硬膜外疗法治疗非分娩女性的重度先兆子痫
Referencias
References to studies included in this review
References to studies excluded from this review
Additional references
References to other published versions of this review
Characteristics of studies
Characteristics of included studies [ordered by study ID]
Ir a:
| Methods | An open randomised, controlled trial with 2 comparison groups. | |
| Participants | Pregnant women at 30 weeks or above period of gestation with a diagnosis of severe pre‐eclampsia according to international criteria, platelet count more than 70.000/mm3, clotting time higher than 70%, without contraindications for the application of epidural block and a signed consent were included. There was a total 24 participants, 12 in each group (control and intervention). | |
| Interventions | Control group received: antihypertensives, plasma expanders, anticonvulsants, dypyridamole and corticosteroids. Intervention group received epidural therapy, plasma expanders, dypyridamole, anticonvulsants and corticosteroids. Epidural therapy consisted of bupivacaine 0.25%: 10 mg bolus followed by 5 mg/hour continuous epidural infusion during 6 hours. | |
| Outcomes | The outcomes assessed in the study were: mean arterial pressure; systolic arterial pressure; diastolic arterial pressure; Apgar score of neonate. | |
| Notes | Subsequently, all 24 women underwent caesarean section. Setting: Pre‐eclampsia‐Eclampsia Research Unit, Mother & Child Institute of the State of Mexico, Toluca Conflicts of interest: not mentioned Funding: not mentioned Dates of study: not mentioned | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Randomisation stated but method of sequence generation not stated. |
| Allocation concealment (selection bias) | High risk | Allocation concealment not described. Assumed not to be concealed. |
| Blinding of participants and personnel (performance bias) | High risk | Blinding of participants and personnel not possible. |
| Blinding of outcome assessment (detection bias) | Unclear risk | Blinding of assessment not stated but would probably not increase the bias as most of the outcomes (blood pressure measurements) assessed were objective. |
| Incomplete outcome data (attrition bias) | Low risk | All participants completed study. |
| Selective reporting (reporting bias) | Low risk | All outcomes reported. |
| Other bias | Low risk | No other biases could be identified. |
Characteristics of excluded studies [ordered by study ID]
Ir a:
| Study | Reason for exclusion |
| Study with a cross‐over design that primarily assessed the Doppler indices of vascular resistance in the uterine arteries (S|D, RI, PI) and the gestational age at delivery as a result of epidural blockade both as a on\off and as a dose–response effect. This study could not be included because it had a cross‐over design ("ACET Stage 1 was a 5 day dose‐ranging study with a randomised, double‐blind, cross‐over design"). | |
| Before and after study. Pregnant women at 26‐32 weeks of gestation with a diagnosis of severe pre‐eclampsia were included after informed consent. There was a total 27 participants. Cytokines levels were estimated and compared before and after the epidural therapy. |
Study flow diagram.
'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
