C: usual care

24

15 (63)

81.1 (7.0)

Lin 2011

I: Montessori

29

Residents with dementia

(cluster RCT & cross‐over RCT)

Taiwan

Residential care home

12 (41)

82.9 (6.0)

C: usual care

Mathey 2001a

I: improved meal ambiance

21

Nursing home residents > 65 years
(cluster‐RCT)

Netherlands

Residential care home

25 (66)

82.2 (7.9)

C: usual care

17

Mathey 2001b

I: flavour enhancement

36

Nursing home residents > 65 years
(parallel RCT)

Netherlands

Residential care home

29 (74)

84.6 (6.1)

C: usual care

31

25 (81)

83.0 (5.5)

Munk 2014

I: energy and protein enriched foods provided via a la carte menu in addition to hospital food

41 (number completing the trial)

New admissions to hospital ward (oncology, orthopaedics or urology)
(parallel RCT)

Denmark

Hospital

25 (61)

75 (10

C: usual care

40

22 (55)

74 (11)

Nijs 2006

I: family‐style meals

94

Nursing home residents

(cluster‐RCT)

Netherlands

Residential care home

70 (74)

78 (11.1)

C: usual care

84

55 (65)

75 (9.9)

Olofsson 2007

I: multi‐component intervention (including nutrition)

102

People > 70 years with femoral neck fracture
(parallel RCT)

Sweden

Geriatric orthopaedic ward

62 (75)

82.1 (6.8)

C: usual care

97

57 (77)

82.2 (5.6)

Pivi 2011

I1: nutrition education

25

Individuals > 65 years old with Alzheimer's disease
(parallel RCT)

Brazil

Neurology outpatients

53 (68)

75.2

I2: oral nutritional supplements

26

C: usual care

27

Potter 2001

I: oral nutritional supplement + normal hospital diet

186

Unwell elderly people
(parallel RCT)

Scotland, UK

Medicine for the elderly unit

140 (75)

Median 83 (61‐79)

C: normal hospital diet

195

139 (71)

Remsburg 2001

I: buffet‐style meals

20

Nursing home residents > 65 years
(parallel RCT)

USA

Residential care home

19 (95)

80 (6)

C: usual care

20

13 (65)

80 (8)

Salva 2011

I: teaching and training

448

People with dementia

(cluster RCT)

Spain

Home care

300 (67)

79.4 (7)

C: usual care

498

344 (69)

78.6 (7.5)

Silver 2008

I: fortified home delivered lunch

Adults > 60 years receiving home‐delivered lunch meals

(cross‐over RCT)

USA

Home care

31(69) of those who completed the trial (N = 45)

84.4 (1) of those who completed the trial (N = 45)

C: usual home delivered lunch

Simmons 2008

I: feeding assistance and/or snacks

35

Nursing home residents

(cluster‐RCT & cross‐over RCT)

USA

Residential care home

Reported for the total group, and not the subgroup to be used in this review

Reported for the total group, and not the subgroup to be used in this review

C: usual diet

34

Simmons 2010

I1: snacks

25

Nursing home residents
(parallel RCT)

USA

Residential care home

39 (62)

86.9 (11.3)

I2: supplements

18

C: usual care

20

Smolliner 2008

I: fortified meals and snacks

Elderly nursing home residents

(cluster RCT)

Germany

Residential care home

17 (77)

82.2 (9.5)

C: usual diet

21 (70)

84.7 (9.5)

Splett 2003

I: medical nutrition therapy

223

Frail elderly nursing home residents

(cluster‐RCT)

USA

Residential care home

143 (67)

Male 79.2 (9.7); Female 82.8 (8.7)

C: usual care

171

125 (73)

Taylor 2006

I: 5‐meal menu

31

Elderly nursing home residents with dysphagia

(cross‐over RCT)

Canada

Residential care home

26 (84)

85 (6.4)

C: usual (3‐meal menu)

Van den Berg 2015

I1: 125 mL ONS twice daily with medication round

Patients newly admitted to medical and surgical wards
(parallel RCT)

The Netherlands

Hospital

34 (52)

70.5 (15)

I2: 62 mL ONS four times daily with medication round

37 (46)

72.6 (10)

C: usual care (125 mL ONS offered in between meals)

34 (39)

70.4 (13)

Van Ort 1995

I: contextual and behavioural intervention

4

Nursing home residents requiring feeding assistance
(parallel RCT)

USA

Residential care home

6 (75)

(65‐93)

C: usual care

4

‐ denotes not reported

C: comparator; I: intervention; ONS: oral nutritional supplement; RCT: randomised controlled trial

Appendix 5. Baseline characteristics (II)

Intervention(s) and comparator(s)

Ethnic groups

Baseline nutritional status
(N (%))

BMI
(mean kg/m² (SD), range)

Duration of intervention (duration of follow‐up)

Comedications/cointerventions

Comorbidities
(N or %)

Barton 2000

I1: reduced portion fortified menu

Maximum of 56 d

I2: normal menu plus cooked breakfast

C: normal hospital menu

Beck 2002

I1: homemade oral supplement (A)

Mini Nutritional Assessment score 17‐23.5 (increased risk of malnutrition)

22.8 (21.3 ‐ 26.1)

2 mo (2 mo)

I2: homemade oral supplement (B)

C: usual diet

Bouillanne 2013

I: pulse diet (78% protein at lunch)

Albumin 25‐35 g/L; BMI < 22 kg/m² and/or weight loss > 10% in 6 months and/or MNA < 23.5

Median 20.7 (95% CI 20‐23.2)

6 wk (6 wk)

C: usual diet (protein distributed between meals)

Median 20.9 (95% CI 20‐25)

Bourdel‐Marchasson 2000

I: oral supplementation + standard diet

15 d or until discharge (15 d or until discharge)

C: standard diet

Brouillette 1991

I: osmotherapy + activities

3 wk (4 wk)

C: activities only

Castellanos 2009

I1: fortified breakfast and lunch menu

2 d (‐)

I2: fortified lunch menu

C: usual menu

Chang 2005

I: training in feeding skills

Intervention: 3 hours "in‐service" within 2 days + 1 h "hands‐on" instruction (‐)

C: no training

Dennis 2005

I: nutritional supplement + normal hospital diet

Duration of hospital stay (6 mo)

C: normal hospital diet

Duncan 2006

I. dietetic assistant

Duration of hospital stay (4 mo)

C: usual care

Essed 2007

I1: monosodium glutamate

22 (27) at increased risk of malnutrition by MNA

16 wk (16 wk)

I2: flavour

I3: monosodium glutamate + flavour

C: maltodextrin

Essed 2009

I: monosodium glutamate + NaCl

8 (15) at increased risk of malnutrition by MNA

26.5 (4.2)

4 wk (4 wk)

C: usual hot meal

Faxen‐Irving 2011

I: 3 x 30 mL of fat emulsion daily

20.4 (3.5)

Median 8 d (median 8 d)

Comorbidities related to anorexia were cancer (N = 6), liver disease (N = 1) and renal failure (N = 1) ‐ in both groups

C: usual care

22.2 (3.7)

Gaskill 2009

I: nutrition education programme

171 (49) moderately or severely malnourished by SGA

6 mo (6 mo)

C: usual care

Germain 2006

I: re‐formed foods

17 (100) unintentional weight loss > 7.5% in previous 3 mo or BMI < 24 kg/m²

22.4 (3.9)

12 wk (12 wk)

C: usual diet

21.2 (2.3)

Hankey 1993

I: ONS

8 wk (8 wk)

C: standard hospital diet

Hickson 2004

I: feeding assistance

282 (96.6) white ethnic group

21.7 (18.6‐25.3)

Duration of hospital stay (duration of hospital stay)

C: usual care

286 (95.3) white ethnic group

21.8 (19.1‐25.7)

Holyday 2012

I: malnutrition care plan

119 (83) malnourished or at risk of malnutrition by MNA score

23.8 (5.9)

Duration of hospital stay (duration of hospital stay)

C: usual care

23.3 (5.9)

Johansen 2004

I: nutrition team

212 (100) ESPEN 2002 NRS (score > 3 nutritionally at risk)

21.2 (0.5)

Duration of hospital stay (duration of hospital stay)

C: usual care

21.8 (0.5)

Kraft 2012

I: ONS + telemedicine monitoring

26 (100) weight loss > 10% in 6 months, BMI < 21 kg/m², albumin < 35 g/L

23.4 (3.7)

6 mo (6 mo)

Number of medications: 7.5 (SD 4.2)

C: usual care

23.4 (4.5)

Number of medications: 8.2 (SD 3.4)

Kretser 2003

I: modified meals on wheels

45 (44) white

97 (96) at risk or malnourished according to MNA

14 (14%) BMI < 18.5

26 wk (26 wk)

A variety of self‐reported health problems reported

C: traditional meals on wheels

38 (58) white

95 (95) at risk or malnourished

9 (9%) BMI < 18.5

Larsson 1990

I: ONS plus normal hospital diet

(28.5) malnourished

26 wk (26 wk)

C: normal hospital diet

Leslie 2012

I: energy enriched meals

100% malnourished (BMI < 18.5 kg/m2

17.1 (1.5)

12 wk (12 wk)

6 participants with dementia

C; usual care

17.3 (1.4)

Lin 2010

I1: spaced‐retrieval

24.7 (4.3)

8 wk (8 wk)

I2: Montessori

21.2 (3.4)

C: usual care

23.1 (2.7)

Lin 2011

I: Montessori

21.4 (3.5)

8 wk (8 wk)

C: usual care

Mathey 2001a

I: improved meal ambiance

12 mo (12 mo)

C: usual care

Mathey 2001b

I: flavour enhancement

28.4 (7.1)

16 wk (16 wk)

Number of medicines/day 2.1 (1.8)

C: usual care

28.1 (7.0)

Number of medicines/day 2.1 (1.6)

Munk 2014

I: energy and protein enriched foods provided via a la carte menu in addition to hospital food

NRS score 0 = 1, 1 = 10, 2 = 18, 3 = 12

21(4)

Duration of hospital stay (duration of hospital stay)

Disease severity score:
0 = 2; 1 = 30; 2 = 8; 3 = 1

C: usual care

NRS score 0 = 0, 1 = 15, 2 = 17, 3 = 8

22(4)

Disease severity score:
0 = 3; 1 = 34; 2 = 3; 3 = 0

Nijs 2006

I: family‐style meals

17 (18) MNA score < 17

28.7 (6.8)

6 mo (6 mo)

CVA: 57%

C: usual care

13 (13) MNA score < 17

28.4 (5.8)

CVA: 50%

Olofsson 2007

I: multi‐component intervention (including nutrition)

48 (58 ) malnourished or at risk by MNA score

25.1 (4.1)

Duration of hospital stay (4 mo)

Staff education; team work, individual care planning; prevention and treatment of delirium and complications; nutrition; rehabilitation; secondary prevention of falls and fractures; osteoporosis prophylaxis

C: usual care

47 (57 ) malnourished or at risk by MNA score

23.3 (4.0)

Pivi 2011

I1: nutrition education

6 mo (6 mo)

I2: ONS

C: usual care

Potter 2001

I: ONS + normal hospital diet

Adequately nourished: 62/186 (33);

moderately malnourished: 90/186 (48);

severely malnourished: 34/186 (18)

Duration of hospital stay (duration of hospital stay)

C: normal hospital diet

Adequately nourished: 68/195 (35);

moderately malnourished: 87/195 (45); severely malnourished: 40/195 (21)

Remsburg 2001

I: buffet‐style meals

17 (85) white ethnic group

24.4 (6.1)

3 mo (3 mo)

CVA: 6 (30%)

CVD: 13 (65%)

C: usual care

15 (75) white ethnic group

24.3 (5.8)

CVA: 10 (50%)

CVD: 12 (60%)

Salva 2011

I: teaching and training

(7.8) malnourished (51.5) or at risk by MNA

26.6 (4.4)

12 mo (12 mo)

Number of comorbidities 4.6 (SD 2.2)

C: usual care

(2.8) malnourished (34.5) or at risk by MNA

27.3 (4.6)

Number of comorbidities 4.2 (SD 2.6)

Silver 2008

I: fortified home‐delivered lunch

24.2 (7)

7 mo (7 mo)

C: usual home‐delivered lunch

Simmons 2008

I: feeding assistance and/or snacks

2 x/d for 5 days/week and 24 wk (24 wk)

C: usual diet

Simmons 2010

I1: snacks

6 wk (6 wk)

I2: supplements

C: usual care

Smolliner 2008

I: fortified meals and snacks

22 (100) by MNA score indicating at risk or malnourished

21.6 (3.6)

12 wk (12 wk)

Number of prescriptions median 4 (IQR 2‐6.5)

GDS: 6.7 (SD 2.9)

C: usual diet

30 (100) by Mini Nutritional Assessment score indicating at risk or malnourished

22.5 (3.4)

Number of prescriptions median 6 (IQR 3.8‐7)

GDS: 7.5 (SD 3)

Splett 2003

I: medical nutrition therapy

19‐180 d (19‐180 d)

Dementia: 24%
congestive heart failure: 25%
depression: 19%
Alzheimer’s disease: 14%
bone/hip fracture: 15%

chronic obstructive: 10%
pulmonary disease
cancer: 5%
pneumonia: 4%
dehydration: 1%

C: usual care

Dementia: 34%
congestive heart failure: 26%
depression: 32%
Alzheimer’s disease: 21%
bone/hip fracture: 19%
chronic obstructive: 17%
pulmonary disease
cancer: 12%
pneumonia: 6%
dehydration: 4%

Taylor 2006

I: 5‐meal menu

31 (100) mean MNA score 16.3

20.4 (3.4)

2 x 4 d, separated by 4 wk) (2 x 4 d, separated by 4 wk)

C: usual (3‐meal menu)

Van den Berg 2015

I1: 125 mL ONS twice daily with medication round

SNAQ score 1 or 2 = 6, 3 = 13, 4 or 5= 6, 6 or 7 = 41

25 (4.3)

median 5 (range 1‐17)

I2: 62 mL ONS four times‐ daily with medication round

SNAQ score 1 or 2 = 6, 3 = 13, 4 or 5= 12, 6 or 7 = 49

23.8 (3.9)

median 5 (range 1‐15)

C: usual care (125 mL ONS offered in between meals)

SNAQ score 1 or 2 = 5, 3 = 13, 4 or 5 = 18, 6 or 7 = 52

24.3 (4.7)

median 6 (range 1‐30)

Van Ort 1995

I: contextual and behavioural intervention

2 wk (6 wk, 1 mo after intervention)

C: usual care

'‐' denotes not reported

BMI: body mass index; C: comparator; CI: confidence interval; CVA: cerebrovascular accident; CVD: cardiovascular diagnosis; d: days; GDS: geriatric depression scale; I: intervention; IQR: interquartile range; mo: month(s); MNA: mini nutritional assessment; NRS: nutritional risk score; ONS: oral nutritional supplement; SD: standard deviation; SGA: subjective global assessment; SNAQ: Simplified Nutritional Appetite Questionnaire; wk: week(s)

Appendix 6. Matrix of study endpoints (publications and trial documents)

Endpoints quoted in trial document(s)
(ClinicalTrials.gov, FDA/EMA document, manufacturer's website, published design paper)a

Trial results/
publications available
in trials register

Endpoints quoted in publication(s)b,c

Endpoints quoted in abstract of publication(s)b,c

Bouillanne 2013

Source:NCT00135590

Primary outcome measure(s):

  • lean mass (dual energy X‐ray absorptiometry (dexa) and bioelectrical‐impedance analysis (bia)) ‐ time frame: 42 days

No/Yes

(last verified: November 2004)

Primary outcome measure(s):

  • lean mass (total lean soft‐tissue mass (LM) index, appendicular muscle mass (ASMM) index or body cell mass (BCM) index, which is the metabolically active compartment))

Primary outcome measure(s):

  • body composition ((lean mass (LM), appendicular skeletal muscle mass (ASMM), and body cell mass (BCM) indices, measured by X‐ray absorptiometry combined with bioelectrical impedance analysis)

Secondary outcome measure(s):

  • immune functions ‐ time frame: 42 days

  • hand‐grip strength ‐ time frame: 42 days

  • biological nutritional parameters ‐ time frame: 42 days

  • mortality and morbidity (infections and bedsores) ‐ time frame: 42 days

  • ADL ‐ time frame: 42 days

  • plasmatic amino acid levels ‐ time frame: 42 days

Secondary outcome measure(s):

  • hand grip strength

  • ADL score

Secondary outcome measure(s):

  • hand grip strength

  • ADL score

Other outcome measure(s): ‐

Other outcome measure(s):

  • albumin

  • transthyretin

  • C‐reactive protein

  • prognostic inflammatory and nutritional index (PINI)

Other outcome measure(s): ‐

History of changes: 6 documented changes

Faxen‐Irving 2011

Source:NCT01042340

Primary outcome measure(s):

  • to detect a significant difference in energy intake of 48 kj/200 kcal between the groups at 5% significance level and with 80% power ‐ time frame: 5 days to 3 weeks intervention

No/Yes

(last verified: December 2009)

Primary outcome measure(s): ‐

Primary outcome measure(s): ‐

Secondary outcome measure(s):

  • effects on serum lipids and appetite ‐ time frame: 5 days to 3 weeks treatment

Secondary outcome measure(s):

  • acceptance and compliance of the concept by the participants at the ward

Secondary outcome measure(s): ‐

Other outcome measure(s): ‐

Other outcome measure(s):

  • sample size calculation was performed: to detect a significant difference in energy intake of 200 kcal between the groups at 5% significance level and with 80% power, 27 participants in each group were needed. To allow for dropouts this was increased to 35 participants in each group

  • nutritional assessment, by the Nutritional Risk Screening (NRS‐2002) form: evaluation of BMI, weight loss, reduced dietary intake, age 70 and presence of severe illness and a sum score (0‐7 points) was calculated

  • biochemical indicators of nutritional status serum levels of albumin, transthyretin and insulin‐like growth factor‐1 (IGF‐1)

  • C‐reactive protein (CRP)

  • total cholesterol, high‐density lipoprotein (HDL) and low‐density lipoprotein (LDL) cholesterol, fasting serum triglyceride concentrations

  • fatty acid (FA) profiles were measured in serum phospholipids

  • function as determined by ADL according to the Katz ADL index

Other outcome measure(s):

  • food intake and self‐rated appetite

  • Nutritional risk screening (NRS) 2000

  • serum lipids and fatty acid profiles

History of changes: 1 documented change

Holyday 2012

Source:NCT01179321

Primary outcome measure(s): length of stay

No/No

(last verified: March 2006)

Primary outcome measure(s): ‐

Primary outcome measure(s): ‐

Secondary outcome measure(s): ‐

Secondary outcome measure(s): ‐

Secondary outcome measure(s): ‐

Other outcome measure(s): ‐

Other outcome measure(s):

  • pre‐study power analysis based on the average length of stay (LOS) of the trial population (11 d) with 0.80 power using a test with significance of 0.05, would require at least 50 participants in each group to detect a reduction in LOS of 20%

  • the number of participants seen by a clinical dietitian, number of consults per participant and total consultation time per participant was captured from the hospital’s computerised dietitians’ statistics system

  • timeliness of intervention was counted as days between date of admission to the ward and the date seen by the clinical dietitian

  • weight change over the course of admission was calculated from the weight on admission and the weight at discharge

  • deaths during admission

  • number of presentations to emergency and number of hospital readmissions

  • cost of hospital admission, additional costs of a screening and nutritional intervention programme

Other outcome measure(s):

  • length of stay LOS)

  • weight change

  • frequency of readmission to hospital

History of changes: 0 documented changes

Munk 2014

Source:NCT01415635

Primary outcome measure(s):

  • Percentage of participants reaching > 75% of their calculated energy and protein requirements

No/No

(last verified: December 2012)

Primary outcome measure(s):

  • Percentage of participants reaching > 75% of their calculated energy and protein requirements

Primary outcome measure(s):

  • Percentage of participants reaching > 75% of their calculated energy and protein requirements

Secondary outcome measure(s):

  • handgrip strength

  • daily energy and protein intake

  • use of tube feeding

  • use of parenteral nutrition

  • length of stay

Secondary outcome measure(s):

  • Mean daily energy and protein intake

  • body weight

  • handgrip strength

  • Length of stay

  • number of participants receiving enteral or parenteral feeding

Secondary outcome measure(s):

  • Mean daily energy and protein intake

  • body weight

  • handgrip strength

  • Length of stay

Other outcome measure(s): none provided

Other outcome measure(s): number of participants receiving ONS

Other outcome measure(s): ‐

History of changes: 1 documented change

Nijs 2006

Source:NCT00114582

Primary outcome measure:

  • nutritional status, quality of life, physical performance

No/Yes

(last verified: February 2009)

Primary outcome measure(s):

  • quality of life

Primary outcome measure(s): ‐

Secondary outcome measure(s): ‐

Secondary outcome measure(s): ‐

Secondary outcome measure(s): ‐

Other outcome measure(s): ‐

Other outcome measure(s):

  • physical performance

  • body weight

  • energy intake

Other outcome measure(s):

  • quality of life (perceived safety; autonomy; and sensory, physical, and psychosocial functioning)

  • gross and fine motor function

  • body weight

History of changes: 4 documented changes

Salva 2011

Source:NCT00479843

Primary outcome measure(s):

  • evaluation of the effectiveness of the intervention ‐ the main evaluation criteria which would allow the effectiveness of this intervention to be evaluated were the reduction in the loss of autonomy measured by the ADL/iADL scale ‐ time frame: baseline, 6 months, 12 months

No/Yes

(last verified: January 2014)

Primary outcome measure(s): ‐

Primary outcome measure(s):

  • main outcome measure was the reduction in the loss of autonomy ((ADL/IADL) scales) assessed at 6 and 12 months

Secondary outcome measure(s):

  • improvement in the participant's state of nutrition ‐ reducing the burden on carers with the Zarit scale

  • evaluation of the use of healthcare and social resources with the RUD scale

  • improvement of medical practice regarding nutrition

(time frame: baseline, 6 months, 12 months)

Secondary outcome measure(s):

  • improvement in nutritional state of the participant evaluated by their change in weight, BMI and MNA

  • reduction in burden on caregiver (ZARIT scale)

  • reduction in the use of healthcare and social resources (RUD scale)

Secondary outcome measure(s):

  • improvement in nutritional status (Mini Nutritional Assessment (MNA), BMI, and weight changes)

  • caregiver burden (Zarit scale)

Other outcome measure(s): ‐

Other outcome measure(s):

  • our primary hypothesis was that participants in the intervention group would achieve a lower level of dependency compared with participants in the usual care‐control group at 12 months. We considered a significant benefit in the intervention group to be a reduction of 30% in the proportion of participants who lost more than 0.5 points according to the ADL score (loss of autonomy) over one year

Other outcome measure(s)‐

History of changes: 2 documented changes

Van den Berg 2015

Source:NTR2535

Primary outcome measure(s): proportion of participants who received their treatment goal. The treatment goal was to receive at least 75% of the prescribed volume of ONS during admission

No (last verified 19 Nov 2010)

Primary outcome measure(s):the percentage of participants who reached the treatment objective of at least 75% of the prescribed volume of ONS during admission

Primary outcome measure(s):

The percentage of participants who consumed at least 75% of the prescribed volume of ONS

Secondary outcome measure(s):

intake (mL of ONS) (nurses and food assistants read the amount of ONS left in the bottle)

Secondary outcome measure(s):

Mean intake of ONS per day in mL and energy and protein

Not stated

Other outcome measure(s):‐

Other outcome measure(s): length of hospital stay, hospital readmissions, time to intervention, duration of intervention, mortality

Median time of taking ONS

History of changes: No documented changes

'‐' denotes not reported

aTrial document(s) refers to all available information from published design papers and sources other than regular publications (e.g. FDA/EMA documents, manufacturer's websites, trials registers)
bPublication(s) refers to trial information published in scientific journals (primary reference, duplicate publications, companion documents or multiple reports of a primary trial)
cOther outcome measures refer to all outcomes not specified as primary or secondary outcome measures

ADL: activities of daily living; BMI: body mass index; EMA: European Medicines Agency; FDA: Food and Drug Administration (US); mo: month(s); N/A: not applicable; N/T: no trial document available; yr: year(s); wk: week(s); ONS oral nutritional supplement

Appendix 7. High risk of outcome reporting bias according to ORBIT classification

Outcome

High risk of bias
(category A)a

High risk of bias
(category D)b

High risk of bias
(category E)c

High risk of bias
(category G)d

Barton 2000

Energy intake

Yes

Food wastage

Yes

Protein intake

Yes

Beck 2002

N/D

Bouillanne 2013

N/D

Bourdel‐Marchasson 2000

Energy intake

Yes

Incidence of death

Yes

Pressure ulcer developments

Yes (40% in intervention group, 48% in control; no further analysis)

Castellanos 2009

3 meal energy intake

Yes

3 meal protein intake

Yes

Chang 2005

N/D

Dennis 2005

Death or poor outcome

Yes

Death

Yes

Complications: pneumonia, UTI, pressure sores

Yes

Length of stay

Yes

Discharge destination

Yes

EUROQoL

Yes

Duncan 2006

N/D

Essed 2007

Pleasantness

Yes

Olfactory sensitivity

Yes (analysed but reported as correlation with energy intake)

Appetite, hunger and sensory perception

Yes

GDS

Yes

Essed 2009

N/D

FaYesen‐Irving 2011

Energy intake

Yes

Body mass index

Yes

Activities of Daily Living

Yes

Length of stay

Yes

Appetite

Fatty acid profiles (myristic acid, margarinic acid,
stearic acid, oleic acid, alpha‐linoleic acid,
eicosapentaenoic acid)

Yes

Pentadecanoic acid

Yes

Gaskill 2009

Subjective global assessment

Yes

Germain 2006

N/D

Hankey 1993

Anthropometry: TSF,
MAC weight

Yes

Serum albumin

Yes

Fiber intake

Yes

Hickson 2004

Serum albumin

Yes

Barthel score

Yes

Cognition and depression score (BASDEC)

Yes

Pressure sore incidence

Yes

Laxative use

Yes

Artificial nutrition use

Yes

Economic analysis

Yes

Dietary intake

In‐hospital mortality

Grip strength

Holyday 2012

N/D

Johansen 2004

N/D

Kraft 2012

N/D

Kretser 2003

Satisfaction with programme

Yes

Larsson 1990

Nutritional assessment (TSF,
MAC)

Yes

Serum protein analysis

Yes

Acute phase reactants (antitrypsin, orosomucoid)

Yes

Length of stay

Yes

Leslie 2012

N/D

Lin 2010

Eating time

Yes

Lin 2011

N/D

Mathey 2001a

Health‐related quality of life

Yes (P < 0.05 stated for intervention but no P value for control)

Philadelphia Geriatric Center Morale Scale

Yes (no P values reported)

Mathey 2001b

N/D

Munk 2014

N/D

Nijs 2006

N/D

Olofsson 2007

N/D

Pivi 2011

N/D

Potter 2001

Anthropometry: TSF, BMI

Yes

Arm muscle circumference

Yes

Mortality

Yes (significant result when severely undernourished analysed in isolation)

Functional recovery (Barthel ADL index)

Yes (significant result when severely undernourished analysed in isolation)

Discharge placement

Yes

Length of hospital stay

Yes

Remsburg 2001

N/D

Salva 2012

Health and social care costs (Resource Utilisation
in Dementia (RUD) scale)

Yes

Silver 2008

Confounding effect of age, sex and BMI on meal
treatment order, total energy, energy density and macronutrients

Yes

Simmons 2008

N/D

Simmons 2010

Weight

Yes

Smolliner 2008

N/D

Splett 2003

N/D

Taylor 2006

N/D

Van den Berg 2015

N/D

Van Ort 1995

Nutritional status (weight change)

Yes

Feeding related interpersonal contact between residents and feeder

Yes

Functional ability of subject, and level of assistance offered by feeder

Yes

aClear that outcome was measured and analysed; trial report states that outcome was analysed but only reports that result was not significant
(Classification 'A', table 2, Kirkham 2010)
bClear that outcome was measured and analysed; trial report states that outcome was analysed but no results reported
(Classification 'D', table 2, Kirkham 2010)
cClear that outcome was measured; clear that outcome was measured but not necessarily analysed; judgement says likely to have been analysed but not reported because of non‐significant results
(Classification 'E', table 2, Kirkham 2010)
dUnclear whether the outcome was measured; not mentioned but clinical judgement says likely to have been measured and analysed but not reported on the basis of non‐significant results
(Classification 'G', table 2, Kirkham 2010)

ADL: activities of daily living; BMI: body mass index; EuroQol: European Quality of Life Scale; GDS: geriatric depression scale; mo: months; N/D: none detected; ORBIT: Outcome Reporting Bias In Trials; TSF: triceps skinfold thickness

Appendix 8. Definition of endpoint measurement (I)

Nutritional intake

Health‐related quality of life/patient satisfaction

Mortality

Morbidity/complications

Nutritional status

Barton 2000

Energy intake (kcal), protein intake (g), food wastage (%)

Beck 2002

Energy intake (MJ)

Weight (kg)

Bouillanne 2013

Yes

Infections

Body composition

Bourdel‐Marchasson 2000

Energy intake (kcal), protein intake (g)

Yes

Brouillette 1991

Energy intake (kcal), % food consumed

Yes

Castellanos 2009

Energy intake (kcal), protein intake (g)

Chang 2005

% meal eaten

Dennis 2005

Quality of life (EUROQoL)

Yes

Incidence of pneumonia, UTI and pressure sores

Duncan 2006

Dietary intake records on day 3‐6

Records of medical and surgical complications

Weight, MAMC, TSF, HGS

Essed 2007

Energy intake (kJ), protein, fat and CHO (g)

Weight (kg), BMI, body composition

Essed 2009

Energy intake (kJ)

Faxen‐Irving 2011

Energy intake (kcal/kg body weight/day)

Yes

Weight, appetite, BMI

Gaskill 2009

SGA

Germain 2006

Dietary intake, energy (kcal), other nutrients (g/mg)

Yes

Weight, BMI

Hankey 1993

Energy intake (kj/24hours), protein intake (g/24hours)

Weight, TSF, MAC, AMC, serum albumin

Hickson 2004

Energy intake (J), protein (g)

EQ‐5D

Yes

Antibiotics prescribed (N), days on antibiotics

Weight, BMI, MAC, TSF, MAMC,

Holyday 2012

Yes

Weight

Johansen 2004

Energy intake (kJ/kg and % requirements), protein intake (g/kg and % requirements)

SF‐36

Yes

Infectious and other complications graded into major and minor (using Buzby et al 1988 and CDC definitions)

Weight change (kg)

Kraft 2012

_

Weight change (kg)

Kretser 2003

Yes

Weight, weight change (lb)

Larsson 1990

Encompassed in the Modified Norton Scale

Yes

Weight index, TSF, MAC, AMC

Leslie 2012

Dietary intake, 3 day weighed records

Yes

Weight change, change in BMI & MUAC

Lin 2010

Eating amount (unit unclear)

No

MNA and BMI

Lin 2011

No

MNA and BMI

Mathey 2001a

Macro‐ and micronutrient intakes

SIP, PGCMS

Yes

No

Weight

Mathey 2001b

Energy intake

_

No

no

Weight

Munk 2014

Percent of participants meeting > 75% of their energy and protein requirements. Mean daily energy and protein intake

Yes

Weight

Nijs 2006

Energy intake (kcal), macronutrient (g)

Dutch QOL nursing home residents questionnaire

Yes

Weight (kg, calf circumference (cm), MAC (cm), MNA score

Olofsson 2007

Yes

Infectious and non‐infectious complications during hospital stay

Weight, BMI, MNA

Pivi 2011

Yes

Weight, BMI, MAC, MAMC, TSF

Potter 2001

Total energy intake (kcal)

Yes

Weight, AMC, TSF, BMI

Remsburg 2001

Yes

Weight (kg)

Salva 2011

Yes

Weight (kg), BMI, MNA

Silver 2008

Total energy (kcal), energy density (kcal/g), macronutrient's (g), micronutrients

Simmons 2008

Total energy (kcal)

Weight (lb), BMI

Simmons 2010

Energy intake (kcal)

Yes

Weight (lb)

Smolliner 2008

Energy (kcal and kcal/kg body weight), protein (g and g/kg body weight)

Yes

Weight, BMI, MNA score, fat‐free mass

Splett 2003

Yes

Weight

Taylor 2006

Energy intake (kcal/day), fluid intake (mL/day)

Van den Berg 2015

Energy intake from ONS (kcal/day)

Yes

Van Ort

Weight

ADL: activities of daily living; AMC: arm muscle circumference; BMI: body mass index; CDC: Centre for Disease Control; CDR: clinical dementia rating scale; CHO: carbohydrate; d: day; EQ‐5D/EuroQol: European Quality of Life Scale; HGS: handgrip strength; iADL: instrumental Activities of Daily Living; MAC: mid‐arm circumference; MAMC: mid‐arm muscle circumference; MJ: mega joules; MMSE: Mini Mental State Examination; MNA: Mini Nutritional Assessment; NPIQ: Neuropyschiatric Inventory Question; PGCMS: Philadelphia Geriatric Centre Morale Scale; QOL: quality of life; RUD: reduction in use of health and social care scale; SF‐36: Short Form ‐ 36; SGA: subjective global assessment; SIP: sickness impact profile; TSF: triceps skinfold thickness

Appendix 9. Definition of endpoint measurement (II)

Functional status

Clinical function

Hospitalisation/
institutionalisation

Severe/serious adverse events

Economic costs

Barton 2000

Beck 2002

Bouillanne 2013

Handgrip strength, ADL score

Biochemical data

Bourdel‐Marchasson 2000

Pressure ulcer development

Brouillette 1991

Castellanos 2009

Chang 2005

Dennis 2005

Discharge destination

Duncan 2006

Length of stay in acute unit and in hospital (days)

Essed 2007

Essed 2009

Faxen‐Irving 2011

Serum/plasma proteins, serum lipids, fatty acid profiles, ADLs

Length of stay

Gaskill 2009

Germain 2006

Hankey 1993

Hickson 2004

Grip strength

Length of stay (d), volume of fluids given

Holyday 2012

Length of stay, readmissions

Estimated

Johansen 2004

Length of stay (LOS28) = LOS from admission to inclusion + LOS from inclusion to discharge (maximum 28 days)

LOS NDI = LOS 28 ‐ number of final days with NDI = 3)

NDI = index of mobility, infections and complications

Kraft 2012

Kretser 2003

iADL, ADL, dependence

Larsson 1990

Encompassed in the Modified Norton Scale

Leslie 2012

Yes

Lin 2010

Eating function (need for verbal and/or physical assistance or feeding + eating time)

Lin 2011

Eating function (need for verbal and/or physical assistance or feeding + eating time)

Mathey 2001a

Biochemical data

_

_

_

Mathey 2001b

Hunger, appetite and sensory perception

Munk 2014

Handgrip strength

Length of hospital stay

Nijs 2006

Motor function (nursing home physical performance test)

Olofsson 2007

Length of hospital stay

Pivi 2011

Biochemical data

Potter 2001

Functional recovery (20‐point Barthel ADL index)

Length of hospital stay, discharge placement

Remsburg 2001

Biochemical status

Salva 2011

ADL, iADL scores

MMSE, CDR, NPIQ

RUD score

Silver 2008

Simmons 2008

Simmons 2010

Cost‐effectiveness

Smolliner 2008

Handgrip strength, peak flow, Barthel score, SF‐36 (physical function only)

Splett 2003

Hospital admissions

Taylor 2006

Van den Berg 2015

Length of stay

Stated as none but not defined

Van Ort

Functional ability of participant

ADL: activities of daily living; AMC: arm muscle circumference; BMI: body mass index; CDC: Centre for Disease Control; CDR: clinical dementia rating scale; CHO: carbohydrate; d: day; EQ‐5D/EuroQol: European Quality of Life Scale; HGS: handgrip strength; iADL: instrumental Activities of Daily Living; MAC: mid‐arm circumference; MAMC: mid‐arm muscle circumference; MJ: mega joules; MMSE: Mini Mental State Examination; MNA: Mini Nutritional Assessment; NPIQ: Neuropyschiatric Inventory Question; PGCMS: Philadelphia Geriatric Centre Morale Scale; QOL: quality of life; RUD: reduction in use of health and social care scale; SF‐36: Short Form ‐ 36; SGA: subjective global assessment; SIP: sickness impact profile; TSF: triceps skinfold thickness

Appendix 10. Adverse events

Intervention(s) and comparator(s)

Deaths
(N/N (%))

Participants with
adverse events
(N/N (%))

Participants with
severe/serious adverse events
(N/N (%))

Participants discontinuing trial
due to adverse event
(N/N (%))

Barton 2000

I1: reduced portion fortified menu

I2: normal menu plus cooked breakfast

C: normal hospital menu

Beck 2002

I1: homemade oral supplement (A)

I2: homemade oral supplement (B)

C: usual diet

Bouillanne 2013

I: pulse diet (78% protein at lunch)

1/30 (3.3)

C: usual diet (protein distributed between meals)

1/36 (2.8)

Bourdel‐Marchasson 2000

I: oral supplementation + standard diet

25/295 (8.5)

C: standard diet

22/377 (5.8)

Brouillette 1991

I: osmotherapy + activities

1/10 (10)

C: activities only

0/10 (0)

Castellanos 2009

I1: fortified breakfast and lunch menu

I2: fortified lunch menu

C: usual menu

Chang 2005

I: training in feeding skills

C: no training

Dennis 2005

I: nutritional supplement + normal hospital diet

241/2016 (12)

138/4023 (3.4)

C: normal hospital diet

253/2007 (12.6)

Duncan 2006

I. dietetic assistant

19/145 (13.1)

C: usual care

36/157 (22.9)

Essed 2007

I1: monosodium glutamate

I2: flavour

I3: monosodium glutamate + flavour

C: maltodextrin

Essed 2009

I: monosodium glutamate + NaCl

C: usual hot meal

Faxen‐Irving 2011

I: 3 x 30 mL of fat emulsion daily

5/34 (14.7)

5/34 (14.7)

C: usual care

2/37 (5.4)

Gaskill 2009

I: nutrition education programme

C: usual care

Germain 2006

I: re‐formed foods

C: usual diet

Hankey 1993

I: oral nutritional supplement

3/10 (30)

C: standard hospital diet

3/10 (30)

Hickson 2004

I: feeding assistance

31/292 (10.6)

C: usual care

35/300 (11.7)

Holyday 2012

I: malnutrition care plan

1/72 (1.4)

C: usual care

4/72 (5.6)

Johansen 2004

I: nutrition team

C: usual care

Kraft 2012

I: oral nutritional supplement + telemedicine monitoring

2/13 (15.4)

C: usual care

Kretser 2003

I: modified meals on wheels

3/102 (2.9)

C: traditional meals on wheels

9/101 (8.9)

Larsson 1990

I: oral nutritional supplement plus normal hospital diet

29/197 (14.7)

C: normal hospital diet

56/238 (23.5)

Leslie 2012

I: energy enriched meals

2/19 (10.5)

C: usual care

5/22 (22.7)

Lin 2010

I1: spaced‐retrieval

I2: Montessori

C: usual care

Lin 2011

I: Montessori

C: usual care

Mathey 2001a

I: improved meal ambiance

7/21 (33.3)

C: usual care

5/17 (29.4)

Mathey 2001b

I: flavour enhancement

C: usual care

Munk 2014

I: energy and protein enriched foods provided via a la carte menu in addition to hospital food

1/44 (2.2)

C: usual care

1/40 (2.5)

Nijs 2006

I: family‐style meals

18/112 (16.1)

C: usual care

16/133 (12.0)

Olofsson 2007

I: multi‐component intervention (including nutrition)

9/102 (8.8)

C: usual care

13/97 (13.4)

Pivi 2011

I1: nutrition education

I2: oral nutritional supplements

C: usual care

Potter 2001

I: oral nutritional supplement + normal hospital diet

21/186 (11.3)

Reported "no serious adverse events"

C: normal hospital diet

33/195 (16.9)

Remsburg 2001

I: buffet‐style meals

C: usual care

Salva 2011

I: teaching and training

43/448 (9.6)

C: usual care

29/498 (5.8)

Silver 2008

I: fortified home‐delivered lunch

C: usual home‐delivered lunch

Simmons 2008

I: feeding assistance and/or snacks

C: usual diet

Simmons 2010

I1: snacks

I2: supplements

C: usual care

Smolliner 2008

I: fortified meals and snacks

2/31 (6.5)

C: usual diet

1/34 (2.9)

Splett 2003

I: medical nutrition therapy

C: usual care

Taylor 2006

I: 5‐meal menu

C: usual (3‐meal menu)

V an den Berg 2015

I1: 125 mL ONS twice daily with medication round

1/66 (1.5)

Reported "no serious adverse events"

11/88 (12.5) (refused further ONS)

I2: 62 mL ONS four times daily with medication round

2/80 (2.5)

9/66 (13.6) (refused further ONS)

C: usual care (125 mL ONS offered in between meals)

4/88 (4.5)

11/80 (13.8) (refused further ONS)

Van Ort 1995

I: contextual and behavioural intervention

C: usual care

C: comparator, I: intervention; ONS: oral nutritional supplement

Appendix 11. Survey of authors' providing information on trials

Trial author contacted

Trial author replied

Trial author provided data

Comments

Barton 2000

Yes

Yes

Yes

Additional data not used

Beck 2002

Yes

Yes

Yes

Additional data not used

Bourdel‐Marchasson 2000

Yes

Yes

Yes

Not used, and unable to provide data requested on weight

Bouillanne 2013

Yes

Yes

Yes

Data received on weight and energy intake

Brouillette 1991

No

N/A

N/A

Castellanos 2009

Yes

No

N/A

Chang 2005

Yes

No

N/A

Dennis 2005

Yes

Yes

Yes

Information used on complication rates

Duncan 2006

Yes

Yes

Yes

Awaiting data on length of stay

Essed 2007

Yes

No

N/A

Essed 2009

Yes

No

N/A

Faxen‐Irving 2011

Yes

Yes

Yes

Data on energy intake, length of stay, BMI and ADLs provided. No data available on infections

Gaskill 2009

Yes

Yes

No

Assume unable to provide data

Germain 2006

Yes

Yes

Yes

Data provided for BMI mean and SD of change

Hankey 1993

Yes

No

N/A

Hickson 2004

Yes

Yes

Yes

Author unable to provide this data on energy intake and hospital readmission as it was not measured, therefore not usable. Data provided on complications as requested

Holyday 2012

Yes

Yes

Yes

Data obtained and used for hospital readmission rates

Johansen 2004

Yes

No

N/A

Data not used

Kraft 2012

Yes

No

N/A

Kretser 2003

No

N/A

N/A

Unable to find contact for author

Larsson 1990

Yes

No

N/A

Data not used

Lin 2010

Yes

No

N/A

Lin 2011

No

N/A

N/A

Mathey 2001a

Yes

No

N/A

Mathey 2001b

Yes

No

N/A

Nijs 2006

No

N/A

N/A

Olofsson 2007

Yes

Yes

Yes

Data used for BMI, weight and complications

Pivi 2011

Yes

No

N/A

Potter 2001

Yes

No

N/A

Remsburg 2001

No

N/A

N/A

Salva 2011

Yes

No

N/A

Silver 2008

No

N/A

N/A

Simmons 2008

Yes

Yes

No

Data not available

Simmons 2010

Yes

Yes

No

Data not available

Smolliner 2008

Yes

Yes

Yes

Data provided for mean and SD of change for weight, BMI, handgrip, and QoL

Splett 2003

Yes

No

N/A

Taylor 2006

No

N/A

N/A

Van Ort 1995

Yes

No

N/A

Leslie 2012

No

N/A

N/A

Munk 2014

No

N/A

N/A

V an den Berg 2015

Yes

Yes

Yes

The clinical trial register number did not allow the trial to be identified within the register. The authors provided a link to the trial protocol via the WHO International Clinical Trials Registry Platform.

ADL: activities of daily living; BMI: body mass index; N/A: not applicable; QoL: (health‐related) quality of life; SD: standard deviation: WHO World Health Organisation

Appendix 12. Checklist to aid consistency and reproducibility of GRADE assessments

(1) All‐cause mortality

(2) Morbidity/complications:
number of participants with complications (any/pressure ulcers/needing oral antibiotics)

(3) Health‐related quality of life and patient satisfaction

(4) Hospitalisation and institutionalisation

(5) Adverse events

(6) Nutritional status (weight change)

(7) Economic costs

Trial limitations
(risk of bias)a

Was random sequence generation used (i.e. no potential for selection bias)?

Unclear

Unclear

Unclear

Yes

Unclear

Unclear

Unclear

Was allocation concealment used (i.e. no potential for selection bias)?

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

Was there blinding of participants and personnel (i.e. no potential for performance bias) or outcome not likely to be influenced by lack of blinding?

Unclear

Unclear

Unclear

No (↓)

Unclear

Unclear

No (↓)

Was there blinding of outcome assessment (i.e. no potential for detection bias) or was outcome measurement not likely to be influenced by lack of blinding?

Unclear

Unclear

No (↓)

Unclear

No (↓)

Unclear

No (↓)

Was an objective outcome used?

Yes

No (↓)

No (↓)

Yes

No (↓)

Yes

Yes

Were more than 80% of participants enrolled in trials included in the analysis (i.e. no potential reporting bias)?e

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Were data reported consistently for the outcome of interest (i.e. no potential selective reporting)?

Yes

Yes

Yes

Yes

Unclear

Yes

Yes

No other biases reported (i.e. no potential of other bias)?

Yes

Yes

No (↓)

Yes

Yes

Yes

No (↓)

Did the trials end up as scheduled (i.e. not stopped early)?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Inconsistencyb

Point estimates did not vary widely?

Yes

No (↓)

N/A

Yes

N/A

Yes

N/A

To what extent did confidence intervals overlap (substantial: all confidence intervals overlap at least one of the included studies point estimate; some: confidence intervals overlapped but not all overlapped at least 1 point estimate; no: at least 1 outlier: where the confidence interval of some of the studies did not overlap with those of most included studies)?

Substantial

Some

N/A

Substantial

N/A

Substantial

N/A

Was the direction of effect consistent?

Yes

No (↓)

N/A

Yes

N/A

Yes

N/A

What was the magnitude of statistical heterogeneity (as measured by I²) ‐ low (I² < 40%), moderate (I² 40%‐60%), high I² > 60%)?

Low

High (↓)

N/A

Moderate

N/A

Moderate

N/A

Was the test for heterogeneity statistically significant (P < 0.1)?

Not statistically significant

Statistically significant (↓)

N/A

Not statistically significant

N/A

Statistically significant (↓)

N/A

Indirectnessa

Were the populations in included studies applicable to the decision context?

Highly applicable

Highly applicable

Highly applicable

Highly applicable

Highly applicable

Highly applicable

Highly applicable

Were the interventions in the included studies applicable to the decision context?

Highly applicable

Highly applicable

Highly applicable

Highly applicable

Highly applicable

Highly applicable

Highly applicable

Was the included outcome not a surrogate outcome?

Yes

Yes

Yes and unclear

Yes

Yes

Yes

Yes

Was the outcome timeframe sufficient?

Sufficient

Sufficient

Sufficient

Sufficient

Sufficient

Sufficient

Sufficient

Were the conclusions based on direct comparisons?

Yes

Yes

N/A

Yes

Yes

Yes

Yes

Imprecisionc

Was the confidence interval for the pooled estimate not consistent with benefit and harm?

Yes

No (↓)

N/A

No (↓)

N/A

Yes

N/A

What is the magnitude of the median sample size (high: 300 participants, intermediate: 100‐300 participants, low: < 100 participants)?e

Intermediate to high

Intermediate

Intermediate

Intermediate

Intermediate

Low

Intermediate

What was the magnitude of the number of included studies (large: > 10 studies, moderate: 5‐10 studies, small: < 5 studies)?e

Large

Moderate

Moderate

Moderate

Small (↓)

Large

Small (↓)

Was the outcome a common event (e.g. occurs more than 1/100)?

Yes

Yes

N/A

N/A

Yes

N/A

N/A

Publication biasd

Was a comprehensive search conducted?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Was grey literature searched?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Were no restrictions applied to study selection on the basis of language?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

There was no industry influence on studies included in the review?

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

There was no evidence of funnel plot asymmetry?

Unclear

Unclear

N/A

Unclear

Unclear

Unclear

N/A

There was no discrepancy in findings between published and unpublished trials?

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

aQuestions on risk of bias are answered in relation to the majority of the aggregated evidence in the meta‐analysis rather than to individual trials
bQuestions on inconsistency are primarily based on visual assessment of forest plots and the statistical quantification of heterogeneity based on I²

cWhen judging the width of the confidence interval it is recommended to use a clinical decision threshold to assess whether the imprecision is clinically meaningful
dQuestions address comprehensiveness of the search strategy, industry influence, funnel plot asymmetry and discrepancies between published and unpublished trials
eDepends on the context of the systematic review area

(↓): key item for possible downgrading the quality of the evidence (GRADE) as shown in the footnotes of the 'Summary of finding' table(s); GRADE: Grading of Recommendations Assessment, Development and Evaluation; N/A: not applicable

original image
Figuras y tablas -
Figure 1

Study flow diagram
Figuras y tablas -
Figure 2

Study flow diagram

Risk of bias summary: review authors' judgements about each risk of bias item for each included trial.
Figuras y tablas -
Figure 3

Risk of bias summary: review authors' judgements about each risk of bias item for each included trial.

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included trials.
Figuras y tablas -
Figure 4

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included trials.

Forest plot of comparison: 1 Supportive interventions for enhancing dietary intake versus comparators, outcome: 1.2 Nutritional status (weight change) (kg)
Figuras y tablas -
Figure 5

Forest plot of comparison: 1 Supportive interventions for enhancing dietary intake versus comparators, outcome: 1.2 Nutritional status (weight change) (kg)

Forest plot of comparison: 1 Supportive interventions for enhancing dietary intake versus comparators, outcome: 1.4 All‐cause mortality
Figuras y tablas -
Figure 6

Forest plot of comparison: 1 Supportive interventions for enhancing dietary intake versus comparators, outcome: 1.4 All‐cause mortality

Comparison 1 Supportive interventions for enhancing dietary intake versus comparators, Outcome 1 No. of participants with complications.
Figuras y tablas -
Analysis 1.1

Comparison 1 Supportive interventions for enhancing dietary intake versus comparators, Outcome 1 No. of participants with complications.

Comparison 1 Supportive interventions for enhancing dietary intake versus comparators, Outcome 2 Nutritional status (weight change).
Figuras y tablas -
Analysis 1.2

Comparison 1 Supportive interventions for enhancing dietary intake versus comparators, Outcome 2 Nutritional status (weight change).

Comparison 1 Supportive interventions for enhancing dietary intake versus comparators, Outcome 3 Hospitalisation.
Figuras y tablas -
Analysis 1.3

Comparison 1 Supportive interventions for enhancing dietary intake versus comparators, Outcome 3 Hospitalisation.

Comparison 1 Supportive interventions for enhancing dietary intake versus comparators, Outcome 4 All‐cause mortality.
Figuras y tablas -
Analysis 1.4

Comparison 1 Supportive interventions for enhancing dietary intake versus comparators, Outcome 4 All‐cause mortality.

Summary of findings for the main comparison. Supportive interventions for enhancing dietary intake versus comparators in malnourished or nutritionally at‐risk adults

Supportive interventions compared with usual care for malnourished or nutritionally at‐risk adults

Population: malnourished or nutritionally at‐risk adults
Settings: residential care (21 trials), hospital (15 trials), outpatients (5 trials)
Intervention: supportive interventions for enhancing dietary intake (changes to the organisation of nutritional care, changes to the feeding environment, modification of meal profile or pattern, additional supplementation of meals, congregate and home meal delivery systems)
Comparison: usual care

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of participants
(trials)

Quality of the evidence
(GRADE)

Comments

Usual care

Supportive interventions

All‐cause mortality
Follow‐up: duration of hospital stay to 12 months

133 per 1000

107 per 1000 (92 to 124)

RR 0.78
(0.66 to 0.92)

6683 (12)

⊕⊕⊕⊝
moderatea

Morbidity/complications (number of participants with any medical complication)

Follow‐up: duration of hospital stay to 6 months

See comment

See comment

See comment

4015 (5)

⊕⊝⊝⊝
very lowb

No summary effect size calculated because of high inconsistency; RR ranged from 0.59 in favour of supportive interventions to 1.42 in favour of usual care

Health‐related quality of life and patient satisfaction

Follow‐up: duration of hospital stay to 12 months

See comment

See comment

See comment

4451 (5)

⊕⊕⊝⊝
lowc

5/41 trials investigated health‐related quality of life using different instruments in participants from a wide range of different clinical backgrounds; overall we noted no substantial differences between intervention and comparator groups

2/41 trials investigated patient satisfaction by means of an unvalidated questionnaire

Hospitalisation and institutionalisation (days)
Follow‐up: 8 days to 4 months

The mean hospitalisation ranged across control groups from 10 days to 40 days

The mean hospitalisation in the intervention groups was
0.5 days shorter (2.6 days shorter to 1.6 days longer)

667 (5)

⊕⊝⊝⊝
very lowd

3/5 trials with data on hospitalisation were in the group of trials of 'Changes to the organisation of nutritional care'

Adverse events

Follow‐up: 8 days to 6 months

See comment

See comment

See comment

4108 (3)

⊕⊝⊝⊝
very lowe

Only 3/41 trials reported on adverse events (all evaluating the impact of supplementation of meals with oral nutritional supplements); 1 trial reported intolerance to the supplement (diarrhoea, vomiting) in 3/34 (15%) of participants. In another large trial 565/2017 (28%) of stroke patients stopped taking the oral nutritional supplements because of refusal or dislike of taste

Nutritional status (weight change in kg)
Follow‐up: 8 days to 12 months

The mean weight change ranged across control groups from ‐3.0 kg to +0.3 kg

The mean weight change in the intervention groups was +0.6 kg higher (0.2 kg to 1.0 kg higher)

2024 (17)

⊕⊕⊕⊝
moderatef

Economic costs

Follow‐up: duration of hospital stay to 12 months

See comment

See comment

See comment

1152 (3)

⊕⊝⊝⊝
very lowg

3/41 trials evaluated and 2/41 trials reported some data on economic costs; none of the trials used accepted health economic methods and the reported data on both costs and effectiveness were generally poor

*The basis for the assumed risk (e.g. the median control group risk across trials) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: confidence interval; RR: risk ratio

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

*aAssumed risk was derived from the event rates in the comparator groups (usual care)

aDowngraded by one level because of risk of bias in several risk of bias domains
bDowngraded by three levels because of risk of bias in several risk of bias domains, serious inconsistency and imprecision
cDowngraded by two levels because of risk of bias in several risk of bias domains, indirectness and few trials investigating health‐related quality of life in substantially diverse trial populations
dDowngraded by three levels because of risk of performance bias and serious imprecision
eDowngraded by three levels because of risk of bias in several risk of bias domains, imprecision and general substandard reporting of adverse events in included trials
fDowngraded by one level because of imprecision
gDowngraded by three levels because of risk of bias in several risk of bias domains, imprecision and few trials investigating economic costs with poor reporting, not using accepted health economic methods

Figuras y tablas -
Summary of findings for the main comparison. Supportive interventions for enhancing dietary intake versus comparators in malnourished or nutritionally at‐risk adults
Table 1. Intervention subcategories

Supportive nutritional care intervention 

Broad intervention category

Examples

1. Changes to the organisation of nutritional care

  • Use of dietetic or healthcare assistants

  • Targeted staff training in nutritional care

  • Monitoring and documentation of nutritional care

  • Implementation of nutritional care pathways/protocols

  • Identification of nutritionally at‐risk individuals (e.g. red trays, mandatory nutrition screening)

2. Changes to the feeding environment

  • Changes to dining arrangements/style/setting

  • Protected meal times

  • Feeding assistance

3. Modification of meal profile or pattern

  • Changes to meal pattern (e.g. 5 small meals/day)

  • Manipulating energy/nutrient density of foods (e.g. food fortification

  • Changes to the taste, flavour, appearance of foods, or a combination

4. Additional supplementation of meals

  • Between‐meal snacks, drinks or both

  • Supplementation with oral nutritional supplements (e.g. routinely provided to entire ward, not individually prescribed)

5. Congregate and home meal delivery systems

  • Home meal delivery systems

  • Community lunch clubs

Figuras y tablas -
Table 1. Intervention subcategories
Table 2. Overview of study populations

Intervention(s) and comparator(s)

Screened/eligible
(N)

Randomised
(N)

ITT
(N)

Finishing trial
(N)

Randomised finishing trial
(%)

Follow‐up

Barton 2000a2
(modification of meal profile or pattern)

I1: reduced portion size, fortified menu

13

b

70c

56 days

I2: cooked breakfast

(8 not randomised)

C: normal hospital diet with usual portion size

14

total:

27a

Beck 2002a1
(additional supplementation of meals)

I1: homemade oral supplement (A)

2 months

I2: homemade oral supplement (B)

C: usual diet

total:

36

Bouillane 2013a1
(modification of meal profile or pattern)

I: 78% protein at lunch

30

30

88

6 weeks

C: usual diet (protein distributed between meals)

36

23

79

total:

66

63

96

Bourdel‐Marchasson 2000a3
(additional supplementation of meals)

I: 2 oral nutritional supplements

295

15 days or until hospital discharge

C: usual care

377

total:

672

Brouillette1991a1
(changes to the feeding environment)

I: osmotherapy + activities

10

9

90

4 weeks

C: activities only

10

7

70

total:

20

16

80

Castellanos 2009a2
(modification of meal profile or pattern)

I1: fortified breakfast and lunch menu

39

d

e

2 days of the study

I2: fortified lunch menu

39

C: usual menu

39

total:

39a

33

85

Chang 2005a3
(changes to the organisation of nutritional care)

I: training in feeding skills

31

12

60

Quote: "Data collection was from February 2004 to May 2004"

Comment: implies 4 months of data collection, following training but not clearly stated

C: no training

36

8

50

total:

67

20f

56

Dennis 2005a1
(additional supplementation of meals)

I: oral nutritional supplement + normal diet

2016

6 months

C: normal hospital diet

2007

total:

4023

Duncan 2006a1
(changes to the organisation of nutritional care)

I: dietetic assistant

363

153

145

95

4 months

C: usual care

165

157

95

total:

318

302

95

Essed 2007a4
(modification of meal profile or pattern)

I1: monosodium glutamate

19

N/A

16 weeks

I2: flavour

19

I3: monosodium glutamate + flavour

22

C: maltodextrin (placebo)

23

total:

97

83

86

Essed 2009a2
(modification of meal profile or pattern)

I: monosodium glutamate + NaCl

59

53

90

4 weeks

C: usual hot meal

59

53

90

total:

59a

53

90

Faxen‐Irving 2011a1
(additional supplementation of meals)

I: 30 mL of fat emulsion 3 x per day

107

34

24

71

Median 8 days

C: usual care

37

27

73

total:

71

51

72

Gaskill 2009a3
(changes to the organisation of nutritional care)

I: nutrition education programme

377

6 months

C: usual care

total:

352

Germain 2006a1
(modification of meal profile or pattern)

I: re‐formed foods

93

8

7

88

12 weeks

C: usual diet

9

8

89

total:

17

15

88

Hankey 1993a1
(additional supplementation of meals)

I: supplemented with nutritionally complete drink
in addition to normal hospital diet

10

7

70

8 weeks

C: standard hospital food

10

7

70

total:

20

14

70

Hickson 2004a1
(changes to the organisation of nutritional care)

I: feeding assistance

1776

292

292

250

86

Duration of hospital stay

C: usual care

300

300

259

86

total:

592

592

509

86

Holyday 2012a1
(changes to the organisation of nutritional care)

I: malnutrition care plan

71

71

71

100

Duration of hospital stay

C: usual care

72

72

72

100

total:

143

143

143

100

Johansen 2004a1
(changes to the organisation of nutritional care)

I: nutrition team

7468

108

N/A

Duration of hospital stay

C: usual care

104

total:

215

212

99

Kraft 2012a1
(changes to the organisation of nutritional care)

I: oral nutritional supplement + telemedicine monitoring

87/50

13

5

1

8

6 months

C: usual care

13

9

4

31

total:

26

14

5

19

Kretser 2003a1
(congregate and home meal delivery systems)

I: modified meals on wheels

324

102

26 weeks

C: traditional meals on wheels

101

total:

203

60

30

Larsson 1990a1
(additional supplementation of meals)

I: oral nutritional supplement + normal hospital diet

197

26 weeks

C: normal hospital diet

238

total:

435

Leslie 2012a3
(modification of meal profile or pattern)

I: energy enriched usual meals

445

22

16

73

12 weeks

C: usual care

19

16

84

total:

41

Lin 2010a3
(changes to the organisation of nutritional care)

I1: spaced‐retrievalg

32

8 weeks

I2: Montessorih

29

C: usual care

24

total:

85

82

97

Lin 2011a2, a3
(changes to the organisation of nutritional care)

I: Montessori

8 weeks

C: usual care

total:

29a

29

100

Mathey 2001aa3
(changes to the feeding environment)

I: improved meal ambiance

60

21

12

57

12 months

C: usual care

17

10

59

total:

38

22

58

Mathey 2001ba1
(changes to the feeding environment)

I: flavour enhancement

31

N/A

16 weeks

C: usual care

36

total:

71

67

94

Munk 2014a1
(modification of meal profile or pattern)

I: energy and protein enriched foods provided via a la carte menu in addition to hospital food

44

41

96

Duration of hospital stay

C: usual care

40

40

total:

84

Nijs 2006a3
(changes to the feeding environment)

I: family‐style meals

282

133

95

71

6 months

C: usual care

112

83

74

total:

245

178

73

Olofsson 2007a1
(changes to the organisation of nutritional care)

I: multi‐component intervention (including nutrition)

353

102

83

81

4 months

C: usual care

97

74

76

total:

199

157

79

Pivi 2011a1
(changes to the organisation of nutritional care)

I1: nutrition education

25

N/A

6 months

I2: oral nutritional supplements

26

C: usual care

27

total:

90

78

87

Potter 2001a1
(additional supplementation of meals)

I: oral nutritional supplement + normal hospital diet

618

186

186

100

Duration of hospital stay

C: normal hospital diet

195

195

100

total:

381

381

100

Remsburg 2001a1
(changes to the feeding environment)

I: buffet‐style meals

62

20

20

100

3 months

C: usual care

20

19

95

total:

40

39

98

Salva 2011a3
(changes to the organisation of nutritional care)

I: teaching and training

448

448

300

67

12 months

C: usual care

498

498

368

74

total:

946

946

668

71

Silver 2008a2
(modification of meal profile or pattern)

I: fortified home‐delivered lunch

7 months

C: usual home‐delivered lunch

total:

52

45

87

Simmons 2008a2, a3
(additional supplementation of meals)

I: feeding assistance and/or snacks

173

30

28

88

24 weeks

C: usual diet

34

32

94

total:

64a

60

94

Simmons 2010a1
(additional supplementation of meals)

I1: snacks

280

25

N/A

6 weeks

I2: additional supplementation of meals

18

C: usual care

20

total:

86

63

73

Smolliner 2008a3
(modification of meal profile or pattern)

I: fortified meals and snacks

295/92

22

N/A

12 weeks

C: usual diet

30

total:

65

52

80

Splett 2003a3
(changes to the organisation of nutritional care)

I: medical nutrition therapy

394

223

200

90

19‐180 days

C: usual care

171

164

96

total:

394

364

92

Taylor 2006a2
(modification of meal profile or pattern)

I: 5‐meal menu

66

2 periods of 4 days

C: usual (3‐meal menu)

total:

31a

31

100

Van den Berg 2015a1
(additional supplementation of meals

I1: offered 125 mL ONS daily with medication rounds

885

88

75

85

Maximum period 30 days

I2: offered 62 mL ONS daily with medication rounds

66

51

77

C: offered 125 mL ONS twice daily in between meals

80

66

83

total:

234

Van Ort 1995a1
(changes to the feeding environment)

I: contextual and behavioural intervention

8

1 month to 6 weeks

C: usual care

total:

8

7

88

Grand total

All interventionsj

All controlsj

All interventions and controls

10,681

a1Parallel RCT; a2cross‐over RCT; a3cluster RCT; a4 factorial RCT
bData presented on 19 participants who had at least 3 days on each menu
cOf those randomised to normal or fortified menu, not stated for those receiving cooked breakfast
dData analysed for 26 participants with complete data
eData were reported on 67% of those who consented
fData on knowledge and attitude of staff to nutrition available on all 67 staff. Data on actual practice at mealtimes from observation available on 20 staff
gMethod to enhance learning, retention and recall of information
hMethod capable of stopping or reducing residents' problem behaviours
iAssmumed 30 per group, two groups included in this review
jNo details because of substantial number of trials not providing data

C: comparator; I: intervention; ITT: intention‐to‐treat

Figuras y tablas -
Table 2. Overview of study populations
Table 3. Summary of outcomes reported in intervention category 1: changes to the organisation of nutritional care

Outcome measure

No. of studies
reporting outcome

No. of participants

Studies potentially with data for meta‐analysis

Energy intake

5

666

1

Health‐related quality of life

1

220

0

Patient satisfaction

2

1105

0

Complications

4

1263

3

Nutritional status: weight

10

2184

9

BMI

7

1537

6

TSF

3

536

3

MAC

3

568

3

Length of stay

5

1256

3

Hospital admission

1

143

1

Mortality

5

2182

5

Costs

2

1089

0

BMI: body mass index; MAC: mid‐arm circumference; TSF: triceps skinfold thickness

Figuras y tablas -
Table 3. Summary of outcomes reported in intervention category 1: changes to the organisation of nutritional care
Table 4. Summary of outcomes reported in intervention category 2: changes to the feeding environment

Outcome measure

No. of studies
reporting outcome

No. of participants
(treatment/control)

Studies with data for meta‐analysis

Energy intake

3

216

3

Health‐related quality of life

2

200

0

Nutritional status: weight

3

239

3

MAC

1

178

1

Clinical function

3

1664

2

Mortality

3

236

3

MAC: mid‐arm circumference

Figuras y tablas -
Table 4. Summary of outcomes reported in intervention category 2: changes to the feeding environment
Table 5. Summary of outcomes reported in intervention category 3: modification of meal profile or pattern

Outcome measure

No. of studies
reporting outcome

No. of participants

Studies potentially with data for meta‐analysis

Energy intake

11

506

7

Health‐related quality of life

1

52

0

Complications

1

66

1

Nutritional status:  weight

7

387

7

BMI

3

98

3

MAC

1

32

1

Clinical function

3

200

3

Length of stay

1

81

1

Mortality

4

243

4

BMI: body mass index; MAC: mid‐arm circumference

Figuras y tablas -
Table 5. Summary of outcomes reported in intervention category 3: modification of meal profile or pattern
Table 6. Summary of outcomes reported in intervention category 4: additional supplementation of meals

Outcome measure

No. of studies
reporting outcome

No. of participants

Studies potentially with data for meta‐analysis

Energy intake

8

1469

7

Health‐related quality of life

1

4023

0

Complications

2

4695

1

Nutritional status: weight

7

605

4

BMI

2

102

1

TSF

2

0

MAC

3

1

Clinical function

2

618

0

Length of stay

4

4689

1

Mortality

5

5745

5

Costs

1

63

0

BMI: body mass index; MAC: mid‐arm circumference; TSF: triceps skinfold thickness

Figuras y tablas -
Table 6. Summary of outcomes reported in intervention category 4: additional supplementation of meals
Table 7. Summary of outcomes reported in all interventions

Outcome measure

No. of studies
reporting outcome

No. of participants
(treatment/control)

Studies included in the meta‐analysis

Energy intake

27

2857

0

Health‐related quality of life

5

4495

0

Patient satisfaction

2

1105

0

Complications

7

6024

5

Nutritional status: weight

28

3618

24

BMI

12

1737

0

TSF

5

0

MAC

8

0

Clinical function

9

2746

0

Length of hospital stay

10

6026

5

Hospital admissions

2

389

0

Mortality

18

8690

17

Economic costs

3

1152

0

BMI: body mass index; MAC: mid‐arm circumference; TSF: triceps skinfold thickness

Figuras y tablas -
Table 7. Summary of outcomes reported in all interventions
Table 8. Reasons for contacting authors, and outcomes of contact with authors

Outcome

Reason the data were not usable

Contact with author

Outcome of contact with author

Action taken

1. Organisational change

Chang 2005

Energy intake

Data reported as amount eaten in ¼, ½, ¾

Yes

No response

Data reported in structured narrative summary

Duncan 2006

Complications

Reported as a median and IQR

Yes

Data provided

Data used

Length of stay

Reported as median and IQR

Yes

Confirmed data skewed

Data reported in structured narrative summary

Gaskill 2009

Measured prevalence of malnutrition with SGA

Not an outcome of interest for this review

Yes, to request weight data (a component of SGA)

Unable to provide data

Data not reported

Hickson 2004

Energy intake

Not measured at baseline, only at follow‐up

Yes, to confirm interpretation of data

Data not measured at baseline

Data reported in structured narrative summary

Complications (antibiotic prescription)

Reported as median and IQR

Yes, to request complications according to group allocation

No. complications according to group allocation was provided

Data reported in structured narrative summary

Hospital admission

States in protocol these are collected, but not reported

Yes, to request data

Author unable to recall what happened with data

Data not reported

Holyday 2012

Costs

An estimate based on local prices, not a complete cost analysis

No, judged unlikely to be available

N/A

Data not reported

Hospital admission

Presented as a frequency

Yes, to request total number of readmissions

Data provided

Data reported in structured narrative summary

Johansen 2004

Energy intake

Reported as kJ/kg/day

Yes, for mean change

No response

Data not reported

Kraft 2012

BMI

Presented as mean and SD at baseline and follow‐up, but no mean change

Yes

No response

Data not reported

Lin 2010

Energy intake

'Amount of each meal consumed' was reported as % eaten

Yes

No response

Data reported in structured narrative summary

Weight

Reported as mean and SD pre and post intervention/control

Yes, to request mean change

No response

Calculated mean change, and imputed the SD of change from Salva 2011

BMI

Reported as mean and SD pre and post intervention/control

Yes, to request mean change

No response

Calculated mean change, and imputed the SD of change from Salva 2011

Olofsson 2007

Weight

Reported as mean and SD pre and post intervention/control

Yes, to request mean change and SD

Data provided

Data reported in structured narrative summary

BMI

Reported as mean and SD pre and post intervention/control

Yes, to request mean change and SD

Data provided

Data reported in structured narrative summary

Complications

Reported as no. falls in men and women

Yes, to request total complications per group

Data provided

Data reported in structured narrative summary

Pivi 2011

Weight

Reported as mean and SD pre and post intervention/control

Yes, to request mean change

No response

Calculated mean change, and imputed the SD of change using the P value

BMI

Reported as mean and SD pre and post intervention/control

Yes, to request mean change

No response

Calculated mean change, and imputed the SD of change from Salva 2011

TSF

Reported as mean and SD pre and post intervention/control

Yes, to request mean change

No response

Calculated mean change, and imputed the SD of change from Salva 2011

MAC

Reported as mean and SD pre and post intervention/control

Yes, to request mean change

No response

Calculated mean change, and imputed the SD of change

Salva 2011

MAC

Methodology reported this was an outcome measured, but not reported in results

Yes

No response

Data not used

Costs

Described as data to be collected, but reported that analysis was not undertaken

No

Not reported

Splett 2003

Intake

Food intake is documented as a nutrition assessment activity

Yes, to request mean energy intake per group

Unable to provide data

Not reported

Weight

Methodology reports this was an outcome measured, but reported in a format not usable

Yes

Unable to provide data

Not reported

2. Feeding environment

Brouilette 1991

Energy

Reported pre and post intervention data, but no SD of change

No, as no author contact details and study published in 1991

N/A

Imputed the SD from Nijs 2006

Van Ort 1995

Weight change

No figures reported

Yes, to request data on mean and SD of change for each group

Waiting response

Not used

Intervention group clarification

Were the behavioural and contextual intervention received at the same time

Yes, to request this detail

Waiting response

Assumed the two interventions were given at the same time

3. Meal modification

Bouillanne 2013

Weight

Did not report weight, but assumed they had the data as Full Body Composition was used

Yes, to request data

Data provided

Data reported

Energy intake

Reported as kcal/kg/day

Yes, to request data

Data provided

Data reported

Hand grip strength

Reported data as mean/median and 95% CI of the median

Yes, to request data

Provided mean and SD of change

Data reported

ADL

Reported data as mean/median and 95% CI of the median

Yes, to request data

Data provided

Data reported

Castellanos 2009

Energy intake

Results were not analysed according to groups randomised, but regrouped subjects into small eaters and large eaters

Yes, to ask for data on mean and SD of change for each group

No response

Data reported

Germain 2006

BMI

They reported the mean BMI rather than mean change

Yes, for mean and SD of change

Data provided

Data reported

Smolliner 2008

Weight change

Reported mean and SD at baseline and end of intervention

Yes, for mean change and SD

Data provided

Data reported

BMI

Reported mean and SD at baseline and end of intervention

Yes, for mean change and SD

Data provided

Data reported

Handgrip strength

Reported mean and SD at baseline and end of intervention

Yes, for mean change and SD

Data provided

Data reported

health‐related quality of life

Reported mean and SD at baseline and end of intervention

Yes, for mean change and SD

Data provided

Data reported

4. Supplementation of meals

Beck 2002

Weight

Reported as median change with 95% CI

Yes, for mean change and SD

Response received but data not available

Data reported in structured narrative summary

Energy intake

Reported as median change with 95% CI

Yes, for mean change and SD

Response received but data not available

Data reported in structured narrative summary

Bourdel‐ Marchasson 2000

Pressure ulcers

Data given as percentage per group

Yes, for number per group

Data provided

Data reported in structured narrative summary

Weight

Data given for baseline only

Yes, for change in weight from baseline to follow‐up

Yes, author stated she did not find the analysis of discharge weight, probably due to the low quality of this data (too many missing data)

Data not reported

Dennis 2005

Complications

Data given as percentages

Yes for data on total complications per group

Data provided

Data reported in structured narrative summary

Health‐related quality of life score

Differences between means provided

Yes, to request mean and SD of changes

Unable to provide data, as EuroQol was only measured at follow‐up

Data reported in structured narrative summary

Faxen‐Irving 2011

Energy intake

Data given in a graph, no numbers available

Yes, for mean and SD of change in energy intake, between the control and intervention groups from baseline to the 2nd registration

Data provided

Data reported in structured narrative summary

Length of stay

Data provided at baseline, not follow‐up

Yes, for mean and SD

Data provided

Data reported in structured narrative summary

Infection

Data provided at baseline, not follow‐up

Yes, for mean and SD

Unable to provide data

Data not reported

BMI

Data provided at baseline, not follow‐up

Yes, for mean and SD

Data provided

Not reported in the summary because few studies measured this outcome

ADL

Data provided at baseline, not follow‐up

Yes, for mean and SD

Data provided

Not reported in the summary because few studies measured this outcome

Hankey 1993

Weight

Presented in graphs, no numbers given

Yes, for mean and SD

Unable to provide data but suggested using data from the review by Milne 2009 which included these data

Data obtained from systematic review by Milne 2009

MAC

Presented in graphs, no numbers given

Yes, for mean and SD

Unable to provide data but suggested using data from the review by Milne 2009 which included these data

Data obtained from systematic review by Milne 2009 but not reported as few studies measured this outcome

TSF

Presented in graphs, no numbers given

Yes, for mean and SD

Unable to provide data but suggested using data from the review by Milne 2009 which included these data

Not reported in the summary because few studies measured this outcome

Energy and protein intake

Presented in graphs, no numbers given

Yes, for mean and SD

Unable to provide data

Data not reported

Larsson 1990

Energy intake

Data included in Modified Norton Scale

Yes, data for change in energy intake between groups (mean and SD)

No response

Data not reported

Weight

Data provided as ‘weight index’

Yes, for change in weight between groups (mean and SD)

No response

Data not reported

TSF

Data provided as differences between men and women, and non‐PEM and PEM groups

Yes, for change between groups (mean and SD)

No response

Data not reported

MAC

Data provided as differences between men and women, and non‐PEM and PEM groups

Yes, for change between groups (mean and SD)

No response

Data not reported

Length of stay

Not given

Yes, for mean and SD between groups

No response

Data not reported

Total number of eligible participants

Unclear across all 4 duplicates of this study

Yes, for a clear number of randomised participants, no finishing study, and deaths

No response

Data not reported

Potter 2001

Length of stay

Provided as median with a range

Yes, for mean and SD between groups

No response

Data reported in structured narrative summary

ADL

Stated as an outcome measure in methodology, then not reported in results

Yes, for mean and SD between groups

No response

Not reported in the summary because few studies measured this outcome

BMI

Stated as an outcome measure in methodology, then not reported in results

Yes, for mean and SD between groups

No response

Not reported in the summary because few studies measured this outcome

TSF

Stated as an outcome measure in methodology, then not reported in results

Yes, for mean and SD between groups

No response

Not reported in the summary because few studies measured this outcome

Simmons 2008

Weight

Data presented as phase 1 and 2 cross‐over combined. The data from phase 1 was needed for this review

Yes, for the phase 1 data

Yes, responded but unable to provide data

Data reported in structured narrative summary

BMI

Data presented as phase 1 and 2 cross‐over combined. The data from phase 1 was needed for this review

Yes, for the phase 1 data

Yes, responded but unable to provide data

Not reported in the summary because few studies measured this outcome

Energy intake

Presented as pre‐ and post intervention

Yes, for mean and SD of change

Yes, responded but unable to provide data

Imputed SD from Nijs 2006

Simmons 2010

Energy

Reported as mean difference without the SD

Yes, requested SD for mean change

Yes, responded but unable to provide data

Imputed SD from Nijs 2006

5. Home meal delivery systems

Kretser 2003

Weight

Reported separately for participants at risk of malnutrition, and those malnourished

No, failed to find contact information for the author

N/A

Combined the mean change data using the formulae for combining groups

ADL: activities of daily living; BMI: body mass index; CI: confidence interval; EuroQol: European Quality of Life Scale; IQR: interquartile range; MAC: midarm muscle circumference; N/A: not applicable; PEM: protein‐energy malnutrition; SD: standard deviation; SGA: subjective global assessment; TSF: triceps skinfold thickness

Figuras y tablas -
Table 8. Reasons for contacting authors, and outcomes of contact with authors
Table 9. No. participants identified in each setting from included studies

Setting

No. participants
[N/N (%)]

No. studies

Hospital

7591/10,681 (71.1)

15

Residential care home

1731/10,681 (16.2)

21

Free‐living/outpatient setting

1305/10,681 (12.2)

5

Figuras y tablas -
Table 9. No. participants identified in each setting from included studies
Table 10. Effects of changes to the organisation of nutritional care on nutritional intake

Outcome

(N)

Results

P Value

Intervention

Control

Dietetic assistants (Hospital)

Duncan 2006

Mean (SD) energy intake (kcal/day)

275 (total N = 302)

1105 (361)

756 (399)

< 0.001

Hickson 2004

Between‐group difference (kcal)

37 (total N = 592)

89

0.538

Specialist training (residential care settings)

Chang 2005

% (SD) meals consumed

67

Pre: 90 % (22)

Post: 85 (25)

Pre: 78 % (34)

Post: 94 % (18)

0.49

Lin 2010

% (SD) meals consumed

85

Spaced retrieval (SR)

Pre: 85 % (11)

Post: 91 % (9)

Montessori (MON)

Pre: 75 % (23)

Post 78 % (10)

Pre: 79 % (19)

Post: 88 % (18)

SR vs control

= NS

MON vs control

< 0.05

Multi‐disciplinary team (hospital)

Johansen 2004

kcal/kg body weight per day (SE)

202 (total N = 212)

30 (SE 1)

25 (SE 1)

< 0.005

kcal: kilocalorie; SD: standard deviation; SE: standard error

Figuras y tablas -
Table 10. Effects of changes to the organisation of nutritional care on nutritional intake
Table 11. Effects of changes to organisation of nutritional care on health‐related quality of life, patient satisfaction and morbidity and complications

Outcome

(N)

Results

P Value

Intervention

Control

Patient satisfaction

Dietetic assistants (hospital)

Duncan 2006

Median score (IQR)

159

6.5 (2)

3.0 (4)

0.0001

Health‐related quality of life

Multi‐disciplinary team (hospital)

Johansen 2004

Change in physical score (SF‐36)

110

2.4 (1.3)

0.2 (1.5)

NS

Change in mental score (SF‐36)

110

2.2 (2.5)

3.3 (2)

NS

Number of complications

Dietetic assistants (hospital)

Duncan 2006

Total number of participants with complications

302

84/125 (67%)

79/130 (61%)

0.29

Hickson 2004

Number of participants receiving oral antibiotics

592

142/292 (49%)

150/300 (50%)

0.67

Multi‐disciplinary team (hospital)

Johansen 2004

Total number of participants with complications

212

34/108 (31%)

23/104 22%)

NS

Olofsson 2007

Total number of participants with complications

157

81/83 (98%)

74/74 (100%)

IQR: interquartile range; NS: not significant; SF‐36: short form‐36

Figuras y tablas -
Table 11. Effects of changes to organisation of nutritional care on health‐related quality of life, patient satisfaction and morbidity and complications
Table 12. Effects of changes to organisation of nutrition care on nutritional status

Outcome

(N)

Results

P Value

Intervention

Control

Dietetic assistants (hospital)

Duncan 2006

Mean change (SD)

Weight (kg)

MAC (cm)

TSF (mm)

(total N = 302)

170

230

205

‐0.36 (3.3)

‐0.9 (2.2)

‐0.88 (2.6)

‐1.0 (2.8)

‐1.3 (1.5)

‐1.23 (3.2)

0.16

0.002

0.087

Hickson 2004

Mean change (SD)

Weight (kg)

MAC (cm)

TSF (mm)

Median (IQR)

MAMC

BMI (kg/m²)

(total N = 592)

191

286

279

429

254

‐0.92 (2.71)

‐0.3 (1)

‐0.4 (1.8)

‐0.1 (‐0.8‐0.4)

‐0.04 (1.1)

‐0.9 (3)

‐0.3 (1)

‐0.4 (1.7)

‐0.1 (‐0.5‐0.3)

‐0.25 (1.18)

0.23

0.65

0.86

0.84

0.68

Specialist training (residential care settings)

Lin 2010

Mean change (SD)

Weight (kg)

BMI (kg/m²)

85

Spaced retrieval

‐0.07 (0.57)

Montessori

‐0.15 (0.57)

Spaced retrieval

0.1 (1.0)

Montessori

‐0.06 (1.0)

‐0.09 (0.57)

‐0.03 (1)

NS

NS

Lin 2011

BMI

29

‐0.26 (0.73)

‐0.09 (0.85)

0.245

Specialist training (free‐living individuals)

Pivi 2011

Mean change (SD)

Weight (kg)

MAC (cm)

TSF (mm)

BMI (kg/m²)

52

1.19 (imputed SD: 3.3)

1.87 (2)

2.3 (5.4)

1.19 (1)

‐2.2 (imputed SD: 3.3)

‐0.4 (0.46)

2.2 (5.3)

‐2.21 (1)

Reported as between‐group differences for 4 groups

Salva 2011

Mean change (SD)

Weight (kg)

BMI (kg/m²)

946

0.26 (0.7)

‐0.01 (2.2)

0.09 (0.5)

‐0.06 (3.2)

0.598

0.843

Multi‐disciplinary team (hospital)

Johansen 2004

Mean change (SD)

Weight (kg)

(total N = 212)

95

‐0.22 (3.9)

0.1 (2)

NS

Olofsson 2007

Mean change (SD)

Weight (kg)

BMI (kg/m²)

(total N = 199)

157

157

‐1.1 (3.6)

‐0.45 (1.3)

‐0.7 (3.8)

‐0.3 (1.5)

0.05

0.05

Protocol‐driven pathway (hospital)

Holyday 2012

Mean change (SD)

Weight (kg)

(total N = 143)

69

‐0.9 (3.6)

‐0.9 (2.3)

0.98

Protocol‐driven pathway (residential care settings)

Splett 2003

Weight

364

No wt loss at baseline: 95% maintained wt.

Wt loss at baseline: 48% maintained or gained wt.

No wt loss at baseline: 58% maintained wt.

Wt loss at baseline: 57% maintained or gained wt.

Telemedicine (free‐living individuals)

Kraft 2012

Mean change (SD)

Weight (kg)

BMI (kg/m²)

26

14

‐4.5 (7.9)

Baseline 24.5 (5.1)

Follow‐up 23.0 (4.2)

‐3 (6.2)

Baseline 23.9 (4.4)

Follow‐up 22.8 (4.3)

NS

NS

BMI: body mass index; IQR: interquartile range; MAC: mid‐arm circumference; MAMC: mid‐arm muscle circumference; NS: not significant; SD: standard deviation; TSF: triceps skinfold thickness; wt: weight

Figuras y tablas -
Table 12. Effects of changes to organisation of nutrition care on nutritional status
Table 13. Effects of changes to the organisation of nutritional care on handgrip strength

Outcome

(N)

Results

P Value

Intervention

Control

Handgrip strength

Dietetic assistants (Hospital)

Duncan 2006

Mean change (SD)

126 (total N = 302)

2.2 (10.7)

0.16 (11.8)

0.32

Hickson 2004

Median change (IQR) (kg)

(total N = 592)

0.8 (‐1.4 to 2.5)

0.7 (‐1.5 to 3)

0.85

IQR: interquartile range; SD: standard deviation

Figuras y tablas -
Table 13. Effects of changes to the organisation of nutritional care on handgrip strength
Table 14. Effects of changes to the organisation of nutritional care on hospitalisation, institutionalisation and death from any cause

Outcome

(N)

Results

P Value

Intervention

Control

Mortality

Dietetic assistants (Hospital)

Duncan 2006

4‐month mortality

(total N = 302)

19/145 (13%)

36/157 (23%)

0.036

Hickson 2004

In‐hospital mortality

(total N = 592)

31/292 (11%)

35/300 (12%)

0.69

Specialist training (free‐living individuals)

Salva 2011

12‐month mortality

946

43/448 (10%)

29/498 (6%)

NR

Multi‐disciplinary team (hospital)

Olofsson 2007

4‐month mortality

199

9/102 (9%)

13/97 (13%)

NR

Protocol‐driven pathway (hospital)

Holyday 2012

Not reported

143

1/72 (1%)

4/71 (6%)

0.21

Length of stay in hospital

Dietetic assistants (hospital)

Duncan 2006

Median (IQR) (days)

167

34 (48)

32 (49)

0.81

Hickson 2004

Median (IQR) (days)

592

21(13‐36)

23(14‐39)

0.41

Multi‐disciplinary team (hospital)

Johansen 2004

Mean (SD)

LOS to 28 days

197

11.6 (8)

11.5( 8)

NS

Olofsson 2007

Mean (SD) (days)

157

27.4 (15.9)

39.8 (41.9)

< 0.05

Protocol‐driven pathway (hospital)

Holyday 2012

Mean (SD) (days)

143

13.7 (11.8)

13.5 (11)

0.85

Hospital readmissions

Protocol‐driven pathway (hospital)

Holyday 2012

Number of readmissions at 6 months

30/71

37/72

NR

IQR: interquartile range; LOS: length of stay; SD: standard deviation

Figuras y tablas -
Table 14. Effects of changes to the organisation of nutritional care on hospitalisation, institutionalisation and death from any cause
Table 15. Effects of changes to the feeding environment on nutritional intake

Outcome

(N)

Results

P Value

Intervention

Control

Changes to the dining room environment

Mathey 2001

Mean change (SD) energy intake (kcal)

22

199 (406)

185( 247)

NR

Nijs 2006

Mean change (SD) energy intake (kcal)

178

116 (456)

‐100 (357)

Mean difference (95% CI)

178

235 (83‐268)

Described as significantly different

but no P value reported

Remsburg 2001

NR

Sensory stimulation

Brouillette 1991

Mean change (SD) in intake of lunch

meal (kcal)

16

‐1.6 (450)

11.14 (360)

0.49

CI: confidence interval; NR: not reported; SD: standard deviation

Figuras y tablas -
Table 15. Effects of changes to the feeding environment on nutritional intake
Table 16. Effects of changes to the feeding environment on health related quality of life

Outcome

(N)

Results

P Value

Intervention

Control

Changes to the dining room environment

Mathey 2001a

Sickness Impact Profile, mean change (SD) in score

16/2

‐2 (11)

‐13 (12)

NR

Nijs 2006

Overall QOL mean change (95% CI) in score

178

0.4 (‐1.8 to 2.5)

‐5 (‐9.4 to ‐0.6)

NR

Mean difference (95% CI)

178

6.1 (2.1 to 10.3)

Described as significantly different

but no P value reported

Physical performance, mean change (95% CI) in score

178

0.2 (‐2.3 to 2.7)

‐2.2 (‐4.1 to ‐0.4)

NR

Mean difference (95% CI)

178

3.2 0.9 to 5.5)

Described as significantly different

but no P value reported

CI: confidence interval; NR: not reported; QOL: quality of life; SD: standard deviation

Figuras y tablas -
Table 16. Effects of changes to the feeding environment on health related quality of life
Table 17. Effects of changes to the feeding environment on nutritional status

Outcome

(N)

Results

P Value

Intervention

Control

Weight

Changes to the dining room environment

Mathey 2001a

Mean change (SD) (kg)

22

3.3 (5)

‐0.4 (4)

I: < 0.05; C: 0.78

Nijs 2006

Mean change (SD) (kg)

178

0.5 (3.9)

‐1.1 (3.7)

NR

Mean difference (95% CI)

178

1.5 (0.6 to 2.4)

Described as significantly different

but no P value reported

Remsburg 2001

Mean change (SD) (kg)

39

‐0.11 (3.1)

0.32 (2.2)

0.638

C: control; I: intervention; NR: not recorded; SD: standard deviation

Figuras y tablas -
Table 17. Effects of changes to the feeding environment on nutritional status
Table 18. Effects of changes to the feeding environment on death from any cause

Outcome

(N)

Results

P Value

Intervention

Control

Changes to the dining room environment

Mathey 2001a

Mortality

38

7/21 (33%)

5/17 (29%)

NR

Nijs 2006

Mortality

178

18/112 (16%)

16/133 (12%)

NR

Sensory stimulation

Brouillette 1991

Mortality

20

1/10 (10%)

0/10 (0%)

NR

NR: not reported

Figuras y tablas -
Table 18. Effects of changes to the feeding environment on death from any cause
Table 19. Effects of modification to meals on nutritional intake

Outcome

(N)

Results

P Value

Intervention

Control

Fortification of food (studies in hospital)

Barton 2000

Total energy intake (kcal/d)

36

1711 (195)

1425 (136)

< 0.001

Munk 2014

Mean (SD) intake (kj/d)

81

5843 (1660)

5149 (1832)

Mean (95% CI) difference between groups

693 (‐80 to 1466)

0.08

Fortification of food (studies in residential care homes)

Leslie 2012

mean (SEM) change in energy intake (baseline to week

12) (kcal/d)

16

133 (89)

‐36 (84)

0.154

Food fortification (studies in free‐living individuals)

Silver 2008

Total energy intake (kcal/d)

45

1876 (543)

1423 (422)

< 0.001

Modifications to meal composition (studies in intermediate care)

Bouillane 2013

Change in energy intake (kcal)

63

50.9 (458)

39.2 (401)

NR

Modifications to meal delivery (studies in residential care homes)

Germain 2006

Change in energy intake (kcal)

15

611 (408)

81 (169)

0.03

Taylor 2006

Total energy intake (kcal/d)

31

1342 (177)

1325 (207)

0.565

Modifications to flavour (studies in residential care homes)

Essed 2007

Change in energy intake (kcal)

83

Flavour: ‐17 (445)

Flavour + MSG: 78 (352)

MSG: ‐32 (28)

102 (452)

NR

Essed 2009

Energy intake from modified meal (kcal)

53

420 (211)

424 (216)

0.896

Mathey 2001b

Change in energy intake (kcal)

67

‐50 (267)

‐115 (298)

Baseline to end of intervention I: NR, C: < 0.05

C: control; I: intervention; MSG: monosodium glutamate; NR: not recorded; SD standard deviation; SEM standard error of the mean; CI confidence interval

Figuras y tablas -
Table 19. Effects of modification to meals on nutritional intake
Table 20. Effects of modifications to meals on nutritional status

Outcome

(N)

Results

P Value

Intervention

Control

Weight and BMI (mean change (SD))

Fortification of food (studies in hospital)

Munk 2014

Mean (SD) within‐group change in

weight (kg)

66

0.4 (2.6)

‐0.4 (1.8)

0.17

Mean (95% CI) between‐group difference in

weight (kg)

‐0.8 (‐1.9 to 0.3)

Fortification of food (studies in residential care homes)

Leslie 2012

Mean (SD) within‐group weight change (kg)

31

1.3 (0.53)*

‐0.2 (1.5)**

*0.03

**0.536

Mean (SD) within‐group change in BMI (kg/m2)

31

0.5 (0.25)*

‐0.1 (0.4)**

*0.042

**0.517

Mean (SD) within‐group change in MUAC (mm)

32

0.4 (0.16)*

‐0.1 (0.3)**

*0.019

**0.691

Smolliner 2008

Mean (SD) change weight (kg)

52

2 (2.1)

1.6 (2)

NS

BMI change (kg/m²)

52

0.77 (1.5)

0.45 (1.1)

Between‐group

difference NS

Modifications to meal composition (studies in intermediate care)

Bouillanne 2013

Mean (SD) change weight (kg)

63

0.4 (2.3)

‐0.7 (3.1)

NR

Modifications to meal delivery (studies in residential care homes)

Germain 2006

Mean (SD) change weight (kg)

15

3.9 (2.3)

‐0.8 (4.2)

0.02

BMI change (kg/m²)

15

1.51 (1.16)

0.27 (1.46)

Data provided by

study author P value NR

Modifications to flavour (studies in residential care homes)

Essed 2007

Mean (SD) change weight (kg)

83

Flavour: 0.1 (2.4)

Flavour + MSG: ‐ 0.8 (3.3)

MSG: ‐ 0.7 (3.6)

0.1 (3.8)

NR

Mathey 2001b

Mean (SD) change weight (kg)

67

1.1 (1.3)

‐0.3 (1.6)

< 0.05

BMI: body mass index; CI: confidence interval; MSG: monosodium glutamate; MUAC: mid‐upper arm circumference; NR: not reported; NS: not significant; SD: standard deviation

Figuras y tablas -
Table 20. Effects of modifications to meals on nutritional status
Table 21. Effects of modifications to meals on clinical function, hospitalisation and death from any cause

Outcome

(N)

Results

P Value

Intervention

Control

Mortality

Fortification of food (studies in hospital)

Munk 2014

Mortality

81

1/44

1/40

NR

Fortification of food (studies in residential care homes)

Leslie 2012

Mortality

32

2/19

5/22

NR

Smolliner 2008

Mortality

65

2/31

1/34

NR

Modifications to meal composition (studies in intermediate care)

Bouillane 2013

Mortality

66

1/30 (3%)

1/36 (3%)

NR

Length of hospital stay

Fortification of food (studies in hospital)

Munk 2014

Days from study inclusion to discharge

81

10 (8)

10 (8)

0.73

Handgrip strength

Fortification of food (studies in hospital)

Munk 2014

Mean change (SD) baseline to day 3 (kg)

76

‐0.1 (2.9)

‐0.4 (4.3)

0.76

Mean difference (95% CI) between I & C

‐0.3 (‐1.9 to ‐1.4)

0.95

Fortification of food (studies in residential care homes)

Smolliner 2008

Mean change (SD) (kg)

61

‐0.81 (3.12)

‐1.29 (3)

NR

Modifications to meal composition (studies in intermediate care)

Bouillane 2013

Mean change (SD) (N)

63

‐0.5 (41.7)

14 (45.1)

0.411 (ANCOVA 0.271)

Bouillane 2013

Change in ADL score (mean (SD)

63

‐0.02 (1.6)

0.54 (1.7)

0.125 (ANCOVA 0.118)

ADL: activities of daily living; ANCOVA: analysis of covariance; N: Newtons; NR: not reported; SD: standard deviation

I: intervention; C: control

Figuras y tablas -
Table 21. Effects of modifications to meals on clinical function, hospitalisation and death from any cause
Table 22. Effects of supplementation of meals on nutritional intake

Outcome

(N)

Results

P Value

Intervention

Control

Supplementation with food (residential care homes)

Beck 2002

Change in energy intake (kcal/d) (median 95% CI)

16

‐24 (‐454 to 860)

24 (‐167 to 478)

NS

Simmons 2008

Change in energy intake kcal/ (mean SD)

64

302 (450)

127 (360)

Baseline to 6 months I: = 0.000; C: NS

Simmons 2010

Change in energy intake (mean SD)

43

‐65 (450)

67 (360)

NS

Supplementation with ONS (in hospital) (reported as mean (SD)

Bourdel‐Marchasson 2000

Total energy intake (kcal/d)

672

1188 (613)

1102 (503)

0.13

Faxen‐Irving 2011

Change in energy intake (kcal/d)

38

94 (350)

6.5 (358)

NR

Potter 2001

Total energy intake (kcal/d)

381

1409 (448)

1090 (417)

S

Van den Berg 2015

Mean (SD) energy intake from ONS (kcal/d)

192

I1:343 (172)*

I2: 469 (111)**

389 (162)

*0.289

**0.006

Supplementation with ONS (long‐term/residential care settings)

Hankey 1993

Total energy intake (kcal/d)

21

1747 (273)

1147 (310)

Baseline to wk 8, I: 0.01; C: NS

Simmons 2010

Change in energy intake

42

28 (450)

67 (360)

0.14

C: control; CI: confidence interval; I: intervention; NS: not significant; NR: not reported; ONS: oral nutritional supplement; S: significant; SD: standard deviation; wk: week

Figuras y tablas -
Table 22. Effects of supplementation of meals on nutritional intake
Table 23. Effects of supplementation of meals on health‐related quality of life, morbidity/complications

Outcome

(N)

Results

P Value

Intervention

Control

Incidence of pressure ulcers

Supplementation with ONS (in hospital)

Bourdel‐Marchasson 2000

Cumulative incidence at end of follow‐up (%)

Number of participants with pressure ulcers at day 15

672

40

101/295

48

164/37

NR

NR

Dennis 2005

Number of participants with pressure ulcers

4023

15/2016

26/2007

0.0507

Total complications

Supplementation with ONS (in hospital)

Dennis 2005

All in‐hospital complications

4023

515/2014 (26%)

448/2001 (22%)

NR

Health‐related quality of life

Supplementation with ONS (in hospital)

Dennis 2005

Utilitiy (median (IQR)) (EUROQoL)

3086

Median group difference 0.52 (0.03 to 0.74)

0.96

EUROQol: European Quality of Life Scale; IQR: interquartile range; NR: not reported; ONS: oral nutritional supplement

Figuras y tablas -
Table 23. Effects of supplementation of meals on health‐related quality of life, morbidity/complications
Table 24. Effects of supplementation of meals on nutritional status

Outcome

(N)

Results

P Value

Intervention

Control

Supplementation with food (residential care homes)

Beck 2002

Change in weight (median 95% CI)

16

1.3 (‐1 to 3)

1.5 (‐2.3 to 9)

NS

Simmonds 2008

Mean change (SD) weight (kg)

Mean (SD) change in BMI

64

The intervention group gained 4 lbs more

The intervention group gained 0.72 kg/m2 than the usual care

NR

NR

0.009

0.009

Simmonds 2010

Mean change (SD) weight (kg)

43

0.02 (1.1)

0.21 (1.7)

NS

Supplementation with ONS (in hospital)

Faxen‐Irving 2011

Mean change (SD) weight (kg)

Mean (SD) BMI at follow‐up (kg/m2)

38

38

0.13 (2.2)

20.4 (3.7)

‐0.95 (2.3)

20.4 (3.7)

21.9 (3.8)

NR

0.17

Potter 2001

Mean change in weight (kg)

Mean change (SD) MAC (cm)

381

381

0.4 (2.6)

‐0.1 (1.3)

‐0.5 (2.9)

‐0.4 (1.2)

0.003

NS

Supplementation with ONS (long‐term care settings)

Hankey 1993

Mean change (SD) weight (kg)

Mean change (SD) MAC

21

21

2.83 (10)

‐1 (10)

‐0.53 (10)

0.6 (10)

NR ‐ data from Milne 2009

NR data from Milne 2009

Simmons 2010

Mean change in weight (kg)

42

0.91 (2.3)

0.24 (1.96)

NS

BMI: body mass index; CI: confidence interval; MAC: mid‐arm circumference; NR: not reported; NS: not significant; ONS: oral nutritional supplement; SD: standard deviation

Figuras y tablas -
Table 24. Effects of supplementation of meals on nutritional status
Table 25. Effects of supplementation of meals on hospitalisation, institutionalisation and death from any cause

Outcome

(N)

Results

P Value

Intervention

Control

Mortality

Supplementation with ONS (in hospital)

Bourdel‐Marchasson 2000

Mortality

672

25/295 (8%)

22/377 (6%)

0.18

Dennis 2005

Mortality

4023

241/2016 (12%)

253/2007 (13%)

0.7

Potter 2001

Mortality

381

21/186 (11%)

33/195 (17%)

0.117

Supplementation with ONS (long‐term care settings)

Larsson 1990

Mortality

435

29/197 (15%)

56/238 (24%)

0.13

Length of stay

Supplementation with ONS (in hospital)

Faxen‐Irving 2011

Length of hospital stay (days)

51

10.5 (SD 5.6)

10.3 (SD 4.9)

NS

Dennis 2005

Length of hospital stay (days)

Median (IQR)

4023

16 (IQR 7–44)

16 (IQR 7–41)

NS

Potter 2001

Length of hospital stay (median (range))

381

16 (3‐141)

18 (2‐76)

0.31

Van den Berg 2015

Length of hospital stay (median (range))

234

I1: 10 (3‐63)

I2: 10 (3‐27)

11 (4‐71)

NR

Hospital readmissions & discharge destination

Supplementation with ONS (in‐hospital)

Potter 2001

Discharge to home

Discharge to institution

381

381

131/186

31/186

127/195

33/195

NS

Van den Berg 2015

Hospital readmissions

246

I1: 13

I2: 24

15

NR

IQR: interquartile range; NR not reported; NS: not significant; ONS: oral nutritional supplement

Figuras y tablas -
Table 25. Effects of supplementation of meals on hospitalisation, institutionalisation and death from any cause
Table 26. Effects of home meal delivery systems on nutritional status and death from any cause

Outcome

(N)

Results

P Value

Intervention

Control

Weight change

Kretser 2003

Mean change in weight (kg)

163

1.86 (5.3)

‐1,04 (5.2)

0.0062

Mortality

Kretser 2003

Mortality

203

3/102 (3%)

9/101 (9%)

NR

NR: not reported

Figuras y tablas -
Table 26. Effects of home meal delivery systems on nutritional status and death from any cause
Comparison 1. Supportive interventions for enhancing dietary intake versus comparators

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 No. of participants with complications Show forest plot

5

4702

Risk Ratio (M‐H, Random, 95% CI)

1.11 [0.86, 1.42]

1.1 Changes to the organisation of nutritional care

3

624

Risk Ratio (M‐H, Random, 95% CI)

1.12 [0.76, 1.67]

1.2 Modification of meal profile or pattern

1

63

Risk Ratio (M‐H, Random, 95% CI)

0.59 [0.06, 6.14]

1.3 Additional supplementation of meals

1

4015

Risk Ratio (M‐H, Random, 95% CI)

1.14 [1.02, 1.28]

2 Nutritional status (weight change) Show forest plot

17

2024

Mean Difference (IV, Random, 95% CI)

0.62 [0.21, 1.02]

2.1 Changes to the organisation of nutritional care

6

1140

Mean Difference (IV, Random, 95% CI)

0.09 [‐0.26, 0.45]

2.2 Changes to the feeding environment

1

39

Mean Difference (IV, Random, 95% CI)

‐0.43 [‐2.11, 1.25]

2.3 Modification of meal profile or pattern

5

253

Mean Difference (IV, Random, 95% CI)

1.16 [0.41, 1.92]

2.4 Additional supplementation of meals

4

475

Mean Difference (IV, Random, 95% CI)

0.90 [0.41, 1.38]

2.5 Congregate and home meal delivery systems

1

117

Mean Difference (IV, Random, 95% CI)

2.90 [1.00, 4.80]

3 Hospitalisation Show forest plot

5

667

Mean Difference (IV, Random, 95% CI)

‐0.48 [‐2.56, 1.59]

3.1 Changes to the organisation of nutritional care

3

515

Mean Difference (IV, Random, 95% CI)

‐2.08 [‐6.75, 2.58]

3.2 Modification of meal profile or pattern

1

81

Mean Difference (IV, Random, 95% CI)

0.0 [‐3.48, 3.48]

3.3 Additional supplementation of meals

1

71

Mean Difference (IV, Random, 95% CI)

0.20 [‐2.26, 2.66]

4 All‐cause mortality Show forest plot

12

6683

Risk Ratio (M‐H, Random, 95% CI)

0.78 [0.66, 0.92]

4.1 Changes to the organisation of nutritional care

4

1237

Risk Ratio (M‐H, Random, 95% CI)

0.71 [0.52, 0.97]

4.2 Changes to the feeding environment

1

20

Risk Ratio (M‐H, Random, 95% CI)

3.00 [0.14, 65.90]

4.3 Modification of meal profile or pattern

2

150

Risk Ratio (M‐H, Random, 95% CI)

1.04 [0.15, 7.22]

4.4 Additional supplementation of meals

4

5073

Risk Ratio (M‐H, Random, 95% CI)

0.77 [0.58, 1.02]

4.5 Congregate and home meal delivery systems

1

203

Risk Ratio (M‐H, Random, 95% CI)

0.33 [0.09, 1.18]

Figuras y tablas -
Comparison 1. Supportive interventions for enhancing dietary intake versus comparators